The broad landscape of follicular lymphoma: Part 1.
Authors: Fratoni S, Zanelli M, Zizzo M, Sanguedolce F, Aimola V, Cerrone G, Ricci L, Filosa A, Martino G, Ascani S Abstract Follicular lymphoma is a neoplasm derived from follicle center B cells, typically both centrocytes and centroblasts, in variable proportions according to the lymphoma grading. The pattern of growth may be entirely follicular, follicular and diffuse, and rarely completely diffuse. It represents the second most common non-Hodgkin lymphoma, after diffuse large B-cell lymphoma and is the most common low-grade mature B-cell lymphoma in western countries. In the majority of cases, follicular lymphom...
Source: Pathologica - February 9, 2020 Category: Pathology Tags: Pathologica Source Type: research

Practical approach to diagnosis of bland-looking spindle cell lesions of the breast.
Authors: Magro G, Salvatorelli L, Puzzo L, Piombino E, Bartoloni G, Broggi G, Vecchio GM Abstract The diagnosis of bland-looking spindle cell lesions of the breast is often challenging because there is a close morphological and immunohistochemical overlap among the different entities. The present review will discuss reactive spindle cell nodule/exuberant scar, nodular fasciitis, inflammatory pseudotumor, myofibroblastoma (classic type), lipomatous myofibroblastoma, palisaded myofibroblastoma, benign fibroblastic spindle cell tumor, spindle cell lipoma, fibroma, leiomyoma, solitary fibrous tumor, myxoma, schwannoma/...
Source: Pathologica - January 24, 2020 Category: Pathology Tags: Pathologica Source Type: research

Pleural chondroid metaplasia in a background of IgG4 plasma cell rich chronic inflammatory infiltrate: report of a rare case with review of literature.
Authors: Spinelli M, Datta A, Fenandez MAM, Viola P Abstract Mesothelial reactive and degenerative changes secondary to inflammatory conditions, toxin exposure, neoplastic and non-neoplastic disease are often encountered in routine histopathology practice. Herein, we report a very rare case of pleural chronic inflammation with features suggestive for IgG4-related disease associated with the formation of a nest of mature, benign looking cartilage in the pleura of a middle age male patient. The review of the pertinent literature reveals that to date, only few cases of chondroid metaplasia or benign tumor (choristoma)...
Source: Pathologica - January 24, 2020 Category: Pathology Tags: Pathologica Source Type: research

Malignant peripheral nerve sheath tumor of the bladder A case report.
Authors: Petracco G, Patriarca C, Spasciani R, Parafioriti A Abstract Malignant peripheral nerve sheath tumor (MPNST) is an uncommon malignant tumor often associated with Neurofibromatosis type 1 (NF1). Although different soft tissue mesenchymal tumors may arise in the bladder, MPNST is a very rare occurrence. Here, we present a case of MPNST of the bladder in a 50 year old patient with NF1 with involvement of the entire wall of the organ leading to a functional exclusion. The principal differential diagnoses and a short review of the literature are presented. PMID: 31965114 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - January 24, 2020 Category: Pathology Tags: Pathologica Source Type: research

Eosinophilic cytoplasmic inclusions in type 2 papillary renal cell carcinoma.
Authors: Ungari M, Trombatore M, Ferrero G, Gusolfino MD, Manotti L, Tanzi G, Varotti E, Bertoni R Abstract A case of a patient with type 2 papillary renal cell carcinoma with eosinophilic cytoplasmatic inclusions is presented. About 50% of tumor cells were characterized by a well-circumscribed intra-cytoplasmatic round-to-oval or irregular inclusion/globule. Inclusions were 7-30 micron in diameter. They were glassy and pale to slightly eosinophilic in color in hematoxylin and eosin, were stained red by trichrome and were negative for periodic acid-Schiff reaction. Immunohistochemically, globules were negative for ...
Source: Pathologica - January 24, 2020 Category: Pathology Tags: Pathologica Source Type: research

