Hyper-Dependence on NHEJ Enables Synergy Between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma
CONCLUSION: Combinations of DNA-PK inhibitors with unconventionally low, sensitizing, doxorubicin dosing showed synergistic effects in LMS in vitro and in vivo models, without discernable toxicity. These findings underscore the relevance of DNA damage repair alterations in LMS pathogenesis and identify dependence on NHEJ as a clinically actionable vulnerability in LMS.PMID:37773632 | DOI:10.1158/1078-0432.CCR-23-0998 (Source: Cell Research)
Source: Cell Research - September 29, 2023 Category: Cytology Authors: Adri án Mariño-Enríquez Jan Philipp Novotny Doga C Gulhan Isabella Klooster Antuan V Tran Macy Kasbo Meijun Z Lundberg Wen-Bin Ou Derrick L Tao Daniel F Pilco-Janeta Victor Y Mao Frank T Zenke Brittaney A Leeper Prafulla C Gokhale Glenn S Cowley Lauren Source Type: research
Hyper-Dependence on NHEJ Enables Synergy Between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma
CONCLUSION: Combinations of DNA-PK inhibitors with unconventionally low, sensitizing, doxorubicin dosing showed synergistic effects in LMS in vitro and in vivo models, without discernable toxicity. These findings underscore the relevance of DNA damage repair alterations in LMS pathogenesis and identify dependence on NHEJ as a clinically actionable vulnerability in LMS.PMID:37773632 | DOI:10.1158/1078-0432.CCR-23-0998 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - September 29, 2023 Category: Cancer & Oncology Authors: Adri án Mariño-Enríquez Jan Philipp Novotny Doga C Gulhan Isabella Klooster Antuan V Tran Macy Kasbo Meijun Z Lundberg Wen-Bin Ou Derrick L Tao Daniel F Pilco-Janeta Victor Y Mao Frank T Zenke Brittaney A Leeper Prafulla C Gokhale Glenn S Cowley Lauren Source Type: research
Inferior vena cava tumor thrombus: clinical outcomes at a canadian tertiary center
CONCLUSION: Different types of malignancy can affect the IVC and surgical intervention is usually indicated for these patients. Herein, we have reported the outcomes of IVC thrombectomy at our center.PMID:37774418 | DOI:10.1177/02676591231202682 (Source: Perfusion)
Source: Perfusion - September 29, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Ali Fatehi Hassanabad Chad G Ball William T Kidd Source Type: research
Hyper-Dependence on NHEJ Enables Synergy Between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma
CONCLUSION: Combinations of DNA-PK inhibitors with unconventionally low, sensitizing, doxorubicin dosing showed synergistic effects in LMS in vitro and in vivo models, without discernable toxicity. These findings underscore the relevance of DNA damage repair alterations in LMS pathogenesis and identify dependence on NHEJ as a clinically actionable vulnerability in LMS.PMID:37773632 | DOI:10.1158/1078-0432.CCR-23-0998 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - September 29, 2023 Category: Cancer & Oncology Authors: Adri án Mariño-Enríquez Jan Philipp Novotny Doga C Gulhan Isabella Klooster Antuan V Tran Macy Kasbo Meijun Z Lundberg Wen-Bin Ou Derrick L Tao Daniel F Pilco-Janeta Victor Y Mao Frank T Zenke Brittaney A Leeper Prafulla C Gokhale Glenn S Cowley Lauren Source Type: research
Inferior vena cava tumor thrombus: clinical outcomes at a canadian tertiary center
CONCLUSION: Different types of malignancy can affect the IVC and surgical intervention is usually indicated for these patients. Herein, we have reported the outcomes of IVC thrombectomy at our center.PMID:37774418 | DOI:10.1177/02676591231202682 (Source: Perfusion)
Source: Perfusion - September 29, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Ali Fatehi Hassanabad Chad G Ball William T Kidd Source Type: research
Hyper-Dependence on NHEJ Enables Synergy Between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma
CONCLUSION: Combinations of DNA-PK inhibitors with unconventionally low, sensitizing, doxorubicin dosing showed synergistic effects in LMS in vitro and in vivo models, without discernable toxicity. These findings underscore the relevance of DNA damage repair alterations in LMS pathogenesis and identify dependence on NHEJ as a clinically actionable vulnerability in LMS.PMID:37773632 | DOI:10.1158/1078-0432.CCR-23-0998 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - September 29, 2023 Category: Cancer & Oncology Authors: Adri án Mariño-Enríquez Jan Philipp Novotny Doga C Gulhan Isabella Klooster Antuan V Tran Macy Kasbo Meijun Z Lundberg Wen-Bin Ou Derrick L Tao Daniel F Pilco-Janeta Victor Y Mao Frank T Zenke Brittaney A Leeper Prafulla C Gokhale Glenn S Cowley Lauren Source Type: research
Anlotinib as a maintenance treatment for advanced soft tissue sarcoma after first-line chemotherapy (ALTER-S006): a multicentre, open-label, single-arm, phase 2 trial
This study is registered with ClinicalTrials.gov, NCT03890068.FINDINGS: At the data cut-off date (August 8, 2022), 49 patients were enrolled, including 17 with liposarcoma (35%) and 15 with leiomyosarcoma (31%). After a median follow-up of 17.1 months (IQR 9.0-27.2), the median PFS from the beginning of maintenance treatment was 9.1 months (95% CI 5.7-12.5), and the median OS was not reached, and the 1-year OS rate for anlotinib maintenance treatment was 98.0%. The best ORR and DCR were 16% (8/49, 95% CI 7-30) and 94% (46/49, 95% CI 83-99), respectively. Most of the treatment-related adverse events were grade 1-2. Of the g...
