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Transplant Delay Not Needed in Lupus Nephritis
(MedPage Today) -- Message: don't wait for lupus symptoms to recede when transplant is indicated. (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - October 6, 2014 Category: Endocrinology Source Type: news

Lupus Nephritis: Delay May Increase Graft Failure Risk in ERSD Lupus Nephritis: Delay May Increase Graft Failure Risk in ERSD
White patients with end-stage renal disease whose kidney transplant was delayed by more than 3 months because of their lupus were at 25% to 37% increased risk of experiencing graft failure. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 2, 2014 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Lupus Nephritis: Delay May Increase Graft Failure Risk in ESRDLupus Nephritis: Delay May Increase Graft Failure Risk in ESRD
White patients with end-stage renal disease whose kidney transplant was delayed by more than 3 months because of their lupus were at 25% to 37% increased risk of experiencing graft failure. Medscape Medical News (Source: Medscape Nephrology Headlines)
Source: Medscape Nephrology Headlines - October 2, 2014 Category: Urology & Nephrology Tags: Nephrology News Source Type: news

Eli Lilly stops development of lupus drug; XTL shares soar
(Reuters) - Eli Lilly and Co said it would stop the development of its drug to treat the autoimmune disorder lupus, after it was found to be not effective enough in late-stage trials. (Source: Reuters: Health)
Source: Reuters: Health - October 2, 2014 Category: Consumer Health News Tags: healthNews Source Type: news

Eli Lilly to drop development of lupus drug
Lupus is a condition in which the body's immune system starts attacking healthy tissues and causes inflammation, pain, and damage. (Source: The Economic Times)
Source: The Economic Times - October 2, 2014 Category: Consumer Health News Source Type: news

Possible New Plant Extract Lupus Treatment with No Side Effects
Lupus, or systemic lupus erythematosus, is a progressive, degenerative disease in which the immune system turns against itself, attacking a person's healthy tissue, cells and organs. Symptoms range from debilitating pain and fatigue to organ failure and a host of other impairments. An estimated 1.5 million Americans, and at least five million people worldwide, have a form of lupus. (Source: Disabled World)
Source: Disabled World - September 26, 2014 Category: Disability Tags: Lupus Source Type: news

Prospects for a Peptide Vaccine for Human LupusProspects for a Peptide Vaccine for Human Lupus
What features are needed in an effective lupus vaccine, and what are the challenges to developing one? International Journal of Clinical Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 26, 2014 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Autoimmune diseases, chronic inflammations: Advancing research
Multiple sclerosis, type 1 diabetes and lupus are autoimmune diseases in which the immune cells can no longer differentiate between friend and foe and thus attack the body's own tissue. Here, the immunoproteasome, which supplies the immune system with information on processes within the cell, plays a central role. Chemists have now discovered a way to inhibit its functionality, thereby laying the foundation for possible optimizations of existing medications. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - September 25, 2014 Category: Science Source Type: news

Spot on against autoimmune diseases and chronic inflammations
(Technische Universitaet Muenchen) Multiple sclerosis, type 1 diabetes and lupus are autoimmune diseases in which the immune cells can no longer differentiate between friend and foe and thus attack the body's own tissue. Here, the immunoproteasome, which supplies the immune system with information on processes within the cell, plays a central role. Chemists at Technische Universität München have now discovered a way to inhibit its functionality, thereby laying the foundation for possible optimizations of existing medications. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 25, 2014 Category: Biology Source Type: news

NIH announces network to accelerate medicines for rheumatoid arthritis and lupus
Partnership includes support from industry and non-profits. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - September 24, 2014 Category: American Health Source Type: news

Findings give hope to plant extract as possible lupus treatment
(University of Houston) Lupus is a chronic autoimmune disease in which the immune system turns against itself, attacking a person's healthy tissue, cells and organs. New findings by a biomedical engineer and his team at the University of Houston raise hope for a new class of drugs to treat lupus that may not include the long list of adverse risks and side effects often associated with current treatments for this disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 24, 2014 Category: Global & Universal Source Type: news

NIH announces network to accelerate medicines for rheumatoid arthritis and lupus
(NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases) The National Institutes of Health has awarded grants to 11 research groups across the United States to establish the Accelerating Medicines Partnership in Rheumatoid Arthritis and Lupus Network. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 24, 2014 Category: Global & Universal Source Type: news

The Pathogenesis, Diagnosis and Treatment of Lupus NephritisThe Pathogenesis, Diagnosis and Treatment of Lupus Nephritis
Get updated on the pathogenesis, diagnosis, and treatment of lupus nephritis. Current Opinion in Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 19, 2014 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

