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Study Suggests Causes for Lupus' Impact on Immune System
Certain cells seem to malfunction and create inflammation instead of fighting the disease, research say Source: HealthDay Related MedlinePlus Page: Lupus (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - March 8, 2016 Category: Consumer Health News Source Type: news

Study Suggests Causes for Lupus' Impact on Immune System
Certain cells seem to malfunction and create inflammation instead of fighting the disease, research say (Source: U.S. News - Health)
Source: U.S. News - Health - March 8, 2016 Category: Consumer Health News Source Type: news

Study Suggests Causes for Lupus' Impact on Immune System
TUESDAY, March 8, 2016 -- Scientists have found new clues that help explain what's going wrong in the immune systems of people with lupus -- insight they hope will lead to new therapies, or help guide current treatment choices. Lupus has several... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - March 8, 2016 Category: Journals (General) Source Type: news

Casting a 'NET' to Find New Therapies for LupusCasting a 'NET' to Find New Therapies for Lupus
Dr Deane discusses a study that first examined the role of neutrophil extracellular traps in lupus pathophysiology, and then evaluated metformin to reduce disease flares in a proof-of-concept trial. Medscape Rheumatology (Source: Medscape Rheumatology Headlines)
Source: Medscape Rheumatology Headlines - March 3, 2016 Category: Rheumatology Tags: Rheumatology Viewpoint Source Type: news

Nick Cannon Looks Back On His 'Super Scary' Lupus Diagnosis
Nick Cannon didn't know anything about lupus nephritis when he was first diagnosed in 2012, so hearing that some of his other health complications were the result of the autoimmune disease came as a surprise. It was only after Cannon did some research on the condition, which had resulted in kidney failure and blood clots in his lungs, that he began to understand and take care of his well-being. Now he hopes his story encourages others to do the same. "[Y]ou realize that this is something that you can live with and actually overcome with the proper research and with the proper support system," he told HuffPos...
Source: Healthy Living - The Huffington Post - February 24, 2016 Category: Consumer Health News Source Type: news

Kirsty Keep left in agony for a decade is desperate to find a cure for her symptoms
Kirsty Keep, 23, of Maidstone, Kent, has been diagnosed with the autoimmune condition lupus, where her immune system attacks healthy cells, tissue and organs. (Source: the Mail online | Health)
Source: the Mail online | Health - February 23, 2016 Category: Consumer Health News Source Type: news

Response to Belimumab Among Patients With SLEResponse to Belimumab Among Patients With SLE
Does belimumab reduce SLE disease activity in real-world clinical practice? Lupus Science & Medicine (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - February 23, 2016 Category: Pathology Tags: Rheumatology Journal Article Source Type: news

Researchers uncover potential target for treating autoimmune disease
A molecule that appears to be a cause of autoimmune diseases such as lupus has been identified by a group of researchers. Elevated levels of the molecule allow self-reactive immune cells to escape into the blood stream and attack the body's own tissues. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 22, 2016 Category: Science Source Type: news

Lyme: The Infectious Disease Equivalent of Cancer, Says Top Duke Oncologist
Last week, I mentioned the case of Dr. Neil Spector, whose long-undiagnosed Lyme Disease resulted in irreversible heart failure and ultimately, a heart transplant. Dr. Spector, author of Gone in a Heartbeat: A Physician's Search for True Healing, is the Sandra Coates Associate Professor of Medicine and Associate Professor of Pharmacology and Cancer Biology at Duke University School of Medicine. As the Director of Developmental Therapeutics at the Duke Cancer Institute, he's a leader in applying translational research to the clinical development of molecularly targeted personalized cancer therapies. Here, Dr. Spector share...
Source: Science - The Huffington Post - February 19, 2016 Category: Science Source Type: news

Lupus Affects Pregnancy Outcome Even Before Diagnosis Lupus Affects Pregnancy Outcome Even Before Diagnosis
Pregnancy-related complications and poor infant outcomes were higher in women with lupus and in women with preclinical SLE. Medscape Medical News (Source: Medscape ObGyn and Womens Health Headlines)
Source: Medscape ObGyn and Womens Health Headlines - February 16, 2016 Category: OBGYN Tags: Rheumatology News Source Type: news

Lupus and Pregnancy: When Is the Highest Risk? (CME/CE)
(MedPage Today) -- Study suggests preclinical disease has worse pregnancy outcome, but an expert disagrees (Source: MedPage Today OB/GYN)
Source: MedPage Today OB/GYN - February 4, 2016 Category: OBGYN Source Type: news

