Preclinical activity of selinexor in combination with eribulin in uterine leiomyosarcoma
In this study, we evaluated the effects of selinexor in combination with doxorubicin and eribulin in the LMS tumor model in vitro and in vivo. Treatment of selinexor combined with eribulin showed synergistic effects on tumor growth inhibition in SK-UT1 LMS-derived xenografts. Immunohistochemical assessment of the tumor tissues showed a significantly reduced expression of proliferation (Ki67) and XPO1 markers following combination therapy compared to the control group. Global transcriptome analyses on tumor tissue revealed that the combination therapy regulates genes from several key cancer-related pathways that are differe...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Sonam Mittal Ishaque Pulikkal Kadamberi Hua Chang Feng Wang Sudhir Kumar Shirng-Wern Tsaih Christopher J Walker Pradeep Chaluvally-Raghavan John Charlson Yosef Landesman Sunila Pradeep Source Type: research
Carcinosarcoma of the Esophagus-A Diagnostic Challenge
Conclusion: Carcinosarcoma can be easily missed in the presence of predominantly sarcomatous components even on immunohistochemical analysis. These tumors may be associated with poor prognosis and may have early recurrence despite surgery and adjuvant treatment.PMID:37711471 | PMC:PMC10498951 | DOI:10.31486/toj.23.0007 (Source: Ochsner Journal)
Source: Ochsner Journal - September 15, 2023 Category: General Medicine Authors: Vishu Jain Peeyush Varshney Divya Aggarwal Subhash Chandra Soni Vaibhav Kumar Varshney B Selvakumar Lokesh Agarwal Source Type: research