Enrico Sertoli and the supporting cells of the testis "Morphology is function".
Enrico Sertoli and the supporting cells of the testis "Morphology is function". Pathologica. 2019 Dec;111(4):375-381 Authors: Patriarca C, Colecchia M, Clerici CA Abstract In 1865, Enrico Sertoli, at the age of 23, published an article in his own name entitled: "About the existence of special branched cells in the seminiferous tubules of the human testis". These were Sertoli's ideal cells; in this paper he arrived at a perspicacious description of the morphology and function of these cells and in the subsequent articles he investigated the topic of spermatogenesis. Despite the impor...
Source: Pathologica - January 24, 2020 Category: Pathology Tags: Pathologica Source Type: research

V Meeting Nazionale Gruppo Italiano di Paleopatologia.
Authors: PMID: 31965117 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - January 24, 2020 Category: Pathology Tags: Pathologica Source Type: research

Dermatofibrosarcoma protuberans: a tumor in the wide spectrum of the bland-looking spindle cell lesions of the breast.
Authors: Vecchio GM, Broggi G, Mulè A, Piombino E, Magro G PMID: 31748754 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - November 22, 2019 Category: Pathology Tags: Pathologica Source Type: research

Immune-related acute and lymphocytic gastritis in a patient with metastatic melanoma treated with pembrolizumab immunotherapy.
Authors: Gaffuri P, Espeli V, Fulciniti F, Paone G, Bergmann M PMID: 31748755 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - November 22, 2019 Category: Pathology Tags: Pathologica Source Type: research

A challenging case of pigmented Bowen's disease and differential diagnosis of pagetoid pigmented skin lesions.
Authors: Caputo V, Caselli E, Ribotta M, Bonoldi E PMID: 31748756 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - November 22, 2019 Category: Pathology Tags: Pathologica Source Type: research

Expression of CDX2 in metastatic prostate cancer.
Authors: Guerrieri C, Jobbagy Z, Hudacko R PMID: 31748757 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - November 22, 2019 Category: Pathology Tags: Pathologica Source Type: research

Proceedings: Congresso Annaule di Anatomia Patologica SIAPEC-IAP 2019.
Authors: PMID: 31748758 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - November 22, 2019 Category: Pathology Tags: Pathologica Source Type: research

Hemangioma of the umbilical cord with associated amnionic inclusion cyst: two uncommon entities occurring simultaneously.
Authors: Angelico G, Spadola S, Ieni A, Gurrera A, Arena MG, Arciuolo D, Valente M, Santoro A, Inzani F, Zannoni GF Abstract This corrects the article DOI: 10.32074/1591-951X-26-17. PMID: 31596275 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - October 11, 2019 Category: Pathology Tags: Pathologica Source Type: research

Thyroid cytopathology: updates and molecular testing.
Authors: Vance J, Gilani SM Abstract The utility of fine needle aspiration (FNA) is well described in the context of evaluating thyroid lesions. Among the various international systems of classification of thyroid cytology, the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has also provided a sound framework to standardize the reporting of FNA cytology results. New molecular evidence and clinical studies demonstrated the need for revision of the nomenclature resulting in introduction of new categories, such as the noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP). ...
Source: Pathologica - August 9, 2019 Category: Pathology Tags: Pathologica Source Type: research

When tumor doesn't read textbook. Third case of TTF1 and p40 co-expression in the same tumour cells in a non-small cell carcinoma. A potential new entity to consider?
Conclusion: The positivity for both "squamous" and "adenocarcinomatous" markers and mutations of TP53 could be the expression of a not fully recognized variant of NSCLC with possible implications for classification, diagnosis and therapy. PMID: 31388196 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - August 9, 2019 Category: Pathology Tags: Pathologica Source Type: research

Stromal IL2 is related to the neutrophil/lymphocyte ratio in epithelial ovarian cancer.
Conclusion: Stromal IL-2 is associated with higher a neutrophil/lymphocyte ratio, suggesting a worse prognosis in ovarian cancer and its role in tumor immunology; a neutrophil/lymphocyte ratio> 2.6 is associated with more advanced stages of malignant ovarian neoplasia. PMID: 31388197 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - August 9, 2019 Category: Pathology Tags: Pathologica Source Type: research

