[ASAP] Metabolic Activation and Cytotoxicity of Labetalol Hydrochloride Mediated by Sulfotransferases
Chemical Research in ToxicologyDOI: 10.1021/acs.chemrestox.1c00060 (Source: Chemical Research in Toxicology)
Source: Chemical Research in Toxicology - April 19, 2021 Category: Toxicology Authors: Lan Yang, Lihua Xin, Junzu Shi, Wei Li, Min Tian, Zixia Hu, Ying Peng, and Jiang Zheng Source Type: research

Impact of intravenous antihypertensives on outcomes among hospitalized patients
This study investigated the effects of IV as-needed (PRN) antihypertensives on blood pressure, hospital length of stay, and mortality.METHODS: We included hospitalized patients with an order for an IV PRN antihypertensive medication. We excluded patients with target organ damage. We performed multivariate analysis to assess whether the medication was independently associated with outcomes.RESULTS: 1784 out of 5680 patients (31%) had an administration of the PRN medication. Patients who received the medication had a longer hospital stay compared to patients with an order for the medication who did not receive it (4.9 &plusm...
Source: American Journal of Hypertension - April 17, 2021 Category: Cardiology Authors: Kelsi Bean-Thompson Julien Exposito Oliver Fowler Rahul Mhaskar Liwei Chen Jose Nicolas Codolosa Source Type: research

Impact of intravenous antihypertensives on outcomes among hospitalized patients
This study investigated the effects of IV as-needed (PRN) antihypertensives on blood pressure, hospital length of stay, and mortality.METHODS: We included hospitalized patients with an order for an IV PRN antihypertensive medication. We excluded patients with target organ damage. We performed multivariate analysis to assess whether the medication was independently associated with outcomes.RESULTS: 1784 out of 5680 patients (31%) had an administration of the PRN medication. Patients who received the medication had a longer hospital stay compared to patients with an order for the medication who did not receive it (4.9 &plusm...
Source: American Journal of Hypertension - April 17, 2021 Category: Cardiology Authors: Kelsi Bean-Thompson Julien Exposito Oliver Fowler Rahul Mhaskar Liwei Chen Jose Nicolas Codolosa Source Type: research

Impact of intravenous antihypertensives on outcomes among hospitalized patients
This study investigated the effects of IV as-needed (PRN) antihypertensives on blood pressure, hospital length of stay, and mortality.METHODS: We included hospitalized patients with an order for an IV PRN antihypertensive medication. We excluded patients with target organ damage. We performed multivariate analysis to assess whether the medication was independently associated with outcomes.RESULTS: 1784 out of 5680 patients (31%) had an administration of the PRN medication. Patients who received the medication had a longer hospital stay compared to patients with an order for the medication who did not receive it (4.9 &plusm...
Source: American Journal of Hypertension - April 17, 2021 Category: Cardiology Authors: Kelsi Bean-Thompson Julien Exposito Oliver Fowler Rahul Mhaskar Liwei Chen Jose Nicolas Codolosa Source Type: research

Labetalol and hypoglycaemia unawareness: two case reports and considerations about its use as an antihypertensive drug for women with diabetes and pregnancy
(Source: Acta Diabetologica)
Source: Acta Diabetologica - February 27, 2021 Category: Endocrinology Source Type: research

807 Oral nifedipine versus intravenous labetalol in the treatment of severe hypertension in the postpartum period
Our aim is to compare the efficacy of oral nifedipine with intravenous labetalol in the treatment of severe hypertension in the postpartum period. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - February 1, 2021 Category: OBGYN Authors: Elizabeth Ludwig, Anna Frappaolo, Shai Bejerano, Melanie Polin, Cynthia Gyamfi-Bannerman, Whitney A. Booker Tags: Poster Session III Source Type: research

