Cutaneous Lupus Erythematosus: An UpdateCutaneous Lupus Erythematosus: An Update
What is the current understanding regarding the immunopathogenesis of cutaneous lupus erythematosus? Read about the latest efforts to define CLE, as well as available treatments, in this update. American Journal of Clinical Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 13, 2016 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

Fertility treatments may impact on breast cancer risk
Infertility and hormonal fertility treatments appear to increase density of breast tissue Related items from OnMedicaNHS must stop restricting IVF treatment, NICE saysPersonalised test could fine tune IVF treatmentCo-morbidities prove large risk factor for maternal deathsBlood test identifies high-risk lupus pregnancies (Source: OnMedica Latest News)
Source: OnMedica Latest News - April 12, 2016 Category: UK Health Source Type: news

Well: Ask Well: Why Is Arthritis More Common in Women Than Men?
More women than men get arthritis over all, but there are many types of arthritis, and some types are more common in men. (Source: NYT)
Source: NYT - April 12, 2016 Category: American Health Authors: RONI CARYN RABIN Tags: Ask Well Arthritis Rheumatoid Arthritis Autoimmune Diseases Lupus Erythematosus Women and Girls Live Featured Aging Osteoarthritis Source Type: news

Well: Ask Well: Why Is Arthritis More Common in Women Than Men?
More women than men get arthritis over all, but there are many types of arthritis, and some types are more common in men. (Source: NYT Health)
Source: NYT Health - April 12, 2016 Category: Consumer Health News Authors: RONI CARYN RABIN Tags: Ask Well Arthritis Rheumatoid Arthritis Autoimmune Diseases Lupus Erythematosus Women and Girls Live Featured Aging Osteoarthritis Source Type: news

Well: Ask Well: Why Is Arthritis More Common in Women Than Men?
More women than men get arthritis over all, but there are many types of arthritis, and some types are more common in men. (Source: NYT)
Source: NYT - April 12, 2016 Category: Nutrition Authors: RONI CARYN RABIN Tags: Ask Well Arthritis Rheumatoid Arthritis Autoimmune Diseases Lupus Erythematosus Women and Girls Live Featured Aging Osteoarthritis Source Type: news

Researchers find new clue in lupus autoantibody production
(Penn State) A signaling molecule called interferon gamma could hold the key to understanding how harmful autoantibodies form in lupus patients. The finding could lead to new treatments for the chronic autoimmune disease, said researchers at Penn State College of Medicine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 12, 2016 Category: Global & Universal Source Type: news

CV Risks Up in Cutaneous Lupus (CME/CE)
(MedPage Today) -- Chance of cerebrovascular events three times higher versus controls (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - April 6, 2016 Category: Primary Care Source Type: news

Distinguishing SLE and Fibromyalgia by Complement ActivationDistinguishing SLE and Fibromyalgia by Complement Activation
Read how testing for cell-bound complement activation products can help establish an accurate diagnosis for SLE. Lupus Science & Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 6, 2016 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Are Lupus & Bipolar Disorder Related?
Nervous system problems caused by Lupus and SLE parallel those of bipolar disorder and may be treated the same, but do not indicate a diagnosis of bipolar. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - April 1, 2016 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Cutaneous lupus may raise risk of stroke, TIA
The higher risk of cardiovascular morbidity and mortality that has been repeatedly observed among patients with systemic lupus erythematosus (SLE) may extend only to stroke and transient ischemic attack among patients with disease limited to the skin and not to ischemic heart disease, heart... (Source: Skin and Allergy News)
Source: Skin and Allergy News - March 31, 2016 Category: Dermatology Source Type: news

Cutaneous lupus may raise risk of stroke, TIA
The higher risk of cardiovascular morbidity and mortality that has been repeatedly observed among patients with systemic lupus erythematosus (SLE) may extend only to stroke and transient ischemic... (Source: Clinical Neurology News)
Source: Clinical Neurology News - March 31, 2016 Category: Neurology Source Type: news

Orencia: Try Again in Lupus? (CME/CE)
(MedPage Today) -- Benefits seen for articular symptoms (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - March 31, 2016 Category: Primary Care Source Type: news

Great American Smokeout Stands Out Among 'Awareness Days'
THURSDAY, March 31, 2016 -- Health-focused awareness days dot the calendar each year. There's World Health Day, World Dolphin Day, World Lupus Day and hundreds more. Whether they actually boost action on specific health issues isn't clear,... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - March 31, 2016 Category: Journals (General) Source Type: news

Kirsty Keep who begged to go to Dignitas told chemo may have been wrong
Kirsty Keep, 23, of Maidstone, Kent, was diagnosed with lupus and treated with chemotherapy. But doctors now say she may have a genetic skin and bone disorder instead. (Source: the Mail online | Health)
Source: the Mail online | Health - March 30, 2016 Category: Consumer Health News Source Type: news

