Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
Croat Med J. 2024 Feb 29;65(1):51-58. doi: 10.3325/cmj.2024.65.51.ABSTRACTUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavorable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpable left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neoplasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, revealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 × 130 m...
Source: Croatian Medical Journal - March 4, 2024 Category: General Medicine Authors: Nermina Ibisevic Kresimir Tomic Alen Humackic Zlatko Guzin Blanka Lukic Semir Vranic Source Type: research
GSE255353 Small RNA sequencing for leiomyosarcoma cells and their extracellular vesicles
This study investigated the expression of miRNAs in leiomyosarcoma cells and their EVs. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - February 29, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Uterine leiomyosarcoma cell-derived extracellular vesicles induce the formation of cancer-associated fibroblasts
CONCLUSION: miR-654-3p and miR-369-3p are highly expressed in ULMS-derived EVs, indicating that these EV-related miRNAs induce the formation of cancer-associated fibroblasts.PMID:38417460 | DOI:10.1016/j.bbadis.2024.167103 (Source: Molecular Medicine)
Source: Molecular Medicine - February 28, 2024 Category: Molecular Biology Authors: Yukari Nagao Akira Yokoi Kosuke Yoshida Masami Kitagawa Eri Asano-Inami Tomoyasu Kato Mitsuya Ishikawa Yusuke Yamamoto Hiroaki Kajiyama Source Type: research
Uterine leiomyosarcoma cell-derived extracellular vesicles induce the formation of cancer-associated fibroblasts
CONCLUSION: miR-654-3p and miR-369-3p are highly expressed in ULMS-derived EVs, indicating that these EV-related miRNAs induce the formation of cancer-associated fibroblasts.PMID:38417460 | DOI:10.1016/j.bbadis.2024.167103 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - February 28, 2024 Category: Biochemistry Authors: Yukari Nagao Akira Yokoi Kosuke Yoshida Masami Kitagawa Eri Asano-Inami Tomoyasu Kato Mitsuya Ishikawa Yusuke Yamamoto Hiroaki Kajiyama Source Type: research
Uterine leiomyosarcoma cell-derived extracellular vesicles induce the formation of cancer-associated fibroblasts
CONCLUSION: miR-654-3p and miR-369-3p are highly expressed in ULMS-derived EVs, indicating that these EV-related miRNAs induce the formation of cancer-associated fibroblasts.PMID:38417460 | DOI:10.1016/j.bbadis.2024.167103 (Source: Molecular Medicine)
Source: Molecular Medicine - February 28, 2024 Category: Molecular Biology Authors: Yukari Nagao Akira Yokoi Kosuke Yoshida Masami Kitagawa Eri Asano-Inami Tomoyasu Kato Mitsuya Ishikawa Yusuke Yamamoto Hiroaki Kajiyama Source Type: research
