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What are expectations that can come from the Accelerating Medicines Partnership?
Virginia Ladd - AMP Submitted by Julie on Mon, 03/17/2014 - 12:45 Autoimmune diseases affect 50 million Americans and are a leading cause of death and disability — yet we have no cure. Historically, the first goal of treatment is to reduce inflammation focusing on making quality of life as good as possible. However, more needs to be done on greater research options for all autoimmune disease-related patients. Share Email Print var switchTo5x = false;var __st_loadLate = true;stLight.options({"publisher":"dr-e0d16a36-b72f-d97...
Source: PHRMA - March 17, 2014 Category: Pharmaceuticals Authors: Julie Source Type: news

Leslie Hanrahan - AMP
We believe this initiative will ultimately lead to new understanding of the underlying causes of lupus along with new therapies for this disease and ultimately an improved quality of life for people living with lupus. For us it is all about the patient! Lupus is  complex and is arguably the most clinically diverse of all autoimmune diseases. Because of this, the scope of the Accelerating Medicines Partnership (AMP)  is tailor made for a collaborative effort among the NIH, industry, academic medical research centers and non profit organization. Lupus was selected for this project because of the lack of effective t...
Source: PHRMA - March 17, 2014 Category: Pharmaceuticals Authors: Julie Source Type: news

Gary Nabel - AMP
It has been said that all boats rise with the tide. That’s the analogy that comes to mind when thinking about the potential of the Accelerating Medicines Partnership (AMP). By bringing together stakeholders from the National Institutes of Health (NIH), biopharmaceutical companies and several non-profit organizations, AMP is a great opportunity for all of us to join together and develop a broad-based understanding about some of the chronic conditions facing patients today. Sanofi is excited to be participating in two of the AMP focus areas: type 2 diabetes and rheumatoid arthritis/lupus. It may seem counterintuitive f...
Source: PHRMA - March 17, 2014 Category: Pharmaceuticals Authors: Julie Source Type: news

Virginia Ladd - AMP
Autoimmune diseases affect 50 million Americans and are a leading cause of death and disability — yet we have no cure. Historically, the first goal of treatment is to reduce inflammation focusing on making quality of life as good as possible. However, more needs to be done on greater research options for all autoimmune disease-related patients. In existing research, 80-100 different autoimmune diseases have been identified and researchers suspect at least 40 additional diseases of having an autoimmune basis. These diseases are chronic and can be life-threatening. The American Autoimmune Related Diseases Association (...
Source: PHRMA - March 17, 2014 Category: Pharmaceuticals Authors: Julie Source Type: news

HIV vaccine hope found in immune system of a unique patient
The Journal of Clinical Investigation has published a new study of a unique patient with an immune system that produces the types of neutralizing antibodies that are considered essential to an effective HIV vaccine response.The patient has a rare combination of HIV and systemic lupus erythematosus or SLE, a disease where the immune system attacks the body's own cells and tissue.Senior author Barton F. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 14, 2014 Category: Consumer Health News Tags: HIV / AIDS Source Type: news

New Antibody Shows Promise in Lupus
(MedPage Today) -- Initial clinical studies of epratuzumab in patients with active, moderate-to-severe systemic lupus erythematosus are suggesting promise for this monoclonal antibody. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - March 12, 2014 Category: Primary Care Source Type: news

Vaccine hope for HIV offered by unique individual's immune response to virus
One person's unique ability to fight HIV has provided key insights into an immune response that researchers now hope to trigger with a vaccine, according to findings reported by a team that includes Duke Medicine scientists.The person had a rare combination of both lupus and HIV. Lupus, specifically systemic lupus erythematosus, or SLE, is a disease in which the immune system attacks the body's cells and tissue. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 12, 2014 Category: Consumer Health News Tags: Immune System / Vaccines Source Type: news

Paid Lupus Clinical Trial Now Enrolling at Achieve Clinical Research...
Achieve is conducting a phase II, placebo-controlled, multi dose, 24-week clinical study to evaluate the efficacy and safety of a new autoimmune medication in participants living with...(PRWeb March 11, 2014)Read the full story at http://www.prweb.com/releases/2014/03/prweb11643043.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - March 11, 2014 Category: Pharmaceuticals Source Type: news