Peripheral nerve mucoid degeneration involving the sciatic nerve.
Authors: Fabbri VP, Valluzzi A, Acciarri N, Foschini MP Abstract Peripheral nerve mucoid degeneration (PNMD) is a rare non-neoplastic degenerative condition characterized by endoneural deposit of mucoid matrix. Herein, we report a case of PNMD involving the sciatic nerve with preoperative features, surgical treatment and pathological findings. PMID: 31388198 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - August 9, 2019 Category: Pathology Tags: Pathologica Source Type: research

Large cell neuroendocrine carcinoma of the submandibular gland: a case report and literature review.
Authors: Mascitti M, Luconi E, Togni L, Rubini C Abstract Neuroendocrine tumors (NET) are a heterogeneous group of malignancies with a broad spectrum of histomorphologies, tissue origins, and clinical outcomes, which arise from neural crest cells with neuroendocrine differentiation. Salivary gland tumors account for 3-6% of all head and neck neoplasms, while large cell neuroendocrine carcinomas (LCNEC) of the salivary gland are extremely rare, with few cases reported in literature, and only 5 cases involving submandibular gland. The rarity of these tumors in salivary glands is probably related to the scarcity of ne...
Source: Pathologica - August 9, 2019 Category: Pathology Tags: Pathologica Source Type: research

Russell body gastritis.
We report a case of Russell body gastritis in a 28-year-old male who presented with abdominal pain and rectal bleeding. Endoscopy showed erosions with edema and vascular congestion in the gastric body and antrum. The biopsy showed chronic gastritis with plasma cell infiltration of the lamina propria. Many plasma cells contained cytoplasmic Russell bodies which stained positive for CD138, CD79a, Kappa and lambda light chains. The Russell bodies were negative for pancytokeratin, excluding signet ring cell carcinoma. Russell body gastritis is an uncommon, benign reactive condition. PMID: 31388200 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - August 9, 2019 Category: Pathology Tags: Pathologica Source Type: research

Traumatic shock and electroshock: the difficult relationship between anatomic pathology and psychiatry in the early 20th century.
Authors: Patriarca C, Clerici CA Abstract In the conviction that a look at the past can contribute to a better understanding of the present in the field of science too, we discuss here two aspects of the relationship between early 20th century anatomic pathology and psychiatry that have received very little attention, in Italy at least. There was much debate between these two disciplines throughout the 19th century, which began to lose momentum in the early years of the 20th, with the arrival on the scene of schizophrenia (a disease histologically sine materia) in all its epidemiological relevance. The First Wo...
Source: Pathologica - August 9, 2019 Category: Pathology Tags: Pathologica Source Type: research

Cribriform-morular variant of thyroid carcinoma.
Authors: Cameselle-Teijeiro JM, Sobrinho-Simões M PMID: 31217615 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - June 21, 2019 Category: Pathology Tags: Pathologica Source Type: research

National survey of anatomical pathology centres in Italy: the questionnaire.
Authors: Mazzoleni G, Barbareschi M, Basciu M, Fassinato D, Vian P, Vittadello F, Truini M, De Rosa G, Mezzopera SM Abstract Objectives: To obtain a picture of the work done in Italian anatomical pathology centres in 2014, and evaluate differences between the various centres in terms of the workloads of medical and non-medical staff. Methods: A self-administered questionnaire designed by a SIAPEC working group was e-mailed to 256 centres and subsequently collected by the Anatomical Pathology Service of Bolzano. QlikView software was used to prepare the final database and check the quality of the data, which wer...
Source: Pathologica - June 21, 2019 Category: Pathology Tags: Pathologica Source Type: research