ESRD in Lupus: A Work in Progress? (CME/CE)
(MedPage Today) -- Declines in disease risk seen since the 1970s, but recent stats have leveled off (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - February 3, 2016 Category: Rheumatology Source Type: news

Highlights from 2015
Your achievements A massive thank you to everyone who ran, hosted coffee mornings and bake sales, jumped out of planes and trekked across the country and indeed the world to fundraise for us. More than 1,300 of you took on a challenge or donated your time and fundraising skills in 2015. Together, you raised over £780,000! If you’d like to join Team A in 2016 and help raise money for our work, have a look at our events or contact localfundraising@arthritisresearchuk.org Improving care for people with arthritis In 2015 we continued to support healthcare professionals to provide the best care to people with art...
Source: Arthritis Research UK - February 3, 2016 Category: Rheumatology Source Type: news

Lupus Raises Mortality by 67%; Young Adults at Highest Risk Lupus Raises Mortality by 67%; Young Adults at Highest Risk
Patients with systemic lupus erythematosus frequently die of circulatory system disease or cancer, just like patients without lupus, but at younger ages, according to a new analysis. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 2, 2016 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Axis I psychiatric disorders high in skin-restricted lupus patients
The prevalence of psychiatric disorders is high among people with skin-restricted lupus (SRL), compared with the general population, yet most do not receive specialist mental health care or appropriate psychotropic treatment, researchers report. Investigators led by psychiatrist Isabelle... (Source: Skin and Allergy News)
Source: Skin and Allergy News - January 31, 2016 Category: Dermatology Source Type: news

Skin Less Affected in Late-Onset Lupus (CME/CE)
(MedPage Today) -- Dermal symptoms less common with SLE onset past age 50 (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - January 30, 2016 Category: Dermatology Source Type: news

Researchers discover ten new lupus genes in Asian population study
10 new genes associated with the autoimmune disease lupus have been identified by researchers. One gene in particular, known as GTF2I, showed a high likelihood of being involved in the development of lupus, say scientists. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 25, 2016 Category: Science Source Type: news

The Real Reason You Get Sick After A Stressful Period Has Ended
Have you ever wondered how you manage to get through a particularly stressful period – whether it's an intense deadline at work, final exams in school or a spate of holiday houseguests – only to get sick after the stress has lifted? It's not a fluke. It's a phenomenon that's often referred to as "the let-down effect," a pattern in which people come down with an illness or develop flare-ups of a chronic condition not during a concentrated period of stress but after it dissipates, explains psychologist Marc Schoen, an assistant clinical professor of medicine at th...
Source: Healthy Living - The Huffington Post - January 24, 2016 Category: Consumer Health News Source Type: news

Antibody Signals Adverse Pregnancy Outcome (CME/CE)
(MedPage Today) -- Lupus anticoagulant was the only antiphospholipid antibody linked with poor birth outcome (Source: MedPage Today OB/GYN)
Source: MedPage Today OB/GYN - January 22, 2016 Category: OBGYN Source Type: news

Mitochondrial troublemakers unmasked in lupus
Mitochondria could provoke the inflammation characteristic of lupus, an autoimmune disorder affecting the joints, skin, heart and brain. Byproducts of cells' power stations goad certain white blood cells into making mesh traps as a precursor to cell death. Mitochondrial DNA is spewed out, triggering a warning and a response that can damage various organ tissues. Mouse studies suggest this disease mechanism might respond to potential drug therapies. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 21, 2016 Category: Science Source Type: news

Assessing the Inhibitory Activity of Oligonucleotides on TLR7 Sensing
Aberrant sensing of self-nucleic acids by Toll-like receptor (TLR) 7, 8, or 9 is associated with several autoimmune disorders, including systemic lupus erythematosus (SLE), rheumatoid arthritis, psoriasis, or systemic sclerosis. In recent years, several classes of synthetic oligonucleotides have been shown to antagonize sensing of immunostimulatory nucleic acids by TLR7/8/9, indicating that these molecules could have therapeutic applications in such autoimmune diseases. Conversely, synthetic oligonucleotides used in therapeutic technologies such as antisense and microRNA inhibitors also have the potential to inhibit TLR7/8...
Source: Springer protocols feed by Immunology - January 7, 2016 Category: Allergy & Immunology Source Type: news