Jury Awards Lupus Sufferer $800,000 For Insurer's Bad Faith Coverage Denial
SAN FRANCISCO - After an eight-day trial, a California federal jury on Feb. 13 found that an insurer breached its contract and acted in bad faith by denying long-term disability (LTD) coverage to a woman diagnosed with lupus, awarding her more than $873,622 in unpaid benefits and compensatory damages (Cassaundra Ellena v. Standard Insurance Co., et al., No. 3:12-cv-05401, N.D. Calif.). (Source: LexisNexis® Mealey's™ Disability Insurance Legal News)
Source: LexisNexis® Mealey's™ Disability Insurance Legal News - March 11, 2014 Category: Medical Law Source Type: news

Unique individual with lupus and HIV demonstrates desired immune response to HIV
One person’s unique ability to fight HIV has provided key insights into an immune response that researchers now hope to trigger with a vaccine, according to new findings. The person had a rare combination of both lupus and HIV. Lupus, specifically systemic lupus erythematosus, or SLE, is a disease in which the immune system attacks the body's cells and tissue. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 10, 2014 Category: Science Source Type: news

JCI online ahead of print table of contents for March 10, 2014
(Journal of Clinical Investigation) This release contains summaries, links to PDFs, and contact information for the following newsworthy papers published online, March 10, 2014 in the JCI: 'Identification of a broadly neutralizing HIV-1 antibody in a lupus patient,' 'Evaluating disease-associated protein turnover kinetics,' 'Transport properties of pancreatic cancer describe gemcitabine delivery and response,' 'HBS1L-MYB intergenic variants modulate fetal hemoglobin via long-range MYB enhancers,' 'iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions,' and more. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 10, 2014 Category: Global & Universal Source Type: news

Medical Marijuana not Recommended for Rheumatoid Arthritis, Lupus, or Fibromyalgia Symptoms
Patients with rheumatic conditions are in need of symptom relief and some are turning to herbal cannabis as a treatment option. However, the effectiveness and safety of medical marijuana to treat symptoms of rheumatic conditions such as rheumatoid arthritis, lupus, or fibromyalgia is not supported by medical evidence. A new article published in Arthritis Care & Research, a journal of the American College of Rheumatology (ACR), explores the risks associated with using herbal cannabis for medicinal purposes and advises healthcare providers to discourage rheumatology patients from using this drug as therapy. (Source: Disabled World)
Source: Disabled World - March 9, 2014 Category: Disability Tags: Medical Marijuana Source Type: news

Researchers discourage rheumatology patients from using cannabis
Patients with rheumatic conditions are in need of symptom relief and some are turning to herbal cannabis as a treatment option. However, the effectiveness and safety of medical marijuana to treat symptoms of rheumatic conditions such as rheumatoid arthritis, lupus, or fibromyalgia is not supported by medical evidence. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 6, 2014 Category: Consumer Health News Tags: Arthritis / Rheumatology Source Type: news

Leslie Hanrahan
Vice President, Education and Research of the Lupus Foundation of America, Inc.Leslie Hanrahan has over 22 years’ experience in health communications, education and research programming. Since 2005, Ms. Hanrahan has led the strategic development and growth of the Education and Research Department of the Lupus Foundation of America (LFA).  The Lupus Foundation of America is the only national force devoted to solving the mystery of lupus, one of the world’s cruelest, most unpredictable and devastating diseases, while giving caring support to those who suffer from its brutal impact.  Prior to joining the...
Source: PHRMA - March 5, 2014 Category: Pharmaceuticals Authors: Sabrina Source Type: news

How Wolves Change Rivers | video | @GrrlScientist
Wolves are top predators that have far-reaching beneficial effects upon entire ecosystems -- including the structure of rivers.Wolves are crucial for maintaining a healthy ecosystem -- a fact that was conveniently forgotten when they were exterminated from almost all of the continental United States by ranchers, farmers, trappers and hunters.Meanwhile, the populations of other animals exploded. The entire ecosystem of the American wilderness was changed by exploding populations of large ungulates -- particularly wapiti, Cervus canadensis. (These animals are more commonly known as "elk" -- note that the narrator i...
Source: Guardian Unlimited Science - March 3, 2014 Category: Science Authors: GrrlScientist Tags: theguardian.com Blogposts Biology National parks Animals Plants Zoology Environment Science Source Type: news

Herbal cannabis not recommended for rheumatology patients
Patients with rheumatic conditions are in need of symptom relief and some are turning to herbal cannabis as a treatment option. However, the effectiveness and safety of medical marijuana to treat symptoms of rheumatic conditions such as rheumatoid arthritis, lupus, or fibromyalgia is not supported by medical evidence. A new article explores the risks associated with using herbal cannabis for medicinal purposes and advises healthcare providers to discourage rheumatology patients from using this drug as therapy. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 3, 2014 Category: Science Source Type: news