Hemangioma of the umbilical cord with associated amnionic inclusion cyst: two uncommon entities occurring simultaneously.
Authors: Angelico G, Spadola S, Ieni A, Gurrera A, Arena MG, Vitale SG, Arciuolo D, Valente M, Santoro A, Inzani F, Zannoni GF Abstract Umbilical cord hemangioma is an uncommon benign vascular neoplasm arising from the free segment of the umbilical cord, distinct from placental and fetal insertion, and is thought to originate from endothelial cells of the umbilical vessels. Cystic changes in the umbilical cord rarely occur as a consequence of the damage to the amnionic surface of the cord caused by the presence of the hemangioma. Until now, a total of 8 cases of umbilical cord hemangioma associated with cystic chan...
Source: Pathologica - June 21, 2019 Category: Pathology Tags: Pathologica Source Type: research

Expression of CD133 as a cancer stem cell marker in invasive gastric carcinoma.
Conclusion: CD133 is a good marker that can predict tumor recurrence and metastasis in gastric carcinoma. Even though, studies regarding CSCs are still in their initial stages especially those related to CD133 in gastric cancer. PMID: 31217618 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - June 21, 2019 Category: Pathology Tags: Pathologica Source Type: research

Histopathological assessment of prognostic factors in pancreatic resection specimens using a standardised protocol.
Conclusion: Ampullary adenocarcinomas had a lower rate of R1 resection and perineural invasion, both of which are parameters associated with a poorer outcome. This correlates with literature indicating ampullary tumours have a better prognosis. Our study also highlights the high rate of detection of microscopic margin involvement when a detailed histopathological examination protocol is employed. PMID: 31217619 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - June 21, 2019 Category: Pathology Tags: Pathologica Source Type: research

Comparative analysis of margin status in breast conservation surgery and its correlation with subsequent re-excision findings.
Conclusion: Margins positive for DCIS are more likely to have residual disease on re-excision in comparison to margins positive for only IBC. The type and extent of DCIS appears to influence the likelihood of residual disease. PMID: 31217620 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - June 21, 2019 Category: Pathology Tags: Pathologica Source Type: research

Case report of a combined oncocytoma and type 1 papillary renal cell carcinoma: a rare entity.
Authors: Gaeta R, Tognetti A, Kauffmann EF, Pollina LE Abstract An extremely rare renal hybrid tumor composed of papillary renal cell carcinoma (PRCC) and renal oncocytoma (RO) within the same tumor is described. Only eight previous cases are documented in the literature. A 44-year-old man showed a 3.5 cm renal mass composed by areas with tubulo-papillary structures made up with small cells with scanty cytoplasm adjacent to polygonal cells forming solid sheet and tubules with abundant eosinophilic cytoplasm and uniform, round central nuclei without mitoses. Complete immunohistochemical panel suggested a diagnos...
Source: Pathologica - June 21, 2019 Category: Pathology Tags: Pathologica Source Type: research

[Camillo Golgi per Pathologica nel 1909].
Authors: Patriarca C PMID: 31217622 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - June 21, 2019 Category: Pathology Tags: Pathologica Source Type: research

Procedures and operating instructions for diagnosis in vascular anomalies and pathology.
Authors: Moneghini L, Mihm MC, Fulcheri E Abstract In the last 30 years a revolution has occurred in the diagnosis and management of vascular anomalies. The great changes began with Mulliken and Glowacki separation of hemangiomas and vascular anomalies. Their work has now morphed into the ISSVA classification. Subsequently the discovery of the significance of the presence of GLUT-1 in the diagnosis of the hemangiomas of infancy gave us a new marker in our quest for accurate classification. Now the genetic breakthroughs have led us into a "Star Wars" like environment in the experimental laboratory. During ...
Source: Pathologica - June 21, 2019 Category: Pathology Tags: Pathologica Source Type: research

Glomus coccygeum: a review.
Authors: Bisceglia M, Bisceglia S, Ciampi C, Panniello G, Galliani C Abstract With limited information about the coccygeal glomus found in classic textbooks, we deemed it necessary to review the subject. The illustrations presented in this article derive from four coccygeal glomera incidentally encountered during examination of pilonidal disease specimens. Familiarization with its microanatomical features may help to avoid inappropriate interpretation of this enigmatic structure. PMID: 30799440 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - February 28, 2019 Category: Pathology Tags: Pathologica Source Type: research

