Physiologically Based Pharmacokinetic Modeling for Multiple Oral Administration Labetalol in Pregnant Women
ConclusionsIn summary, this work initially established a PBPK model for multiple oral administration of labetalol for pregnant women. This PBPK model may lead to personalized labetalol medication in the future. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - May 4, 2023 Category: Drugs & Pharmacology Source Type: research
Evaluation of intravenous infusion of labetalol versus magnesium sulfate on cerebral hemodynamics of preeclampsia patients with severe features using transcranial doppler
ConclusionBoth magnesium sulfate and labetalol reduce CPP while maintaining cerebral blood flow (CBF) in preeclampsia patients with severe features.Trial registrationThe institutional review board of the Faculty of Medicine, Zagazig University approved this study with the reference number (ZU-IRB#: 6353-23-3-2020) and it was registered at clinicaltrials.gov (NCT04539379). (Source: Journal of Clinical Monitoring and Computing)
Source: Journal of Clinical Monitoring and Computing - April 19, 2023 Category: Information Technology Source Type: research
Paraganglioma in pregnancy, a mimic of preeclampsia: a case report
ConclusionThis case demonstrates how paraganglioma/pheochromocytoma can be misdiagnosed as preeclampsia due to the overlapping features of new-onset hypertension late in pregnancy accompanied by headache and proteinuria. It is impractical to routinely screen for paraganglioma/pheochromocytoma in all pregnant patients diagnosed with preeclampsia due to the rarity of these tumors and the harm from high false-positive rates. Therefore, it is incumbent on the provider to have a high degree of suspicion for paraganglioma/pheochromocytoma when clinical features are unusual for preeclampsia, such as intermittent palpitations, dia...
Source: Journal of Medical Case Reports - April 7, 2023 Category: General Medicine Source Type: research
Comparison of efficacy of intravenous labetalol and intravenous hydralazine for management of pre-eclampsia in pregnant women
Conclusion: The results of this study show that Labetalol is more effective as compared to Hydralazine in terms of reducing the systolic and diastolic blood pressure and number of doses (Drugs) for in patients with severe preeclampsia.Keywords: Preeclampsia; bolus dose; Hydralazine; Labetalol. (Source: African Health Sciences)
Source: African Health Sciences - April 6, 2023 Category: African Health Authors: Mauzma Kausar, Samia Husain, Rubina Hussain Source Type: research
Labetalol, Low-dose Aspirin, and Vitamin E and Calcium for Gestational Hypertension and Influence on MicroRNA-126 and PLGF Levels
CONCLUSIONS: The combined therapy of labetalol + low-dose aspirin + vitamin E and calcium had a high efficacy rate and could significantly reduce blood pressure and 24h urine protein and significantly increase microRNA-126 and PLGF levels, with a high safety profile.PMID:36933245 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 18, 2023 Category: Complementary Medicine Authors: Xuejun Kou Jing Yang Source Type: research
Labetalol, Low-dose Aspirin, and Vitamin E and Calcium for Gestational Hypertension and Influence on MicroRNA-126 and PLGF Levels
CONCLUSIONS: The combined therapy of labetalol + low-dose aspirin + vitamin E and calcium had a high efficacy rate and could significantly reduce blood pressure and 24h urine protein and significantly increase microRNA-126 and PLGF levels, with a high safety profile.PMID:36933245 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 18, 2023 Category: Complementary Medicine Authors: Xuejun Kou Jing Yang Source Type: research
Labetalol, Low-dose Aspirin, and Vitamin E and Calcium for Gestational Hypertension and Influence on MicroRNA-126 and PLGF Levels
CONCLUSIONS: The combined therapy of labetalol + low-dose aspirin + vitamin E and calcium had a high efficacy rate and could significantly reduce blood pressure and 24h urine protein and significantly increase microRNA-126 and PLGF levels, with a high safety profile.PMID:36933245 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 18, 2023 Category: Complementary Medicine Authors: Xuejun Kou Jing Yang Source Type: research
Labetalol, Low-dose Aspirin, and Vitamin E and Calcium for Gestational Hypertension and Influence on MicroRNA-126 and PLGF Levels
CONCLUSIONS: The combined therapy of labetalol + low-dose aspirin + vitamin E and calcium had a high efficacy rate and could significantly reduce blood pressure and 24h urine protein and significantly increase microRNA-126 and PLGF levels, with a high safety profile.PMID:36933245 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 18, 2023 Category: Complementary Medicine Authors: Xuejun Kou Jing Yang Source Type: research
Identifying Targets to Improve the Management of Severe Hypertension in Pregnancy and Postpartum
CONCLUSION: We defined quality indicators for severe hypertension management. Time-to-target BP within 60 minutes was achieved in a minority of patients, and chronic hypertension was associated with delayed severe hypertension resolution. Process issues in severe hypertension management were described.PMID:36924992 | DOI:10.1016/j.jogc.2023.02.016 (Source: Journal of Obstetrics and Gynaecology Canada : JOGC)
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - March 16, 2023 Category: OBGYN Authors: Marie-Julie Trahan Marianne Plourde Karen Wou Menal Huroy Rayan Itani Antonina Pavilanis Alexandria Flannery Sabrina Haas Ginette Aucoin Pierre-Olivier Monast Maral Koolian Noura Hassan Eva Suarthana Stella S Daskalopoulou Isabelle Malham é Source Type: research
Permissive Hypotension in Rhinoplasty: A Literature Review of Therapeutics and Associated Outcomes
ConclusionGiven its intra- and postoperative benefits, permissive hypotension can be leveraged to improve outcomes in rhinoplasty. This study presents an updated comprehensive review of various modalities used to achieve permission hypotension in rhinoplasty. Future studies should explore how comorbidities may impact choice of treatment regimen among patients undergoing rhinoplasty.Level of Evidence III This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authorswww....
Source: Aesthetic Plastic Surgery - March 6, 2023 Category: Cosmetic Surgery Source Type: research
Labetalol and soluble endoglin aggravate bile acid retention in mice with ethinylestradiol-induced cholestasis
In conclusion, we demonstrated that labetalol increases plasma concentrations of BAs in estrogen-induced cholestasis, and sEng aggravates this retention. Importantly, increased sEng levels in experimental and clinical forms of ICPs might present a novel mechanism explaining the coincidence of ICP with preeclampsia. Our data encourage BA monitoring in the plasma of pregnant women with preeclampsia and labetalol therapy. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 26, 2023 Category: Drugs & Pharmacology Source Type: research
