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Anorexic woman, 20, reveals how eating disorder gave her Lupus and left her with 'witch-like' fingers
Amy Lewis, 20, from Manchester, was told her hands might have to be amputated after lupus ravaged her immune system. (Source: the Mail online | Health)
Source: the Mail online | Health - September 5, 2013 Category: Consumer Health News Source Type: news

How DNA damage may trigger lupus erythematosus
Summer, sun and the sea - a dream vacation for most - can turn sour for those affected by lupus erythematosus. For them, absorption of the UV-light component in sunlight may cause florid inflammation and redness of the skin. Scientists of the University Hospital Bonn, Germany have now discovered which signaling pathway of the innate immune system promotes autoimmune symptoms following sun-induced DNA damage. The results are now published online in the academic journal Immunity... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 2, 2013 Category: Consumer Health News Tags: Lupus Source Type: news

Too old for acne?
Chicken pox? Lupus? Impetigo? Your dx? (Source: Consultant Live)
Source: Consultant Live - August 29, 2013 Category: Primary Care Source Type: news

Sunlight induced DNA crash
(University of Bonn) Summer, sun and the sea -- a dream vacation for most -- can turn sour for those affected by lupus erythematosus. For them, absorption of the UV-light component in sunlight may cause florid inflammation and redness of the skin. Scientists of the University Hospital Bonn, Germany have now discovered which signaling pathway of the innate immune system promotes autoimmune symptoms following sun-induced DNA damage. The results are now published online in the academic journal Immunity. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 29, 2013 Category: Global & Universal Source Type: news

Systemic Lupus Erythematosus (SLE) Epidemiology 2022 Forecasts in a...
This EpiCast report...(PRWeb August 27, 2013)Read the full story at http://www.prweb.com/releases/systemic-lupus-epicast/erythematosus-2022-report/prweb11064421.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - August 28, 2013 Category: Pharmaceuticals Source Type: news

Lupus Nephritis Linked to Defective Immune Control Gene Lupus Nephritis Linked to Defective Immune Control Gene
Patients with SLE who had variations in the gene encoding the ABIN1 protein were at increased risk for kidney damage; the NF-kB pathway might provide new treatment targets in lupus nephritis. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 27, 2013 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Gene variants identifed that may cause kidney problems in lupus patients
Variants in a particular gene are linked with an increased risk for kidney complications in patients with lupus, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings could lead to better treatments to protect the kidney health of patients with the disease. Lupus is an autoimmune disease that affects many different body systems, including the central nervous system, joints, skin, heart, lungs, and kidneys... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 26, 2013 Category: Consumer Health News Tags: Lupus Source Type: news

Gene Variations Tie Lupus to Nephritis (CME/CE)
(MedPage Today) -- Lupus nephritis was more common in individuals of European or African-American descent with particular gene variants, researchers found. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - August 24, 2013 Category: Primary Care Source Type: news

Kidney Disease in Lupus Is Not Always 'Lupus Nephritis'Kidney Disease in Lupus Is Not Always 'Lupus Nephritis'
Kidney disease in lupus is not always lupus nephritis. A kidney biopsy will help determine appropriate management. Arthritis Research & Therapy (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 23, 2013 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Baseline Factors Predict Lupus Flares (CME/CE)
(MedPage Today) -- Patients with systemic lupus erythematosus who had renal involvement and high autoantibody titers were at consistently high risk for disease flares while on conventional treatment, a post-hoc analysis determined. (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - August 1, 2013 Category: Rheumatology Source Type: news

Nephritis May Raise Death Risk in Lupus (CME/CE)
(MedPage Today) -- The presence of renal involvement in patients with lupus was associated with a significantly increased mortality risk, a longitudinal Chinese study found. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - July 31, 2013 Category: Primary Care Source Type: news

British Watchdog Rejects GSKs Lupus Drug AgainBritish Watchdog Rejects GSKs Lupus Drug Again
Britain's healthcare cost watchdog has rejected GlaxoSmithKline's lupus drug belimumab (Benlysta) a second time after the company offered an undisclosed discount, saying it still failed to offer good value for money. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 24, 2013 Category: Consumer Health News Tags: Rheumatology News Source Type: news