Detection and genotyping of HPV-DNA through different types of diagnostic platforms in liquid-based cervical-cytology samples.
Discussion: The present study highlights the following: 1) Positive results' percentage for high-risk HPV-DNA genotypes, deriving from the three diagnostic platforms used and with the same vial to collect and store samples, does not significantly vary on the basis of the type of equipment and it is congruent with the Italian percentage already detected during organized screening programs. 2) Even the molecular diagnostic approach could give false negative results, preventing the detection in the screened population of cervical HPV-related lesions and theoretically endangering women to develop "interval cancer". 3...
Source: Pathologica - February 28, 2019 Category: Pathology Tags: Pathologica Source Type: research

Unclassified sex cord/gonadal stromal testis tumor with a "pure" spindle cell component: a case report.
Unclassified sex cord/gonadal stromal testis tumor with a "pure" spindle cell component: a case report. Pathologica. 2018 Dec;110(4):302-306 Authors: Spairani C, Squillaci S, Pitino A, Montefiore F, Fusco W Abstract Unclassified sex cord/gonadal stromal tumors (SCSTs) composed predominantly of spindle cells are rare. Very few cases have been documented to date. Here, we report a case of "pure" spindle cell tumor of the left testis in a 83-year old man whose morphological and immunohistochemical findings were consistent with a diagnosis of unclassified SCST and review the literature....
Source: Pathologica - February 28, 2019 Category: Pathology Tags: Pathologica Source Type: research

Calcifying aponeurotic fibroma: a core biopsy-based diagnosis.
Authors: Motta F, Scavo S, Vecchio GM, Fuccio-Sanzà G, Nicolosi F, Magro G Abstract Calcifying aponeurotic fibroma (CAF) is a very rare tumor of the extremities, which can be difficult to diagnose due to its wide cyto-architectural pattern. We herein report the clinicopathologic features of a case of CAF localized on the dorsal face of the foot in a 5-year-old male child, diagnosed by needle core biopsy. Differential diagnostic problems are discussed. The present case emphasizes that the diagnosis of CAF can be confidentially rendered on core needle biopsy if the main morphological components of this tumor a...
Source: Pathologica - February 28, 2019 Category: Pathology Tags: Pathologica Source Type: research

Lymphnode metastasis of thyroid cancer misinterpreted as lateral aberrant thyroid 40 years before identification of primary tumor. Case report and review of the literature.
Authors: Riva G, Villanova M, Francia G, Valotto G, Mezzetto L, Toaiari M, Eccher A, Novelli L Abstract The differential diagnosis between lateral ectopic thyroid tissue with orthotopic normal gland and metastatic thyroid carcinoma is challenging. Lateral cervical site is a very rare location for ectopic tissue since only a few cases have been reported. The peculiarity of this clinical case is the finding of a thyroid carcinoma forty years after surgical resection of the ectopic thyroid lesion. This asynchronous association, never reported in literature, raises the question of the differential diagnosis between a t...
Source: Pathologica - February 28, 2019 Category: Pathology Tags: Pathologica Source Type: research

Pathologica in the time of "Spanish flu".
Pathologica in the time of "Spanish flu". Pathologica. 2018 Dec;110(4):316-320 Authors: Patriarca C, Clerici CA Abstract The pandemic "Spanish flu", that in a few weeks of the autumn 1918 caused in Italy a number of deaths between 350.000 and 600.000, was widely discussed by the scientific community, although very little of that debate leaked out, because of the military censorship. In the present article we comment on the original papers describing the hemorrhagic pneumonia, and on discussions about the ideas of the origin of the pandemic infection (Pfeiffer bacillus, vs strept...
Source: Pathologica - February 28, 2019 Category: Pathology Tags: Pathologica Source Type: research

