It is feasible to offer laparoscopically approach hysterectomy with contained morcelation even with huge uteri
Multiple studies show improved outcomes of laparoscopic hysterectomy compared to laparotomy, including decreased blood loss, shorter hospitalization and faster recovery. These outcomes are preserved even with longer operative time. Huge uteri make minimally invasive surgery technically challenging. Due to the risk of leiomyosarcoma in a presumed benign uterus, we offer patients contained morcellation as part of the minimally invasive approach. Very few publications describe the technical challenges of laparoscopic surgery for very large uteri, particularly if contained morcellation is planned. (Source: American Journal of ...
Source: American Journal of Obstetrics and Gynecology - March 21, 2024 Category: OBGYN Authors: D Pino, A Romo Source Type: research

Contained specimen extraction in MIGS: a decision algorithm
In 2013, gynecologic tissue extraction came to worldwide media attention due to a case of disseminated leiomyosarcoma. Concern about dissemination of benign and malignant disease led to a decline in minimally invasive techniques despite their recognized advantages. Since then, a variety of contained specimen extraction techniques have been described in appropriately selected patients for whom the risk of occult sarcoma is low. For these patients, part of the preoperative counseling and shared decision making should include a discussion of the anticipated specimen extraction technique. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - March 21, 2024 Category: OBGYN Authors: A Ramanathan, M Alzamora, L Cosgriff, E Klein, N Hazen, J Robinson Source Type: research

Synchronous Anal Squamous Cell Carcinoma and Diffuse Large B Cell Lymphoma of Stomach: the First Report of an Odd Couple
AbstractThe unique case study presented here explores an exceptionally rare occurrence in an HIV-positive female —synchronous diagnoses of anal squamous cell carcinoma and diffuse large B cell lymphoma (DLBCL) of the stomach. With limited existing literature on such clinical scenarios, this case serves as an unprecedented insight into the complexities of managing such synchronous malignancies in HIV-positive patients. The article also examines the heightened risk of specific cancer types in individuals living with HIV compared to those without the virus, focusing on AIDS-defining cancers such as Kaposi sarcoma, various l...
Source: Indian Journal of Surgical Oncology - March 19, 2024 Category: Cancer & Oncology Source Type: research

Developing Novel Genomic Risk Stratification Models in Soft Tissue and Uterine Leiomyosarcoma
CONCLUSIONS: Compared to traditional clinicopathologic models, genomic risk stratification demonstrates superior prediction of clinical outcome in STLMS and is comparable in ULMS.PMID:38488807 | DOI:10.1158/1078-0432.CCR-24-0148 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 15, 2024 Category: Cancer & Oncology Authors: Josephine K Dermawan Sarah Chiang Samuel Singer Bhumika Jadeja Martee L Hensley William D Tap Sujana Movva Robert G Maki Cristina R Antonescu Source Type: research

Developing Novel Genomic Risk Stratification Models in Soft Tissue and Uterine Leiomyosarcoma
CONCLUSIONS: Compared to traditional clinicopathologic models, genomic risk stratification demonstrates superior prediction of clinical outcome in STLMS and is comparable in ULMS.PMID:38488807 | DOI:10.1158/1078-0432.CCR-24-0148 (Source: Cancer Control)
Source: Cancer Control - March 15, 2024 Category: Cancer & Oncology Authors: Josephine K Dermawan Sarah Chiang Samuel Singer Bhumika Jadeja Martee L Hensley William D Tap Sujana Movva Robert G Maki Cristina R Antonescu Source Type: research

Developing Novel Genomic Risk Stratification Models in Soft Tissue and Uterine Leiomyosarcoma
CONCLUSIONS: Compared to traditional clinicopathologic models, genomic risk stratification demonstrates superior prediction of clinical outcome in STLMS and is comparable in ULMS.PMID:38488807 | DOI:10.1158/1078-0432.CCR-24-0148 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 15, 2024 Category: Cancer & Oncology Authors: Josephine K Dermawan Sarah Chiang Samuel Singer Bhumika Jadeja Martee L Hensley William D Tap Sujana Movva Robert G Maki Cristina R Antonescu Source Type: research

Developing Novel Genomic Risk Stratification Models in Soft Tissue and Uterine Leiomyosarcoma
CONCLUSIONS: Compared to traditional clinicopathologic models, genomic risk stratification demonstrates superior prediction of clinical outcome in STLMS and is comparable in ULMS.PMID:38488807 | DOI:10.1158/1078-0432.CCR-24-0148 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 15, 2024 Category: Cancer & Oncology Authors: Josephine K Dermawan Sarah Chiang Samuel Singer Bhumika Jadeja Martee L Hensley William D Tap Sujana Movva Robert G Maki Cristina R Antonescu Source Type: research