What are some realistic expectations that can come from the Accelerating Medicines Partnership?
Opinionconversations48254827Autoimmune diseases affect 50 million Americans and are a leading cause of death and disability — yet we have no cure. Historically, the first goal of treatment is to reduce inflammation focusing on making quality of life as good as possible. However, more needs to be done on greater research options for all autoimmune disease-related patients. In existing research, 80-100 different autoimmune diseases have been identified and researchers suspect at least 40 additional diseases of having an autoimmune basis. These diseases are chronic and can be life-threatening. The American Autoimmune Re...
Source: PHRMA - February 26, 2014 Category: Pharmaceuticals Authors: Julie Source Type: news

Virginia T. Ladd
President & Executive Director, American Autoimmune Related Diseases Association, Inc. Virginia T. Ladd, R.T. – Virginia Ladd is the President and Executive Director of the American Autoimmune Related Diseases Association, Inc. (AARDA), an organization that she founded to bring a national focus to autoimmunity and increase collaboration in autoimmune research, education, awareness, and advocacy. She has been involved in the nonprofit community for over 30 years as a patient advocate and educator. Mrs. Ladd served as president and executive director of the Lupus Foundation of America. Mrs. Ladd was instrumental in...
Source: PHRMA - February 26, 2014 Category: Pharmaceuticals Authors: Julie Source Type: news

What are our greatest challenges as we address managing chronic diseases like diabetes?
conversationsphrmapediaOpinion480448091404Despite many attempts by prominent researchers utilizing different approaches, there is no cure for diabetes. While continuing extensive research looking into “the cure”, much work is being conducted in the day –to- day management of diabetes. As such, it is essential to develop treatments that not only help measure and adjust blood glucose levels- thus preventing hyper and hypoglycemia, but also to improve the quality of life in our patients with diabetes. The amount of self care skills required to manage diabetes is extensive, requiring blood glucose monitoring,...
Source: PHRMA - February 11, 2014 Category: Pharmaceuticals Authors: Julie Source Type: news

Progression From Cutaneous to Systemic Lupus Erythematosus Progression From Cutaneous to Systemic Lupus Erythematosus
Most patients who progress from cutaneous lupus erythematosus (CLE) to systemic lupus erythematosus (SLE) do not develop significant systemic manifestations, according to a longitudinal study. Reuters Health Information (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - February 7, 2014 Category: Dermatology Tags: Dermatology News Source Type: news

Measuring Interferon Alpha and Other Cytokines in SLE
We describe a functional assay to measure type I IFN activity in SLE plasma and have also measured the response of peripheral blood cells to that cytokine family. This method can be scaled to assess IFN functional activity, as well as activity and cellular response to other cytokines, in relation to cellular and serologic parameters relevant to SLE. (Source: Springer protocols feed by Immunology)
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

Induced Murine Models of Systemic Lupus Erythematosus
Induced mouse models of systemic lupus erythematosus (SLE) have been developed to complement the spontaneous models. This chapter describes the methods used in the pristane-induced model and the chronic graft-versus-host disease (cGVHD) model, both of which have been extensively used. We will also outline the specific mechanisms of systemic autoimmunity that can be best characterized using each of these models. (Source: Springer protocols feed by Immunology)
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

TLC Immunostaining for Detection of “Antiphospholipid” Antibodies
Thin-layer chromatography (TLC) is a nonquantitative technique, which has been employed in the detection of antiphospholipid (aPL) antibodies. Antiphospholipid syndrome (APS) is the most frequently acquired thrombophilia, characterized by thrombosis and obstetric manifestations associated to an autoimmune trait, represented by the positivity of antiphospholipid (aPL) antibodies. Immunoassays for anticardiolipin (aCL) and anti-β2 glycoprotein I (aβ2GPI) antibodies and clotting tests for lupus anticoagulant (LA) represent the standard tests for the routine detection of aPL. The term “seronegative APS” h...
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