IV Meeting Nazionale Gruppo Italiano di Paleopatologia.
Authors: PMID: 30799446 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - February 28, 2019 Category: Pathology Tags: Pathologica Source Type: research

Pathologica: un tesoro antico da proiettare nel futuro.
Authors: Truini M, Barbareschi M PMID: 30546141 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - December 16, 2018 Category: Pathology Tags: Pathologica Source Type: research

Proceedings: Congresso Annaule di Anatomia Patologica SIAPEC-IAP 2018.
Authors: PMID: 30546142 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - December 16, 2018 Category: Pathology Tags: Pathologica Source Type: research

A National Quality Assurance program for breast immunohistochemistry: an Italian perspective.
Authors: Guadagno E, De Rosa G, Nappi O Abstract A national project for the quality assessment of breast immunohistochemistry, involving 155 pathology laboratories distributed all over the Italian territory ( 19 regions), was carried out. The Project lasted one year from December 2014 to December 2015 and it was strongly supported by the Italian Society of Anatomic Pathology (SIAPEC/IAP). Proficiency tests were carried out by the Nordic Immunohistochemical Quality Control (NordiQC) organization. The main aim of the project was to investigate on the general performance of immunohistochemistry (ER, PR and HER2) in th...
Source: Pathologica - December 16, 2018 Category: Pathology Tags: Pathologica Source Type: research

Intestinal-type adenocarcinoma of the vagina: clinico-pathologic features of a common tumor with a rare localization.
Authors: Broggi G, Piombino E, Magro G, Vecchio GM Abstract Intestinal-type adenocarcinoma is a rare primary vaginal carcinoma and considerably more uncommon than metastatic lesions which represent the most frequent malignancy at this anatomic site. Among all malignant tumors, colorectal, breast and female genital tract carcinomas have the tendency to metastasize to the vagina. As morphologic and immunohistochemical features of intestinal-type adenocarcinoma occurring primarily in the vagina are not specific, clinical and radiologic information is crucial to exclude a metastatic lesion. Herein we present a ...
Source: Pathologica - December 16, 2018 Category: Pathology Tags: Pathologica Source Type: research

Primary pseudomyogenic hemangioendothelioma of bone: case report and review of the literature.
We report the clinicopathological features of a further intraosseous PMH occurring in a 46-year-old woman involving the right patella. Histologic examination showed an infiltrating growth composed of sheets and fascicles of spindled to epithelioid large cells, with ample eosinophilic cytoplasm, large vesicular nuclei and prominent nucleoli, sometimes resembling rhabdomyoblastic tumor cells, without morphologic signs of vascular differentiation. At immunohistochemical examination, neoplastic cells stained diffusely for AE1/AE3 keratins, vimentin, ERG, FLI-1, INI-1, FOSB with only focal CD31 expression. The morphologic c...
Source: Pathologica - December 16, 2018 Category: Pathology Tags: Pathologica Source Type: research

Well-differentiated extraskeletal chondrosarcoma: about a new case.
This report  describes the case of a 58-year-old woman presented with a large palpable mass in the right buttock. Imaging studies revealed a well-defined soft tissue mass, with extensive calcification. A histological examination after surgical resection confirmed the diagnosis of well-differentiated extraosseous chondrosarcoma. The outcome was favorable, without recurrence or metastasis. PMID: 30546146 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - December 16, 2018 Category: Pathology Tags: Pathologica Source Type: research

Primary thyroid biphasic synovial sarcoma and synchronous papillary carcinoma: report of a remarkable case.
We describe a case of a 42-ys-old female patient complaining a cervical swelling due to left intrathyroid nodule, measuring 35 mm in its greatest dimension. A Fine Needle Aspiration Cytology (FNAC) was performed and diagnosis of indeterminate neoplastic lesion, indefinite whether primary or metastatic, was formulated. After complete thyroidectomy, the histological picture of the nodule was characterized by a dual cellular population: several glandular structures composed by columnar cells with clear cytoplasm were embedded in a highly cellular stroma composed of spindle-shaped elements. Immunohistochemistry and molecular b...
Source: Pathologica - December 16, 2018 Category: Pathology Tags: Pathologica Source Type: research