An Open Letter to the Boston Globe About Lyme Disease
Today, the Boston Globe editorial board spoke out against a bill "that would require insurers in Massachusetts to cover Lyme disease treatments for as long as a doctor says they're needed." The Globe writes: Lawmakers may have good intentions, but they don't possess the expertise to decide whether it's beneficial, cost-efficient, or safe, to keep using strong medicines to treat a condition the medical establishment doubts is real. Such questions should be resolved by a consensus of doctors and researchers -- and buttressed by convincing clinical date [sic] -- not determined by legislative mandate. Who among the B...
Source: Healthy Living - The Huffington Post - March 28, 2016 Category: Consumer Health News Source Type: news

Benlysta Found Steroid-Sparing in Lupus (CME/CE)
(MedPage Today) -- Modest effects in prednisone dose reduction seen in post-hoc analyses (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - March 26, 2016 Category: Primary Care Source Type: news

Targeting Interferon Shows Promise in Lupus (CME/CE)
(MedPage Today) -- Sifalimumab effective in a phase IIb trial, particularly for skin manifestations (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - March 25, 2016 Category: Rheumatology Source Type: news

Lupus patients’ transition to adult care leaves gaps, delays in care
Patients with childhood-onset systemic lupus erythematosus (SLE) who transitioned to adult care without a formal transitioning process had long periods without care despite having moderate disease... (Source: Pediatric News)
Source: Pediatric News - March 25, 2016 Category: Journals (General) Source Type: news

Claims that man flu 'really exists' are unsupported
Conclusion This small laboratory study points to specific biological mechanisms that might explain why women are more likely to suffer autoimmune disorders, such as SLE, than men. It found the second silenced copy of the X chromosome in women can be partially reactivated and express immune-related genes, instead of staying completely silent. Though this is a plausible reason for the overactive immune system found in SLE, it does not explain why men can also have the condition. Also, only SLE was investigated in this study and with blood samples from just five children with the condition. It is not clear at this stage how...
Source: NHS News Feed - March 23, 2016 Category: Consumer Health News Tags: Lifestyle/exercise Medical practice Source Type: news

Regulatory B Cell Processes Appear Aberrant in LupusRegulatory B Cell Processes Appear Aberrant in Lupus
Disruption of the processes that govern the differentiation of immature B cells into regulatory B cells (Bregs) that restrain inflammation may contribute to the pathogenesis of systemic lupus erythematosus (SLE). Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - March 22, 2016 Category: Pathology Tags: Rheumatology News Source Type: news

Penn vet study identifies mechanism explaining female bias in autoimmunity
(University of Pennsylvania) Possessing two X chromosomes is a double-edged sword, immunologically speaking. Females are better at fighting off infection than males, but they are also more susceptible to many autoimmune conditions, such as lupus. A new study published in Proceedings of the National Academy of Sciences and led by researchers from the University of Pennsylvania now offers the first mechanistic explanation for why this is the case. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - March 21, 2016 Category: Global & Universal Source Type: news

Getting a leg up on bone comorbidities in lupus
MAUI, HAWAII – Patients with systemic lupus erythematosus (SLE) really need to be placed on bone protection therapy as soon as they start on corticosteroids because their risks of steroid-related... (Source: Clinical Endocrinology News)
Source: Clinical Endocrinology News - March 19, 2016 Category: Endocrinology Source Type: news

Precision medicine's potential to define the genetics of autoimmune disease
Demonstrating the potential of precision medicine, an international study used next-generation DNA sequencing technology to identify more than 1,000 gene variants that affect susceptibility to systemic lupus erythematosus (SLE). (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 18, 2016 Category: Science Source Type: news

Study shows precision medicine's potential to define the genetics of autoimmune disease
(UT Southwestern Medical Center) Demonstrating the potential of precision medicine, an international study based at UT Southwestern Medical Center used next-generation DNA sequencing technology to identify more than 1,000 gene variants that affect susceptibility to systemic lupus erythematosus (SLE). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 18, 2016 Category: Global & Universal Source Type: news

Healthy IVF Egg Produces Offspring With LupusHealthy IVF Egg Produces Offspring With Lupus
Neonatal lupus can develop even when the newborn has not inherited a genetic susceptibility to autoimmunity from the mother, California-based researchers report. Reuters Health Information (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - March 17, 2016 Category: Dermatology Tags: Dermatology News Source Type: news

