Bickerstaff encephalitis in childhood: a review of 74 cases in the literature from 1951 to today
Bickerstaff brainstem encephalitis (BBE) is a rare autoimmune disease characterized by the subacute onset of bilateral external ophthalmoplegia, ataxia, and decreased level of consciousness. BBE is part of a group of rare autoimmune diseases in children that can affect the nervous system at any level. The onset of neurological deficits is often sudden and nonspecific. The diagnosis is based on clinical findings and abnormal findings on cerebrospinal fluid (CSF), electroencephalography (EEG), electromyography (EMG), and magnetic resonance imaging (MRI). BBE is associated with the presence of the antiganglioside antibody, an...
Source: Frontiers in Neurology - March 12, 2024 Category: Neurology Source Type: research
Cerebrospinal Fluid Biomarkers of Symptomatic Neurosyphilis in People With HIV Compared with Uninfected Individuals
AbstractWe evaluated the diagnostic clinical performance characteristics (DCPC) of cerebrospinal fluid (CSF) total protein (TP), white blood cell count (WBC), and lactate (LA) with different cutoff points as adjunct biomarkers of confirmed or presumptive symptomatic neurosyphilis (NS) and the impact of HIV infection. From 5,640 participants who underwent lumbar punctures, 236 participants were included, and classified as either people with HIV (PWH) or people without HIV (PWoH) according to the CDC criteria for confirmed NS (n = 42), presumptive NS (n = 74), systemic syphilis (SS) (n = 38), serological diagnos...
Source: Journal of NeuroVirology - March 12, 2024 Category: Neurology Source Type: research
Neurolymphomatosis as primary presentation of extra-nodal NK/T-cell lymphoma, nasal type
We describe a case of a 64-year-old female patient with NL associated with extra-nodal NK/T-cell lymphoma (ENKTL), nasal type, presenting as a painful progressive mononeuropathy multiplex with an oral cavity lesion. ENKTL is usually associated with Epstein-Barr virus (EBV) infection and rarely affects the central and peripheral nervous system. Lumbar puncture, magnetic resonance imaging (MRI), nerve biopsy, and18F-fluorodeoxyglucose positron emission tomography (FDG-PET) help to establish the diagnosis. Thereby, NL should be considered in the differential diagnosis of painful progressive multiple neuropathies, even in pati...
Source: Neurological Sciences - March 12, 2024 Category: Neurology Source Type: research
Post-lumbar puncture intracranial hypotension with spinal extradural collection: Lessons from a case report
Rev Neurol (Paris). 2024 Mar 7:S0035-3787(24)00424-7. doi: 10.1016/j.neurol.2024.01.004. Online ahead of print.NO ABSTRACTPMID:38458838 | DOI:10.1016/j.neurol.2024.01.004 (Source: Revue Neurologique)
Source: Revue Neurologique - March 8, 2024 Category: Neurology Authors: A Haddad M Faillot R Bacquet P Decq C Henry M Bonnan Source Type: research
Case report: Psychosis with catatonia in an adult man: a presentation of neurosarcoidosis
ConclusionsClinicians should consider organic causes when confronted with a middle-aged patient experiencing a first psychotic episode with an atypical onset, catatonic features, or dysfunction in orientation and/or memory, a complete lack of a positive familial psychiatric history and/or an atypical response to (psycho)pharmacological treatment. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - March 4, 2024 Category: Psychiatry Source Type: research
Prognostic impact of clinical and radiological factors on leptomeningeal metastasis from solid cancers
ConclusionsThis study validated the efficacy of prognostication according to the EANO-ESMO guidelines for LM. Systemic therapy after LM diagnosis improves the survival of NSCLC patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 2, 2024 Category: Cancer & Oncology Source Type: research
Blood-Based Biomarkers for Early Alzheimer's Disease Diagnosis in Real-World Settings
Methods Mol Biol. 2024;2785:3-14. doi: 10.1007/978-1-0716-3774-6_1.ABSTRACTAs our knowledge about the biology of Alzheimer's disease (AD) expands and we recognize the significance of early intervention for effective treatment, there is a shift in focus toward detecting the disease at an early stage. AD is characterized by the accumulation of misfolded amyloid-β (Aβ) and phosphorylated tau proteins in the brain, leading to the formation of senile plaques and neurofibrillary tangles. While a definitive diagnosis of AD can only be confirmed through autopsy by examining these pathological features, there are now reliable met...
Source: Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Robert Perneczky Niels Hansen Anna Hofmann Christoph Laske Josef Priller Timo Grimmer Lutz Fr ölich Emrah D üzel Frank Jessen Jens Wiltfang German Network Memory Clinics – Diagnostic Tools Working Group Source Type: research
Blood-Based Biomarkers for Early Alzheimer's Disease Diagnosis in Real-World Settings
Methods Mol Biol. 2024;2785:3-14. doi: 10.1007/978-1-0716-3774-6_1.ABSTRACTAs our knowledge about the biology of Alzheimer's disease (AD) expands and we recognize the significance of early intervention for effective treatment, there is a shift in focus toward detecting the disease at an early stage. AD is characterized by the accumulation of misfolded amyloid-β (Aβ) and phosphorylated tau proteins in the brain, leading to the formation of senile plaques and neurofibrillary tangles. While a definitive diagnosis of AD can only be confirmed through autopsy by examining these pathological features, there are now reliable met...