184 Among pregnant women with chronic hypertension, do outcomes differ between those on nifedipine versus labetalol?
This study aims to identify if perinatal outcomes differ in pregnant women with chronic hypertension managed on nifedipine versus labetalol. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - February 1, 2021 Category: OBGYN Authors: Christy Gandhi, Phinnara Has, David A. Savitz, Valery A. Danilack, Adam K. Lewkowitz Tags: Poster Session I Source Type: research

Pharmacological strategies to prevent haemodynamic changes after intubation in parturient women with hypertensive disorders of pregnancy: A network meta-analysis.
Conclusions : High-dose remifentanil produces minimum blood pressure changes, while labetalol is most effective in maintaining normal heart rate in parturient women with hypertensive disorders of pregnancy during caesarean section under general anaesthesia. PMID: 33456362 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - January 20, 2021 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Labetalol treatment in estrogen-induced cholestasis – A pilot study
Background and Aims: Preeclampsia and intrahepatic cholestasis (ICP) are serious complications of pregnancy, which threaten mothers and fetuses with adverse outcomes such as stillbirth or preterm delivery. Clinical studies demonstrated strong coincidence of both pathologies but the cause of this simultaneous worsening and especially regarding liver functions is unknown. Labetalol, an alpha-/beta-adrenergic receptor antagonist is recommended in the therapy of hypertension in pregnancy. Therefore, in these pilot experiments, we aimed to elucidate the effect of labetalol therapy on mechanisms of bile formation in an animal mo...
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: I.C. Igreja E S á, K. Tripská, S. Micuda, P. Nachtigal Source Type: research

Effect of magnesium sulfate combined with labetalol on serum sFlt-1/PlGF ratio in patients with early-onset severe pre-eclampsia.
In conclusion, magnesium sulfate combined with labetalol could be effectively used for the treatment of ES-PE. The results of ELISA revealed that the balance of sFlT-1 and PlGF was improved after treatment and the sFlT-1/PlGF ratio was decreased. The assessment of sFlt-1/PlGF ratio before treatment was shown to have a certain predictive value for the efficacy of ES-PE treatment. PMID: 33200001 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - November 19, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Ginger extract attenuates labetalol induced apoptosis, DNA damage, histological and ultrastructural changes in the heart of rat fetuses
Publication date: Available online 27 October 2020Source: Saudi Journal of Biological SciencesAuthor(s): Hend T. El-Borm, Marwa S. Gobara, Gamal M. Badawy (Source: Saudi Journal of Biological Sciences)
Source: Saudi Journal of Biological Sciences - October 27, 2020 Category: Biology Source Type: research

Effect of intraoperative dexmedetomidine infusion during functional endoscopic sinus surgery: a prospective cohort study.
Abstract Background: Dexmedetomidine, an α2 agonist, has well-known anesthetic and analgesic-sparing effects. We designed this study to evaluate the effect of intraoperative dexmedetomidine infusion on intra operative blood loss and postoperative pain in functional endoscopic sinus surgery. Methods: This prospective cohort study included 90 patients planning to undergo endoscopic sinus surgery, who were randomly divided into three groups. 2 to 2.5 mg/kg of propofol was used in all groups to induce anesthesia. One group received dexmedetomidine 0.2 μg/kg per hour infusion whereas the oth...
Source: Patient Safety in Surgery - October 20, 2020 Category: Surgery Authors: Fazel MR, Ahmadi ZS, Akbari H, Abam F Tags: Patient Saf Surg Source Type: research

Oral Antihypertensive Regimens (Nifedipine-retard, Labetalol, and Methyldopa) for Management of Severe Hypertension in Pregnancy: An Open-Label, Randomized Controlled Trial
(Lancet. 2019;394:1011–1021) (Source: Obstetric Anesthesia Digest)
Source: Obstetric Anesthesia Digest - September 1, 2020 Category: Anesthesiology Tags: Mother, Fetus, Neonate Source Type: research

