Physiologic Treatment of Severe Hypertension in Pregnancy and Postpartum
Obstet Gynecol. 2023 Nov 30. doi: 10.1097/AOG.0000000000005472. Online ahead of print.ABSTRACTWe aimed to evaluate physiologic treatment of severe hypertension. This was a retrospective cohort study of pregnant and postpartum patients with severe hypertension (systolic blood pressure [BP] 160 mm Hg or higher or diastolic BP 110 mm Hg or higher) treated with intravenous labetalol or hydralazine at a single tertiary care center between 2013 and 2018. Patients were classified as having physiologic treatment if they had hyperdynamic physiology (pulse pressure 65 mm Hg or higher) and received labetalol or had vasoconstrictive p...
Source: Obstetrics and Gynecology - November 30, 2023 Category: OBGYN Authors: Allison M Davis Christina T Blanchard Akila Subramaniam Rachel G Sinkey Alan T Tita Ashley N Battarbee Source Type: research
Further exploration of the collision ‐induced dissociation of select beta blockers: Acebutolol, atenolol, bisoprolol, carteolol, and labetalol
AbstractBeta blockers are a class of drugs commonly used to treat heart-related diseases; they are also regulated under the World Anti-Doping Agency. Tandem mass spectrometry is often used in the pharmaceutical industry, clinical analysis laboratory, and antidoping laboratory for detection and characterization of drugs and their metabolites. A deeper chemical understanding of dissociation pathways may eventually lead to an improved ability to predict tandem mass spectra of compounds based strictly on their chemical structure (or vice versa), which is especially important for characterization of unknowns such as emerging de...
Source: Journal of Mass Spectrometry - November 22, 2023 Category: Chemistry Authors: Matthew J. Carlo,
Amanda L. Patrick Tags: RESEARCH ARTICLE Source Type: research
Hypertensive Emergency: Parenteral Antihypertensives and Population Data
AbstractPurpose of ReviewReview parenteral therapeutic choices in treatment of hypertensive crises by mechanism of action and summarize recent literature on the management of hypertensive crises.Recent FindingsRecent data have documented the safety and efficacy of labetalol and nicardipine in treatment of hypertensive crises as well as characterized the hypertensive emergency population to a much greater extent.SummaryBased on recent data, hypertensive emergencies are seen in 0.5% of all emergency room visits. Ischemic stroke and heart failure/pulmonary edema are the most common forms of organ damage seen in hypertensive e...
Source: Current Hypertension Reports - November 17, 2023 Category: Primary Care Source Type: research
Statement of Retraction: Methyldopa versus labetalol or no medication for treatment of mild and moderate chronic hypertension during pregnancy: a randomized clinical trial
Hypertens Pregnancy. 2023 Dec;42(1):2268991. doi: 10.1080/10641955.2023.2268991. Epub 2023 Oct 17.NO ABSTRACTPMID:37847187 | DOI:10.1080/10641955.2023.2268991 (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - October 17, 2023 Category: OBGYN Source Type: research
