Cancers, Vol. 16, Pages 1075: Longitudinal Muscle Biopsies Reveal Inter- and Intra-Subject Variability in Cancer Cachexia: Paving the Way for Biopsy-Guided Tailored Treatment
This study aims to introduce longitudinal muscle biopsies as a potential framework for disease monitoring and treatment. The initial feasibility and safety assessment was performed for healthy mice and rats that received two consecutive muscle biopsies. The assessment was performed by utilizing three different tools. Subsequently, the protocol was also applied in leiomyosarcoma tumor-bearing rats. Longitudinal muscle biopsies proved to be a safe and feasible technique, especially in rat models. The application of this protocol to tumor-bearing rats further affirmed its tolerability and feasibility, while microscopic evalua...
Source: Cancers - March 6, 2024 Category: Cancer & Oncology Authors: Panagiotis Filis Nikolaos P. Tzavellas Dimitrios Stagikas Christianna Zachariou Panagiotis Lekkas Dimitrios Kosmas Evangelia Dounousi Ioannis Sarmas Evangelia Ntzani Davide Mauri Anastasios Korompilias Yannis V. Simos Konstantinos I. Tsamis Dimitrios Pesc Tags: Article Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 mm), initially diagnosed as sy...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 mm), initially diagnosed as sy...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