British watchdog rejects GSK's lupus drug again
LONDON (Reuters) - Britain's healthcare cost watchdog has rejected GlaxoSmithKline's lupus drug Benlysta a second time after the company offered an undisclosed discount, saying it still failed to offer good value for money. (Source: Reuters: Health)
Source: Reuters: Health - July 24, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

New functions identified for autoimmune disease 'risk' gene
Researchers at the University of Minnesota have identified infection-fighting and inflammation-suppressing functions for a gene associated with human autoimmune disease. The discovery, centered on a gene known as PTPN22, could set into motion new treatment approaches for autoimmune diseases like lupus, rheumatoid arthritis and type 1 diabetes. The key to these advances may lie with a better understanding of how a variant of PTPN22, known as a "risk variant," impacts autoimmune disease development and the behavior of myeloid cells that act as the body's "first responders... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 24, 2013 Category: Consumer Health News Tags: Immune System / Vaccines Source Type: news

U of M researchers identify new functions for autoimmune disease 'risk' gene
(University of Minnesota Academic Health Center) Researchers at the University of Minnesota have identified infection-fighting and inflammation-suppressing functions for a gene associated with human autoimmune disease. The discovery, centered on a gene known as PTPN22, could set into motion new treatment approaches for autoimmune diseases like lupus, rheumatoid arthritis and type 1 diabetes. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 19, 2013 Category: Global & Universal Source Type: news

Lupus Nephritis Tamed Without Steroids (CME/CE)
(MedPage Today) -- A combination regimen of rituximab (Rituxan) and mycophenolate mofetil (CellCept) successfully controlled lupus nephritis in 90% of patients without the need for oral corticosteroids, a prospective observational study found. (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - July 18, 2013 Category: Rheumatology Source Type: news

Case Links Chemo to Cutaneous Lupus
(MedPage Today) -- A patient who developed subacute cutaneous lupus erythematosus during chemotherapy adds to a small but growing literature linking multiple chemotherapeutic agents to the skin disorder. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - July 10, 2013 Category: Hematology Source Type: news

Upstate student is one of only 4 in U.S. to receive special fellowship to study lupus
Hans Kim will use nuclear magnetic resonance spectroscopy to get close-up look of lupus cells as he searchers for disease biomarkers, which may aid in the early detection of the disease and earlier treatment. (Source: SUNY Upstate Medical)
Source: SUNY Upstate Medical - July 8, 2013 Category: Universities & Medical Training Source Type: news

Women With Lupus Seem at Higher Risk for Hip Fractures
Study followed nearly 15,000 patients for 6 years (Source: WebMD Health)
Source: WebMD Health - July 5, 2013 Category: Consumer Health News Source Type: news

Women With Lupus Seem at Higher Risk for Hip Fractures
Title: Women With Lupus Seem at Higher Risk for Hip FracturesCategory: Health NewsCreated: 7/4/2013 10:35:00 AMLast Editorial Review: 7/5/2013 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - July 5, 2013 Category: Rheumatology Source Type: news

Women with Lupus Seem at Higher Risk for Hip Fractures
Study followed nearly 15,000 patients for 6 years Source: HealthDay Related MedlinePlus Pages: Fractures, Hip Injuries and Disorders, Lupus (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - July 4, 2013 Category: Consumer Health News Source Type: news

Low Vitamin D Linked with Worse Lupus (CME/CE)
(MedPage Today) -- Patients with systemic lupus erythematosus (SLE) who had low levels of vitamin D and received supplementation reduced their likelihood of having high disease activity, a large longitudinal study found. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - July 3, 2013 Category: Primary Care Source Type: news

What Causes Lymphocytosis?
Discussion Lymphocytes are an important part of the cellular and humoral immunity. Absolute lymphocyte count (ALC) is usually used to determine ranges of normal for lymphocytes. The ALC is higher in neonates and young children (up to 8000 cells/microL) but in those> 12 years of age is normally> 4000 cells/microL. Lymphopenia is usually defined as
Source: PediatricEducation.org - June 24, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

