Biphenotypic lung carcinoma with coexpression of TTF-1 and ΔNP63/P40 within most of the same individual cells: a further case confirming poor prognosis and a review of literature

Pathologica. 2024 Feb;116(1):13-21. doi: 10.32074/1591-951X-957.ABSTRACTThe WHO Classification of Tumors, Thoracic Tumors, 5th edition, has outlined the use of TTF-1 and ΔNP63/P40 to discriminate between adenocarcinoma and squamous cell carcinoma. In 2015, the first description of a rare non-small cell lung carcinoma featuring co-expression of glandular and squamous differentiation within most of the same individual tumor cells was reported on, with ultrastructural and molecular demonstration of such a biphenotypic differentiation. We herein describe an additional case of this rare tumor entity, which is confirmed to be an aggressive neoplasm despite potential targets of therapy.PMID:38482671 | PMC:PMC10938280 | DOI:10.32074/1591-951X-957

Source: Pathologica - March 14, 2024 Category: Pathology Authors: Alessandro Marando Moreno Zagni Mariachiara Negrelli Emanuele Valtorta Calogero Lauricella Valentina Motta Silvio Veronese Giulio Cerea Laura Giuseppina Giannetta Gabriele Ciarlo Diego Signorelli Elio Gregory Pizzutilo Emanuela Bonoldi Giuseppe Pelosi Source Type: research