The effect of mixing on the dispersibility of adhesive mixtures for inhalation. Comparison of high shear and Turbula mixers
This study investigates the effect of different mixers and the applicability of the mixing energy (ME) concept to dry powder formulations for inhalation. With the aim to step-wise build and expand this concept, adhesive mixtures of 2 % budesonide and lactose carrier were investigated, both with 1 % magnesium stearate (MgSt) added in a 'coating' step, and without, the latter referred to as 'naked' formulations. For high shear mixed formulations, the fine particle fraction (FPF) was found to increase with increasing ME up to 60 % and thereafter decreased, using the Novolizer device. The data could be well fitted to the model...
Source: European Journal of Pharmaceutical Sciences - December 21, 2023 Category: Drugs & Pharmacology Authors: Kyrre Thalberg Love Ivarsson M årten Svensson Peter Elfman Ann Ohlsson Jackie Stuckel Ann-Marie Lyberg Source Type: research
Retracted: Preparation of Curcumin Solid Lipid Nanoparticles Loaded with Flower-Shaped Lactose for Lung Inhalation and Preliminary Evaluation of Cytotoxicity In Vitro
Evid Based Complement Alternat Med. 2023 Dec 13;2023:9809240. doi: 10.1155/2023/9809240. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2021/4828169.].PMID:38125160 | PMC:PMC10732876 | DOI:10.1155/2023/9809240 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - December 21, 2023 Category: Complementary Medicine Authors: Evidence-Based Complementary And Alternative Medicine Source Type: research
Lactose Utilisation to Furan Carboxylates: A Unique Source for Platform Molecules
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Joseph Install, An že Zupanc, Mikko Nikunen, Janne Jänis, Timo Repo Presented is a highly efficient utilisation of a lactose, a widely produced side-stream product to produce furancarboxylates in two steps. Firstly an enhanced nitric acid oxidation of lactose with Fe(NO)3... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Green Chem. latest articles)
Source: RSC - Green Chem. latest articles - December 20, 2023 Category: Chemistry Authors: Joseph Install Source Type: research
Identification of glycosylated nucleosides in small synthetic glyco-RNAs
Chembiochem. 2023 Dec 20:e202300784. doi: 10.1002/cbic.202300784. Online ahead of print.ABSTRACTRecently, the post-transcriptional modification of RNA with N-glycans was reported, changing the paradigm that RNAs are not commonly N-glycosylated. Moreover, glycan modifications of RNA are investigated for therapeutic targeting purposes. But the glycoRNA field is in its infancy with many challenges to overcome. One question is how to accurately characterize glycosylated RNA constructs. Thus, we generated glycosylated forms of Y5 RNA mimics, a short non-coding RNA. The simple glycans lactose and sialyllactose were attached to t...
Source: Chembiochem - December 20, 2023 Category: Biochemistry Authors: Frank St Michael Maha Ben Hamouda Jacek Stupak Jianjun Li Angela Pearson Janelle Sauvageau Source Type: research
Discrimination of Disaccharide Isomers of Different Glycosidic Linkages Using a Modified MspA Nanopore
Angew Chem Int Ed Engl. 2023 Dec 20:e202316766. doi: 10.1002/anie.202316766. Online ahead of print.ABSTRACTDisaccharides are composed of two monosaccharide subunits joined by a glycosidic linkage in an α or β configuration. Different combinations of isomeric monosaccharide subunits and different glycosidic linkages result in different isomeric disaccharide products. Thus, direct discrimination of these disaccharide isomers from a mixture is extremely difficult. In this paper, a hetero-octameric Mycobacterium smegmatis porin A (MspA) nanopore conjugated with a phenylboronic acid (PBA) adapter was applied for disaccharide ...
Source: Angewandte Chemie - December 20, 2023 Category: Chemistry Authors: Shanyu Zhang Zhenyuan Cao Pingping Fan Wen Sun Yunqi Xiao Panke Zhang Yuqin Wang Shuo Huang Source Type: research
Evaluation of universal preenrichment broth and comparison of rapid molecular methods for the detection of Salmonella from spent sprout irrigation water (SSIW)
This study aimed to compare universal preenrichment broth (UPB) and lactose broth (LB) as preenrichment media for cultural and rapid screening methods and to compare their abilities to recover Salmonella in SSIW samples from different sprout varieties (i.e., alfalfa, broccoli, and mung bean sprouts). The associated co-enriched microbiota with different sprout varieties using different preenrichment media were also examined using a quasi-metagenomic approach. The performance of media and detection methods was compared using the relative level of detection (RLOD) value, as recommended by ISO 16140-2:2016. The level of detect...