Duloxetine-induced hypertensive urgency in type 2 diabetes mellitus with diabetic neuropathy
We present a case of hypertensive urgency in a diabetic patient with painful diabetic neuropathy on duloxetine treatment. The patient's blood pressure was high after taking 1-day dose of duloxetine and the patient was diagnosed with hypertensive urgency. The patient was managed with labetalol, leading to reduction in blood pressure. The patient's medication was switched to telmisartan and metoprolol, which leads to resolution of increased blood pressure. This case report is a possible case of hypertensive urgency after the initiation of duloxetine managed with antihypertensives and resolves with the discontinuation...
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Ravindra Shukla Sameer Khasbage Mahendra Kumar Garg Surjit Singh Source Type: research

Labetalol-Induced Hepatotoxicity during Pregnancy: A Case Report
Conclusion Labetalol-induced hepatitis should be considered in the differential for transaminitis during pregnancy to prevent iatrogenic preterm delivery. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - August 3, 2020 Category: Perinatology & Neonatology Authors: Whelan, Anna Izewski, Joanna Berkelhammer, Charles Walloch, Jami Kay, Helen H. Tags: Case Report Source Type: research

Duloxetine-induced hypertensive urgency in type 2 diabetes mellitus with diabetic neuropathy
We present a case of hypertensive urgency in a diabetic patient with painful diabetic neuropathy on duloxetine treatment. The patient's blood pressure was high after taking 1-day dose of duloxetine and the patient was diagnosed with hypertensive urgency. The patient was managed with labetalol, leading to reduction in blood pressure. The patient's medication was switched to telmisartan and metoprolol, which leads to resolution of increased blood pressure. This case report is a possible case of hypertensive urgency after the initiation of duloxetine managed with antihypertensives and resolves with the discontinuation...
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Ravindra Shukla Sameer Khasbage Mahendra Kumar Garg Surjit Singh Source Type: research

Labetalol Infusion Controls Paradoxical Hypertension and Decreases Plasma Renin Activity Following Repair of Coarctation of the Aorta in Children
The recently published article by Gareth et al.1 investigated the effects of labetalol infusion on blood pressure, plasma catecholamine levels, and plasma renin activity in children undergoing repair of coarctation of the aorta. The final results indicated that labetalol could effectively inhibit the activation of the renin-angiotensin system (RAS) and is beneficial in the control of paradoxical hypertension. Although this study provided certain evidence for the repair of coarctation of the aorta, the following limitations need to be considered. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - July 29, 2020 Category: Anesthesiology Authors: Xiuling Zhu Tags: Letter to the Editor Source Type: research

Methyldopa versus labetalol or no medication for treatment of mild and moderate chronic hypertension during pregnancy: a randomized clinical trial.
Authors: Rezk M, Emarh M, Masood A, Dawood R, El-Shamy E, Gamal A, Badr H Abstract OBJECTIVE: to assess the maternal and fetal outcome in women with mild to moderate chronic hypertension on antihypertensive drug (methyldopa or labetalol) therapy compared to no medication. METHODS: This multicenter randomized clinical study was conducted at Menoufia University hospital, Shibin El-kom Teaching hospital at Menoufia governorate, Egypt.486 pregnant women with mild to moderate chronic hypertension were randomized into three groups; methyldopa group (n = 164), labetalol group (n = 160), and control...
Source: Hypertension in Pregnancy - July 24, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Retrospective evaluation of labetalol as antihypertensive agent in dogs
To evaluate the effect on arterial blood pressure (ABP) of labetalol infusion as treatment for perioperative non nociceptive acute hypertension in dogs. The clinical records of dogs receiving intra or postoper... (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - July 24, 2020 Category: Veterinary Research Authors: Francesco Zublena, Chiara De Gennaro and Federico Corletto Tags: Research article Source Type: research

