Lumbar Puncture Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Safety Concerns with Nusinersen, Risdiplam, and Onasemnogene Abeparvovec in Spinal Muscular Atrophy: A Real-World Pharmacovigilance Study
ConclusionsThis study highlights the importance of monitoring injection-related injuries and transient deafness events in patients treated with nusinersen. For onasemnogene abeparvovec, careful monitoring for renal impairment, liver injury, and myocardial damage is necessary. Risdiplam requires attention to the potential risk of rare but severe gastrointestinal damage events and hypoglycemia. Importantly, risdiplam exhibited lower liver and renal toxicity, making it a potential consideration for patients with liver or renal insufficiency or for combined use with other drugs that possess high liver or renal toxicity. These ...
Source: Clinical Drug Investigation - November 23, 2023 Category: Drugs & Pharmacology Source Type: research

Recurrent reflex syncope in idiopathic intracranial hypertension patient resolved after lumbar puncture: pathogenetic implications
Idiopathic intracranial hypertension is a disease characterized by increased intracranial cerebrospinal fluid volume and pressure without evidence of other intracranial pathology. Dural sinuses are rigid struc... (Source: BMC Neurology)
Source: BMC Neurology - November 21, 2023 Category: Neurology Authors: Roberto De Simone, Mattia Sansone, Francesco Curcio, Cinzia Valeria Russo, Gianluigi Galizia, Angelo Miele, Antonio Stornaiuolo, Andrea Piccolo, Simone Braca and Pasquale Abete Tags: Case Report Source Type: research

Authors ’ Reply
We appreciate the authors ’ interest in our recently published “ACR Appropriateness Criteria® Headache: 2022 Update.” The authors raise an important consideration with respect to the use of head CT angiography (CTA) for patients presenting with sudden-onset severe headache that reaches maximal intensity within 1 hour (Variant 1). Although we stand by our “may be appropriate” recommendation, we agree that a more nuanced discussion as to the benefits and drawbacks of CTA versus lumbar puncture in patients presenting after 6 hours is important. (Source: Journal of the American College of Radiology : JACR)
Source: Journal of the American College of Radiology : JACR - November 18, 2023 Category: Radiology Authors: Pallavi S. Utukuri, Robert Shih, Judah Burns Tags: Letters to the Editor Source Type: research

Letter to the Editor: Ultrasound Measurement of the Intervertebral Space in the Lateral Recumbent Versus Sitting Positions
I thoroughly enjoyed reading the article “Ultrasound Measurement of the Intervertebral Space in the Lateral Recumbent Versus Sitting Positions” by Dorothy Shi et al. (1). It was fortunate to read this manuscript and the authors’ efforts should be commended. We agree with the utmost conclusion that the size of the interspinous space in the seated position on ultrasound was found to be larger than the lateral recumbent position, suggesting that lumbar puncture may be more successful in the seated position (1). (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - November 17, 2023 Category: Emergency Medicine Authors: Sobul Khan Tags: Letter to the Editor Source Type: research

Language Barriers in Care for Low-Risk Febrile Neonates
The management of febrile neonates has evolved as clinical evidence and disease epidemiology have instructed updated guidelines and practice patterns. While there has been extensive investigation of clinical determinants to identify neonates at low risk for invasive bacterial infection (IBI), there has been little investigation into the impact of sociodemographic characteristics on management of this population. The study by Gutman et al in JAMA Pediatrics examines the impact of race, ethnicity, and language for care on interventions performed for well-appearing febrile infants at low risk for IBI by clinical criteria in p...
Source: JAMA Pediatrics - November 13, 2023 Category: Pediatrics Source Type: research

Determining the Spinal Canal Depth in Neonates Using Bedside Ultrasonography
CONCLUSION: Knowledge of the spinal canal depth using the formula may facilitate accurate needle placement, thereby decreasing traumatic lumbar puncture.PMID:37950466 (Source: Indian Pediatrics)
Source: Indian Pediatrics - November 11, 2023 Category: Pediatrics Authors: Nidhi Gupta H A Venkatesh Rajath Pejaver Cherry Garg Karthik Nagesh Source Type: research