Ocrelizumab for Active Proliferative Lupus NephritisOcrelizumab for Active Proliferative Lupus Nephritis
Ocrelizumab does not significantly improve active proliferative lupus nephritis, but it does increase the rate of serious infections in some patients, according to the BELONG study. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 19, 2013 Category: Consumer Health News Tags: Rheumatology News Source Type: news

UCB Announces New Results From Phase 2b Open-Label Extension Study Evaluating The Long-Term Effects Of Epratuzumab In SLE
UCB have announced new data from an open-label extension (SL0008) of the EMBLEM™ phase 2b study evaluating the long-term effects of epratuzumab treatment in adult patients with moderate-to-severe systemic lupus erythematosus (SLE). The primary outcome of the open-label extension was to assess the safety of epratuzumab in patients with SLE.4 Relative to the 12 week, double-blind, placebo-controlled EMBLEM™ study, data from the open-label, long-term extension identified no new safety or tolerability signals... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 15, 2013 Category: Consumer Health News Tags: Lupus Source Type: news

UCB announces results of Phase IIb lupus study of epratuzumab
Global biopharmaceutical company UCB has announced positive results from its Phase IIb open-label extension study of epratuzumab, which is being developed to treat systemic lupus erythematosus (SLE) or lupus. (Source: Drug Development Technology)
Source: Drug Development Technology - June 13, 2013 Category: Pharmaceuticals Source Type: news

Systemic lupus, folie a trois and homicide - Caribé AC, Daltro-Oliveira R, Araújo RH, Cardoso AP, Guimarães PB, Miranda-Scippa A, Quarantini LC.
Folie a trois is a syndrome characterized by the transfer of delusional ideas from one person to two other persons. This condition rarely ends in the murder of any involved and we are unaware of where the primary case had the diagnosis of acute psychosis i... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - June 3, 2013 Category: Global & Universal Tags: Jurisprudence, Laws, Legislation, Policies, Rules Source Type: news

Update on the Treatment of Lupus NephritisUpdate on the Treatment of Lupus Nephritis
What are the latest treatment strategies for lupus nephritis? Are there any new therapies available to treat the disease? Current Opinion in Nephrology and Hypertension (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 28, 2013 Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news

Running Out of Lupus Drug Options: A CaseRunning Out of Lupus Drug Options: A Case
Jonathan Kay reports the case of a woman who is proving to be intolerant of lupus treatments. Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 21, 2013 Category: Consumer Health News Tags: Rheumatology Commentary Source Type: news

What Causes Spontaneous Pneumothorax?
Discussion “A pneumothorax is a collection of air in the pleural space, and it can be categorized into spontaneous, traumatic or iatrogenic. Spontaneous pneumothorax can be further classified into primary with no clinical evidence of underlying lung disease or secondary due to pre-existing lung disease.” Spontaneous pneumothorax is a condition that is relatively rare in pediatrics. There is a bimodal age distribution – neonates and late adolescence. It is caused by tearing of the visceral pleural. Clinical signs include chest pain, dyspnea, tachycardia, tracheal deviation towards contralateral side, hypot...
Source: PediatricEducation.org - May 20, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

Paper-Thin Device Performs Pulse Wave Monitoring in a Tiny Package
Engineers at Stanford developed a tiny new sensor that is capable of monitoring the pulse with impressive resolution. About the size of a postage stamp, the device can be worn under a bandage on one of the body spots where a pulse is easily felt.The flexible pressure-sensitive organic thin film transistors inside the device feature “maximum sensitivity of 8.4 kPa−1, a fast response time of 15,000 cycles and a low power consumption of
Source: Medgadget Anesthesiology - May 15, 2013 Category: Anesthesiology Authors: Editors Tags: Anesthesiology Cardiology Critical Care Diagnostics Medicine Source Type: news

OGT Marks World Lupus Day With Announcement Of Novel Biomarker Panel To Support Earlier SLE Diagnosis
Superior sensitivity and specificity compared to current laboratory tests Oxford Gene Technology (OGT), provider of innovative genetics research and biomarker solutions to advance molecular medicine, has today announced the development of a novel autoantibody biomarker panel for improved diagnosis of systemic lupus erythematosus (SLE). The panel has been developed in partnership with King's College London, utilising OGT's proprietary protein array platform technology... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 14, 2013 Category: Consumer Health News Tags: Lupus Source Type: news

