Sarcina ventriculi associated gastritis
Pathologica. 2023 Dec;115(6):341-343. doi: 10.32074/1591-951X-927.NO ABSTRACTPMID:38180142 | DOI:10.32074/1591-951X-927 (Source: Pathologica)
Source: Pathologica - January 5, 2024 Category: Pathology Authors: Rida Noor Muhammad Ahsan Fnu Poombal Samina Zaman Source Type: research

Think "HER2" different: integrative diagnostic approaches for HER2-low breast cancer
Pathologica. 2023 Dec;115(6):292-301. doi: 10.32074/1591-951X-942.ABSTRACTThis work explores the complex field of HER2 testing in the HER2-low breast cancer era, with a focus on methodological aspects. We aim to propose clear positions to scientific societies, institutions, pathologists, and oncologists to guide and shape the appropriate diagnostic strategies for HER2-low breast cancer. The fundamental question at hand is whether the necessary tools to effectively translate our knowledge about HER2 into practical diagnostic schemes for the lower spectrum of expression are available. Our investigation is centered on the sig...
Source: Pathologica - January 5, 2024 Category: Pathology Authors: Caterina Marchi ò Carmen Criscitiello Cristian Scatena Alfredo Santinelli Paolo Graziano Umberto Malapelle Giulia Cursano Konstantinos Venetis Giuseppe Nicol ò Fanelli Francesco Pepe Enrico Berrino Carmine De Angelis Giuseppe Perrone Giuseppe Curigliano Source Type: research

How to measure your microscope's HPF. A critical guide for residents
Pathologica. 2023 Dec;115(6):302-307. doi: 10.32074/1591-951X-900.ABSTRACTCounting stuff under the microscope is part of the duties of a surgical pathologist. Many textbooks and articles still report the surface area as the number of high-power fields (HPFs) counted. This is bad, since the area displayed by an HPF varies between two microscopes. It is therefore necessary to express the surface as mm2. This is a how to guide written for the resident who has to measure the HPF of the microscope for the first time. The Resident can either calibrate the microscope with a stage micrometer slide (a small ruler on a glass slide) ...
Source: Pathologica - January 5, 2024 Category: Pathology Authors: Salvatore Lorenzo Renne Source Type: research

Natural Language Processing to extract SNOMED-CT codes from pathological reports
CONCLUSIONS: AI tools allow the automatic SNOMED-CT labeling of the pathology archives, providing a retrospective fix to the large lack of organization of narrative reports.PMID:38180139 | DOI:10.32074/1591-951X-952 (Source: Pathologica)
Source: Pathologica - January 5, 2024 Category: Pathology Authors: Giorgio Cazzaniga Albino Eccher Enrico Munari Stefano Marletta Emanuela Bonoldi Vincenzo Della Mea Moris Cadei Marta Sbaraglia Angela Guerriero Angelo Paolo Dei Tos Fabio Pagni Vincenzo L'Imperio Source Type: research

Pulmonary leiomyosarcoma arising in pulmonary hamartoma: an exceptional occurrence in a rare tumor
Pathologica. 2023 Dec;115(6):325-332. doi: 10.32074/1591-951X-941.ABSTRACTA solitary peripheral lung nodule was found in the left lung of a 52-year-old man. It was located in the lower lobe and measured 18.5 cm of major axis on chest computed tomography. A tru-cut core biopsy was obtained and a proliferation of bland, monomorphic, spindle cells in interlacing fascicles was observed. Accordingly, a surgical resection of the neoplasm was subsequently carried out. Macroscopically, the tumor appeared as a well-circumscribed nodule with a firm and whitish cut surface. Histologically, the neoplasm was predominantly composed of b...
Source: Pathologica - January 5, 2024 Category: Pathology Authors: Stefano Luc à Marco Montella Riccardo Monti Marina Accardo Giovanni Savarese Roberto Sirica Alfonso Fiorelli Floriana Morgillo Renato Franco Source Type: research

