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Antibody Signals Adverse Pregnancy Outcome (CME/CE)
(MedPage Today) -- Lupus anticoagulant was the only antiphospholipid antibody linked with poor birth outcome (Source: MedPage Today OB/GYN)
Source: MedPage Today OB/GYN - January 22, 2016 Category: OBGYN Source Type: news

Mitochondrial troublemakers unmasked in lupus
Mitochondria could provoke the inflammation characteristic of lupus, an autoimmune disorder affecting the joints, skin, heart and brain. Byproducts of cells' power stations goad certain white blood cells into making mesh traps as a precursor to cell death. Mitochondrial DNA is spewed out, triggering a warning and a response that can damage various organ tissues. Mouse studies suggest this disease mechanism might respond to potential drug therapies. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 21, 2016 Category: Science Source Type: news

Assessing the Inhibitory Activity of Oligonucleotides on TLR7 Sensing
Aberrant sensing of self-nucleic acids by Toll-like receptor (TLR) 7, 8, or 9 is associated with several autoimmune disorders, including systemic lupus erythematosus (SLE), rheumatoid arthritis, psoriasis, or systemic sclerosis. In recent years, several classes of synthetic oligonucleotides have been shown to antagonize sensing of immunostimulatory nucleic acids by TLR7/8/9, indicating that these molecules could have therapeutic applications in such autoimmune diseases. Conversely, synthetic oligonucleotides used in therapeutic technologies such as antisense and microRNA inhibitors also have the potential to inhibit TLR7/8...
Source: Springer protocols feed by Immunology - January 7, 2016 Category: Allergy & Immunology Source Type: news

Toll-Like Receptor-Dependent Immune Complex Activation of B Cells and Dendritic Cells
High titers of autoantibodies reactive with DNA/RNA molecular complexes are characteristic of autoimmune disorders such as systemic lupus erythematosus (SLE). In vitro and in vivo studies have implicated the endosomal Toll-like receptor 9 (TLR9) and Toll-like receptor 7 (TLR7) in the activation of the corresponding autoantibody producing B cells. Importantly, TLR9/TLR7-deficiency results in the inability of autoreactive B cells to proliferate in response to DNA/RNA-associated autoantigens in vitro, and in marked changes in the autoantibody repertoire of autoimmune-prone mice. Uptake of DNA/RNA-associated autoantigen immune...
Source: Springer protocols feed by Immunology - January 7, 2016 Category: Allergy & Immunology Source Type: news

Insider’s guide to care: Doctors and dogs
Olivia and Dayton Olivia Burgess knows every nook and cranny of Boston Children’s Hospital. The 13-year-old and her parents have traveled from their home in Bermuda to Boston since Olivia was three years old for ongoing treatments for systemic onset juvenile rheumatoid (idiopathic) arthritis and pediatric lupus. “The unpredictable and severe nature of Olivia’s condition and the frequent travel required for medical treatment can be stressful at times,” says her mother Traci. Olivia sees providers in multiple departments: cardiology, nephrology, pulmonology, dermatology, neurology, gastroenterology an...
Source: Thrive, Children's Hospital Boston - January 4, 2016 Category: Pediatrics Authors: Lisa Fratt Tags: Our Patients’ Stories Fatma Dedeoglu juvenile rheumatoid arthritis Marybeth Son Pawprints Program pediatric lupus rheumatology program Robert Geggel Sitaram Emani Source Type: news

ACR: Actual-weight hydroxychloroquine dosing works in SLE, up to a point
SAN FRANCISCO – Hydroxychloroquine (Plaquenil) dosing based on actual body weight – instead of ideal weight – is appropriate for patients with systemic lupus erythematosus (SLE), according to a review of... (Source: Skin and Allergy News)
Source: Skin and Allergy News - December 30, 2015 Category: Dermatology Source Type: news