A New Era in Lupus TherapyA New Era in Lupus Therapy
Dr. Ronald van Vollenhoven reviews the state of small-biologic therapies in the treatment of systemic lupus erythematosus. Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 7, 2013 Category: Consumer Health News Tags: Rheumatology Expert Column Source Type: news

Conveyco Launches “Likes for LUPUS”
Goal is to raise awareness of LUPUS and funds for LUPUS research during the month of May.(PRWeb May 01, 2013)Read the full story at http://www.prweb.com/releases/2013/5/prweb10683380.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - May 2, 2013 Category: Pharmaceuticals Source Type: news

Steroids at High Doses Raise CV Risk in Lupus (CME/CE)
(MedPage Today) -- BIRMINGHAM, England -- Use of high-dose steroids by lupus patients, even in very early disease, was associated with higher risk for metabolic syndrome and may influence long-term cardiovascular risk, researchers reported. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - April 24, 2013 Category: Cardiology Source Type: news

Lupus Drugs in Pregnancy Won't Harm Offspring (CME/CE)
(MedPage Today) -- BIRMINGHAM, England -- Treatment of pregnant women with systemic lupus erythematosus using conventional agents did not appear to influence the health or behavior of their children, a researcher said here. (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - April 24, 2013 Category: Pediatrics Source Type: news

New genomics center will study rheumatoid arthritis and lupus with $5.6 million grant
(Hospital for Special Surgery) Hospital for Special Surgery in New York City has received a $5.6 million grant from The Tow Foundation to establish the Hospital for Special Surgery Genomics Center. The new center will apply genomic approaches to study two autoimmune diseases, rheumatoid arthritis and systemic lupus erythematosus, with the aim of developing more effective therapies. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 24, 2013 Category: Global & Universal Source Type: news

What Causes Spontaneous Pneumothorax?
Discussion “A pneumothorax is a collection of air in the pleural space, and it can be categorized into spontaneous, traumatic or iatrogenic. Spontaneous pneumothorax can be further classified into primary with no clinical evidence of underlying lung disease or secondary due to pre-existing lung disease.” Spontaneous pneumothorax is a condition that is relatively rare in pediatrics. There is a bimodal age distribution – neonates and late adolescence. It is caused by tearing of the visceral pleural. Clinical signs include chest pain, dyspnea, tachycardia, tracheal deviation towards contralateral side, hypot...
Source: PediatricEducation.org - April 22, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

Study Illuminates Biology Behind Promising Therapy for Graft-versus-host Disease
In a study published in the journal Science Translational Medicine, the researchers detail how low doses of the drug interleukin-2 (IL-2) can alleviate chronic graft-versus-host disease (GVHD), a debilitating condition that often occurs in patients who have received a stem cell transplant. In patients with chronic GVHD, donor immune cells launch an attack on healthy tissue. IL-2 is so versatile at restoring immune system balance, the researchers found, that it may eventually become a primary treatment for chronic GVHD and may even hold promise for treating autoimmune diseases, such as rheumatoid arthritis and lupus, which ...
Source: Kidney Cancer Association - April 15, 2013 Category: Cancer & Oncology Source Type: news

Lupus Hits Hardest Among Poor (CME/CE)
(MedPage Today) -- Systemic lupus erythematosus disproportionately affects individuals of lower socioeconomic status, who not only have greater prevalence of disease but who also face difficulties in access to care, an analysis of Medicaid data showed. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - March 1, 2013 Category: Primary Care Source Type: news

Takeda And Resolve Therapeutics Enter Autoimmune Partnership
Takeda Pharmaceutical Company Limited ("Takeda") andResolve Therapeutics, LLC("Resolve") today jointly announced that they have entered into a partnership to develop compounds for the treatment of lupus (also known as Systemic Lupus Erythematosus, or SLE) and other autoimmune diseases. (Source: Pharmaceutical Online News)
Source: Pharmaceutical Online News - March 1, 2013 Category: Pharmaceuticals Source Type: news

