Series of patients operated for masses and cysts in the heart in a Spanish general hospital: A 20-year experience
CONCLUSIONS: We describe the features of masses and cysts in the heart (77% female patients) and provide information scarcely available in the literature, e.g., the most frequent cardiovascular risk factors for this population. A case of cardiac leiomyosarcoma and a case of intimal sarcoma of the pulmonary trunk are described, two extremely rare tumors for which there are few described cases.PMID:38146947 | DOI:10.23938/ASSN.1060 (Source: Anales del Sistema Sanitario de Navarra)
Source: Anales del Sistema Sanitario de Navarra - December 26, 2023 Category: General Medicine Authors: Adri án Gil-Korilis Claudia Esqu íroz-Patiño Aroa Llamas-Llamazares Rebeca Manrique Agnes Diaz-Dorronsoro Source Type: research
Series of patients operated for masses and cysts in the heart in a Spanish general hospital: A 20-year experience
CONCLUSIONS: We describe the features of masses and cysts in the heart (77% female patients) and provide information scarcely available in the literature, e.g., the most frequent cardiovascular risk factors for this population. A case of cardiac leiomyosarcoma and a case of intimal sarcoma of the pulmonary trunk are described, two extremely rare tumors for which there are few described cases.PMID:38146947 | DOI:10.23938/ASSN.1060 (Source: Anales del Sistema Sanitario de Navarra)
Source: Anales del Sistema Sanitario de Navarra - December 26, 2023 Category: General Medicine Authors: Adri án Gil-Korilis Claudia Esqu íroz-Patiño Aroa Llamas-Llamazares Rebeca Manrique Agnes Diaz-Dorronsoro Source Type: research
Survivin-Sodium Iodide Symporter Reporter as a Non-Invasive Diagnostic Marker to Differentiate Uterine Leiomyosarcoma from Leiomyoma
This study aimed to evaluate the use of Survivin-Sodium iodide symporter (Ad-Sur-NIS) as a reporter gene biomarker to differentiate malignant LMS from benign LM by using an F18-NaBF4 PET/CT scan. The PET/CT scan images showed a significantly increased radiotracer uptake and a decreased radiotracer decay attributable to the higher abundance of Ad-Sur-NIS in the LMS tumors compared to LM (p < 0.05). An excellent safety profile was observed, with no pathological or metabolic differences detected in Ad-Sur-NIS-treated animal versus the vehicle control. Ad-Sur-NIS as a PET scan reporter is a promising imaging biomarker that ...
Source: Cancer Control - December 22, 2023 Category: Cancer & Oncology Authors: Natalia Garcia Mara Ulin Qiwei Yang Mohamed Ali Maarten C Bosland Weiqiao Zeng Liaohai Chen Ayman Al-Hendy Source Type: research
GSE250089 Immune Evasion in Lung Metastasis of Leiomyosarcoma: Upregulation of EPCAM Inhibits CD8+ T Cell Infiltration
Conclusions: EPCAM was upregulated in lung metastases of leiomyosarcoma, suggesting inhibition of CD8+ T cell migration. Our findings suggest that EPCAM could serve as a potential novel therapeutic target for leiomyosarcoma. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - December 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Phase I study of mTORC1/2 inhibitor sapanisertib in combination with metformin in patients with mTOR/AKT/PI3K pathway alterations and advanced solid malignancies
CONCLUSIONS: The safety profile of mTORC1/2 inhibitor sapanisertib in combination with metformin was generally tolerable, with anti-tumor activity observed in patients with advanced malignancies harboring PTEN/ AKT/mTOR pathway alterations.PMID:38126764 | DOI:10.1158/2767-9764.CRC-22-0260 (Source: Cancer Control)
Source: Cancer Control - December 21, 2023 Category: Cancer & Oncology Authors: Vivek Subbiah Niamh Coleman Sarina A Piha-Paul Apostolia M Tsimberidou Filip Janku Jordi Rodon Shubham Pant Ecaterina E Dumbrava Siqing Fu David S Hong Shizhen Zhang Ming Sun Yunfang Jiang Jason Roszik Juhee Song Ying Yuan Funda Meric-Bernstam Aung Naing Source Type: research
Challenges in the diagnosis of the enigmatic primary adrenal leiomyosarcoma: two case reports and review of the literature
Primary adrenal leiomyosarcoma is a rare and aggressive mesenchymal tumor derived from the smooth muscle wall of a central adrenal vein or its tributaries; therefore, tumors tend to invade the inferior vena ca... (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - December 18, 2023 Category: Endocrinology Authors: Sawako Suzuki, Naoya Takahashi, Masafumi Sugo, Kazuki Ishiwata, Akiko Ishida, Suzuka Watanabe, Katsushi Igarashi, Yutaro Ruike, Kumiko Naito, Masanori Fujimoto, Hisashi Koide, Yusuke Imamura, Shinichi Sakamoto, Tomohiko Ichikawa, Yoshihiro Kubota, Takeshi Tags: Case report Source Type: research
LMNA::NTRK1 Fusion-positive Leiomyosarcoma: Discrepancy between DNA-based Comprehensive Genomic Profiling and RNA Sequencing
Intern Med. 2023 Dec 18. doi: 10.2169/internalmedicine.2879-23. Online ahead of print.ABSTRACTA 26-year-old man presented with a tumor in the left soleus muscle. The tumor was diagnosed as a locally advanced leiomyosarcoma. The patient was treated with irradiation followed by wide resection. One year after surgery, the patient presented with multiple lung metastases. Despite aggressive sequential chemotherapy, systemic metastatic tumors continued to develop. To explore therapeutic options for the patient, we performed DNA-based CGP with FoundationOne® CDx (F1). F1 identified anout-of-strand rearrangement of the NOS1AP::NT...
Source: Internal Medicine - December 17, 2023 Category: Internal Medicine Authors: Norito Suzuki Masashi Idogawa Makoto Emori Kazuyuki Murase Yohei Arihara Hajime Nakamura Makoto Usami Tomohiro Kubo Ichiro Kinoshita Shintaro Sugita Takashi Tokino Tadashi Hasegawa Akihiro Sakurai Kohichi Takada Source Type: research
