Headache associated with intracranial hypotension: diagnostic challenges and difficulties in everyday neurological practice
Neurol Neurochir Pol. 2024;58(1):21-30. doi: 10.5603/pjnns.97407. Epub 2024 Feb 23.ABSTRACTLow pressure of cerebrospinal fluid (CSF) is a rare cause of headache, except when the patient undergoes a lumbar puncture. Headache associated with a low CSF pressure i.e. intracranial hypotension causes diagnostic difficulties. Headaches related to spontaneous intracranial hypotension (SIH) pose a significant diagnostic challenge in everyday neurological practice. Patients with headaches due to SIH are usually diagnosed only after a long delay. Diagnostic problems may result in unnecessary invasive diagnostic procedures, or even ne...
Source: Neurologia i Neurochirurgia Polska - February 23, 2024 Category: Neurology Authors: Magdalena Boczarska-Jedynak Daniel Stompel Source Type: research
Postoperative Neurologic Complications in the Older Adult
AbstractPurpose of ReviewThe older patient population is at increased risk of postoperative neurologic complications. With an ever-increasing proportion of older adults requiring advanced surgical interventions, surgeons should be knowledgeable in contemporary diagnostic and management paradigms. In this review, we detail neurologic complications common encountered in elderly populations, reviewing relevant literature and practices.Recent FindingsCommon postoperative neurologic complications in the elderly include delirium, cerebrovascular accidents, and seizures. The mainstay of treatment of postoperative delirium is non-...
Source: Current Geriatrics Reports - February 23, 2024 Category: Geriatrics Source Type: research
Brain structural indicators of β-amyloid neuropathology
Neurobiol Aging. 2024 Jan 18;136:157-170. doi: 10.1016/j.neurobiolaging.2024.01.005. Online ahead of print.ABSTRACTRecent efforts demonstrated the efficacy of identifying early-stage neuropathology of Alzheimer's disease (AD) through lumbar puncture cerebrospinal fluid assessment and positron emission tomography (PET) radiotracer imaging. These methods are effective yet are invasive, expensive, and not widely accessible. We extend and improve the multiscale structural mapping (MSSM) procedure to develop structural indicators of β-amyloid neuropathology in preclinical AD, by capturing both macrostructural and microstructur...
Source: Neurobiology of Aging - February 21, 2024 Category: Geriatrics Authors: Ikbeom Jang Binyin Li Barnaly Rashid John Jacoby Susie Y Huang Bradford C Dickerson David H Salat Alzheimer ’s Disease Neuroimaging Initiative Source Type: research
Brain structural indicators of β-amyloid neuropathology
Neurobiol Aging. 2024 Jan 18;136:157-170. doi: 10.1016/j.neurobiolaging.2024.01.005. Online ahead of print.ABSTRACTRecent efforts demonstrated the efficacy of identifying early-stage neuropathology of Alzheimer's disease (AD) through lumbar puncture cerebrospinal fluid assessment and positron emission tomography (PET) radiotracer imaging. These methods are effective yet are invasive, expensive, and not widely accessible. We extend and improve the multiscale structural mapping (MSSM) procedure to develop structural indicators of β-amyloid neuropathology in preclinical AD, by capturing both macrostructural and microstructur...
Source: Neurobiology of Aging - February 21, 2024 Category: Geriatrics Authors: Ikbeom Jang Binyin Li Barnaly Rashid John Jacoby Susie Y Huang Bradford C Dickerson David H Salat Alzheimer ’s Disease Neuroimaging Initiative Source Type: research
Brain structural indicators of β-amyloid neuropathology
Neurobiol Aging. 2024 Jan 18;136:157-170. doi: 10.1016/j.neurobiolaging.2024.01.005. Online ahead of print.ABSTRACTRecent efforts demonstrated the efficacy of identifying early-stage neuropathology of Alzheimer's disease (AD) through lumbar puncture cerebrospinal fluid assessment and positron emission tomography (PET) radiotracer imaging. These methods are effective yet are invasive, expensive, and not widely accessible. We extend and improve the multiscale structural mapping (MSSM) procedure to develop structural indicators of β-amyloid neuropathology in preclinical AD, by capturing both macrostructural and microstructur...
Source: Neurobiology of Aging - February 21, 2024 Category: Geriatrics Authors: Ikbeom Jang Binyin Li Barnaly Rashid John Jacoby Susie Y Huang Bradford C Dickerson David H Salat Alzheimer ’s Disease Neuroimaging Initiative Source Type: research
Case report: Resolution of Guillain-Barr é syndrome in a patient with dual primary tumors after treatment with rituximab
We report a rare case of GBS in a 64-year-old male patient with dual primary tumors of the colon and stomach who received toripalimab and chemotherapy for liver metastases. After five treatments, the patient experienced weakness and numbness in his limbs. Lumbar puncture, electromyography, and other tests confirmed the diagnosis of GBS. Intravenous immunoglobulin (IVIG) and methylprednisolone did not improve the patient’s symptoms, but rituximab, which is not a standard regimen for GBS, was effective in eliminating B cells and improving symptoms. Following this, we effectively shifted from a regimen combining immunothera...
Source: Frontiers in Neurology - February 21, 2024 Category: Neurology Source Type: research
Real-word application of the AT(N) classification and disease-modifying treatment eligibility in a hospital-based cohort
This study aims to apply the AT(N) classification to a hospital-based cohort of patients with cognitive decline and/or dementia, within and outside the Alzheimer ’s disease (AD) continuum, to enhance our understanding of the multidimensional aspects of AD and related disorders. Furthermore, we wish to investigate how many cases from our cohort would be eligible for the available disease modifying treatments, such as aducanemab and lecanemab.MethodsWe conducted a retrospective evaluation of 429 patients referred to the Memory Center of IRCCS San Raffaele Hospital in Milan. Patients underwent clinical/neuropsychological as...