Bifunctional Antibody Fragment-Based Fusion Proteins for the Targeted Elimination of Pathogenic T-Cell Subsets
Pathogenic effector T cells are key contributors to autoimmune diseases such as systemic lupus erythematosus (SLE). General inhibition of T cells using, e.g., methotrexate, prednisolone, or TNF blockers, has prominent therapeutic effects frequently at the cost of severe long-term side effects and toxicity. Therefore, targeted strategies that can selectively inhibit or eliminate pathogenic T cells are sought after as a new approach to safely block perpetual inflammatory T-cell responses and inhibit concomitant progressive tissue destruction. Of particular interest in this respect is the use of the so-called single-chain fra...
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

Measurement of Malondialdehyde, Glutathione, and Glutathione Peroxidase in SLE Patients
Oxidative stress contributes to chronic inflammation of tissues and plays a central role in immunomodulation, which may lead to autoimmune diseases such as systemic lupus erythematosus (SLE) and antiphospholipid syndrome. Markers of oxidative damage include malondialdehyde (MDA), antioxidant scavengers as glutathione (GSH), and glutathione peroxidase (GSH Px), which all correlate well with SLE disease activity. Amelioration of some clinical manifestations of SLE may be expected by targeting lipid peroxidation with dietary or pharmacological antioxidants. (Source: Springer protocols feed by Immunology)
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

Generation of Self-Peptides to Treat Systemic Lupus Erythematosus
Synthetic peptides are attracting increasing attention as therapeutics. Despite their potential, however, only a few selected peptides have been able to enter in clinical trials for chronic autoimmune diseases and systemic lupus erythematosus (SLE) in particular. Here, we describe and discuss a series of assays, which may help in characterizing valuable candidate peptides that were applied in our laboratory to develop the lupus P140 peptide program. The different steps of selection include the choice of the initial autoantigen, the design, synthesis and purification of peptides, their preliminary screen by measuring cytoki...
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

Detection of SLE Antigens in Neutrophil Extracellular Traps (NETs)
Neutrophils are sentinel cells of the innate immune system with a primary role of clearing extracellular pathogens. The release of weblike structures decorated with granular proteins called neutrophil extracellular traps (NETs) has recently been implicated in the pathogenesis of inflammatory and autoimmune diseases. Indeed, NETs may represent an important source of autoantigens and immunostimulatory proteins in systemic lupus erythematosus (SLE). In this chapter, we describe protocols to isolate human peripheral neutrophils, to generate and isolate NETs, and to detect SLE antigens in NETs using immunofluorescence and immun...
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

Isolation, Polarization, and Expansion of CD4+ Helper T Cell Lines and Clones Using Magnetic Beads
Autoreactive CD4+ helper T cells specific for a range of nucleoprotein-derived autoantigens are an important feature of systemic lupus erythematosus, driving B cell differentiation and autoantibody production and contributing to the inflammatory lesions caused by immune complex deposition. Several peptide epitopes from nucleoprotein antigens have been identified and offer a means selectively to manipulate T cell responses by skewing toward a profile of cytokines that is less pro-inflammatory. (Source: Springer protocols feed by Immunology)
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

Meta-analysis as a Diagnostic Tool for Predicting Disease Onset and/or Activity in Systemic Lupus Erythematosus
Systemic lupus erythematous (SLE) is a relatively rare disorder with prevalence rates between 5 and 50 per 100,000 population. This means performing any epidemiological analysis in a specific research center is difficult, due to the low number of cases within any one location. There is a need for biomarkers and diagnostic aids to monitor SLE disease activity and severity prior, during, and after treatment. Many specialist lupus clinics worldwide have published trials following in detail small numbers of patients that have been monitored for a disease biomarker, e.g., an autoantibody against a self-molecule in prospective a...
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

Microarray Technology for Analysis of MicroRNA Expression in Renal Biopsies of Lupus Nephritis Patients
This article offers a technological overview of microarray technology for analysis of microRNA gene expression in kidney biopsies from SLE patients. (Source: Springer protocols feed by Immunology)
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

Laboratory Tests for the Antiphospholipid Syndrome
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent vascular thrombosis (VT) and/or pregnancy morbidity (PM) in the presence of persistent antiphospholipid antibodies (aPL), detected by lupus anticoagulant (LA), anticardiolipin (aCL) antibody, and/or anti‐β2 glycoprotein I (aβ2GPI) antibody assays. These aPL, considered to be diagnostic markers and pathogenic drivers of APS, are a heterogeneous group of antibodies directed against anionic phospholipids, phospholipid-binding plasma proteins, and phospholipid–protein complexes. Although APS is currently considered as a singl...
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