A rare case of extrarenal Wilms tumor of the uterine corpus: comprehensive genomic profile and review of the literature
We present the case of an adult woman who underwent total abdominal hysterectomy due to a uterine mass causing persistent abdominal pain. The characteristic triphasic morphology (composed of epithelial, stromal, and blastemal elements) supported by a broad immunohistochemical panel, along with the imaging exclusion of a renal neoplasm, was diagnostic of WT of the uterus. For the first time, a comprehensive genomic profiling of a uterine primary WT was also performed by next-generation sequencing, disclosing alterations at the level of copy number variations in the genes ERBB2, FGFR23, FGF6, FGFR2, and RPS6KB1. All previous...
Source: Pathologica - January 5, 2024 Category: Pathology Authors: Lara Alessandrini Angela Guerriero Giada Munari Biancamaria Del Forno Luisa Santoro Matteo Marchetti Margherita Nardin Roberto Tozzi Matteo Fassan Angelo Paolo Dei Tos Source Type: research

Sarcina ventriculi associated gastritis
Pathologica. 2023 Dec;115(6):341-343. doi: 10.32074/1591-951X-927.NO ABSTRACTPMID:38180142 | DOI:10.32074/1591-951X-927 (Source: Pathologica)
Source: Pathologica - January 5, 2024 Category: Pathology Authors: Rida Noor Muhammad Ahsan Fnu Poombal Samina Zaman Source Type: research

COVID-19. Biology, pathophysiology, and immunology: a pathologist view
Pathologica. 2023 Oct;115(5):248-256. doi: 10.32074/1591-951X-954.ABSTRACTEven if the SARS-CoV-2 pandemic has been declared over, several risks and clinical problems remain to be faced, including long-COVID sequelae and possible outbreaks of pathogenic variants. Intense research on COVID-19 has provided in these few years a striking amount of data covering different fields and disciplines, which can help to provide a knowledge shield against new potential infective spreads, and may also potentially be applied to other fields of medicine, including oncology and neurology. Nevertheless, areas of uncertainty still remain rega...
Source: Pathologica - December 6, 2023 Category: Pathology Authors: Marco Chilosi Claudio Doglioni Claudia Ravaglia Sara Piciucchi Alessandra Dubini Lavinia Stefanizzi Venerino Poletti Source Type: research

Management of post-mortem examination in SARS-CoV-19 infections
Pathologica. 2023 Oct;115(5):257-262. doi: 10.32074/1591-951X-921.ABSTRACTA brief overview on the management of autopsies during the SARS-CoV-19 epidemic is proposed. In particular, the point is made of the Italian laws on the subject, the characteristics required for the autopsy room and the sampling suggested for the histological examination.PMID:38054900 | PMC:PMC10699335 | DOI:10.32074/1591-951X-921 (Source: Pathologica)
Source: Pathologica - December 6, 2023 Category: Pathology Authors: Mattia Riefolo Francesca Ambrosi Alessandra De Palma Carmine Gallo Stefania Damiani Source Type: research

COVID-19: detection methods in post-mortem samples
Pathologica. 2023 Oct;115(5):263-274. doi: 10.32074/1591-951X-933.ABSTRACTCOVID-19 identification is routinely performed on fresh samples, such as nasopharyngeal and oropharyngeal swabs, even if, the detection of the virus in formalin-fixed paraffin-embedded (FFPE) autopsy tissues could help to underlie mechanisms of the pathogenesis that are not well understood.The gold standard for COVID-19 detection in FFPE samples remains the qRT-PCR as in swab samples, contextually other methods have been developed, including immunohistochemistry (IHC), and in situ hybridization (ISH). In this manuscript, we summarize the main data re...
Source: Pathologica - December 6, 2023 Category: Pathology Authors: Ilaria Tedesco Federica Zito Marino Andrea Ronchi Amaro Nunes Duarte Neto Marisa Dolhnikoff Maurizio Municin ò Carlo Pietro Campobasso Giuseppe Pannone Renato Franco Source Type: research