Definition of remission for lupus patients 'may need refining'
A new international study has highlighted the need for the clinical definition of remission for lupus (SLE) patients to be further refined. The study, led by Germany's Heinrich-Heine University and involving the UK's Royal Blackburn Hospital, suggested that many systemic lupus erythematosus (SLE) patients deemed to be in remission still experience a range of debilitating symptoms. Data for 1,227 patients was drawn from a multinational real-world survey of patients with SLE, consulting rheumatologists and nephrologists in France, Germany, Italy, Spain and the UK. The team compared the reported symptom burden as recorded by...
Source: Arthritis Research UK - December 18, 2015 Category: Rheumatology Source Type: news

Dog DNA study reveals the incredible journey of man's best friend
Descended from the grey wolf, domesticated dogs have been companions to humans for about 33,000 years, a genetic study has shownMan’s proverbial first best friend was probably a grey wolf that may have made contact with the first human companions about 33,000 years ago, somewhere in south-east Asia.About 15,000 years ago, a small pack of domesticated dogs began trotting towards the Middle East and Africa. Canis lupus familiaris made it to Europe about 10,000 years ago, and when civilisation began in the Fertile Crescent, and humans began to build farmsteads and villages with walls, dogs were already there to help kee...
Source: Guardian Unlimited Science - December 15, 2015 Category: Science Authors: Tim Radford Tags: Genetics Science Animals Biology World news Evolution Source Type: news

Dog DNA study reveals the incredible journey of man's best friend
Descended from the grey wolf, domesticated dogs have been companions to humans for about 33,000 years, a genetic study has shownMan ’s proverbial first best friend was probably a grey wolf that may have made contact with the first human companions about 33,000 years ago, somewhere in south-east Asia.About 15,000 years ago, a small pack of domesticated dogs began trotting towards the Middle East and Africa.Canis lupus familiaris made it to Europe about 10,000 years ago, and when civilisation began in theFertile Crescent, and humans began to build farmsteads and villages with walls, dogs were already there to help keep...
Source: Guardian Unlimited Science - December 15, 2015 Category: Science Authors: Tim Radford Tags: Genetics Science Animals Biology World news Evolution Source Type: news

Treatment of lupus
LupuzorTM may become the first specific and non-immunosuppressant therapy for lupus, a disabling autoimmune disease that is currently incurable. This peptide is the subject of a patent (granted in 2009) and has already successfully completed phases I and II of its regulatory clinical trials. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 15, 2015 Category: Science Source Type: news

Diseases that cause skin problems also can trigger serious neurological conditions
(Loyola University Health System) Diseases such as lupus that cause rashes and other skin problems also can trigger migraine headaches, strokes and other serious neurological conditions, according to an article in a new volume of the Handbook of Clinical Neurology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 15, 2015 Category: Global & Universal Source Type: news

Why Is It Called Christmas Disease?
Discussion Too much or too little causes the important homeostatic balance of life to be upset. This is true of the interactions between the circulatory and hematology systems of the body and their important function in ensuring that the circulatory system plumbing is not leaking (i.e. bleeding) and also not getting plugged up (i.e. thrombosis). A healthy system has adequate numbers of functional platelets, and protein synthesis of the factors needed for a balanced hemostasis system. An adequate amount of Vitamin K is needed for some factors activity. Additionally the absence of any drugs that interfere with platelets or t...
Source: PediatricEducation.org - December 14, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Chemotherapy Isn't Only for Cancer Patients
When you hear the word chemotherapy what immediately comes to mind? Cancer. Bald. Nausea. Vomiting. Infusions. Sterility. Bone Pain? Upon hearing that word, most people jump to the same conclusions, with the same general consensus on how chemo works, who receives it, and what side effects it has on the body. The truth is chemotherapy isn't only for cancer patients, and affects each patient differently depending on how it is used. Chemotherapy is a widely used class of drugs to treat many different disorders including, but not limited to: cancers, blood disorders, and a plethora of autoimmune diseases. Similarly it can be ...
Source: Healthy Living - The Huffington Post - December 8, 2015 Category: Consumer Health News Source Type: news

