Cancers, Vol. 16, Pages 1633: What Is the Impact of Multimodal Treatment in Patients with Leiomyosarcoma of Bone? A Multicenter Study of 35 Patients with an Ultra-Rare Tumor Entity
Dimosthenis Andreou
Primary leiomyosarcoma of bone (LMSoB) is extremely rare, comprising only <0.7% of primary malignant bone tumors, and is therefore considered an ultra-rare tumor entity. There is currently no consensus as to whether therapeutic strategies should be based on the biological characteristics of soft tissue leiomyosarcoma or on primary tumor localization in the bone. The use of perioperative chemotherapy and its effectiveness in this rare tumor entity remains unclear. We aimed to evaluate the impact of different treatment approaches in a multicenter setting with a total of 35 patients included...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Maya Niethard Carolin Knebel Andreas Leithner Per-Ulf Tunn Janosch Schoon Peter Reichardt Athanasios Pogkas Joanna Szkandera Daniel Pink Dimosthenis Andreou Tags: Article Source Type: research
Molecular Heterogeneity in Leiomyosarcoma and Implications for Personalised Medicine
Opinion statementLeiomyosarcoma (LMS) is one of the more common subtypes of soft tissue sarcomas (STS), accounting for about 20% of cases. Differences in anatomical location, risk of recurrence and histomorphological variants contribute to the substantial clinical heterogeneity in survival outcomes and therapy responses observed in patients. There is therefore a need to move away from the current one-size-fits-all treatment approach towards a personalised strategy tailored for individual patients. Over the past decade, tissue profiling studies have revealed key genomic features and an additional layer of molecular heteroge...
Source: Current Treatment Options in Oncology - April 24, 2024 Category: Cancer & Oncology Source Type: research
ASO Author Reflections: Inferior Vena Cava (IVC) Resection Without Reconstruction for IVC Leiomyosarcomas: Heading Toward a New Reality
Ann Surg Oncol. 2024 Apr 23. doi: 10.1245/s10434-024-15350-5. Online ahead of print.NO ABSTRACTPMID:38652197 | DOI:10.1245/s10434-024-15350-5 (Source: Ann Oncol)
Source: Ann Oncol - April 23, 2024 Category: Cancer & Oncology Authors: Gurudutt P Varty Shraddha Patkar Mahesh Goel Source Type: research
GSE264332 Transcriptome analysis of RNA-sequencing data for 2-D08-treated SK-LMS-1 cells
Contributors : Hyunju Liu ; Hosouk JoungSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens2 ʹ,3ʹ,4ʹ-trihydroxyflavone (2-D08) is a synthetic flavone that mechanistically has been identified as a specific inhibitor of protein SUMOylation. Recent studies have demonstrated that 2-D08 has various biological functions, including anticancer. We aimed to obtain additional insights into the eff ects of 2-D08 and conducted transcriptome analyses using RNA-sequencing (RNA-seq) in SK-LMS-1 leiomyosarcoma cells. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Benign metastasizing fumarate hydratase (FH)-deficient uterine leiomyomas: clinicopathological and molecular study with first documentation of multi-organ metastases
AbstractLeiomyoma is the most prevalent benign tumor of the female reproductive system. Benign metastasizing leiomyoma (BML) is a rare phenomenon that presents at distant sites, typically the lungs, exhibiting histopathological features similar to the primary uterine tumor in the absence of malignancy features in both. Fumarate hydratase-deficient uterine leiomyoma (FH-d UL) is an uncommon subtype among uterine smooth muscle tumors (0.5 –2%), showing distinctive histomorphology andFH inactivation. The majority of FH-d ULs are sporadic, caused by somaticFH inactivation, while a minority of cases occur in the context of th...
Source: Virchows Archiv - April 20, 2024 Category: Pathology Source Type: research
Cancers, Vol. 16, Pages 1570: Machine Learning Applied to Pre-Operative Computed-Tomography-Based Radiomic Features Can Accurately Differentiate Uterine Leiomyoma from Leiomyosarcoma: A Pilot Study
Conclusions: CECT images integrated with radiomics have great potential in differentiating uterine leiomyomas from leiomyosarcomas. Such a tool can be used to mitigate the risks of eventual surgical spread in the case of leiomyosarcoma and allow for safer fertility-sparing treatment in patients with benign uterine lesions. (Source: Cancers)
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Miriam Santoro Vladislav Zybin Camelia Alexandra Coada Giulia Mantovani Giulia Paolani Marco Di Stanislao Cecilia Modolon Stella Di Costanzo Andrei Lebovici Gloria Ravegnini Antonio De Leo Marco Tesei Pietro Pasquini Luigi Lovato Alessio Giuseppe Morganti Tags: Article Source Type: research
En Bloc Inferior Vena Cava (IVC) Resection Without Reconstruction With Right Hepatectomy and Right Nephrectomy for a Large IVC Leiomyosarcoma
CONCLUSIONS: Meticulous preoperative planning and expertise in liver resection and retroperitoneal surgeries facilitates such radical yet safe multivisceral resection for a large retrohepatic IVC leiomyosarcoma without the need for a cardiopulmonary bypass.PMID:38634962 | DOI:10.1245/s10434-024-15254-4 (Source: Ann Oncol)
Source: Ann Oncol - April 18, 2024 Category: Cancer & Oncology Authors: Gurudutt P Varty Shraddha Patkar Kunal Nandy Mahesh Goel Source Type: research
