Comparison of pregnancy latency in preterm preeclampsia with oral labetalol versus extended-release nifedipine
To compare pregnancy latency achieved with oral labetalol versus extended-release nifedipine during expectant management of preterm preeclampsia with severe features (PEC-SF). (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2023 Category: OBGYN Authors: Anthony Melendez Torres, Jessica A. Meyer, Meralis V. Lantigua-Martinez, Steven Friedman, Erinn M. Hade, Ashley S. Roman, Christina A. Penfield Tags: Poster Session III Source Type: research
Outcomes of nifedipine versus labetalol for oral treatment of chronic hypertension in pregnancy
A recent randomized trial showed that treating chronic hypertension (CHTN) in pregnancy reduced risks of adverse outcomes including preeclampsia and preterm birth (PTB). We tested whether maternal and neonatal outcomes differ by use of labetalol vs. nifedipine for antihypertensive therapy in pregnancy. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2023 Category: OBGYN Authors: Ayodeji Sanusi, Alan T. Tita Tags: Oral Concurrent Session 1 - Hypertension Source Type: research
Analytical enantioseparation of N-alkyl drugs by reversed-phase liquid chromatography with carboxymethyl- β-cyclodextrin as mobile phase additive
Chirality. 2022 Nov 8. doi: 10.1002/chir.23516. Online ahead of print.ABSTRACTCarboxymethyl-β-cyclodextrins (CM-β-CDs) with five kinds of degrees of substitution were synthesized and characterized. Analytical enantioseparation of six basic drugs containing N-alkyl groups, including pheniramine, chlorpheniramine, labetalol, propranolol, venlafaxine, and trans-paroxol, was achieved by reversed-phase high-performance liquid chromatography (RP-HPLC) using the synthesized CM-β-CD as chiral mobile phase additives. Key influence factors were optimized, including organic modifier, pH value, CM-β-CD with different degrees of su...
Source: Chirality - November 8, 2022 Category: Molecular Biology Authors: Haibo You Ben Chen Liqun Fang Tingting Lin Ping Xu Chu Chu Shengqiang Tong Source Type: research
Analytical enantioseparation of N-alkyl drugs by reversed-phase liquid chromatography with carboxymethyl- β-cyclodextrin as mobile phase additive
Chirality. 2022 Nov 8. doi: 10.1002/chir.23516. Online ahead of print.ABSTRACTCarboxymethyl-β-cyclodextrins (CM-β-CDs) with five kinds of degrees of substitution were synthesized and characterized. Analytical enantioseparation of six basic drugs containing N-alkyl groups, including pheniramine, chlorpheniramine, labetalol, propranolol, venlafaxine, and trans-paroxol, was achieved by reversed-phase high-performance liquid chromatography (RP-HPLC) using the synthesized CM-β-CD as chiral mobile phase additives. Key influence factors were optimized, including organic modifier, pH value, CM-β-CD with different degrees of su...
Source: Chirality - November 8, 2022 Category: Molecular Biology Authors: Haibo You Ben Chen Liqun Fang Tingting Lin Ping Xu Chu Chu Shengqiang Tong Source Type: research
Analytical enantioseparation of N-alkyl drugs by reversed-phase liquid chromatography with carboxymethyl- β-cyclodextrin as mobile phase additive
Chirality. 2022 Nov 8. doi: 10.1002/chir.23516. Online ahead of print.ABSTRACTCarboxymethyl-β-cyclodextrins (CM-β-CDs) with five kinds of degrees of substitution were synthesized and characterized. Analytical enantioseparation of six basic drugs containing N-alkyl groups, including pheniramine, chlorpheniramine, labetalol, propranolol, venlafaxine, and trans-paroxol, was achieved by reversed-phase high-performance liquid chromatography (RP-HPLC) using the synthesized CM-β-CD as chiral mobile phase additives. Key influence factors were optimized, including organic modifier, pH value, CM-β-CD with different degrees of su...
Source: Chirality - November 8, 2022 Category: Molecular Biology Authors: Haibo You Ben Chen Liqun Fang Tingting Lin Ping Xu Chu Chu Shengqiang Tong Source Type: research
False-positive Fentanyl Urine Detection after Initiation of Labetalol Treatment for Hypertension in Pregnancy: A Case Report
We present 3 pregnant or postpregnant persons with SUDs who experienced presumptive positive urine immunoassays for fentanyl while prescribed LH for perinatal HD.