Perineurioma of the colon: an uncommon tumor with an unusual location. Report of a case and review of the literature.
Authors: Motta F, Spadola S, Bosco A, Aprile G, Piombino E, Magro G Abstract Perineurioma is a relatively rare benign peripheral nerve sheath tumor composed of cells resembling to normal perineurium. Although this tumor may arise in the context of a nerve (intraneural perineurioma), extraneural perineurioma does occur, frequently involving the soft tissues of the lower and upper extremities, trunk and head and neck. Rarely it has also been reported in visceral organs, including gastrointestinal tract. We herein describe the clinicopathologic features of a rare case of a perineurioma presenting as a polypoid lesion ...
Source: Pathologica - December 16, 2018 Category: Pathology Tags: Pathologica Source Type: research

Clinico-pathological features of the intradiaphragmatic bronchogenic cysts: report of a case and review of the literature.
We report a case of a 54 year old man showing a large lobulated cystic lesion in the left hemidiaphragm. Complete surgery was performed and histological diagnosis of intradiaphragmatic bronchogenic cyst was made during surgery and confirmed after a total section analysis. Moreover we reviewed the other cases published in the English literature, including clinical, surgical and pathological data. PMID: 30546149 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - December 16, 2018 Category: Pathology Tags: Pathologica Source Type: research

Ovarian steroid cell tumor, not otherwise specified.
Authors: Sharma R, Goel RK, Rana A, Sachdev R Abstract Ovarian steroid cell tumours are rare virilizing tumours. They are three types of tumours of ovary which are characterized by steroid cell proliferation : Leydig cell tumour, steroid cell tumour, Not Otherwise Specified (NOS) and stromal luteoma. Here we present a case of 36 year old female, who presented with history of weight loss since last two and half months. There is history of amenorrhoea and hirsuitism. Her CA was 125: 11.4 IU/ml (0-35 U/mL). Blood Testosterone levels was elevated with value of 150 ng/ml (5.71-77 ng/ml). Serum Inhibin A, Inhibin B, FSH,...
Source: Pathologica - December 16, 2018 Category: Pathology Tags: Pathologica Source Type: research

Going fully digital: utopia or reality?
Authors: Fraggetta F, Pantanowitz L PMID: 30259907 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - September 28, 2018 Category: Pathology Tags: Pathologica Source Type: research

What's new in the WHO classification of tumors of lung and pleura.
Authors: Rossi G, Nappi O PMID: 30259908 [PubMed - in process] (Source: Pathologica)
Source: Pathologica - September 28, 2018 Category: Pathology Tags: Pathologica Source Type: research

Adenocarcinoma classification: patterns and prognosis.
Authors: Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE Abstract Lung cancer is the most frequent human malignancy and the principal cause of cancer-related death worldwide. Adenocarcinoma is now the main histologic type, accounting for almost half of all the cases. The 2015 World Health Organization has adopted the classification recently developed by the International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society. This new adenocarcinoma classification has incorporated up-to-date advances in radiological, molecular and oncological knowledge...
Source: Pathologica - September 28, 2018 Category: Pathology Tags: Pathologica Source Type: research

What's new in mesothelioma.
Authors: Ascoli V, Murer B, Nottegar A, Luchini C, Carella R, Calabrese F, Lunardi F, Cozzi I, Righi L Abstract Malignant pleural mesothelioma is a neoplasm characterized by a very poor prognosis and medico-legal implications. Diagnosis, prognosis and therapy are often challenging and include several issues. Cytological diagnosis is frequently the first step of the diagnostic process, and although its sensitivity may be somewhat lower, diagnostic criteria should be taken into account. When effusion cytology is inconclusive for the diagnosis, tissue biopsies should be taken. Even if the morphologic criteria for deci...
Source: Pathologica - September 28, 2018 Category: Pathology Tags: Pathologica Source Type: research