Clinical Experiences of Intravenous Hydralazine and Labetalol for Acute Treatment of Severe Hypertension in Pregnant Thai Women.
Abstract Response to acute treatment of severe hypertension during pregnancy in Asian women was not known. Labor and delivery checklists of Thai women treated with intravenous hydralazine or labetalol for systolic blood pressure (SBP) ≥ 160 or diastolic blood pressure (DBP) ≥ 110 mm Hg from January 2011 to December 2013 were reviewed as parts of an audit. Primary outcome was prompt achievement of SBP 140-150 and DBP 90-100 mm Hg after the first bolus. Secondary outcomes were medication-related undesired effects. The mean ± standard deviation age and prevalence of chronic hypertension in hydr...
Source: The Journal of Clinical Pharmacology - June 28, 2020 Category: Drugs & Pharmacology Authors: Chera-Aree P, Tengtrakulcharoen P, Leetheeragul J, Sampaojarean U, Surasereewong S, Wataganara T Tags: J Clin Pharmacol Source Type: research

Labetalol Infusion Attenuates Paradoxical Hypertension and Decreases Plasma Renin Activity After Repair of Coarctation of the Aorta in Children
SEVERE hypertension after repair of coarctation of the aorta in children is a common clinical problem that requires pharmacologic treatment in the majority of patients.1-3 Such hypertension is termed “paradoxical hypertension” because it occurs after the aortic obstruction has been surgically relieved. The following 2 phases of the hypertension have been described: the first, a marked elevation of predominantly systolic pressure occurring within the first 12- to- 48 hours after surgery and t he second, an elevation of systolic and predominantly diastolic pressure occurring at 2- to- 4 days after surgery. (Sourc...
Source: Journal of Cardiothoracic and Vascular Anesthesia - June 23, 2020 Category: Anesthesiology Authors: Gareth A. Charlton, David R. Ladd, Richard M. Friesen, Robert H. Friesen Tags: Original Article Source Type: research

Intravenous labetalol versus oral nifedipine for acute hypertension in pregnancy: effects on cerebral perfusion pressure
Pregnant women with preeclampsia have been shown to have elevated cerebral perfusion pressure and impaired cerebral autoregulation compared to normal pregnant women. Transcranial Doppler is a non-invasive technique used to estimate cerebral perfusion pressure. The effects of different antihypertensives on cerebral perfusion pressure in preeclampsia is unknown. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - June 12, 2020 Category: OBGYN Authors: Mary Catherine TOLCHER, Karin A. FOX, Haleh SANGI-HAGHPEYKAR, Steven L. CLARK, Michael A. BELFORT Tags: Original Research: Obstetrics Source Type: research

Wrong-Patient Ordering Errors in Peripartum Mother-Newborn Pairs: A Unique Patient-Safety Challenge in Obstetrics.
We describe two clinical scenarios of wrong-patient ordering errors between mother-newborn pairs. The first involves an intravenous labetalol order that was placed for a postpartum patient but was released from the automated dispensing cabinet under the newborn's name. The medication was administered correctly, but an automatic order for labetalol was generated in the neonate's chart. Another scenario involves a woman presenting in labor with acute psychotic symptoms. The psychiatry service placed a note and orders for antipsychotic medications in the neonate's chart. These orders were cancelled shortly thereafter and repl...
Source: Obstetrics and Gynecology - June 10, 2020 Category: OBGYN Authors: Kern-Goldberger AR, Adelman J, Applebaum JR, Manzano W, Goffman D Tags: Obstet Gynecol Source Type: research

To study the changes in maternal hemodynamics with intravenous labetalol or nifedipine in acute severe hypertension
Publication date: Available online 29 May 2020Source: Pregnancy HypertensionAuthor(s): Monika Thakur, Shalini Gainder, S.C. Saha, Mahesh Prakash (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 30, 2020 Category: OBGYN Source Type: research