Source: Journal of Neurology - February 21, 2024 Category: Neurology Source Type: research
Full sample analysis of cerebral venous sinus thrombosis in ophthalmology inpatients
CONCLUSION: The main reasons interfering with the diagnosis of CVST might be its nonspecific ocular symptoms and the physicians' clinical thought process being limited to the scope of common ophthalmological diseases.PMID:38377844 | DOI:10.1016/j.jfo.2024.104074 (Source: Journal Francais d Ophtalmologie)
Source: Journal Francais d Ophtalmologie - February 20, 2024 Category: Opthalmology Authors: H Li S Wei Q Xu Source Type: research
Computerised modified paramedian approach technique versus conventional midline approach technique of lumbar puncture: a randomised control trial protocol
Introduction
The lumbar puncture (LP) technique is widely used for diagnostic and therapeutic purposes. In recent years, the paramedian approach technique (PAT) has gained increasing interest due to its advantages over the conventional midline approach technique (MAT) that has been traditionally employed in clinical practice for LP. However, there have been inconsistent discussions regarding the efficacy of different LP techniques. Based on digital virtual human and computer simulation techniques, a new approach called computerised modified PAT (CMPAT) was proposed. Therefore, the aim of this study is to discuss a randomis...
Source: BMJ Open - February 20, 2024 Category: General Medicine Authors: Zhuang, Y.-D., Chen, Y.-Z., Lin, Q.-Y., Chen, Y.-X., Zhong, S.-Q., Lei, D., Chen, C.-M. Tags: Open access, Surgery Source Type: research
Psychosocial stress moderates the relationship between cerebrospinal fluid lactate dehydrogenase and the duration of untreated psychosis in first-episode psychosis
ConclusionsOur study suggests that psychosocial stress moderates the relationship between the onset of psychosis and CSF biomarkers related to bioenergetic systems. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - February 15, 2024 Category: Psychiatry Source Type: research
Emergence of Extracellular Vesicles as "Liquid Biopsy" for Neurological Disorders: Boom or Bust
Pharmacol Rev. 2024 Feb 13;76(2):199-227. doi: 10.1124/pharmrev.122.000788.ABSTRACTExtracellular vesicles (EVs) have emerged as an attractive liquid biopsy approach in the diagnosis and prognosis of multiple diseases and disorders. The feasibility of enriching specific subpopulations of EVs from biofluids based on their unique surface markers has opened novel opportunities to gain molecular insight from various tissues and organs, including the brain. Over the past decade, EVs in bodily fluids have been extensively studied for biomarkers associated with various neurological disorders, such as Alzheimer's disease, Parkinson...
Source: Pharmacological Reviews - February 13, 2024 Category: Drugs & Pharmacology Authors: Ashish Kumar Michael A Nader Gagan Deep Source Type: research
Emergence of Extracellular Vesicles as "Liquid Biopsy" for Neurological Disorders: Boom or Bust
Pharmacol Rev. 2024 Feb 13;76(2):199-227. doi: 10.1124/pharmrev.122.000788.ABSTRACTExtracellular vesicles (EVs) have emerged as an attractive liquid biopsy approach in the diagnosis and prognosis of multiple diseases and disorders. The feasibility of enriching specific subpopulations of EVs from biofluids based on their unique surface markers has opened novel opportunities to gain molecular insight from various tissues and organs, including the brain. Over the past decade, EVs in bodily fluids have been extensively studied for biomarkers associated with various neurological disorders, such as Alzheimer's disease, Parkinson...
Source: Pharmacological Reviews - February 13, 2024 Category: Drugs & Pharmacology Authors: Ashish Kumar Michael A Nader Gagan Deep Source Type: research
Cerebellar encephalitis associated with anti-mGluR1 antibodies: a case report and comprehensive literature review
Anti-metabotropic glutamate receptor 1 encephalitis is an uncommon autoimmune condition characterized by a subacute onset of cerebellar syndrome. Frequently, it also manifests as sleep disorders and cognitive or behavioral changes. While immunotherapy is the primary treatment approach, the disease remains poorly understood. Herein, we present a case of anti-metabotropic glutamate receptor 1 encephalitis, highlighting its primary cerebellar syndrome manifestation. The first magnetic resonance imaging scan showed no obvious abnormality. Lumbar puncture showed increased cerebrospinal fluid pressure, increased white blood cell...
Source: Frontiers in Neurology - February 12, 2024 Category: Neurology Source Type: research
Influenza B-induced longitudinally extensive transverse myelitis and bithalamic acute disseminated encephalomyelitis
AbstractIn the COVID-era, other viral pathogens, like influenza B, gain less attention in scientific reporting. However, influenza still is endemic, and rarely affects central nervous system (CNS). Here, we report the case of a 35-year-old male who presented with fever since 1 week, and developed acute ascending flaccid paralysis and urinary retention. The clinical presentation of paraparesis in combination with the inflammation proven by the lumbar puncture, and the MRI full spine, fulfilled the diagnostic criteria of longitudinally extensive transverse myelitis (LETM) . In this case, it is most likely based on a post-v...
Source: Neurological Sciences - February 10, 2024 Category: Neurology Source Type: research
