Tailored physiologic treatment of severe hypertension in pregnancy: a novel approach to hypertension management
A recent Cochrane review found no differences in efficacy or safety between hydralazine and labetalol for treatment of acute severe HTN. Our objective was to determine if a tailored physiologic approach to treatment of severe HTN was associated with improved BP control. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 23, 2021 Category: OBGYN Authors: Allison M. Davis, Christina T. Blanchard, Akila Subramaniam, Rachel G. Sinkey, Alan T. Tita, Ashley N. Battarbee Tags: Poster Session II Source Type: research
Evaluation of β-adrenergic ligands for development of pharmacological heart failure and transparency models in zebrafish
In conclusion, we proposed two novel pharmacological models in zebrafish; i.e., epinephrine-dependent heart failure and isoetharine-dependent transparent zebrafish. We provided strong evidence that the zebrafish model constitutes a valuable tool for cardiovascular research.PMID:34838787 | DOI:10.1016/j.taap.2021.115812 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - November 28, 2021 Category: Toxicology Authors: Monika Maciag Artur Wnorowski Kinga Bednarz Anita Plazinska Source Type: research
Evaluation of β-adrenergic ligands for development of pharmacological heart failure and transparency models in zebrafish
In conclusion, we proposed two novel pharmacological models in zebrafish; i.e., epinephrine-dependent heart failure and isoetharine-dependent transparent zebrafish. We provided strong evidence that the zebrafish model constitutes a valuable tool for cardiovascular research.PMID:34838787 | DOI:10.1016/j.taap.2021.115812 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - November 28, 2021 Category: Toxicology Authors: Monika Maciag Artur Wnorowski Kinga Bednarz Anita Plazinska Source Type: research
Clinical Evaluation of Pinggan Yiqi Yangshen Recipe Combined with Labetalol Hydrochloride and Magnesium Sulfate in the Treatment of PIH
CONCLUSION: Pinggan Yiqi Yangshen recipe combined with labetalol hydrochloride and magnesium sulfate can effectively reduce the blood pressure of patients with PIH, help patients to return to normal levels of biochemical indexes and renal function indexes, and improve pregnancy outcomes with high safety, which is worthy of further promotion and application in clinical practice.PMID:34745277 | PMC:PMC8568534 | DOI:10.1155/2021/3135043 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2021 Category: Complementary Medicine Authors: Ping Li Jie Zhao Peipei Gao Hongcui Qu Source Type: research
Application of comprehensive bioinformatics approaches to reconnoiter crucial genes and pathways underpinning hepatocellular carcinoma: a drug repurposing endeavor
In conclusion, this study discloses a series of key genetic underpinnings of HCC and recommends the pertinence of labetalol as a potential repurposable drug against HCC. (Source: Medical Oncology)
Source: Medical Oncology - October 23, 2021 Category: Cancer & Oncology Source Type: research
Amlodipine/labetalol/spironolactone
(Source: Reactions Weekly)
Source: Reactions Weekly - September 1, 2021 Category: Drugs & Pharmacology Source Type: research
Regional Differences in Early BP Management After Acute Ischemic Stroke in the ENCHANTED International Randomized Controlled Trials
Conclusion: Regional variations in early BP management in acute stroke translated into differences in early BP control parameters. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - August 27, 2021 Category: Neurology Source Type: research
[ASAP] Solubility Measurement and Thermodynamic Properties of Labetalol Hydrochloride in Different Solvents
Journal of Chemical& Engineering DataDOI: 10.1021/acs.jced.1c00432 (Source: Journal of Chemical and Engineering Data)
Source: Journal of Chemical and Engineering Data - August 18, 2021 Category: Chemistry Authors: Yuyuan Dong, Yongli Wang, Xin Huang, Ting Wang, Shuangxi Li, Danning Li, Xiaowei Cheng, Shuyu Li, Han Liu, and Hongxun Hao Source Type: research
Blood Pressure Control in Acute Stroke: Labetalol or Nicardipine?
To assess the safety and efficacy of continuous infusion (CIV)-labetalol compared to -nicardipine in controlling blood pressure (BP) in the acute stroke setting. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 30, 2021 Category: Neurology Authors: Heba El-Ghoroury, David M. Sudekum, Jason P. Hecht Source Type: research
Unrecognised pheochromocytoma in pregnancy discovered through metoclopramide-triggered hypertensive emergency
CONCLUSIONS: Both metoclopramide, a selective dopamine type-2 receptor antagonist and partial agonist of 5-hydroxytryptamine 4 receptor, and labetalol, a non-selective β-adrenoreceptor-blocker with weak α1-adrenergic antagonism, exacerbated an acute hypertensive crisis revealing an unrecognised pheochromocytoma in a pregnant patient. Careful attention to potential drug-triggered catecholamine crises and especially early recognition of pheochromocytomas, are mandatory in hypertensive pregnant women. A missed or delayed diagnosis could result in catastrophic results affecting foetal and maternal outcomes.PMID:34176388 | DO...
Source: Blood Pressure - June 28, 2021 Category: Hematology Authors: Aurelio Negro Ignazio Verzicco Stefano Tedeschi Rosaria Santi Barbara Palladini Anna Calvi Alessandro Giunta Davide Cunzi Pietro Coghi Riccardo Volpi Aderville Cabassi Source Type: research