Pain Coping and Catastrophising in Patients With SLEPain Coping and Catastrophising in Patients With SLE
What factors influence pain coping or catastrophising in patients with systemic lupus erythematosus? Lupus Science & Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 8, 2015 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Polycystic ovarian syndrome and autism link
Children born to PCOS mothers - at risk Related items from OnMedicaPolycystic ovarian syndromeWomen with PCOS at much greater risk of diabetesBlood test identifies high-risk lupus pregnanciesMaternal gestational diabetes increases risk of autismEndometriosis increases risk of miscarriage and ectopic pregnancy (Source: OnMedica Latest News)
Source: OnMedica Latest News - December 8, 2015 Category: UK Health Source Type: news

Biomarker ID'd for Poor Outcome in Lupus With Autoimmune Hepatitis (CME/CE)
(MedPage Today) -- Could guide use of intensive immunosuppression, liver function testing (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - December 7, 2015 Category: Rheumatology Source Type: news

Researchers answer perplexing question about Lupus
Biomedical researchers have suspected that a specific set of immune cells are responsible for causing disease in late-stage lupus patients, but until now they haven’t known for sure. An immunologist has found that these cells do not, in fact, contribute to late-stage lupus in mice. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 7, 2015 Category: Science Source Type: news

Mayo Clinic Minute: Diagnosing Lupus, Heart-Healthy Cranberries
Watch today's Mayo Clinic Minute In today's Mayo Clinic Minute, we look at cranberries – they're not just for Thanksgiving! Research shows drinking cranberry juice is good for heart health. Plus, why lupus can be difficult to diagnose. Reporter Vivien Williams has more. Journalists: Video is available in the downloads. [TRT 1:04] Click here for the [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - November 24, 2015 Category: Databases & Libraries Source Type: news

Complete Lupus Remission is Possible; So is Eventual Relapse (CME/CE)
(MedPage Today) -- About 15% in one cohort were symptom-free for at least 3 years (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - November 23, 2015 Category: Rheumatology Source Type: news

Call the CDC -- A Celebrity Is Sick
You couldn't miss the headline: Charlie Sheen is HIV positive. Networks scrambled to cover the news that he had a virus that could someday, maybe or maybe not, lead to AIDS. I admit, as a journalist, I too told his tale of woe, describing how, despite a reckless past, he had now learned his lesson and sought the medical treatment necessary to make the virus undetectable in his blood. I also, on a daily basis, have updated Lamar Odom's condition and that of other celebrities that wound up in the hospital. But, in my quiet hours at home I wondered, is this news? Do we really need to act as if the entire nation or the Centers...
Source: Healthy Living - The Huffington Post - November 19, 2015 Category: Consumer Health News Source Type: news

Experts warn of high sugar level dangers in pregnancy
74% of pregnant women have potentially dangerously high blood glucoseRelated items from OnMedicaChild health risks of gestational diabetes Probiotics in newborns might lower diabetes riskNICE might underestimate gestational diabetesNICE recommends tighter blood sugar control in diabetes Blood test identifies high-risk lupus pregnancies (Source: OnMedica Latest News)
Source: OnMedica Latest News - November 18, 2015 Category: UK Health Source Type: news

Nephrologists to help find treatment for lupus
(Texas Tech University Health Sciences Center El Paso) Nephrologists at Texas Tech University Health Science Center El Paso have been invited to participate in a national consortium that's investigating the key causes of lupus nephritis -- an autoimmune disease that can cause kidney failure. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 16, 2015 Category: Biology Source Type: news

AstraZeneca lupus drug impresses in mid-stage trial
LONDON (Reuters) - AstraZeneca's experimental lupus drug anifrolumab significantly cut disease activity in a mid-stage clinical trial, boosting hopes for a medicine the company believes could become a $1 billion-a-year seller. (Source: Reuters: Health)
Source: Reuters: Health - November 10, 2015 Category: Consumer Health News Tags: healthNews Source Type: news

