TROP-2, NECTIN-4 and predictive biomarkers in sarcomatoid and rhabdoid bladder urothelial carcinoma
CONCLUSION: Sarcomatoid and rhabdoid BUC do harbor positive expression of the ADC targets TROP-2 or NECTIN-4 in a relatively modest subset of cases, whereas the majority do not. Different combinations of other positive biomarkers may help the choice of medical therapies. Overall, these findings have important clinical implications for targeted therapy for BUC.PMID:38482675 | PMC:PMC10938277 | DOI:10.32074/1591-951X-937 (Source: Pathologica)
Source: Pathologica - March 14, 2024 Category: Pathology Authors: Matteo Brunelli Stefano Gobbo Giorgio Malpeli Grazia Sirgiovanni Claudia Caserta Enrico Munari Simona Francesconi Anna Cali ò Guido Martignoni Alessia Cimadamore Alessandro Veccia Alessandro Antonelli Marcello Tucci Francesco Pierconti Isabelle Malak Hat Source Type: research

Pleomorphic/solid lobular carcinoma of male breast with PALB2 germline mutation: case report and literature review
Pathologica. 2024 Feb;116(1):62-68. doi: 10.32074/1591-951X-936.ABSTRACTMale breast cancer (MBC) accounts for approximately 1% of all breast cancers and among these infiltrating lobular carcinomas (ILC) represents only 1-2% of all MBC cases. Pleomorphic invasive lobular carcinoma (PILC) is an aggressive variant of ILC with only eight cases reported until now in males. Up to 10% of MBC cases have a germline pathogenic variant in a predisposing gene such as BRCA1 and BRCA2 genes. Mutations in PALB2 (partner and localizer of BRCA2) have been reported in men with breast cancer, with a frequency that ranges from 0.8 to 6.4%, bu...
Source: Pathologica - March 14, 2024 Category: Pathology Authors: Evelina Rogges Tiberio Corati Michelina Amato Domenico Campagna Juliette Farro Simona De Toffol Lucio Fortunato Leopoldo Costarelli Source Type: research

Testicular metastasis of prostate adenocarcinoma: the other side of orchiepididymitis
CONCLUSION: Although metastatic prostate adenocarcinoma is rare, a correct diagnosis is of paramount importance because the therapy changes accordingly. Patients who complain of scrotal pain need to be examined accurately. Although the most common cause behind this symptom is infectious, the patient's past medical history should be reviewed to exclude previous malignancies.PMID:38482677 | PMC:PMC10938275 | DOI:10.32074/1591-951X-940 (Source: Pathologica)
Source: Pathologica - March 14, 2024 Category: Pathology Authors: Gianluca Di Rienzo Alessandro Tafuni Umberto Maestroni Livia Ruffini Enrico Maria Silini Donatello Gasparro Francesco Paolo Pilato Letizia Gnetti Source Type: research

Biphenotypic lung carcinoma with coexpression of TTF-1 and ΔNP63/P40 within most of the same individual cells: a further case confirming poor prognosis and a review of literature
Pathologica. 2024 Feb;116(1):13-21. doi: 10.32074/1591-951X-957.ABSTRACTThe WHO Classification of Tumors, Thoracic Tumors, 5th edition, has outlined the use of TTF-1 and ΔNP63/P40 to discriminate between adenocarcinoma and squamous cell carcinoma. In 2015, the first description of a rare non-small cell lung carcinoma featuring co-expression of glandular and squamous differentiation within most of the same individual tumor cells was reported on, with ultrastructural and molecular demonstration of such a biphenotypic differentiation. We herein describe an additional case of this rare tumor entity, which is confirmed to be a...
Source: Pathologica - March 14, 2024 Category: Pathology Authors: Alessandro Marando Moreno Zagni Mariachiara Negrelli Emanuele Valtorta Calogero Lauricella Valentina Motta Silvio Veronese Giulio Cerea Laura Giuseppina Giannetta Gabriele Ciarlo Diego Signorelli Elio Gregory Pizzutilo Emanuela Bonoldi Giuseppe Pelosi Source Type: research

Changes in breast cancer grade from biopsy to excision following surgery or primary chemotherapy
CONCLUSIONS: The reversal of M and G underestimation in CNB to "overestimation" in the PST group can only be explained with the effect of mitosis reduction following chemotherapy. Whether the posttreatment decrease in G reflects any prognostic value remains to be elucidated.PMID:38482672 | PMC:PMC10938276 | DOI:10.32074/1591-951X-958 (Source: Pathologica)
Source: Pathologica - March 14, 2024 Category: Pathology Authors: Ádám Ferenczi G ábor Cserni Source Type: research

Biomarker characterization in endometrial cancer in Europe: first survey data analysis from 69 pathological academic and hospital labs
CONCLUSION: Guidelines consultation and standardization of laboratory procedures are efficient means for EC prognostic risk stratification and improving the quality of care.PMID:38482673 | PMC:PMC10938279 | DOI:10.32074/1591-951X-926 (Source: Pathologica)
Source: Pathologica - March 14, 2024 Category: Pathology Authors: Angela Santoro Emma Bragantini Francesca Castiglione Raji Ganesan Xavier Matias-Guiu Milo Frattini Valerio Gallotta Pablo Garcia Yatish Pattni Julia Tsiampali-Laprell Brigitte Bisaro Mattia Barbareschi Gian Franco Zannoni Collaborators (IT ESP UK, CH) Source Type: research