Lupus study highlights importance of B cells
A new study has been published that could shed additional light on the factors that come into play for individuals who go on to develop lupus.   Carried out by senior researcher Claudia Mauri, professor of immunology at University College London in the UK, the study showed that some of the body's own anti-inflammatory B cells may be maturing in the wrong way in individuals with lupus - meaning they are actively creating inflammation, rather than fighting it.   These cells play an important part in the body's immune response system, managing the number of antibodies that are produced to fight infection. Ho...
Source: Arthritis Research UK - March 17, 2016 Category: Rheumatology Source Type: news

Pneumovax Falls Short in Lupus (CME/CE)
(MedPage Today) -- Fewer than a third of patients had a four-fold increase in anti-pneumococcal IgG (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - March 13, 2016 Category: Infectious Diseases Source Type: news

Lupus Lipids Improve With Combo Tx (CME/CE)
(MedPage Today) -- Treatment with pravastatin and ezetimibe also benefited endothelial function (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - March 12, 2016 Category: Primary Care Source Type: news

Study Suggests Causes for Lupus' Impact on Immune System
Title: Study Suggests Causes for Lupus' Impact on Immune SystemCategory: Health NewsCreated: 3/8/2016 12:00:00 AMLast Editorial Review: 3/9/2016 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - March 9, 2016 Category: Rheumatology Source Type: news

Xencor begins Phase II trials of XmAb5871 for IgG4-related disease and SLE
US-based Xencor has started a Phase II trial of its drug candidate XmAb5871 in patients with IgG4-related disease (IgG4-RD), as well as patients with systemic lupus erythematosus (SLE). (Source: Drug Development Technology)
Source: Drug Development Technology - March 9, 2016 Category: Pharmaceuticals Source Type: news

What Causes Lupus' Impact on Immune System?
Certain cells seem to malfunction and create inflammation instead of fighting the disease, research say (Source: WebMD Health)
Source: WebMD Health - March 8, 2016 Category: Consumer Health News Source Type: news

Study Suggests Causes for Lupus' Impact on Immune System
Certain cells seem to malfunction and create inflammation instead of fighting the disease, research say Source: HealthDay Related MedlinePlus Page: Lupus (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - March 8, 2016 Category: Consumer Health News Source Type: news

Study Suggests Causes for Lupus' Impact on Immune System
Certain cells seem to malfunction and create inflammation instead of fighting the disease, research say (Source: U.S. News - Health)
Source: U.S. News - Health - March 8, 2016 Category: Consumer Health News Source Type: news

Study Suggests Causes for Lupus' Impact on Immune System
TUESDAY, March 8, 2016 -- Scientists have found new clues that help explain what's going wrong in the immune systems of people with lupus -- insight they hope will lead to new therapies, or help guide current treatment choices. Lupus has several... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - March 8, 2016 Category: Journals (General) Source Type: news

Casting a 'NET' to Find New Therapies for LupusCasting a 'NET' to Find New Therapies for Lupus
Dr Deane discusses a study that first examined the role of neutrophil extracellular traps in lupus pathophysiology, and then evaluated metformin to reduce disease flares in a proof-of-concept trial. Medscape Rheumatology (Source: Medscape Rheumatology Headlines)
Source: Medscape Rheumatology Headlines - March 3, 2016 Category: Rheumatology Tags: Rheumatology Viewpoint Source Type: news

Nick Cannon Looks Back On His 'Super Scary' Lupus Diagnosis
Nick Cannon didn't know anything about lupus nephritis when he was first diagnosed in 2012, so hearing that some of his other health complications were the result of the autoimmune disease came as a surprise. It was only after Cannon did some research on the condition, which had resulted in kidney failure and blood clots in his lungs, that he began to understand and take care of his well-being. Now he hopes his story encourages others to do the same. "[Y]ou realize that this is something that you can live with and actually overcome with the proper research and with the proper support system," he told HuffPos...
Source: Healthy Living - The Huffington Post - February 24, 2016 Category: Consumer Health News Source Type: news

Kirsty Keep left in agony for a decade is desperate to find a cure for her symptoms
Kirsty Keep, 23, of Maidstone, Kent, has been diagnosed with the autoimmune condition lupus, where her immune system attacks healthy cells, tissue and organs. (Source: the Mail online | Health)
Source: the Mail online | Health - February 23, 2016 Category: Consumer Health News Source Type: news

Response to Belimumab Among Patients With SLEResponse to Belimumab Among Patients With SLE
Does belimumab reduce SLE disease activity in real-world clinical practice? Lupus Science & Medicine (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - February 23, 2016 Category: Pathology Tags: Rheumatology Journal Article Source Type: news

Researchers uncover potential target for treating autoimmune disease
A molecule that appears to be a cause of autoimmune diseases such as lupus has been identified by a group of researchers. Elevated levels of the molecule allow self-reactive immune cells to escape into the blood stream and attack the body's own tissues. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 22, 2016 Category: Science Source Type: news

