Role of Complementary Medicine (Music, Acupuncture, Acupressure, TENS and Audio-visual distraction) in Shockwave Lithotripsy (SWL): A Systematic Review from EAU sections of urolithiasis (EULIS) and uro-technology (ESUT)
We performed a systematic review to look at the role of alternative or complementary medicine such as music, acupressure, acupuncture, transcutaneous electrical nerve stimulation (TENS) and audiovisual distractions to decrease analgesia requirement and alleviate anxiety during SWL. Twenty-three papers(2439 participants) were included: Music (n=10,56.6%), Acupuncture (n=5,17.7%), Acupressure (n=1,3.8%), TENS (n=6,17.2%) and audiovisual distraction (n=1,4.6%). Most of the studies showed that complementary therapy, lowered pain and anxiety with higher patient satisfaction and willingness to undergo the procedure. (Source: Urology)
Source: Urology - July 5, 2020 Category: Urology & Nephrology Authors: M Saraogi, RM Geraghty, BMZ Hameed, S Rob, A Pietropaolo, K Sarica, A Gozen, E Liatsikos, BK Somani Tags: Review Source Type: research

Imaging modalities and treatment of paediatric upper tract urolithiasis: a systematic review and update on behalf of the EAU Urolithiasis Guidelines Panel
Prompt diagnosis and treatment of paediatric urolithiasis are required to avoid long term sequelae of renal damage. (Source: Journal of Pediatric Urology)
Source: Journal of Pediatric Urology - July 4, 2020 Category: Urology & Nephrology Authors: Nikolaos Grivas, Kay Thomas, Tamsin Drake, James Donaldson, Andreas Neisius, Ale š Petřík, Yasir Ruhayel, Christian Seitz C, Christian Türk, Andreas Skolarikos Tags: Review Article Source Type: research

Use of Baidu Index to Track Chinese Online Behavior and Interest in Kidney Stones
(Source: Risk Management and Healthcare Policy)
Source: Risk Management and Healthcare Policy - July 2, 2020 Category: Health Management Tags: Risk Management and Healthcare Policy Source Type: research

Prediction of stone-free rates following extracorporeal shockwave lithotripsy in a contemporary cohort of patients with stone densities exceeding 1000 HU.
Conclusion: Stone size was the only significant success predictor in our cohort, with 76% SF rate for stones  1000 HU may be suitable to SWL. PMID: 32597283 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Urology)
Source: Scandinavian Journal of Urology - July 2, 2020 Category: Urology & Nephrology Tags: Scand J Urol Source Type: research

Thlaspi Bursa Pastoris in Treatment of Urinary Stones: A Case Series.
CONCLUSION:  TBP was observed to be effective in eliminating renal stones within a short span of time and without any complications. PMID: 32610348 [PubMed - as supplied by publisher] (Source: Homeopathy)
Source: Homeopathy - July 1, 2020 Category: Complementary Medicine Authors: Nayak C, Sahoo AR, Nayak C Tags: Homeopathy Source Type: research

Guideline-adherence in the treatment of symptomatic urolithiasis in children and adolescents in southwestern Germany
Approximately 1% of urolithiasis cases in Germany affect children. Interdisciplinary groups have agreed on national and international guidelines for children to recommend appropriate treatment pathways. The ai... (Source: BMC Urology)
Source: BMC Urology - June 26, 2020 Category: Urology & Nephrology Authors: Felix Blasl-Kling, Simone Katrin Dold, Jan-Thorsten Klein, Gamal Anton Wakileh, Ulrich Humke and Anne-Karoline Ebert Tags: Research article Source Type: research

Seven cases of parathyroid carcinoma and review of the literature.
Authors: Apaydın T, Yavuz DG Abstract Parathyroid cancer is a rare malignancy and an uncommon cause of hyperparathyroidism. In the present study, we present seven cases of parathyroid carcinoma. The female ratio was 5/7 (71.4%). Median age at diagnosis was 47 years, and median follow-up duration was 60 months (IQR 29-75). Mean calcium level at diagnosis was 12.7 mg/dL (range, 11.3-13.9), and mean parathormone level was 1115 ng/L (IQR 287-1470). Two patients (28.5%) had a palpable neck mass. Coexisting brown tumor was present in three patients (42.8%), and nephrolithiasis was found in one patien...
Source: Hormones - June 25, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Clinical-grade Garcinia cambogia extract dissolves calcium oxalate crystals in Drosophila kidney stone models.
CONCLUSIONS: Garcinia cambogia extract removes calcium oxalate kidney stones from Drosophila Malpighian tubules via directly dissolving calcium oxalate stones by HCA. Our study strongly suggests that clinical-grade Garcinia cambogia extract could be used to treat patients with nephrolithiasis in the future. PMID: 32572941 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - June 25, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

The efficacy and safety of the tranexamic acid in reducing blood loss and transfusion requirements during percutaneous nephrolithotomy: a systematic review and meta-analysis of randomized controlled trials.
Authors: Feng D, Zhang F, Liu S, Han P, Wei W Abstract INTRODUCTION: Percutaneous nephrolithotomy (PCNL) is a minimally invasive approach used for large kidney stones. Although tranexamic acid (TA) has the property of reducing perioperative bleeding, the effect of this drug on PCNL is equivocal. This meta-analysis was conducted to determine the efficacy and safety of TA in preventing hemorrhagic complications, transfusion requirements and other perioperative outcomes during PCNL with available randomized-controlled trials (RCTs). EVIDENCE ACQUISITION: We performed a systematic review of the literature according...
Source: Minerva Urologica e Nefrologica - June 24, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