Lupus and diffuse large B-cell lymphoma share genetic risk
SAN FRANCISCO – Single-nucleotide polymorphisms in genes for interleukin 10 and human leukocyte antigen are significantly associated with both systemic lupus erythematosus (SLE) and diffuse large B-cell lymphoma, according to a meta-analysis of data from three genome-wide association studies. The... (Source: Skin and Allergy News)
Source: Skin and Allergy News - November 9, 2015 Category: Dermatology Source Type: news

Patient reported outcome measurement system (PROMIS) valid in assessing patient experience
(Hospital for Special Surgery) Hospital for Special Surgery researchers evaluated the Patient Reported Outcomes Measurement Information System (PROMIS) in patients with lupus and found that the questionnaire is valid in assessing subjective patient experience. Researchers also observed a disconnect between the patient perspective and objective signs and symptoms, underscoring the need to integrate patient-reported outcomes into clinical care to ensure optimal disease management. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 7, 2015 Category: Global & Universal Source Type: news

Lupus: Can it cause hair loss?
(Source: MayoClinic.com - Ask a Specialist)
Source: MayoClinic.com - Ask a Specialist - November 5, 2015 Category: Consumer Health News Source Type: news

Your Health Is Not Something to Be Earned
Actress and singer Selena Gomez recently revealed that she underwent chemotherapy for Lupus, which is the same treatment that I endured in 2010. My personal journey in pursuit of wellness has been, and continues to be, long and arduous. In my pre-teen years, I began having uncontrollable nose bleeds that would last for hours coupled with shooting pain through my chest and left arm. I spent several years thereafter poked and prodded -- bone marrow samples, seemingly endless tubes of blood, EKG tests and beyond. It wasn't until four years later that I received the fateful diagnosis: Systemic Lupus Erythematosus. SLE, as it...
Source: Healthy Living - The Huffington Post - November 3, 2015 Category: Consumer Health News Source Type: news

RheumNow: Should Lupus Patients Get Flu/Pneumococcal Vaccines?
(MedPage Today) -- A rheumatologist reviews the evidence (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - November 1, 2015 Category: Primary Care Source Type: news

Comorbidities Common in Lupus -- at All Ages (CME/CE)
(MedPage Today) -- Elevated risks for infections and cancer, as well as cardiac and kidney complications (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - October 29, 2015 Category: Cardiology Source Type: news

New NHS screening for Down's expected soon
DNA test will improve performance in screening and reduce miscarriagesRelated items from OnMedicaThe 6-8 week baby check and screening testsPregnant women likely to be tested earlier for rare genetic abnormalitiesLeading the way with NHS Screening ProgrammesHunt confirms need to boost midwife headcountBlood test identifies high-risk lupus pregnancies (Source: OnMedica Latest News)
Source: OnMedica Latest News - October 27, 2015 Category: UK Health Source Type: news

ICYMI: The Truth About Social Anxiety And Why We Like Mobsters
ICYMI Health features what we're reading this week. This week, writers answered so many of our longstanding questions. Why do we admire mobsters? (Answer: They're dangerous, but not too dangerous.) And what, exactly, is social anxiety? (Answer: Being afraid of rejection by peers to an extreme degree.)  And on a heavier note, we got answers to questions we didn't even know to ask, including: "What is 'airborne cancer'?" One of our own Healthy Living editors also investigated the hypocrisy in blaming someone for a substance use disorder. We also read about the nature of adult friendships and, ye...
Source: Healthy Living - The Huffington Post - October 24, 2015 Category: Consumer Health News Source Type: news

Medical News Today: Lupus: a serious disease we know little about
Most Americans have either have not heard of lupus or know nothing more than the name. In this Spotlight, we take an in-depth look at this potential life-threatening disease. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 22, 2015 Category: Consumer Health News Tags: Lupus Source Type: news