Regulation of magnesium sulfate combined with nifedipine and labetalol on disease-related molecules in serum and placenta in the treatment of preeclampsia.
Authors: Wu Y, Wang DJ, Zhang Y, Zhang YX, Zhang R Abstract OBJECTIVE: To explore the regulatory effect of magnesium sulfate combined with nifedipine and labetalol on disease-related molecules in serum and placenta in the treatment of preeclampsia. PATIENTS AND METHODS: Altogether 100 patients with preeclampsia admitted to the Children & Women's Healthcare of Laiwu City were selected. They were divided into control group and experimental group according to different treatment methods. Among them, 51 patients in the control group were treated with magnesium sulfate combined with nifedipine, and 49 patients i...
Source: European Review for Medical and Pharmacological Sciences - May 22, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Rational targeting of Wzb phosphatase and Wzc kinase interaction inhibits extracellular polysaccharides synthesis and biofilm formation in Acinetobacter baumannii.
In this study, we have modelled the Wzb, and Wzc proteins and further validated using PSVS, ProSA, RAMPAGE, and PDBsum. The modelled proteins were used for protein-protein docking. The docked protein-protein complex was minimized by Schrodinger software using OPLS_2005 force field. The binding site of the minimized Wzb-Wzc complex was identified by Sitemap. The high throughput virtual screening identified Labetalol hydrochloride and 4-{1-hydroxy-2-[(1-methyl-3-phenylpropyl) amino] propyl} phenol from FDA-approved drug library based on their interaction at the interface of Wzb-Wzc complex. The inhibitor-protein complex was ...
Source: Carbohydrate Research - April 30, 2020 Category: Genetics & Stem Cells Authors: Tiwari M, Panwar S, Kothidar A, Tiwari V Tags: Carbohydr Res Source Type: research

Effects of nitroglycerin versus labetalol on peripheral perfusion during deliberate hypotension for sinus endoscopic surgery: a randomized, controlled, double-blinded trial
Deliberate hypotension is used to provide a bloodless field during functional endoscopic sinus surgery; however, the impact of controlled hypotension during anesthesia on peripheral tissue perfusion has not be... (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - April 17, 2020 Category: Anesthesiology Authors: Marwa Zayed, Heba Nassar, Ahmed Hasanin, Amany H. Saleh, Passaint Hassan, Dalia Saad, Sahar Mahmoud, Ghada Abo Bakr, Eman Fouad, Norhan Saleh, Maha Ismail and Hani El-Hadi Tags: Research article Source Type: research

Chiral separation of beta-blockers by high-performance liquid chromatography and determination of bisoprolol enantiomers in surface waters.
E, Galić N Abstract Beta-blockers are chiral compounds with enantiomers that have different bioactivity, which means that while one is active, the other can be inactive or even harmful. Due to their high consumption and incomplete degradation in waste water, they may reach surface waters and affect aquatic organisms. To address this issue we developed a chromatographic method suitable for determining beta-blocker enantiomers in surface waters. It was tested on five beta-blockers (acebutolol, atenolol, bisoprolol, labetalol and metoprolol) and validated on bisoprolol enantiomers. Good enantioseparation of all anal...
Source: Arhiv za Higijenu Rada i Toksikologiju - February 29, 2020 Category: Occupational Health Authors: Pocrnić M, Ansorge M, Dovhunová M, Habinovec I, Tesařová E, Galić N Tags: Arh Hig Rada Toksikol Source Type: research

Identification of Factors Associated with Delayed Treatment of Obstetric Hypertensive Emergencies
Obstetric hypertensive emergency is defined as having systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥110 mmHg, confirmed 15 min apart. ACOG recommends that acute-onset, severe hypertension be treated with first line-therapy (IV labetalol, IV hydralazine or PO nifedipine) within 60 minutes to reduce risk of maternal morbidity and mortality. Therefore, our o bjective was to identify barriers that lead to delayed treatment of obstetric hypertensive emergency. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - February 13, 2020 Category: OBGYN Authors: Agata Kantorowska, Cassandra J. Heiselman, Tara A. Halpern, Meredith B. Akerman, Ashley Elsayad, Jolene C. Muscat, Genevieve B. Sicuranza, Anthony M. Vintzileos, Hye J. HEO Tags: Original Research: Obstetrics Source Type: research