JCI early table of contents for Mar. 1, 2013
(Journal of Clinical Investigation) The following release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Mar. 1, 2013, in the JCI: Coordinating adaptive responses to cardiac stress; A nanogel-based therapy for the treatment of lupus; and many more. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 1, 2013 Category: Global & Universal Source Type: news

A nanogel-based treatment for lupus
(Journal of Clinical Investigation) In this issue of the Journal of Clinical Investigation, Tarek Fahmy and colleagues at Yale University report the development of a nanogel-based delivery system that targets an immunosuppressive drug (mycophenolic acid) directly to tissues associated with immune cells. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 1, 2013 Category: Global & Universal Source Type: news

Takeda and Resolve Therapeutics Enter Autoimmune Partnership
Partners to Develop Novel Nuclease Proteins for Lupus   OSAKA, Japan and SEATTLE, Feb. 27, 2013 /PRNewswire/ -- Takeda Pharmaceutical Company Limited ("Takeda") and Resolve Therapeutics, LLC ("Resolve") today jointly announced that they... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 28, 2013 Category: Pharmaceuticals Source Type: news

What Causes Constipation?
Discussion Constipation generally is defined as infrequent or painful defecation. Constipation can be very disturbing to the patient and family who believe the stools are too infrequent, too hard or too difficult to pass. Most children develop constipation after the child begins to associate pain (e.g. a hard bowel movement) with defecation. The child then begins to withhold the stools trying to decrease the defecation discomfort. As stool withholding continues, the rectum dilates and gradually accommodates with the normal defecation urge disappearing. Passing large hard stools infrequently reinforces the defecation pain. ...
Source: PediatricEducation.org - February 25, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

New Enzyme Discovered That Acts As Innate Immunity Sensor
Two studies by researchers at UT Southwestern Medical Center could lead to new treatments for lupus and other autoimmune diseases and strengthen current therapies for viral, bacterial, and parasitic infections. The studies identify a new enzyme that acts as a sensor of innate immunity - the body's first line of defense against invaders - and describe a novel cell signaling pathway. This pathway detects foreign DNA or even host DNA when it appears in a part of the cell where DNA should not be... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 19, 2013 Category: Consumer Health News Tags: Lupus Source Type: news

Researchers reveal new enzyme that acts as innate immunity sensor
Two studies by UT Southwestern researchers could lead to new treatments for lupus and other autoimmune diseases and strengthen current therapies for viral, bacterial, and parasitic infections. (Source: UT Southwestern Medical Center News)
Source: UT Southwestern Medical Center News - February 16, 2013 Category: Hospital Management Source Type: news

UTSW researchers identify new enzyme that acts as innate immunity sensor
(UT Southwestern Medical Center) Two studies by researchers at UT Southwestern Medical Center could lead to new treatments for lupus and other autoimmune diseases and strengthen current therapies for viral, bacterial, and parasitic infections. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 15, 2013 Category: Global & Universal Source Type: news

Horizon scanning: Development of tabalumab for rheumatoid arthritis halted
Source: Reuters Health Area: News Eli Lilly and Co have halted development of the experimental anti-B-cell activating (BAFF) human monoclonal antibody tabalumab for rheumatoid arthritis following data from a late-stage trial which showed the drug was unlikely to prove effective.   Tabalumab will continue to be tested in late-stage development as a treatment for systemic lupus erythematosus, and in mid-stage development for multiple myeloma. (Source: NeLM - News)
Source: NeLM - News - February 8, 2013 Category: Drugs & Pharmacology Source Type: news

Lilly Discontinues Phase 3 Rheumatoid Arthritis Program for Tabalumab Based on Efficacy Results
Decision not based on safety concerns; Phase 3 lupus program continues as planned INDIANAPOLIS, Feb. 7, 2013 /PRNewswire/ -- Eli Lilly and Company (NYSE:LLY) announced today that it will discontinue the Phase 3 rheumatoid arthritis (RA)... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 7, 2013 Category: Pharmaceuticals Source Type: news