Toll-Like Receptor-Dependent Immune Complex Activation of B Cells and Dendritic Cells
High titers of autoantibodies reactive with DNA/RNA molecular complexes are characteristic of autoimmune disorders such as systemic lupus erythematosus (SLE). In vitro and in vivo studies have implicated the endosomal Toll-like receptor 9 (TLR9) and Toll-like receptor 7 (TLR7) in the activation of the corresponding autoantibody producing B cells. Importantly, TLR9/TLR7-deficiency results in the inability of autoreactive B cells to proliferate in response to DNA/RNA-associated autoantigens in vitro, and in marked changes in the autoantibody repertoire of autoimmune-prone mice. Uptake of DNA/RNA-associated autoantigen immune...
Source: Springer protocols feed by Immunology - January 7, 2016 Category: Allergy & Immunology Source Type: news

Insider’s guide to care: Doctors and dogs
Olivia and Dayton Olivia Burgess knows every nook and cranny of Boston Children’s Hospital. The 13-year-old and her parents have traveled from their home in Bermuda to Boston since Olivia was three years old for ongoing treatments for systemic onset juvenile rheumatoid (idiopathic) arthritis and pediatric lupus. “The unpredictable and severe nature of Olivia’s condition and the frequent travel required for medical treatment can be stressful at times,” says her mother Traci. Olivia sees providers in multiple departments: cardiology, nephrology, pulmonology, dermatology, neurology, gastroenterology an...
Source: Thrive, Children's Hospital Boston - January 4, 2016 Category: Pediatrics Authors: Lisa Fratt Tags: Our Patients’ Stories Fatma Dedeoglu juvenile rheumatoid arthritis Marybeth Son Pawprints Program pediatric lupus rheumatology program Robert Geggel Sitaram Emani Source Type: news

ACR: Actual-weight hydroxychloroquine dosing works in SLE, up to a point
SAN FRANCISCO – Hydroxychloroquine (Plaquenil) dosing based on actual body weight – instead of ideal weight – is appropriate for patients with systemic lupus erythematosus (SLE), according to a review of... (Source: Skin and Allergy News)
Source: Skin and Allergy News - December 30, 2015 Category: Dermatology Source Type: news

Definition of remission for lupus patients 'may need refining'
A new international study has highlighted the need for the clinical definition of remission for lupus (SLE) patients to be further refined. The study, led by Germany's Heinrich-Heine University and involving the UK's Royal Blackburn Hospital, suggested that many systemic lupus erythematosus (SLE) patients deemed to be in remission still experience a range of debilitating symptoms. Data for 1,227 patients was drawn from a multinational real-world survey of patients with SLE, consulting rheumatologists and nephrologists in France, Germany, Italy, Spain and the UK. The team compared the reported symptom burden as recorded by...
Source: Arthritis Research UK - December 18, 2015 Category: Rheumatology Source Type: news

Dog DNA study reveals the incredible journey of man's best friend
Descended from the grey wolf, domesticated dogs have been companions to humans for about 33,000 years, a genetic study has shownMan’s proverbial first best friend was probably a grey wolf that may have made contact with the first human companions about 33,000 years ago, somewhere in south-east Asia.About 15,000 years ago, a small pack of domesticated dogs began trotting towards the Middle East and Africa. Canis lupus familiaris made it to Europe about 10,000 years ago, and when civilisation began in the Fertile Crescent, and humans began to build farmsteads and villages with walls, dogs were already there to help kee...
Source: Guardian Unlimited Science - December 15, 2015 Category: Science Authors: Tim Radford Tags: Genetics Science Animals Biology World news Evolution Source Type: news

Dog DNA study reveals the incredible journey of man's best friend
Descended from the grey wolf, domesticated dogs have been companions to humans for about 33,000 years, a genetic study has shownMan ’s proverbial first best friend was probably a grey wolf that may have made contact with the first human companions about 33,000 years ago, somewhere in south-east Asia.About 15,000 years ago, a small pack of domesticated dogs began trotting towards the Middle East and Africa.Canis lupus familiaris made it to Europe about 10,000 years ago, and when civilisation began in theFertile Crescent, and humans began to build farmsteads and villages with walls, dogs were already there to help keep...
Source: Guardian Unlimited Science - December 15, 2015 Category: Science Authors: Tim Radford Tags: Genetics Science Animals Biology World news Evolution Source Type: news

Treatment of lupus
LupuzorTM may become the first specific and non-immunosuppressant therapy for lupus, a disabling autoimmune disease that is currently incurable. This peptide is the subject of a patent (granted in 2009) and has already successfully completed phases I and II of its regulatory clinical trials. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 15, 2015 Category: Science Source Type: news

Diseases that cause skin problems also can trigger serious neurological conditions
(Loyola University Health System) Diseases such as lupus that cause rashes and other skin problems also can trigger migraine headaches, strokes and other serious neurological conditions, according to an article in a new volume of the Handbook of Clinical Neurology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 15, 2015 Category: Global & Universal Source Type: news