Oral Antihypertensive Regimens (Nifedipine Retard, Labetalol, and Methyldopa) for Management of Severe Hypertension in Pregnancy: An Open-Label, Randomized Controlled Trial
(Abstracted from Lancet 2019;394:1011–1121) Hypertension complicates 1 in 10 pregnancies and has been associated with a number of maternal, fetal, and neonatal adverse events. In cases of severe hypertension (defined by a systolic blood pressure [BP] ≥ 160 mm Hg or diastolic BP ≥ 110 mg), urgent antihypertensive treatment is warranted. (Source: Obstetrical and Gynecological Survey)
Source: Obstetrical and Gynecological Survey - February 1, 2020 Category: OBGYN Tags: OBSTETRICS: MEDICAL COMPLICATIONS OF PREGNANCY Source Type: research

Erratum to “IV labetalol and oral nifedipine in acute control of severe hypertension in pregnancy–A randomized controlled trial” [Eur. J. Obstet. Gynecol. Reprod. Biol. 236 (May) (2019) 46–52]
Publication date: Available online 21 January 2020Source: European Journal of Obstetrics & Gynecology and Reproductive BiologyAuthor(s): Momina Zulfeen, Radha Tatapudi, Ravella Sowjanya (Source: European Journal of Obstetrics and Gynecology and Reproductive Biology)
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - January 22, 2020 Category: OBGYN Source Type: research

The flipside of hydralazine in pregnancy: A systematic review and meta-analysis
Publication date: Available online 21 January 2020Source: Pregnancy HypertensionAuthor(s): Christina Antza, Chrisa Dimou, Ioannis Doundoulakis, Evangelos Akrivos, Stella Stabouli, Anna Bettina Haidich, Dimitrios G. Goulis, Vasilios kotsisAbstractThe present systematic review and meta-analysis investigated the effects of hydralazine compared with other antihypertensive drugs in maternal, perinatal and neonatal outcomes of pregnant women with hypertensive disorders. Twenty studies with 1283 participants were included. Of them, 626 received hydralazine and 657 other antihypertensive treatments, such as labetalol, nifedipine, ...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 21, 2020 Category: OBGYN Source Type: research

Erratum to “IV labetalol and oral nifedipine in acute control of severe hypertension in pregnancy–A randomized controlled trial” [Eur. J. Obstet. Gynecol. Reprod. Biol. 236 (May) (2019) 46–52]
The publisher regrets that the Table 2 was published with incorrect alignment of the Table columns. Correct Table 2: (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - January 20, 2020 Category: OBGYN Authors: Momina Zulfeen, Radha Tatapudi, Ravella Sowjanya Tags: Erratum Source Type: research

22: Intravenous labetalol versus oral nifedipine for acute hypertension in pregnancy: effects on cerebral perfusion pressure
To compare cerebral perfusion pressure (CPP) before and after IV labetalol versus oral nifedipine in the setting of acute, severe hypertension in pregnancy. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 31, 2019 Category: OBGYN Authors: Mary Catherine Tolcher, Karin A. Fox, Haleh Sangi-Haghpeykar, Steven Clark, Michael A. Belfort Tags: Oral Concurrent 2 Source Type: research

20: Ethnic differences in anti-hypertensive medication response among pregnant and postpartum patients
In the non-pregnant literature, it is suggested that Black patients respond better to calcium channel blockers than beta-blockers for the treatment of hypertension. In contrast, there are no ethnic specific recommendations in the treatment of acute, severe range pressures in pregnancy. The hypothesis of this study was that labetalol is less effective than nifedipine for treatment of acute, severe hypertension in pregnant and postpartum Black women relative to women of other ethnicities. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 31, 2019 Category: OBGYN Authors: Dyese Taylor, Poroshat Shekarloo, Chima Ndubizu, Melissa T. Chu Lam, Farrah N. Hussain, Lois Brustman Tags: Oral Concurrent 2 Source Type: research