What Women Can Do About Hair Loss
SPECIAL FROM Next Avenue By Sheryl Kraft Everyone loses hair. In fact, it’s normal to lose between 50 and 100 hairs a day, according to the American Academy of Dermatology. But what if it seems like there’s significantly more loss than that? “Once you exceed that, you’re losing it at an abnormal rate,” says Dr. David J. Wong, clinical associate professor of dermatology at Stanford University. Contrary to popular notion, hair loss is not just a condition that men face: up to 40 percent of women in America also experience it. No ‘Bald Is Beautiful’ for Women Bruce Willis, Patric...
Source: Healthy Living - The Huffington Post - October 20, 2015 Category: Consumer Health News Source Type: news

We Wouldn't Shame Lamar Odom For A Heart Attack. Why Do It For Drug Use?
According to the latest reports, Lamar Odom, the former NBA player who was found unconscious in a Nevada brothel on Oct. 13, is breathing on his own and can even get out of bed. Authorities confirmed that cocaine was found in Odom's system, which indicates that he had been using it in the days before his hospitalization.  Now that he's improving, it's time to talk about how we react to medical emergencies like Odom's. While Odom has publicly distanced himself from the label "drug addict," the way that the public talks about his drug use affects millions of people struggling with addi...
Source: Science - The Huffington Post - October 19, 2015 Category: Science Source Type: news

Scientists Put Shamanic Medicine Under The Microscope
Ten years ago, Mark Pischea, then a 42-year-old political consultant and father of five from Williamston, Michigan, was rushed to the hospital with severe stomach pain. Pischea was diagnosed with Crohn's disease, a chronic autoimmune condition that can cause extreme abdominal discomfort, weight loss, fatigue and fevers. For the next decade of his life, the formerly healthy husband and father lived in a constant cycle of flare-ups, surgery and recovery. After his fifth surgery, Pischea was bedridden for six weeks. At that point, he was told his only remaining options were a sixth surgery or the removal o...
Source: Healthy Living - The Huffington Post - October 16, 2015 Category: Consumer Health News Source Type: news

New Treatment for Lupus: Medicine's Next Big Thing?
SAN ANTONIO. (Ivanhoe Newswire) -- More than 1.5 million Americans have lupus, a disease where the body’s immune system attacks healthy tissue. It can lead to heart attacks, strokes, and kidney failure. In the past 50 years, only one new drug for lupus has been approved by the FDA. Just this summer, there have been two very major trials of a new lupus drug that both failed but now there is hope on the horizon. (Source: Medical Headlines From Ivanhoe.com)
Source: Medical Headlines From Ivanhoe.com - October 14, 2015 Category: Consumer Health News Source Type: news

Why Selena Gomez Is Using Chemotherapy for Lupus
Singer said she is taking chemotherapy drugs to treat the disease. (Source: ABC News: Health)
Source: ABC News: Health - October 9, 2015 Category: Consumer Health News Tags: Health Source Type: news

Lupus (Systemic Lupus Erythematosus or SLE)
Title: Lupus (Systemic Lupus Erythematosus or SLE)Category: Diseases and ConditionsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 10/9/2015 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - October 9, 2015 Category: Rheumatology Source Type: news

What is lupus? Selena Gomez case prompts questions
Why the pop star needed chemotherapy for this autoimmune disease (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - October 9, 2015 Category: Consumer Health News Source Type: news

Lupus: Your body's immune system attacks your own tissues and organs
Lupus is a chronic inflammatory disease that occurs when your body's immune system attacks your own tissues and organs. Mayo Clinic rheumatologist Thomas Osborn, M.D., says the inflammation caused by lupus can affect many different body systems — including your joints, skin, kidneys, blood cells, brain, heart and lungs. Dr. Osborn adds that lupus can be difficult to [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - October 9, 2015 Category: Databases & Libraries Source Type: news