Source: International Journal of Food Microbiology - December 20, 2023 Category: Food Science Authors: Jie Zheng Elizabeth Reed Anna Maounounen-Laasri Xiaohong Deng Shizhen S Wang Padmini Ramachandran Christina Ferreira Rebecca Bell Eric W Brown Thomas S Hammack Hua Wang Source Type: research
Identification of glycosylated nucleosides in small synthetic glyco-RNAs
Chembiochem. 2023 Dec 20:e202300784. doi: 10.1002/cbic.202300784. Online ahead of print.ABSTRACTRecently, the post-transcriptional modification of RNA with N-glycans was reported, changing the paradigm that RNAs are not commonly N-glycosylated. Moreover, glycan modifications of RNA are investigated for therapeutic targeting purposes. But the glycoRNA field is in its infancy with many challenges to overcome. One question is how to accurately characterize glycosylated RNA constructs. Thus, we generated glycosylated forms of Y5 RNA mimics, a short non-coding RNA. The simple glycans lactose and sialyllactose were attached to t...
Source: Chembiochem - December 20, 2023 Category: Biochemistry Authors: Frank St Michael Maha Ben Hamouda Jacek Stupak Jianjun Li Angela Pearson Janelle Sauvageau Source Type: research
Discrimination of Disaccharide Isomers of Different Glycosidic Linkages Using a Modified MspA Nanopore
Angew Chem Int Ed Engl. 2023 Dec 20:e202316766. doi: 10.1002/anie.202316766. Online ahead of print.ABSTRACTDisaccharides are composed of two monosaccharide subunits joined by a glycosidic linkage in an α or β configuration. Different combinations of isomeric monosaccharide subunits and different glycosidic linkages result in different isomeric disaccharide products. Thus, direct discrimination of these disaccharide isomers from a mixture is extremely difficult. In this paper, a hetero-octameric Mycobacterium smegmatis porin A (MspA) nanopore conjugated with a phenylboronic acid (PBA) adapter was applied for disaccharide ...
Source: Angewandte Chemie - December 20, 2023 Category: Chemistry Authors: Shanyu Zhang Zhenyuan Cao Pingping Fan Wen Sun Yunqi Xiao Panke Zhang Yuqin Wang Shuo Huang Source Type: research
Evaluation of universal preenrichment broth and comparison of rapid molecular methods for the detection of Salmonella from spent sprout irrigation water (SSIW)
This study aimed to compare universal preenrichment broth (UPB) and lactose broth (LB) as preenrichment media for cultural and rapid screening methods and to compare their abilities to recover Salmonella in SSIW samples from different sprout varieties (i.e., alfalfa, broccoli, and mung bean sprouts). The associated co-enriched microbiota with different sprout varieties using different preenrichment media were also examined using a quasi-metagenomic approach. The performance of media and detection methods was compared using the relative level of detection (RLOD) value, as recommended by ISO 16140-2:2016. The level of detect...
Source: International Journal of Food Microbiology - December 20, 2023 Category: Food Science Authors: Jie Zheng Elizabeth Reed Anna Maounounen-Laasri Xiaohong Deng Shizhen S Wang Padmini Ramachandran Christina Ferreira Rebecca Bell Eric W Brown Thomas S Hammack Hua Wang Source Type: research
GSE207392 Gene expression and metabolic activity of Streptococcus mutans during exposure to dietary carbohydrates glucose, sucrose, lactose and xylitol
Contributors : Veronika Zajdlikova ; Veronika Krestakova ; Jiri Kucera ; Katerina Dadakova ; Martina Zapletalova ; Katerina Paskova ; Roman Reminek ; Zdenek Glatz ; Lydie Izakovicova Holla ; Filip Ruzicka ; Jan Lochman ; Petra Borilova LinhartovaSeries Type : Expression profiling by high throughput sequencingOrganism : Streptococcus mutansRecent RNA-seq studies have given us a deeper insight into the cariogenic impact of carbohydrate sources in the bacterium Streptococcus mutans, the principal etiological agent of human dental caries. The process of dental caries development is given by the ability of this bact...
Source: GEO: Gene Expression Omnibus - December 18, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Streptococcus mutans Source Type: research