Discussion
Labetalol hydrochloride treatment for HD in pregnancy can result in presumptive positive urine immunoassays for fentanyl. Unrecognized or misinterpreted, this phenomenon can lead to significant consequences for pregnant and postpartum persons with co-occurring substance use and hypertensive disorders. Clinicians caring for pregnant persons with SUDs must be aware of this phenomenon and its sequelae when ordering and interpreting urine immunoassa...
Source: Journal of Addiction Medicine - November 1, 2022 Category: Addiction Tags: Case Reports Source Type: research
Effects of Nifedipine and Labetalol Combined with Magnesium Sulfate on Blood Pressure Control, Blood Coagulation Function, and Maternal and Infant Outcome in Patients with Pregnancy-Induced Hypertension
CONCLUSION: Nifedipine, in combination with magnesium sulfate and labetalol, is effective at treating PIH, reducing blood pressure, improving blood coagulation, preventing cardiovascular events and vascular endothelial function, and further improve the pregnancy outcome.PMID:36277012 | PMC:PMC9584663 | DOI:10.1155/2022/9317114 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - October 24, 2022 Category: Statistics Authors: Yuping Shao Siyi Gu Xiaoping Zhang Source Type: research
Labetalol-Associated Raynaud ’s Phenomenon of the Nipple: A Rare Case Report with Review of Literature
(Source: The Journal of Obstetrics and Gynecology of India)
Source: The Journal of Obstetrics and Gynecology of India - October 21, 2022 Category: OBGYN Source Type: research
Nicardipine versus Labetalol for Hypertension during Acute Stroke: A Systematic Review and Meta-Analysis
Conclusion: More prospective, comparative trials are needed to investigate the efficacy of BP management as well as clinical outcomes in acute stroke patients receiving continuous labetalol and nicardipine infusions. (Source: Neurology India)
Source: Neurology India - October 21, 2022 Category: Neurology Authors: Fang Hao Suna Yin Lina Tang Xueguang Zhang Shubao Zhang Source Type: research
Pharmacokinetics of the most commonly used antihypertensive drugs throughout pregnancy methyldopa, labetalol, and nifedipine: a systematic review
ConclusionWe conclude that despite decades of prescribing methyldopa, labetalol, and nifedipine throughout pregnancy, descriptions of their PK during pregnancy are hampered by a large heterogeneity in the low number of available studies. Aiming for evidence-based and personalized dosing of antihypertensive medication in the future, further studies on the relationship of both PK and pharmacodynamics (including the optimal blood pressure targeting) during pregnancy and pregnancy-related pathology are urgently needed to prevent undertreatment, overtreatment, and side effects. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 12, 2022 Category: Drugs & Pharmacology Source Type: research
Labetalol
(Source: Reactions Weekly)
Source: Reactions Weekly - October 1, 2022 Category: Drugs & Pharmacology Source Type: research
Pharmacokinetics of the most commonly used antihypertensive drugs throughout pregnancy methyldopa, labetalol, and nifedipine: a systematic review
ConclusionWe conclude that despite decades of prescribing methyldopa, labetalol, and nifedipine throughout pregnancy, descriptions of their PK during pregnancy are hampered by a large heterogeneity in the low number of available studies. Aiming for evidence-based and personalized dosing of antihypertensive medication in the future, further studies on the relationship of both PK and pharmacodynamics (including the optimal blood pressure targeting) during pregnancy and pregnancy-related pathology are urgently needed to prevent undertreatment, overtreatment, and side effects. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - September 15, 2022 Category: Drugs & Pharmacology Source Type: research
Postpartum Readmission for Hypertension After Discharge on Labetalol or Nifedipine
CONCLUSION: Postpartum discharge on labetalol was associated with increased risk of readmission for hypertension compared with discharge on nifedipine.PMID:36075068 | DOI:10.1097/AOG.0000000000004918 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - September 8, 2022 Category: OBGYN Authors: Samantha C Do Stephanie A Leonard Peiyi Kan Danielle M Panelli Anna I Girsen Deirdre J Lyell Yasser Y El-Sayed Maurice L Druzin Tiffany Herrero Source Type: research