Why Is It Called Christmas Disease?
Discussion Too much or too little causes the important homeostatic balance of life to be upset. This is true of the interactions between the circulatory and hematology systems of the body and their important function in ensuring that the circulatory system plumbing is not leaking (i.e. bleeding) and also not getting plugged up (i.e. thrombosis). A healthy system has adequate numbers of functional platelets, and protein synthesis of the factors needed for a balanced hemostasis system. An adequate amount of Vitamin K is needed for some factors activity. Additionally the absence of any drugs that interfere with platelets or t...
Source: PediatricEducation.org - December 14, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Chemotherapy Isn't Only for Cancer Patients
When you hear the word chemotherapy what immediately comes to mind? Cancer. Bald. Nausea. Vomiting. Infusions. Sterility. Bone Pain? Upon hearing that word, most people jump to the same conclusions, with the same general consensus on how chemo works, who receives it, and what side effects it has on the body. The truth is chemotherapy isn't only for cancer patients, and affects each patient differently depending on how it is used. Chemotherapy is a widely used class of drugs to treat many different disorders including, but not limited to: cancers, blood disorders, and a plethora of autoimmune diseases. Similarly it can be ...
Source: Healthy Living - The Huffington Post - December 8, 2015 Category: Consumer Health News Source Type: news

Pain Coping and Catastrophising in Patients With SLEPain Coping and Catastrophising in Patients With SLE
What factors influence pain coping or catastrophising in patients with systemic lupus erythematosus? Lupus Science & Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 8, 2015 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Polycystic ovarian syndrome and autism link
Children born to PCOS mothers - at risk Related items from OnMedicaPolycystic ovarian syndromeWomen with PCOS at much greater risk of diabetesBlood test identifies high-risk lupus pregnanciesMaternal gestational diabetes increases risk of autismEndometriosis increases risk of miscarriage and ectopic pregnancy (Source: OnMedica Latest News)
Source: OnMedica Latest News - December 8, 2015 Category: UK Health Source Type: news

Biomarker ID'd for Poor Outcome in Lupus With Autoimmune Hepatitis (CME/CE)
(MedPage Today) -- Could guide use of intensive immunosuppression, liver function testing (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - December 7, 2015 Category: Rheumatology Source Type: news

Researchers answer perplexing question about Lupus
Biomedical researchers have suspected that a specific set of immune cells are responsible for causing disease in late-stage lupus patients, but until now they haven’t known for sure. An immunologist has found that these cells do not, in fact, contribute to late-stage lupus in mice. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 7, 2015 Category: Science Source Type: news

Mayo Clinic Minute: Diagnosing Lupus, Heart-Healthy Cranberries
Watch today's Mayo Clinic Minute In today's Mayo Clinic Minute, we look at cranberries – they're not just for Thanksgiving! Research shows drinking cranberry juice is good for heart health. Plus, why lupus can be difficult to diagnose. Reporter Vivien Williams has more. Journalists: Video is available in the downloads. [TRT 1:04] Click here for the [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - November 24, 2015 Category: Databases & Libraries Source Type: news

Complete Lupus Remission is Possible; So is Eventual Relapse (CME/CE)
(MedPage Today) -- About 15% in one cohort were symptom-free for at least 3 years (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - November 23, 2015 Category: Rheumatology Source Type: news

Call the CDC -- A Celebrity Is Sick
You couldn't miss the headline: Charlie Sheen is HIV positive. Networks scrambled to cover the news that he had a virus that could someday, maybe or maybe not, lead to AIDS. I admit, as a journalist, I too told his tale of woe, describing how, despite a reckless past, he had now learned his lesson and sought the medical treatment necessary to make the virus undetectable in his blood. I also, on a daily basis, have updated Lamar Odom's condition and that of other celebrities that wound up in the hospital. But, in my quiet hours at home I wondered, is this news? Do we really need to act as if the entire nation or the Centers...
Source: Healthy Living - The Huffington Post - November 19, 2015 Category: Consumer Health News Source Type: news

Experts warn of high sugar level dangers in pregnancy
74% of pregnant women have potentially dangerously high blood glucoseRelated items from OnMedicaChild health risks of gestational diabetes Probiotics in newborns might lower diabetes riskNICE might underestimate gestational diabetesNICE recommends tighter blood sugar control in diabetes Blood test identifies high-risk lupus pregnancies (Source: OnMedica Latest News)
Source: OnMedica Latest News - November 18, 2015 Category: UK Health Source Type: news