Source: Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Robert Perneczky Niels Hansen Anna Hofmann Christoph Laske Josef Priller Timo Grimmer Lutz Fr ölich Emrah D üzel Frank Jessen Jens Wiltfang German Network Memory Clinics – Diagnostic Tools Working Group Source Type: research
Spontaneous Intracranial Hypotension
Spontaneous intracranial hypotension (SIH) typically presents as an acute orthostatic headache during an upright position, secondary to spinal cerebrospinal fluid leaks. New evidence indicates that a lumbar puncture may not be essential for diagnosing every patient with SIH. Spinal neuroimaging protocols used for diagnosing and localizing spinal cerebrospinal fluid leaks include brain/spinal MRI, computed tomography myelography, digital subtraction myelography, and radionuclide cisternography. Complications of SIH include subdural hematoma, cerebral venous thrombosis, and superficial siderosis. Treatment options encompass ...
Source: Neurologic Clinics - February 28, 2024 Category: Neurology Authors: Jr-Wei Wu, Shuu-Jiun Wang Source Type: research
Diagnostic utility of point-of-care ultrasound and optical coherence tomography for papilloedema in children: a prospective pilot study
CONCLUSION: Both OCT and POCUS are potentially useful tools to help diagnose papilloedema in children. Larger studies are needed to further define the role and accuracy of POCUS and OCT in assessing papilloedema in children.PMID:38413191 | DOI:10.1136/bjo-2023-324552 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - February 27, 2024 Category: Opthalmology Authors: Hannah H Chiu Nouf Al-Farsi Agnes M F Wong Adrienne Davis Mark O Tessaro Michael J Wan Source Type: research
Diagnostic utility of point-of-care ultrasound and optical coherence tomography for papilloedema in children: a prospective pilot study
CONCLUSION: Both OCT and POCUS are potentially useful tools to help diagnose papilloedema in children. Larger studies are needed to further define the role and accuracy of POCUS and OCT in assessing papilloedema in children.PMID:38413191 | DOI:10.1136/bjo-2023-324552 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - February 27, 2024 Category: Opthalmology Authors: Hannah H Chiu Nouf Al-Farsi Agnes M F Wong Adrienne Davis Mark O Tessaro Michael J Wan Source Type: research
Headache associated with intracranial hypotension: diagnostic challenges and difficulties in everyday neurological practice
Neurol Neurochir Pol. 2024 Feb 23. doi: 10.5603/pjnns.97407. Online ahead of print.ABSTRACTLow pressure of cerebrospinal fluid (CSF) is a rare cause of headache, except when the patient undergoes a lumbar puncture. Headache associated with a low CSF pressure i.e. intracranial hypotension causes diagnostic difficulties. Headaches related to spontaneous intracranial hypotension (SIH) pose a significant diagnostic challenge in everyday neurological practice. Patients with headaches due to SIH are usually diagnosed only after a long delay. Diagnostic problems may result in unnecessary invasive diagnostic procedures, or even ne...
Source: Neurologia i Neurochirurgia Polska - February 23, 2024 Category: Neurology Authors: Magdalena Boczarska-Jedynak Daniel Stompel Source Type: research
Headache associated with intracranial hypotension: diagnostic challenges and difficulties in everyday neurological practice
Neurol Neurochir Pol. 2024 Feb 23. doi: 10.5603/pjnns.97407. Online ahead of print.ABSTRACTLow pressure of cerebrospinal fluid (CSF) is a rare cause of headache, except when the patient undergoes a lumbar puncture. Headache associated with a low CSF pressure i.e. intracranial hypotension causes diagnostic difficulties. Headaches related to spontaneous intracranial hypotension (SIH) pose a significant diagnostic challenge in everyday neurological practice. Patients with headaches due to SIH are usually diagnosed only after a long delay. Diagnostic problems may result in unnecessary invasive diagnostic procedures, or even ne...
Source: Neurologia i Neurochirurgia Polska - February 23, 2024 Category: Neurology Authors: Magdalena Boczarska-Jedynak Daniel Stompel Source Type: research
Headache associated with intracranial hypotension: diagnostic challenges and difficulties in everyday neurological practice
Neurol Neurochir Pol. 2024 Feb 23. doi: 10.5603/pjnns.97407. Online ahead of print.ABSTRACTLow pressure of cerebrospinal fluid (CSF) is a rare cause of headache, except when the patient undergoes a lumbar puncture. Headache associated with a low CSF pressure i.e. intracranial hypotension causes diagnostic difficulties. Headaches related to spontaneous intracranial hypotension (SIH) pose a significant diagnostic challenge in everyday neurological practice. Patients with headaches due to SIH are usually diagnosed only after a long delay. Diagnostic problems may result in unnecessary invasive diagnostic procedures, or even ne...
Source: Neurologia i Neurochirurgia Polska - February 23, 2024 Category: Neurology Authors: Magdalena Boczarska-Jedynak Daniel Stompel Source Type: research
Headache associated with intracranial hypotension: diagnostic challenges and difficulties in everyday neurological practice
Neurol Neurochir Pol. 2024 Feb 23. doi: 10.5603/pjnns.97407. Online ahead of print.ABSTRACTLow pressure of cerebrospinal fluid (CSF) is a rare cause of headache, except when the patient undergoes a lumbar puncture. Headache associated with a low CSF pressure i.e. intracranial hypotension causes diagnostic difficulties. Headaches related to spontaneous intracranial hypotension (SIH) pose a significant diagnostic challenge in everyday neurological practice. Patients with headaches due to SIH are usually diagnosed only after a long delay. Diagnostic problems may result in unnecessary invasive diagnostic procedures, or even ne...
Source: Neurologia i Neurochirurgia Polska - February 23, 2024 Category: Neurology Authors: Magdalena Boczarska-Jedynak Daniel Stompel Source Type: research