Source: Cancer Control - September 28, 2023 Category: Cancer & Oncology Authors: Bushu Xu Qiuzhong Pan Hua Pan Haomiao Li Xianan Li Jing Chen Danmei Pang Baoqing Zhang Desheng Weng Ruiqing Peng Meiyu Fang Xing Zhang Source Type: research
ASO Visual Abstract: Prognostic Impact of Tumor-Infiltrating Lymphocytes, Tertiary Lymphoid Structures, and Neutrophil-to-Lymphocyte Ratio in Pulmonary Metastases from Uterine Leiomyosarcoma
Ann Surg Oncol. 2023 Sep 27. doi: 10.1245/s10434-023-14311-8. Online ahead of print.NO ABSTRACTPMID:37759101 | DOI:10.1245/s10434-023-14311-8 (Source: Ann Oncol)
Source: Ann Oncol - September 27, 2023 Category: Cancer & Oncology Authors: Naoki Matsuda Hiromasa Yamamoto Tomohiro Habu Kazuma Iwata Kei Matsubara Shin Tanaka Kohei Hashimoto Kazuhiko Shien Ken Suzawa Kentaroh Miyoshi Tomohiro Toji Mikio Okazaki Seiichiro Sugimoto Katsuhito Takahashi Shinichi Toyooka Source Type: research
Clinical characteristics of sarcoma patients: a population-based data analysis from a German clinical cancer registry
CONCLUSIONS: Histological grade, tumor size, nodal and distant metastasis, tumor localization and histological subtype were determined as prognostic factors in terms of survival.PMID:37750956 | DOI:10.1007/s00432-023-05350-5 (Source: Cancer Control)
Source: Cancer Control - September 26, 2023 Category: Cancer & Oncology Authors: J örg Andreas Müller Karl-Stefan Delank Kevin Laudner Ian Wittenberg Alexander Zeh Dirk Vordermark Daniel Medenwald Source Type: research
Surgical Outcomes of Patients With Inferior Vena Cava Leiomyosarcoma
Vascular leiomyosarcomas are rare tumors, particularly those arising from the inferior vena cava (IVC). The disease has a poor prognosis with surgical resection being the only curative treatment option for patients. The purpose of this study was to analyze surgical outcomes of patients with inferior vena cava leiomyosarcoma. There is limited data on the surgical management of IVC leiomyosarcoma, specifically when to ligate or reconstruct the IVC; thus, we are contributing to the literature on the management of this rare tumor. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - September 20, 2023 Category: Surgery Authors: Hana Shafique, Antanina Voit, Trey Blazer, Young Kim, Leila Mureebe, Zachary Williams Tags: Venous Disease Source Type: research
A systematic review of the world-wide experience with primary inferior vena cava leiomyosarcoma
Asian J Surg. 2023 Sep 16:S1015-9584(23)01431-8. doi: 10.1016/j.asjsur.2023.09.018. Online ahead of print.NO ABSTRACTPMID:37723036 | DOI:10.1016/j.asjsur.2023.09.018 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - September 18, 2023 Category: Surgery Authors: Feng Li Chengqing Li Wenyi Guo Xue Meng Source Type: research
A systematic review of the world-wide experience with primary inferior vena cava leiomyosarcoma
Asian J Surg. 2023 Sep 16:S1015-9584(23)01431-8. doi: 10.1016/j.asjsur.2023.09.018. Online ahead of print.NO ABSTRACTPMID:37723036 | DOI:10.1016/j.asjsur.2023.09.018 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - September 18, 2023 Category: Surgery Authors: Feng Li Chengqing Li Wenyi Guo Xue Meng Source Type: research
Pancreatic metastasis 4 years after primary leiomyosarcoma resection in the left leg
Am J Med Sci. 2023 Sep 14:S0002-9629(23)01337-X. doi: 10.1016/j.amjms.2023.09.013. Online ahead of print.NO ABSTRACTPMID:37716603 | DOI:10.1016/j.amjms.2023.09.013 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - September 16, 2023 Category: General Medicine Authors: Qinghua Cao Baohua Li Jun Li Jikai Xia Source Type: research
Pancreatic metastasis 4 years after primary leiomyosarcoma resection in the left leg
Am J Med Sci. 2023 Sep 14:S0002-9629(23)01337-X. doi: 10.1016/j.amjms.2023.09.013. Online ahead of print.NO ABSTRACTPMID:37716603 | DOI:10.1016/j.amjms.2023.09.013 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - September 16, 2023 Category: General Medicine Authors: Qinghua Cao Baohua Li Jun Li Jikai Xia Source Type: research
Carcinosarcoma of the Esophagus-A Diagnostic Challenge
Conclusion: Carcinosarcoma can be easily missed in the presence of predominantly sarcomatous components even on immunohistochemical analysis. These tumors may be associated with poor prognosis and may have early recurrence despite surgery and adjuvant treatment.PMID:37711471 | PMC:PMC10498951 | DOI:10.31486/toj.23.0007 (Source: Ochsner Journal)
Source: Ochsner Journal - September 15, 2023 Category: General Medicine Authors: Vishu Jain Peeyush Varshney Divya Aggarwal Subhash Chandra Soni Vaibhav Kumar Varshney B Selvakumar Lokesh Agarwal Source Type: research