RheumShorts: Kineret, Shingles Vax, Home Rehab (CME/CE)
(MedPage Today) -- Recently published studies in rheumatology covered use of anakinra (Kineret) in pregnancy, varicella-zoster vaccines in lupus patients, and home exercise after knee replacement. (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - September 18, 2014 Category: Rheumatology Source Type: news

Math model designed to replace invasive kidney biopsy for lupus patients
Mathematics might be able to reduce the need for invasive biopsies in patients suffering kidney damage related to the autoimmune disease lupus. The model could also be used to monitor the effectiveness of experimental treatments for inflammation and fibrosis, researchers say. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - September 17, 2014 Category: Science Source Type: news

Math model designed to replace invasive kidney biopsy for lupus patients
(Ohio State University) Mathematics might be able to reduce the need for invasive biopsies in patients suffering kidney damage related to the autoimmune disease lupus. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 17, 2014 Category: Global & Universal Source Type: news

RheumShorts: Pediatric Update (CME/CE)
(MedPage Today) -- This week several studies have focused on rheumatologic disorders among young patients -- depression and anxiety in systemic lupus erythematosus and maternal smoking and jaw involvement in juvenile idiopathic arthritis. (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - September 12, 2014 Category: Pediatrics Source Type: news

Low Vitamin D May Hasten CVD in Lupus
(MedPage Today) -- Among teens with lupus, vitamin D insufficiency may diminish the cardioprotective effect of statin therapy, researchers reported. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - September 12, 2014 Category: Cardiology Source Type: news

Jim Sullivan on Improving the Lives of Patients
At AbbVie, research and innovation are the cornerstones of our business as a global biopharmaceutical company. We focus on developing medicines that deliver strong clinical performance, provide more patient benefit and deliver economic value, particularly where there is significant need around the world in certain disease areas.  Arthritis is an example of a disease where we have the opportunity to continue to make headway to improve the lives of patients. According to the U.S. Centers for Disease Control and Prevention (CDC) prevalence of musculoskeletal diseases could increase from 52 million people in the U.S. to 6...
Source: PHRMA - September 9, 2014 Category: Pharmaceuticals Authors: Emily Source Type: news

Cosmic forecast: Dark clouds will give way to sunshine
Lupus 4, a spider-shaped blob of gas and dust, blots out background stars like a dark cloud on a moonless night in this intriguing new image. Although gloomy for now, dense pockets of material within clouds such as Lupus 4 are where new stars form and where they will later burst into radiant life. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - September 3, 2014 Category: Science Source Type: news

Type I Interferon Blockade in Systemic Lupus ErythematosusType I Interferon Blockade in Systemic Lupus Erythematosus
IFN-blocking strategies for the treatment of SLE are currently being evaluated in clinical trials. Are the results looking promising? Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 3, 2014 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Sabotage as therapy: Aiming lupus antibodies at vulnerable cancer cells
(Yale University) Yale Cancer Center researchers may have discovered a new way of harnessing lupus antibodies to sabotage cancer cells made vulnerable by deficient DNA repair.The study, led by James E. Hansen, M.D., assistant professor of therapeutic radiology at Yale School of Medicine, found that cancer cells with deficient DNA repair mechanisms (or the inability to repair their own genetic damage) were significantly more vulnerable to attack by lupus antibodies. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 2, 2014 Category: Global & Universal Source Type: news

Lupus and the Atomic Bomb? (CME/CE)
(MedPage Today) -- Could "fallout" from a Cold War era uranium-processing plant in rural Ohio explain lupus cases diagnosed today? MedPage Today reporter Nancy Walsh digs down seeking an answer. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - August 22, 2014 Category: Primary Care Source Type: news

Certain Symptoms Can Delay Lupus Diagnosis, Researchers Report
Title: Certain Symptoms Can Delay Lupus Diagnosis, Researchers ReportCategory: Health NewsCreated: 8/19/2014 7:36:00 PMLast Editorial Review: 8/20/2014 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - August 20, 2014 Category: Rheumatology Source Type: news

Certain Symptoms Can Delay Lupus Diagnosis, Researchers Report
Headache, seizures often lead doctors down the wrong path (Source: WebMD Health)
Source: WebMD Health - August 20, 2014 Category: Consumer Health News Source Type: news

Certain Symptoms Can Delay Lupus Diagnosis, Researchers Report
Headache, seizures often lead doctors down the wrong path Source: HealthDay Related MedlinePlus Page: Lupus (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - August 19, 2014 Category: Consumer Health News Source Type: news

Genetic key to lupus shows potential of personalized medicine
DNA sequencing of a lupus patient has identified a specific genetic mutation that is causing the disease, opening the way for personalized treatments. Researchers identified a variant in the TREX1 gene. This mutation caused the patient's cells to produce a molecule called interferon-alpha. Clinical trials are already underway for drugs to target interferon-alpha in adults. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - August 19, 2014 Category: Science Source Type: news