171: Pulse pressure and acute response to labetalol in women with severe hypertension in pregnancy
Pulse pressure (PP) is a proposed measure by which to tailor antihypertensive choice to achieve a more effective therapeutic response in the treatment of acute-onset, severe hypertension (HTN) in pregnancy. We sought to determine whether PP at the time of treatment for severe HTN influences time to therapeutic response to intravenous (IV) labetalol as a first line agent. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 31, 2019 Category: OBGYN Authors: Samantha J. Mullan, Jennifer E. Powel, Alexandra M. Edwards, Megan L. Lawlor, Samantha K. Ong, Xujia Li, Laura K. Vricella, Shilpa Babbar Tags: Poster Session I Source Type: research

425: Does pulse pressure help to determine the effectiveness of labetalol in severe hypertension?
To evaluate the association of pulse pressure measurements on the effectiveness of parenteral labetalol as a first line antihypertensive in severe hypertension during pregnancy. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 31, 2019 Category: OBGYN Authors: James Liu, Perry Friedman, Zeynep Alpay Savasan Tags: Poster Session II Source Type: research

530: Revisiting the limits of labetalol in the pregnant population: a Trinity Health system analysis
The objective of this study is to compare adverse events in pregnant women who received>300mg IV labetalol versus those who received ≤300mg IV labetalol in a 24-hour period. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 31, 2019 Category: OBGYN Authors: Katherine Riddle, Jason Hecht, Caleb Scheidel, Pooja Green, Jennifer Williams Tags: Poster Session II Source Type: research

Ventricular fibrillation associated with Graves' disease and amiodarone induced thyrotoxicosis
This case involves a 55-year-old male patient with systolic heart failure and refractory atrial fibrillation due to thyrotoxicosis, who was electrically cardioverted but then developed torsade de pointes and ventricular fibrillation. Rate control was unsuccessful with digoxin, cardizem, labetalol, esmolol and amiodorone. Patient was externally cardioverted after which ECGs showed prolonged QT with frequent premature ventricular contractions. ECGs also showed ‘R-on-T' phenomenon leading to torsades and ventricular fibrillation. Atrial overdrive pacing was used to terminate the dangerous arrhythmia and the patient retu...
Source: Cardiovascular Endocrinology - November 8, 2019 Category: Cardiology Tags: Case Report Source Type: research

First-line antihypertensive treatment for severe hypertension in pregnancy: A systematic review and network meta-analysis
ConclusionsGiven the results of this systematic review and network meta-analysis, maternity care providers should feel comfortable initiating management of severe hypertension in pregnancy using oral nifedipine. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - November 1, 2019 Category: OBGYN Source Type: research

Labetalol or Amphetamine: A Case of Mistaken Identity With Clinical Consequence
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - November 1, 2019 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Management of non-severe pregnancy hypertension – A summary of the CHIPS Trial (Control of Hypertension in Pregnancy Study) research publications
Publication date: October 2019Source: Pregnancy Hypertension, Volume 18Author(s): Laura A. Magee, Evelyne Rey, Elizabeth Asztalos, Eileen Hutton, Joel Singer, Michael Helewa, Terry Lee, Alexander G. Logan, Wessel Ganzevoort, Ross Welch, Jim G. Thornton, Peter von DadelszenAbstractThe international CHIPS Trial (Control of Hypertension In Pregnancy Study) enrolled 987 women with chronic (75%) or gestational (25%) hypertension. Pre-eclampsia developed in 48%; women remained on their allocated BP control and delivered an average of two weeks later. ‘Less tight’ control (target diastolic BP 100 mmHg) achieved BP t...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 15, 2019 Category: OBGYN Source Type: research

Perioperative beta-blockers for preventing surgery-related mortality and morbidity in adults undergoing non-cardiac surgery.
CONCLUSIONS: The evidence for early all-cause mortality with perioperative beta-blockers was uncertain. We found no evidence of a difference in cerebrovascular events or ventricular arrhythmias, and the certainty of the evidence for these outcomes was low and very low. We found low-certainty evidence that beta-blockers may reduce atrial fibrillation and myocardial infarctions. However, beta-blockers may increase bradycardia (low-certainty evidence) and probably increase hypotension (moderate-certainty evidence). Further evidence from large placebo-controlled trials is likely to increase the certainty of these findings, and...
Source: Cochrane Database of Systematic Reviews - September 25, 2019 Category: General Medicine Authors: Blessberger H, Lewis SR, Pritchard MW, Fawcett LJ, Domanovits H, Schlager O, Wildner B, Kammler J, Steinwender C Tags: Cochrane Database Syst Rev Source Type: research