Evaluating a Particular Circulating MicroRNA Species from an SLE Patient Using Stem-Loop qRT-PCR
Systemic lupus erythematosus (SLE) is a complex autoimmune disease, and correct judgment of SLE activity is very important in guiding precise clinical treatment. Circulating microRNAs (miRNAs) could serve as potential biomarkers of disease activity or status in SLE, and here we describe a modified qRT-PCR method for detecting them. Stem loop has become one of the most powerful methods for determining miRNA expression because it is highly sensitive and accurate and requires only small amount of sample. In this chapter, we focus on a stem-loop reverse transcription-bound SYBR green qRT-PCR protocol for evaluating a particula...
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

The Lupus Biomarker Odyssey: One Experience
The last decade has witnessed an explosion in efforts to discover and validate lupus biomarkers. The currently steep trajectory of this progress is unprecedented. However, advances in the lupus biomarker field remain fewer and slower than physicians, patients, and pharmaceutical companies have hoped for. This chapter will review the challenges confronted by physicians and scientists in pursuit of lupus biomarkers and will present our experience on this path and specific efforts to surmount some of the obstacles in this endeavor. A comprehensive review of the current landscape in lupus biomarker research has recently been p...
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

Pathology of Systemic Lupus Erythematosus: The Challenges Ahead
Many studies have explored the pathology of systemic lupus erythematosus (SLE), an autoimmune rheumatic disorder with a striking female predominance. Numerous autoimmune phenomena are present in this disease, which ultimately result in organ damage. However, the specific cellular and humoral mechanisms underlying the immune dysfunction are not yet fully understood. (Source: Springer protocols feed by Immunology)
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

Recombinant Antibody Microarray for Profiling the Serum Proteome of SLE
Systemic lupus erythematosus (SLE) is a severe autoimmune connective tissue disease. Our current knowledge about the serum proteome, or serum biomarker panels, reflecting disease and disease status is still very limited. Affinity proteomics, represented by recombinant antibody arrays, is a novel, multiplex technology for high-throughput protein expression profiling of crude serum proteomes in a highly specific, sensitive, and miniaturized manner. The antibodies are deposited one by one in an ordered pattern, an array, onto a solid support. Next, the sample is added, and any specifically bound proteins are detected and quan...
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

Detection of Antinuclear Antibodies in SLE
The antinuclear antibodies (ANA) also known as antinuclear factors (ANF) are unwanted molecules which bind and destroy certain structures within the nucleus. In systemic lupus erythematosus (SLE), they are produced in excess; hence their detection in the blood of patients is important for diagnosis and monitoring of the disease. Several methods are available which can be used to detect ANA; nevertheless, indirect immunofluorescence antinuclear antibody test (IF-ANA) is considered a “reference method” for their detection. Though IF-ANA is relatively easier to perform, its interpretation requires considerable ski...
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

Tests for Circulating Immune Complexes
Antigen–antibody complexes in tissues play a central role in the pathogenesis of lupus. Some of the immune complexes are formed in situ, i.e., in the tissues. Others are present in the blood stream, and these circulating immune complexes may deposit in tissues and incite inflammatory mechanisms in those tissues. A variety of techniques are available to measure circulating immune complexes. The assays that have been most studied in SLE include approaches that rely on the interaction of immune complexes with complement proteins, and therefore bind to C1q or contain bound C3. (Source: Springer protocols feed by Immunology)
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

Delist gray wolf from threatened and endangered list? Panel issues report on science
As the Endangered Species Act celebrated its 40th anniversary at the end of 2013, its administrative agency, the US Fish and Wildlife Service, was mired in controversy. At issue was a proposal to remove the gray wolf (Canis lupus) from the List of Endangered and Threatened Wildlife and add the Mexican gray wolf (Canis lupus baileyi). (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 7, 2014 Category: Science Source Type: news

Panel issues report on gray wolf science
(University of California - Santa Barbara) As the Endangered Species Act celebrated its 40th anniversary at the end of 2013, its administrative agency, the US Fish and Wildlife Service, was mired in controversy. At issue was a proposal to remove the gray wolf (Canis lupus) from the List of Endangered and Threatened Wildlife and add the Mexican gray wolf (Canis lupus baileyi). (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 7, 2014 Category: Biology Source Type: news

Heart Disease and Lupus: Mayo Clinic Radio Health Minute
In this Mayo Clinic Radio Health Minute, Dr. Vaidehi Chowdhary tells us about the increased risk of heart disease in patients with lupus. To listen, click the link below. 2014Feb05Heart Disease and Lupus (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - February 5, 2014 Category: Databases & Libraries Source Type: news