Lupus, Selena Gomez's Autoimmune Disease, Explained
In an interview with Billboard magazine this week, Selena Gomez confirmed she's been struggling with an autoimmune disease that forced her to take a step back from her work and cancel tours in 2013 and 2014. "I was diagnosed with lupus, and I’ve been through chemotherapy," she told Billboard. "That’s what my break was really about. I could’ve had a stroke." What is lupus? Similar to other autoimmune diseases, lupus causes the body's immune system to attack its own tissue and organs.  Lupus can be difficult to diagnose because its symptoms -- including join...
Source: Healthy Living - The Huffington Post - October 8, 2015 Category: Consumer Health News Source Type: news

Selena Gomez says she has lupus, went through chemo
The pop star also has a message for her haters (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - October 8, 2015 Category: Consumer Health News Source Type: news

Selena Gomez reveals she has lupus
Pop singer Selena Gomez has revealed in Billboard that her diagnosis with the autoimmune disease lupus was behind a recent hiatus from the spotlight. (Source: WDSU.com - Health)
Source: WDSU.com - Health - October 8, 2015 Category: Consumer Health News Source Type: news

Dear Lupus, I want me back
My name is Lauren Johnson. I'm an associate producer at CNN, and I have systemic lupus erythematosus. (Source: CNN.com - Health)
Source: CNN.com - Health - October 8, 2015 Category: Consumer Health News Source Type: news

Selena Gomez reveals she has lupus and treating with chemo
(Source: CNN.com - Health)
Source: CNN.com - Health - October 8, 2015 Category: Consumer Health News Source Type: news

Lupus Flares Common During Renal Replacement TherapyLupus Flares Common During Renal Replacement Therapy
Patients with lupus remain at risk for extrarenal flares during renal replacement therapy, and various clinical predictors may identify those at risk, a new study has suggested. Medscape Medical News (Source: Medscape Nephrology Headlines)
Source: Medscape Nephrology Headlines - October 8, 2015 Category: Urology & Nephrology Tags: Rheumatology News Source Type: news

VBAC clinically safe choice for most women
‘Green-top’ guideline says vaginal birth succeeds in 75% of cases – same as for first birthsRelated items from OnMedicaWide European variations in C-section ratesPlanned caesarean safest for breech deliveryAdvise a year between pregnancies after preterm birthNICE might underestimate gestational diabetesBlood test identifies high-risk lupus pregnancies (Source: OnMedica Latest News)
Source: OnMedica Latest News - October 6, 2015 Category: UK Health Source Type: news

Suicidal drug overdose in patients with systemic lupus erythematosus, a nationwide population-based case-control study - Tang KT, Lin CH, Chen HH, Chen YH, Chen DY.
OBJECTIVE: A four-fold increase of suicide mortality has been demonstrated in systemic lupus erythematosus (SLE) patients. Prior studies showed that the most common method of suicide attempts in SLE patients involves drug overdose. Therefore, we conducted ... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - October 4, 2015 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Blood test identifies high-risk lupus pregnancies
First-trimester biomarkers reliable in spotting women who need greatest monitoringRelated items from OnMedicaNo impact of antidepressants taken during pregnancy on child’s developmentAdvise a year between pregnancies after preterm birthScientists identify substance that protects against preterm birthNICE might underestimate gestational diabetesAdverse pregnancy outcomes far more likely in epilepsy (Source: OnMedica Latest News)
Source: OnMedica Latest News - September 30, 2015 Category: UK Health Source Type: news

CellCept Useful for Lupus Nephritis in Hispanics (CME/CE)
(MedPage Today) -- In comparison, azathioprine had more than twice the risk of flares during maintenance (Source: MedPage Today Nephrology)
Source: MedPage Today Nephrology - September 29, 2015 Category: Urology & Nephrology Source Type: news