Distinct outcomes of labetalol exposed infants: case reports and systematic review
. (Source: Journal of Maternal-Fetal and Neonatal Medicine)
Source: Journal of Maternal-Fetal and Neonatal Medicine - September 11, 2019 Category: Perinatology & Neonatology Authors: Xiying Yang Liyuan Hui Hui Long Liping Zou Source Type: research

Comparing the effect of dexmedetomidine and labetalol on hemodynamic variables in patients undergoing microlaryngoscopy
This study was conducted to compare the effect of dexmedetomidine and labetalol on hemodynamic variables in patients undergoing microlaryngoscopy.Material and methodsIn this randomized clinical trial study 70 patients undergoing microlaryngoscopy were involved. The patients were randomly assigned into two groups. Patients in dexmedetomidine group received 0.5  μg/kg of dexmedetomidine diluted in 100 ml of saline solution and the patients in the second group received 0.25 mg/kg of labetalol before anesthesia induction. At the beginning of the surgery, dexmedetomidine was infused at the dose of 0.4 &mu...
Source: European Archives of Oto-Rhino-Laryngology - August 5, 2019 Category: ENT & OMF Source Type: research

Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial
This study is registered with ClinicalTrials.gov, number NCT01912677, and the Clinical Trial Registry, India, number ctri/2013/08/003866.FindingsBetween April 1, 2015, and Aug 21, 2017, we screened 2307 women for their inclusion in the study. We excluded 1413 (61%) women who were ineligible, declined to participate, had impending eclampsia, were in active labour, or had a combination of these factors. 11 (4%) women in the nifedipine group, ten (3%) women in the labetalol group, and 11 (4%) women in the methyldopa group were ineligible for treatment (because they had only one qualifying blood pressure measurement) or had tr...
Source: The Lancet - August 2, 2019 Category: General Medicine Source Type: research

Raynaud's phenomenon of the nipple as a side-effect of labetalol: Case report and literature review
Publication date: Available online 24 July 2019Source: Case Reports in Women's HealthAuthor(s): Jesus Avila Vega, Enrique Urrea-Mendoza, Christy LeeAbstractRaynaud's phenomenon of the nipple is an unusual side-effect of labetalol use. There is one official report from the United Kingdom. The present case concerns a 30-year-old woman, gravida 1, para 0, who developed pre-eclampsia and was treated with labetalol but subsequently reported neuropathic pain of the nipple. Nifedipine was then started as part of her treatment plan for blood pressure control and she no longer reported pain, despite being given six more doses of la...
Source: Case Reports in Womens Health - July 26, 2019 Category: OBGYN Source Type: research

Pharmacokinetic variability of beta ‐adrenergic blocking agents used in cardiology
AbstractThe aim of this study was to evaluate the pharmacokinetic variability of beta ‐adrenergic blocking agents used in cardiology by reviewing single‐dose and steady‐state pharmacokinetic studies from the literature. PubMed was searched for pharmacokinetic studies of beta‐adrenergic blocking agents, both single‐dose and steady‐state studies. The studies included report ed maximum plasma concentration (Cmax) and/or area under the concentration curve (AUC). The coefficient of variation (CV%) was calculated for all studies, and a CV%40% was considered high variability. The Cmax and AUC were reported a total of ...
Source: Pharmacology Research and Perspectives - July 11, 2019 Category: Drugs & Pharmacology Authors: Frederik N. Ågesen, Peter E. Weeke, Peer Tfelt‐Hansen, Jacob Tfelt‐Hansen, for ESCAPE‐NET Tags: ORIGINAL ARTICLE Source Type: research