New treatment strategies for uterine sarcoma using secreted frizzled ‑related proteins
In conclusion, SFRP4 may suppress the viability and migration, and enhance the adhesion of sarcoma cells. These results suggested that SFRP4 could be considered as a novel therapeutic target for uterine sarcoma.PMID:38628655 | PMC:PMC11019650 | DOI:10.3892/etm.2024.12520 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Tomohiro Kagawa Ayuka Mineda Tomotaka Nakagawa Ayaka Shinohara Ryosuke Arakaki Hiroaki Inui Hiroki Noguchi Atsuko Yoshida Riyo Kinouchi Yuri Yamamoto Kanako Yoshida Takashi Kaji Masato Nishimura Takeshi Iwasa Source Type: research
LP-184, a novel acylfulvene molecule, exhibits anti-cancer activity against diverse solid tumors with homologous recombination deficiency
Cancer Res Commun. 2024 Apr 17. doi: 10.1158/2767-9764.CRC-23-0554. Online ahead of print.ABSTRACTHomologous recombination (HR) related gene alterations are present in a significant subset of prostate, breast, ovarian, pancreatic, lung and colon cancers rendering these tumors as potential responders to specific DNA damaging agents. A small molecule acylfulvene prodrug, LP-184, metabolizes to an active compound by the oxidoreductase activity of enzyme Prostaglandin Reductase 1 (PTGR1), which is frequently elevated in multiple solid tumor types. Prior work demonstrated that cancer cell lines deficient in a spectrum of (DNA d...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Aditya Kulkarni Jianli Zhou Neha Biyani Umesh Kathad Partha P Banerjee Shiv Srivastava Zsombor Prucsi Kamil Solarczyk Kishor Bhatia Reginald B Ewesuedo Panna Sharma Source Type: research
New treatment strategies for uterine sarcoma using secreted frizzled ‑related proteins
In conclusion, SFRP4 may suppress the viability and migration, and enhance the adhesion of sarcoma cells. These results suggested that SFRP4 could be considered as a novel therapeutic target for uterine sarcoma.PMID:38628655 | PMC:PMC11019650 | DOI:10.3892/etm.2024.12520 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Tomohiro Kagawa Ayuka Mineda Tomotaka Nakagawa Ayaka Shinohara Ryosuke Arakaki Hiroaki Inui Hiroki Noguchi Atsuko Yoshida Riyo Kinouchi Yuri Yamamoto Kanako Yoshida Takashi Kaji Masato Nishimura Takeshi Iwasa Source Type: research
Deep learning radiomics-based prediction model of metachronous distant metastasis following curative resection for retroperitoneal leiomyosarcoma: a bicentric study
Combining conventional radiomics models with deep learning features can result in superior performance in predicting the prognosis of patients with tumors; however, this approach has never been evaluated for t... (Source: Cancer Imaging)
Source: Cancer Imaging - April 16, 2024 Category: Radiology Authors: Zhen Tian, Yifan Cheng, Shuai Zhao, Ruiqi Li, Jiajie Zhou, Qiannan Sun and Daorong Wang Tags: Research article Source Type: research
Thinking Twice about the Cervical Mass: A Case Report of Primary Vaginal Leiomyosarcoma and Review of the Literature
Case Rep Obstet Gynecol. 2024 Apr 1;2024:1829000. doi: 10.1155/2024/1829000. eCollection 2024.ABSTRACTPrimary vaginal leiomyosarcoma (LMS) is an unusual cause of aggressive gynecologic cancer which requires prompt surgical treatment for favorable outcomes. Definitive diagnosis and treatment render unique challenges to clinicians based on vague presentation and limited evidence for management. Here, we describe a case of vaginal LMS in a middle-aged woman with a history of cervical dysplasia found to have a proximal vaginal mass after presenting with vaginal discharge and cramping pain. The patient was diagnosed on patholog...
Source: Cancer Control - April 9, 2024 Category: Cancer & Oncology Authors: Caroline C Davitt Yingao Zhang Anthony B Costales Source Type: research
Case report: Highly response to low-dose brachytherapy in recurrent retroperitoneal leiomyosarcoma with FANCD2 frameshift mutation: a unique case study
We report a case of recurrent retroperitoneal leiomyosarcoma in a male who achieved a rapid and robust but transient clinical response to low-dose iodine-125 brachytherapy. A FANCD2 frameshift mutation was detected by gene sequencing in the cancerous tissue. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research
Primary left ventricular leiomyosarcoma: a case report
Cardiac leiomyosarcomas are a rare subset of the already infrequent, primary malignant cardiac neoplasia spectrum. The most common site for a primary leiomyosarcoma of the ventricle is on the right with fewer ... (Source: Journal of Cardiothoracic Surgery)
Source: Journal of Cardiothoracic Surgery - April 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Vipin Balachandran, Vanessa Young, Tina Baillie and Allen James Tags: Case Report Source Type: research
Retracted: Analysis of Extended Resection of Limb Soft Tissue Leiomyosarcoma
Biomed Res Int. 2024 Mar 20;2024:9852153. doi: 10.1155/2024/9852153. eCollection 2024.ABSTRACT[This retracts the article DOI: 10.1155/2021/2106972.].PMID:38550208 | PMC:PMC10977147 | DOI:10.1155/2024/9852153 (Source: Biomed Res)
Source: Biomed Res - March 29, 2024 Category: Research Authors: BioMed Research International Source Type: research