Lyme: The Infectious Disease Equivalent of Cancer, Says Top Duke Oncologist
Last week, I mentioned the case of Dr. Neil Spector, whose long-undiagnosed Lyme Disease resulted in irreversible heart failure and ultimately, a heart transplant. Dr. Spector, author of Gone in a Heartbeat: A Physician's Search for True Healing, is the Sandra Coates Associate Professor of Medicine and Associate Professor of Pharmacology and Cancer Biology at Duke University School of Medicine. As the Director of Developmental Therapeutics at the Duke Cancer Institute, he's a leader in applying translational research to the clinical development of molecularly targeted personalized cancer therapies. Here, Dr. Spector share...
Source: Science - The Huffington Post - February 19, 2016 Category: Science Source Type: news

Lupus Affects Pregnancy Outcome Even Before Diagnosis Lupus Affects Pregnancy Outcome Even Before Diagnosis
Pregnancy-related complications and poor infant outcomes were higher in women with lupus and in women with preclinical SLE. Medscape Medical News (Source: Medscape ObGyn and Womens Health Headlines)
Source: Medscape ObGyn and Womens Health Headlines - February 16, 2016 Category: OBGYN Tags: Rheumatology News Source Type: news

Lupus and Pregnancy: When Is the Highest Risk? (CME/CE)
(MedPage Today) -- Study suggests preclinical disease has worse pregnancy outcome, but an expert disagrees (Source: MedPage Today OB/GYN)
Source: MedPage Today OB/GYN - February 4, 2016 Category: OBGYN Source Type: news

ESRD in Lupus: A Work in Progress? (CME/CE)
(MedPage Today) -- Declines in disease risk seen since the 1970s, but recent stats have leveled off (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - February 3, 2016 Category: Rheumatology Source Type: news

Highlights from 2015
Your achievements A massive thank you to everyone who ran, hosted coffee mornings and bake sales, jumped out of planes and trekked across the country and indeed the world to fundraise for us. More than 1,300 of you took on a challenge or donated your time and fundraising skills in 2015. Together, you raised over £780,000! If you’d like to join Team A in 2016 and help raise money for our work, have a look at our events or contact localfundraising@arthritisresearchuk.org Improving care for people with arthritis In 2015 we continued to support healthcare professionals to provide the best care to people with art...
Source: Arthritis Research UK - February 3, 2016 Category: Rheumatology Source Type: news

Lupus Raises Mortality by 67%; Young Adults at Highest Risk Lupus Raises Mortality by 67%; Young Adults at Highest Risk
Patients with systemic lupus erythematosus frequently die of circulatory system disease or cancer, just like patients without lupus, but at younger ages, according to a new analysis. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 2, 2016 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Axis I psychiatric disorders high in skin-restricted lupus patients
The prevalence of psychiatric disorders is high among people with skin-restricted lupus (SRL), compared with the general population, yet most do not receive specialist mental health care or appropriate psychotropic treatment, researchers report. Investigators led by psychiatrist Isabelle... (Source: Skin and Allergy News)
Source: Skin and Allergy News - January 31, 2016 Category: Dermatology Source Type: news

Skin Less Affected in Late-Onset Lupus (CME/CE)
(MedPage Today) -- Dermal symptoms less common with SLE onset past age 50 (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - January 30, 2016 Category: Dermatology Source Type: news

Researchers discover ten new lupus genes in Asian population study
10 new genes associated with the autoimmune disease lupus have been identified by researchers. One gene in particular, known as GTF2I, showed a high likelihood of being involved in the development of lupus, say scientists. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 25, 2016 Category: Science Source Type: news

The Real Reason You Get Sick After A Stressful Period Has Ended
Have you ever wondered how you manage to get through a particularly stressful period – whether it's an intense deadline at work, final exams in school or a spate of holiday houseguests – only to get sick after the stress has lifted? It's not a fluke. It's a phenomenon that's often referred to as "the let-down effect," a pattern in which people come down with an illness or develop flare-ups of a chronic condition not during a concentrated period of stress but after it dissipates, explains psychologist Marc Schoen, an assistant clinical professor of medicine at th...
Source: Healthy Living - The Huffington Post - January 24, 2016 Category: Consumer Health News Source Type: news

Antibody Signals Adverse Pregnancy Outcome (CME/CE)
(MedPage Today) -- Lupus anticoagulant was the only antiphospholipid antibody linked with poor birth outcome (Source: MedPage Today OB/GYN)
Source: MedPage Today OB/GYN - January 22, 2016 Category: OBGYN Source Type: news