Exploring the pathologist's role in understanding COVID-19: from pneumonia to long-COVID lung sequelae
Pathologica. 2023 Oct;115(5):275-283. doi: 10.32074/1591-951X-906.ABSTRACTThe crucial role of pathologists in enhancing our understanding of SARS-CoV-2-related disease, from initial pneumonia manifestations to persistent long COVID lung symptoms, is the focus of this review. Pathological explorations have offered unprecedented insights into the early stages of severe COVID-19, shedding light on the interplay between the virus and subsequent complications, thereby shaping clinical approaches. Growing interest is directed to residual lung abnormalities of COVID-19 survivors. Although various radiological studies reported lon...
Source: Pathologica - December 6, 2023 Category: Pathology Authors: Gheorghe-Emilian Olteanu Federica Pezzuto Francesca Lunardi Francesco Fortarezza Alessandra Dubini Fiorella Calabrese Source Type: research

COVID-19 and lung cancer
Pathologica. 2023 Oct;115(5):284-291. doi: 10.32074/1591-951X-908.ABSTRACTCOVID-19 pandemic had affected health services around the world, also reducing the diagnosis of lung cancer. On the other hand, examination of surgical specimens in patients with lung cancer and SARS-CoV-2 gave the opportunity to evidence early histologic features related to this emerging pandemic.Different prioritization of health organizations during COVID-19 pandemic resulted in a significant decline of lung cancer screening (up to 56%), delayed diagnosis (up to 30-40%) and higher advanced stage, with some exceptions (i.e., Canada). Increased use ...
Source: Pathologica - December 6, 2023 Category: Pathology Authors: Laura Melocchi Maria Cecilia Mengoli Giuseppe Bogina Mattia Facchetti Federica Migliorati Laura Gandolfi Giulio Rossi Source Type: research

COVID-19. Biology, pathophysiology, and immunology: a pathologist view
Pathologica. 2023 Oct;115(5):248-256. doi: 10.32074/1591-951X-954.ABSTRACTEven if the SARS-CoV-2 pandemic has been declared over, several risks and clinical problems remain to be faced, including long-COVID sequelae and possible outbreaks of pathogenic variants. Intense research on COVID-19 has provided in these few years a striking amount of data covering different fields and disciplines, which can help to provide a knowledge shield against new potential infective spreads, and may also potentially be applied to other fields of medicine, including oncology and neurology. Nevertheless, areas of uncertainty still remain rega...
Source: Pathologica - December 6, 2023 Category: Pathology Authors: Marco Chilosi Claudio Doglioni Claudia Ravaglia Sara Piciucchi Alessandra Dubini Lavinia Stefanizzi Venerino Poletti Source Type: research

Management of post-mortem examination in SARS-CoV-19 infections
Pathologica. 2023 Oct;115(5):257-262. doi: 10.32074/1591-951X-921.ABSTRACTA brief overview on the management of autopsies during the SARS-CoV-19 epidemic is proposed. In particular, the point is made of the Italian laws on the subject, the characteristics required for the autopsy room and the sampling suggested for the histological examination.PMID:38054900 | PMC:PMC10699335 | DOI:10.32074/1591-951X-921 (Source: Pathologica)
Source: Pathologica - December 6, 2023 Category: Pathology Authors: Mattia Riefolo Francesca Ambrosi Alessandra De Palma Carmine Gallo Stefania Damiani Source Type: research

COVID-19: detection methods in post-mortem samples
Pathologica. 2023 Oct;115(5):263-274. doi: 10.32074/1591-951X-933.ABSTRACTCOVID-19 identification is routinely performed on fresh samples, such as nasopharyngeal and oropharyngeal swabs, even if, the detection of the virus in formalin-fixed paraffin-embedded (FFPE) autopsy tissues could help to underlie mechanisms of the pathogenesis that are not well understood.The gold standard for COVID-19 detection in FFPE samples remains the qRT-PCR as in swab samples, contextually other methods have been developed, including immunohistochemistry (IHC), and in situ hybridization (ISH). In this manuscript, we summarize the main data re...
Source: Pathologica - December 6, 2023 Category: Pathology Authors: Ilaria Tedesco Federica Zito Marino Andrea Ronchi Amaro Nunes Duarte Neto Marisa Dolhnikoff Maurizio Municin ò Carlo Pietro Campobasso Giuseppe Pannone Renato Franco Source Type: research