Soft tissue tumours of the penis. The 30-year Istituto Nazionale Tumori di Milano experience
CONCLUSIONS: Among sarcomas of the genitourinary tract, tumours of the soft tissues of the penis are the rarest. Penile sarcomas can present at a young age. Kaposi's sarcoma in HIV-negative patients has a favorable outcome, while deep sarcomas have an aggressive behavior and poor prognosis.PMID:38482674 | PMC:PMC10938274 | DOI:10.32074/1591-951X-953 (Source: Pathologica)
Source: Pathologica - March 14, 2024 Category: Pathology Authors: Maurizio Colecchia Giacomo Maria Pini Giancarlo Pruneri Nicola Nicolai Sascia Servillo Source Type: research

TROP-2, NECTIN-4 and predictive biomarkers in sarcomatoid and rhabdoid bladder urothelial carcinoma
CONCLUSION: Sarcomatoid and rhabdoid BUC do harbor positive expression of the ADC targets TROP-2 or NECTIN-4 in a relatively modest subset of cases, whereas the majority do not. Different combinations of other positive biomarkers may help the choice of medical therapies. Overall, these findings have important clinical implications for targeted therapy for BUC.PMID:38482675 | PMC:PMC10938277 | DOI:10.32074/1591-951X-937 (Source: Pathologica)
Source: Pathologica - March 14, 2024 Category: Pathology Authors: Matteo Brunelli Stefano Gobbo Giorgio Malpeli Grazia Sirgiovanni Claudia Caserta Enrico Munari Simona Francesconi Anna Cali ò Guido Martignoni Alessia Cimadamore Alessandro Veccia Alessandro Antonelli Marcello Tucci Francesco Pierconti Isabelle Malak Hat Source Type: research

Pleomorphic/solid lobular carcinoma of male breast with PALB2 germline mutation: case report and literature review
Pathologica. 2024 Feb;116(1):62-68. doi: 10.32074/1591-951X-936.ABSTRACTMale breast cancer (MBC) accounts for approximately 1% of all breast cancers and among these infiltrating lobular carcinomas (ILC) represents only 1-2% of all MBC cases. Pleomorphic invasive lobular carcinoma (PILC) is an aggressive variant of ILC with only eight cases reported until now in males. Up to 10% of MBC cases have a germline pathogenic variant in a predisposing gene such as BRCA1 and BRCA2 genes. Mutations in PALB2 (partner and localizer of BRCA2) have been reported in men with breast cancer, with a frequency that ranges from 0.8 to 6.4%, bu...
Source: Pathologica - March 14, 2024 Category: Pathology Authors: Evelina Rogges Tiberio Corati Michelina Amato Domenico Campagna Juliette Farro Simona De Toffol Lucio Fortunato Leopoldo Costarelli Source Type: research

Testicular metastasis of prostate adenocarcinoma: the other side of orchiepididymitis
CONCLUSION: Although metastatic prostate adenocarcinoma is rare, a correct diagnosis is of paramount importance because the therapy changes accordingly. Patients who complain of scrotal pain need to be examined accurately. Although the most common cause behind this symptom is infectious, the patient's past medical history should be reviewed to exclude previous malignancies.PMID:38482677 | PMC:PMC10938275 | DOI:10.32074/1591-951X-940 (Source: Pathologica)
Source: Pathologica - March 14, 2024 Category: Pathology Authors: Gianluca Di Rienzo Alessandro Tafuni Umberto Maestroni Livia Ruffini Enrico Maria Silini Donatello Gasparro Francesco Paolo Pilato Letizia Gnetti Source Type: research

Advances in radiology and pathology of prostate cancer: a review for the pathologist
In this study we address the role, advantages and shortcomings of novel imaging techniques for Pca, and discuss future directions including the applications of artificial intelligence-based techniques to imaging as well as histology. The significance of these findings for the practicing pathologist is discussed.PMID:38349336 | PMC:PMC10938278 | DOI:10.32074/1591-951X-925 (Source: Pathologica)
Source: Pathologica - February 13, 2024 Category: Pathology Authors: Pietro Pepe Andrea Fandella Michele Barbera Pasquale Martino Francesco Merolla Alessandro Caputo Filippo Fraggetta Source Type: research

Advances in radiology and pathology of prostate cancer: a review for the pathologist
In this study we address the role, advantages and shortcomings of novel imaging techniques for Pca, and discuss future directions including the applications of artificial intelligence-based techniques to imaging as well as histology. The significance of these findings for the practicing pathologist is discussed.PMID:38349336 | DOI:10.32074/1591-951X-925 (Source: Pathologica)
Source: Pathologica - February 13, 2024 Category: Pathology Authors: Pietro Pepe Andrea Fandella Michele Barbera Pasquale Martino Francesco Merolla Alessandro Caputo Filippo Fraggetta Source Type: research