Pulmonary leiomyosarcoma arising in pulmonary hamartoma: an exceptional occurrence in a rare tumor
Pathologica. 2023 Dec;115(6):325-332. doi: 10.32074/1591-951X-941.ABSTRACTA solitary peripheral lung nodule was found in the left lung of a 52-year-old man. It was located in the lower lobe and measured 18.5 cm of major axis on chest computed tomography. A tru-cut core biopsy was obtained and a proliferation of bland, monomorphic, spindle cells in interlacing fascicles was observed. Accordingly, a surgical resection of the neoplasm was subsequently carried out. Macroscopically, the tumor appeared as a well-circumscribed nodule with a firm and whitish cut surface. Histologically, the neoplasm was predominantly composed of b...
Source: Pathologica - January 5, 2024 Category: Pathology Authors: Stefano Luc à Marco Montella Riccardo Monti Marina Accardo Giovanni Savarese Roberto Sirica Alfonso Fiorelli Floriana Morgillo Renato Franco Source Type: research
Unresectable leiomyosarcoma of the inferior vena cava with right atrium tumor thrombus: when to deem this tumor inoperable? A case report and literature review
We present a case of a 68-year-old man with primary LMS of the IVC with a tumor thrombus extending into the right atrium that was initially deemed inoperable. After extensive neoadjuvant chemo-radiation with minimal tumor effect, the patient underwent en bloc surgical resection of the tumor along with removal of the infrarenal IVC and right kidney and adrenal without the need for cardiopulmonary bypass. This case demonstrates the successful management of a primary LMS of the IVC with right atrial extension using a multimodal approach of neoadjuvant chemo-radiation and en bloc surgical resection without cardiopulmonary bypa...
Source: Frontiers in Oncology - January 4, 2024 Category: Cancer & Oncology Source Type: research
Establishment and characterization of NCC-LMS3-C1: a novel patient-derived cell line of leiomyosarcoma
AbstractLeiomyosarcoma (LMS) is an aggressive mesenchymal malignancy, which originates from the smooth muscle cells or from the precursor mesenchymal stem cells that potentially differentiate into smooth muscle cells. LMS is one of the most common sarcomas. LMS has genomic instability, reflecting complex and unbalanced karyotypes, and the cytogenetic and molecular changes in LMS are not consistent. The standard treatment of the primary LMS is complete resection, and the metastasis is often observed even after curative surgery. Patient-derived cancer models are a key bioresource to develop a novel therapy, and we aimed to e...
Source: Human Cell - January 1, 2024 Category: Cytology Source Type: research
Cancers, Vol. 16, Pages 192: A Ten-Year Real-Life Experience with Pazopanib in Uterine Leyomiosarcoma in Two High-Specialized Centers in Italy: Effectiveness and Safety
Conclusions: Pazopanib in everyday clinical practice is safe and shows a good disease control rate with prolonged survival. (Source: Cancers)
Source: Cancers - December 30, 2023 Category: Cancer & Oncology Authors: Mara Mantiero Marta Bini Maggie Polignano Luca Porcu Roberta Sanfilippo Chiara Fabbroni Gabriella Parma Mariateresa Lapresa Carmelo Calidona Cecilia Silvestri Andrea Franza Francesco Raspagliesi Nicoletta Colombo Monika Ducceschi Tags: Article Source Type: research
Surgery and stereotactic radiosurgery for spinal leiomyosarcoma: a single-institution retrospective series and systematic review
CONCLUSIONS: The authors present the largest series in the literature of spinal LMS and the first on SRS for spinal LMS. This study shows that LTC is statistically significantly better in patients receiving upfront SRS instead of surgery. The OS does not appear different between the two groups.PMID:38157539 | DOI:10.3171/2023.10.SPINE23666 (Source: Journal of Neurosurgery.Spine)
Source: Journal of Neurosurgery.Spine - December 29, 2023 Category: Neurosurgery Authors: Aroosa Zamarud Neelan J Marianayagam Vashisht Sekar Stefano Testa David J Park Ulas Yener Tamra-Lee McCleary Kelly H Yoo Sara Emrich Armine Tayag Louisa Ustrzynski Erqi Pollom Scott Soltys Lei Wang Greg Charville Kristen Ganjoo Steven D Chang Antonio Meol Source Type: research
Surgery and stereotactic radiosurgery for spinal leiomyosarcoma: a single-institution retrospective series and systematic review
CONCLUSIONS: The authors present the largest series in the literature of spinal LMS and the first on SRS for spinal LMS. This study shows that LTC is statistically significantly better in patients receiving upfront SRS instead of surgery. The OS does not appear different between the two groups.PMID:38157539 | DOI:10.3171/2023.10.SPINE23666 (Source: Journal of Neurosurgery.Spine)
Source: Journal of Neurosurgery.Spine - December 29, 2023 Category: Neurosurgery Authors: Aroosa Zamarud Neelan J Marianayagam Vashisht Sekar Stefano Testa David J Park Ulas Yener Tamra-Lee McCleary Kelly H Yoo Sara Emrich Armine Tayag Louisa Ustrzynski Erqi Pollom Scott Soltys Lei Wang Greg Charville Kristen Ganjoo Steven D Chang Antonio Meol Source Type: research
Surgery and stereotactic radiosurgery for spinal leiomyosarcoma: a single-institution retrospective series and systematic review
CONCLUSIONS: The authors present the largest series in the literature of spinal LMS and the first on SRS for spinal LMS. This study shows that LTC is statistically significantly better in patients receiving upfront SRS instead of surgery. The OS does not appear different between the two groups.PMID:38157539 | DOI:10.3171/2023.10.SPINE23666 (Source: Journal of Neurosurgery.Spine)
Source: Journal of Neurosurgery.Spine - December 29, 2023 Category: Neurosurgery Authors: Aroosa Zamarud Neelan J Marianayagam Vashisht Sekar Stefano Testa David J Park Ulas Yener Tamra-Lee McCleary Kelly H Yoo Sara Emrich Armine Tayag Louisa Ustrzynski Erqi Pollom Scott Soltys Lei Wang Greg Charville Kristen Ganjoo Steven D Chang Antonio Meol Source Type: research
Comments on and illustrations of the WFUMB CEUS liver guidelines: Rare malignant mesenchymal liver lesions
Med Ultrason. 2023 Nov 22. doi: 10.11152/mu-4302. Online ahead of print.ABSTRACTThe diagnosis or rare mesenchymal malignant lesions of the liver may be a challenge owing to the rarity of the disease and is usually made by histological confirmation. An ultrasound examination with, if required, color Doppler sonography and contrast-enhanced ultrasound, taking into account the clinical background of the patient, may help to focus the differential diagnosis. In this review, we describe the pathological and ultrasound features of several rare mesenchymal malignant liver lesions which include undifferentiated sarcoma of the live...
Source: Medical Ultrasonography - December 27, 2023 Category: Radiology Authors: Ehsan Safai Zadeh Nicole Schreiber Christian G örg Katharina Paulina Huber Kathleen M öller Analisa Berzigotti Thomas Thomsen Christian Jenssen Ernst-Michael Jung Adrian Lim Masayuki Kitano Ryo Shimizu Yi Dong Xin Wu Cui David Srivastava Christoph F Die Source Type: research