Nicky Clarke's girlfriend Kelly Simpkin reveals struggle with disease lupus
Kelly Simpson, 32, girlfriend of Nicky Clarke, 55, suffers from lupus, which causes the body’s immune system to turn on itself and start killing its own cells. (Source: the Mail online | Health)
Source: the Mail online | Health - February 2, 2014 Category: Consumer Health News Source Type: news

Rheumatology Top News: Lupus and Football Injuries
(MedPage Today) -- Low vitamin D in lupus was the top story this week in rheumatology, followed by the hazards of football. (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - January 31, 2014 Category: Rheumatology Source Type: news

Low Vitamin D Linked With Worse Lupus (CME/CE)
(MedPage Today) -- Low levels of vitamin D among patients with systemic lupus erythematosus (SLE) were associated with greater disease activity and an increased likelihood of cardiovascular risk factors such as high blood pressure and elevated lipids, a large cohort study found. (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - January 30, 2014 Category: Endocrinology Source Type: news

This Week in Rheumatology: ACR Seeks Input on RA Tx
(MedPage Today) -- The American College of Rheumatology invites comments for proposed 2014 recommendations for the treatment of rheumatoid arthritis. Also, a podcast on preventing pregnancy complications in women with lupus. (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - January 27, 2014 Category: Rheumatology Source Type: news

JCI early table of contents for Jan. 27, 2014
(Journal of Clinical Investigation) This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Jan. 27, 2014, in the JCI: "Inhibition of kidney glucose transport improves hyperglycemia but increases glucose production," "Targetting lipid metabolism restores function in T cells from lupus patients," "Clinical evaluation of teriparatid treatment for osteogenesis imperfecta," and more... (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 27, 2014 Category: Cancer & Oncology Source Type: news

What Evaluation Should Be Considered for Heavy Menstrual Bleeding?
Discussion Heavy menstrual bleeding is a common problem. The rates depend on the population and underlying cause, but can occur 30% of adolescent females who go to a gynecologist. Average menstrual blood loss is 30-40 ml. Hypermenorrhea or menorrhagia are regular menstrual cycles that last too long (>7 days) or are too heavy (> 80 ml blood loss). Metrorrhagia is irregular menstrual bleeding. Menometrorrhagia is abnormally heavy bleeding that occurs with an irregular timing. Dysfunctional uterine bleeding is a more generic term describing prolonged, excessive or frequent, unpatterned uterine bleeding that is not relat...
Source: PediatricEducation.org - January 20, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Triable Issues Over Lupus Condition, Treatment Bar Summary Judgment, Judge Says
SAN FRANCISCO - Although he found no problems with an insurer's definition of disability, a California federal judge on Dec. 10 held that triable issues of fact surrounding an employee's diagnosis and treatment of her lupus precluded him from granting summary judgment to an insurer on a bad faith claim against it (Cassaundra Ellena v. Standard Insurance Co., et al., No. 3:12-cv-05401, N.D. Calif.; 2013 U.S. Dist. LEXIS 173163). (Source: LexisNexis® Mealey's™ Disability Insurance Legal News)
Source: LexisNexis® Mealey's™ Disability Insurance Legal News - January 14, 2014 Category: Medical Law Source Type: news

Suicidal ideation in patients with systemic lupus erythematosus: Incidence and risk factors - Mok CC, Chan KL, Cheung EF, Yip PS.
Objective. To study the incidence of suicidal ideation in patients with SLE and the associated risk factors.Methods. Consecutive patients who fulfilled four or more ACR criteria for SLE were recruited. Suicidal thought in the preceding month was assessed b... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - January 12, 2014 Category: Global & Universal Tags: Suicide and Self-Harm Source Type: news

This Week in Rheumatology: NIAMS research, FDA hearing
(MedPage Today) -- The research agenda for the National Institute of Arthritis and Musculoskeletal and Skin Diseases is likely to be the big story in rheumatology this week, but an FDA hearing and a new lupus journal will also drive headlines. (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - January 6, 2014 Category: Rheumatology Source Type: news

Suicidal Thoughts Are Common in SLESuicidal Thoughts Are Common in SLE
Suicidal thoughts are common in patients with systemic lupus erythematosus and are more intense in patients with depressive symptoms, recent life events, cardiovascular damage and previous suicide attempts. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 2, 2014 Category: Consumer Health News Tags: Rheumatology News Source Type: news