Rheumatologic diseases like lupus can initially look like neurological disorders
(Loyola University Health System) Lupus and other rheumatologic diseases can initially present as neurological disorders such as headaches and seizures, and thus delay diagnosis for many months. And treatments can cause adverse neurological effects. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 18, 2014 Category: Global & Universal Source Type: news

What Causes Proteinuria?
Discussion Proteinuria occurs relatively often in pediatric practice with 5-15% of school children having transient proteinuria, the most common cause. However, proteinuria can be a sign of kidney disease. Therefore, it is important to evaluate the proteinuria in light of the clinical situation. A good history and physical examination along with a full urinalysis and/or BUN and creatinine, or urine protein/creatinine ratio may be all that is necessary. Another patient with edema, hypertension or hematuria needs a fuller evaluation and treatment. Proteinuria is usually categorized into three groups to assist with evaluation...
Source: PediatricEducation.org - August 18, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Lupus Patients Face High Rehospitalization Rates
Title: Lupus Patients Face High Rehospitalization RatesCategory: Health NewsCreated: 8/11/2014 12:36:00 PMLast Editorial Review: 8/12/2014 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - August 12, 2014 Category: Rheumatology Source Type: news

Lupus Patients Face High Rehospitalization Rates
Drugs that suppress the immune system make it harder to fight infection, study says (Source: WebMD Health)
Source: WebMD Health - August 11, 2014 Category: Consumer Health News Source Type: news

'Worm pill' could ease autoimmune disease symptoms
Experts believe a molecule in parasitic worms could help explain why worm infections can effectively treat a range of autoimmune diseases, including multiple sclerosis, psoriasis, rheumatoid arthritis and lupus. The study successfully identified peptides from parasitic worms that suppress the body's immune response. Researchers believe this could pave the way for a new drug containing the peptide to provide relief from the symptoms of autoimmune diseases. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - August 11, 2014 Category: Science Source Type: news

Readmission Rates High in Lupus
(MedPage Today) -- One in six patients with lupus discharged from the hospital was readmitted within a month, with underserved minority populations being most vulnerable, researchers found. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - August 11, 2014 Category: Primary Care Source Type: news

Lupus Patients Face High Rehospitalization Rates
Drugs that suppress the immune system make it harder to fight infection, study says Source: HealthDay Related MedlinePlus Pages: Health Facilities, Lupus, Medicines (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - August 11, 2014 Category: Consumer Health News Source Type: news

One in 6 lupus patients readmitted to hospital within 30 days of discharge
(Wiley) A new study reveals that one in six patients with systemic lupus erythematosus is readmitted to the hospital within 30 days of being discharged. Results published in Arthritis & Rheumatology, a journal of the American College of Rheumatology, show that black and Hispanic systemic lupus erythematosus patients were more likely to be readmitted than white patients. Readmissions among patients insured by Medicare or Medicaid were also more likely compared to patients covered by private insurance. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 11, 2014 Category: Global & Universal Source Type: news

RheumShorts: IL-6 and RA, Life and Death, Surgery in Lupus (CME/CE)
(MedPage Today) -- The September issue of the Annals of the Rheumatic Diseases featured studies on an investigational interleukin-6 inhibitor for rheumatoid arthritis, mortality effects of early remission in inflammatory arthritis, and adverse surgical outcomes for patients with lupus. (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - August 6, 2014 Category: Geriatrics Source Type: news

Gabriela Lavezzari on Improving the Lives of Patients with Arthritis
Many people are unaware of the impact of arthritis and related musculoskeletal diseases in the United States. They affect approximately 52.5 million Americans of all ages, races and genders. The biopharmaceutical industry is making great strides towards new treatments with 92 medicines in the pipeline which have the potential to help patients live more active and productive lives. Work on these treatments is more imperative than ever as 67 million people could be diagnosed with some form of musculoskeletal disease by 2030, according to the U.S. Centers for Disease Control and Prevention. Earlier this year, PhRMA joined 10...
Source: PHRMA - August 4, 2014 Category: Pharmaceuticals Authors: Emily Source Type: news

Overview of Neonatal LupusOverview of Neonatal Lupus
What is the presentation of neonatal lupus and how is it treated? Journal of Pediatric Health Care (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 4, 2014 Category: Consumer Health News Tags: Pediatrics Journal Article Source Type: news