Nephrologists to help find treatment for lupus
(Texas Tech University Health Sciences Center El Paso) Nephrologists at Texas Tech University Health Science Center El Paso have been invited to participate in a national consortium that's investigating the key causes of lupus nephritis -- an autoimmune disease that can cause kidney failure. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 16, 2015 Category: Biology Source Type: news

AstraZeneca lupus drug impresses in mid-stage trial
LONDON (Reuters) - AstraZeneca's experimental lupus drug anifrolumab significantly cut disease activity in a mid-stage clinical trial, boosting hopes for a medicine the company believes could become a $1 billion-a-year seller. (Source: Reuters: Health)
Source: Reuters: Health - November 10, 2015 Category: Consumer Health News Tags: healthNews Source Type: news

Lupus and diffuse large B-cell lymphoma share genetic risk
SAN FRANCISCO – Single-nucleotide polymorphisms in genes for interleukin 10 and human leukocyte antigen are significantly associated with both systemic lupus erythematosus (SLE) and diffuse large B-cell lymphoma, according to a meta-analysis of data from three genome-wide association studies. The... (Source: Skin and Allergy News)
Source: Skin and Allergy News - November 9, 2015 Category: Dermatology Source Type: news

Patient reported outcome measurement system (PROMIS) valid in assessing patient experience
(Hospital for Special Surgery) Hospital for Special Surgery researchers evaluated the Patient Reported Outcomes Measurement Information System (PROMIS) in patients with lupus and found that the questionnaire is valid in assessing subjective patient experience. Researchers also observed a disconnect between the patient perspective and objective signs and symptoms, underscoring the need to integrate patient-reported outcomes into clinical care to ensure optimal disease management. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 7, 2015 Category: Global & Universal Source Type: news

Lupus: Can it cause hair loss?
(Source: MayoClinic.com - Ask a Specialist)
Source: MayoClinic.com - Ask a Specialist - November 5, 2015 Category: Consumer Health News Source Type: news

Your Health Is Not Something to Be Earned
Actress and singer Selena Gomez recently revealed that she underwent chemotherapy for Lupus, which is the same treatment that I endured in 2010. My personal journey in pursuit of wellness has been, and continues to be, long and arduous. In my pre-teen years, I began having uncontrollable nose bleeds that would last for hours coupled with shooting pain through my chest and left arm. I spent several years thereafter poked and prodded -- bone marrow samples, seemingly endless tubes of blood, EKG tests and beyond. It wasn't until four years later that I received the fateful diagnosis: Systemic Lupus Erythematosus. SLE, as it...
Source: Healthy Living - The Huffington Post - November 3, 2015 Category: Consumer Health News Source Type: news

RheumNow: Should Lupus Patients Get Flu/Pneumococcal Vaccines?
(MedPage Today) -- A rheumatologist reviews the evidence (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - November 1, 2015 Category: Primary Care Source Type: news

Comorbidities Common in Lupus -- at All Ages (CME/CE)
(MedPage Today) -- Elevated risks for infections and cancer, as well as cardiac and kidney complications (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - October 29, 2015 Category: Cardiology Source Type: news

New NHS screening for Down's expected soon
DNA test will improve performance in screening and reduce miscarriagesRelated items from OnMedicaThe 6-8 week baby check and screening testsPregnant women likely to be tested earlier for rare genetic abnormalitiesLeading the way with NHS Screening ProgrammesHunt confirms need to boost midwife headcountBlood test identifies high-risk lupus pregnancies (Source: OnMedica Latest News)
Source: OnMedica Latest News - October 27, 2015 Category: UK Health Source Type: news

ICYMI: The Truth About Social Anxiety And Why We Like Mobsters
ICYMI Health features what we're reading this week. This week, writers answered so many of our longstanding questions. Why do we admire mobsters? (Answer: They're dangerous, but not too dangerous.) And what, exactly, is social anxiety? (Answer: Being afraid of rejection by peers to an extreme degree.)  And on a heavier note, we got answers to questions we didn't even know to ask, including: "What is 'airborne cancer'?" One of our own Healthy Living editors also investigated the hypocrisy in blaming someone for a substance use disorder. We also read about the nature of adult friendships and, ye...
Source: Healthy Living - The Huffington Post - October 24, 2015 Category: Consumer Health News Source Type: news

Medical News Today: Lupus: a serious disease we know little about
Most Americans have either have not heard of lupus or know nothing more than the name. In this Spotlight, we take an in-depth look at this potential life-threatening disease. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 22, 2015 Category: Consumer Health News Tags: Lupus Source Type: news