Stephen I. Katz on Improving the Lives of Patients with Arthritis
To improve the lives of people with arthritis, the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is working toward a better understanding of the basic biology of diseases affecting the joints, better diagnosis and treatment of arthritis, and better tools to facilitate clinical trials. NIAMS was a key contributor to the development of tofacitinib, the first oral disease modifying antirheumatic drug (DMARD) for rheumatoid arthritis (RA) in a decade, which recently received  approval from the U.S. Food and Drug Administration. In the early 1990’s, NIAMS intramural researchers discove...
Source: PHRMA - July 30, 2014 Category: Pharmaceuticals Authors: Emily Source Type: news

Amanda Niskar on Improving the Lives of Patients with Arthritis
For almost 70 years, the Arthritis Foundation has initiated and supported scientific discoveries that improve health outcomes for people with arthritis. Research holds the key to finding better diagnostics and treatments—and one day a cure—for more than 50 million Americans who face the daily challenges of arthritis. At the Foundation, we are focused on providing scientific leadership and direction to improve everyday life for people with arthritis and to find a cure.   Information from the Medicines in Development report issued by the Pharmaceutical Research Manufacturers of America (PhRMA), about medicin...
Source: PHRMA - July 30, 2014 Category: Pharmaceuticals Authors: Emily Source Type: news

Update: Progress in Lupus Tx Slow But Sure (CME/CE)
(MedPage Today) -- Progress toward improving the treatment of systemic lupus erythematosus continues to be slow and incremental -- but progress is clearly being made, according to lupus management specialists who spoke with MedPage Today. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - July 24, 2014 Category: Primary Care Source Type: news

Biomedical engineer looks at new applications for novel lupus drug
(University of Houston) Expanding on his work with a new drug that successfully treated lupus in mice, a biomedical engineer at the University of Houston has received a $250,000 grant to expand his research to a new version of the drug in an effort to treat a wider range of autoimmune diseases.The drug that Chandra Mohan and his collaborators at a biopharmaceutical firm are focused on targets B cells, key cells in the immune system that lead to the development of lupus. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 24, 2014 Category: Global & Universal Source Type: news

Living With Lupus: Mayo Clinic Radio Health Minute
In this Mayo Clinic Radio Health Minute, Dr. Vai Chowdhary has insights into living with lupus. To listen, click the link below. Living With Lupus (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - July 24, 2014 Category: Databases & Libraries Source Type: news

An Important Shift in Lupus CareAn Important Shift in Lupus Care
Ronald van Vollenhoven argues that despite somewhat limited data, the time is right for introducing treat-to-target management of SLE. Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 21, 2014 Category: Consumer Health News Tags: Rheumatology Article Source Type: news

Common drug for Sjögren’s does not help symptoms
Hydroxychloroquine didn’t reduce dryness, pain or fatigue more than placebo Related items from OnMedicaNewer RA drugs no better than old in keeping patients at workThyroid patients need better monitoringDrugs regulators “put profits before patients”Lupus anticoagulant greatly raises stroke risk (Source: OnMedica Latest News)
Source: OnMedica Latest News - July 17, 2014 Category: UK Health Source Type: news

Antiphospholipid Antibodies and Bleeding From Renal BiopsyAntiphospholipid Antibodies and Bleeding From Renal Biopsy
A study identified the clinical and histologic risk factors for bleeding after renal biopsy in patients with lupus nephritis. Medscape Rheumatology (Source: Medscape Rheumatology Headlines)
Source: Medscape Rheumatology Headlines - July 16, 2014 Category: Rheumatology Tags: Rheumatology Viewpoint Source Type: news

Lots of Autoantibodies Equal Lupus?Lots of Autoantibodies Equal Lupus?
No one antibody target or class of autoantibody mark the transition to SLE, but an increasing number of autoantibodies together may be the culprit. Arthritis Research & Therapy (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 11, 2014 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Living with Sjogren’s – When your grin shows, but your illness hides…
An autoimmune disorder is any illness in which the body turns on itself – white blood cells which are designed to protect your body’s intricate systems malfunction and attack. Types of autoimmune disorder are many and varied, but the majority are able to pass under the radar because they chiefly affect the interior working of glands, joints and the nervous system. One example which is prevalent in women aged over 40 is Sjogren’s syndrome. As an invisible illness, this one is quite the heavy-hitter. It may be unfamiliar to you, and you might well be wondering how to even say it! Aptly, Sjogren’s is p...
Source: The Hysterectomy Association - July 3, 2014 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Women's Health invisible illness Sjogren’s venus williams Source Type: news

New B-Cell Drug Disappoints in Lupus
(MedPage Today) -- Atacicept, a biologic agent that targets two B-cell factors in patients with moderate-to-severe lupus, failed to meet the primary endpoint in a yearlong phase II/III trial, researchers reported. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - June 25, 2014 Category: Primary Care Source Type: news