A Rare Case of T-Cell Lymphoma Presenting with Bilateral Nephrolithiasis and Acute Renal Failure
In this report, we discuss the identification and management of this rare condition. (Source: Urology)
Source: Urology - June 24, 2020 Category: Urology & Nephrology Authors: David Cochran, Gates Cook, Adam Rensing, Dominic Frimberger, Bhalaajee Meenakshi-Sundaram Tags: Pediatric Case Reports Source Type: research

Comparative analysis of direct and indirect costs of two minimally invasive techniques for the treatment of renal/ureteral calculi smaller than 2 cm.
CONCLUSIONS: The ESWL technique requires a higher number of sessions for the resolution of kidney stones under 2 cm, but it has a lower impact on total costs and on the perceived degree of affectation. PMID: 32593640 [PubMed - as supplied by publisher] (Source: Actas Urologicas Espanolas)
Source: Actas Urologicas Espanolas - June 24, 2020 Category: Urology & Nephrology Authors: Perez-Ardavin J, Lorenzo L, Caballer-Tarazona V, Budía-Alba A, Vivas-Consuelo D, Bahilo-Mateu P, Ordaz-Jurado G, Trassierra-Villa M, López-Acón JD, Boronat-Tormo F Tags: Actas Urol Esp Source Type: research

Cancers, Vol. 12, Pages 1654: Prognostic Effect of Comorbid Disease and Immune Gene Expression on Mortality in Kidney Cancer —A Population Based Study
Cancers, Vol. 12, Pages 1654: Prognostic Effect of Comorbid Disease and Immune Gene Expression on Mortality in Kidney Cancer—A Population Based Study Cancers doi: 10.3390/cancers12061654 Authors: Chung-Shun Wong Tzu-Ting Chen Wei-Pin Chang Henry Sung-Ching Wong Mei-Yi Wu Wirawan Adikusuma Yuh-Feng Lin Wei-Chiao Chang The effect of comorbidities and the immune profiles of the kidney cancer microenvironment play a major role in patients’ prognosis and survival. Using the National Health Insurance Research Database (Taiwan), we identified patients aged >20 years with a firs...
Source: Cancers - June 22, 2020 Category: Cancer & Oncology Authors: Chung-Shun Wong Tzu-Ting Chen Wei-Pin Chang Henry Sung-Ching Wong Mei-Yi Wu Wirawan Adikusuma Yuh-Feng Lin Wei-Chiao Chang Tags: Article Source Type: research

Letter to the Editor - Reply
We thank the authors for their interest in our manuscript, and we acknowledge their concerns regarding the potential downstream effects of elevated sodium intake in our AA patients. While we agree that the recommendation of a low sodium diet ( ≤2300mg daily) is frequently offered to nephrolithiasis patients for conservative dietary management due to concern for the correlation between increased sodium intake and hypercalciuria, the two prospective studies in which low sodium diet was correlated to decreased urine calcium were performed in patients in hypercalciuric patients with elevated baseline 24-hr urine sodium. (Source: Urology)
Source: Urology - June 22, 2020 Category: Urology & Nephrology Authors: Russell Terry, Kohldon Boydston, Michael Lipkin, Glenn M. Preminger Tags: Letters to the Editor Source Type: research

The influence of dysbiosis on kidney stones that risk up renal cell carcinoma (RCC)
Publication date: Available online 20 June 2020Source: Seminars in Cancer BiologyAuthor(s): Shruti Gupta, Shamsher Singh Kanwar (Source: Seminars in Cancer Biology)
Source: Seminars in Cancer Biology - June 21, 2020 Category: Cancer & Oncology Source Type: research

Harm of IV High-Dose Vitamin C Therapy in Adult Patients: A Scoping Review
Conclusions: There is no consistent evidence that IV high-dose vitamin C therapy is more harmful than placebo in double-blind randomized controlled trials. However, reports of oxalate nephropathy, hypernatremia, glucometer error, and hemolysis in glucose-6-phosphate dehydrogenase deficiency patients warrant specific monitoring. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 20, 2020 Category: Emergency Medicine Tags: Online Review Articles Source Type: research

Primary hyperoxaluria Type 1: A case report in an extended family with a novel AGXT gene mutation
Conclusion: High index of suspicion of PH1 before ESRD should be considered in any patient who has recurrent urolithiasis since early life especially in presence of strong family history. (Source: Medicine)
Source: Medicine - June 19, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

The efficacy and safety of diuretics on extracorporeal shockwave lithotripsy treatment of urolithiasis: A systematic review and meta analysis
Background: The aim of this systematic review and meta-analysis was to demonstrate the efficacy and safety of diuretics on extracorporeal shockwave lithotripsy (SWL) treatment of urolithiasis. Methods: The databases MEDLINE, EMBASE, and the Cochrane Controlled Trial Register of Controlled Trials from January 1980 until November 2019 were searched to identify randomized controlled trials that referred to the use of diuretics on extracorporeal SWL treatment of urolithiasis. Results: Six randomized controlled trials containing 1344 patients were included in this meta-analysis, which compared diuretics with placebo on ...
Source: Medicine - June 19, 2020 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Letter-to-the-Editor: Re: Boydston K, Terry R, Winship B, Davis L, Yttri S, Carlos E, Scales C, Lipkin M, Preminger GM. The impact of alternative alkalinizing agents on 24-hour urine parameters. Urology 2020 Apr 21;S0090-4295(20)30428-3. doi: 10.1016/j.urology.2020.04.047.
We congratulate the authors for sharing their results with the use of sodium bicarbonate (NAB) (n=65) and potassium bicarbonate (KB) (n=5) in patients with nephrolithiasis who on metabolic evaluation were found to have urinary pH of (Source: Urology)
Source: Urology - June 19, 2020 Category: Urology & Nephrology Authors: Apul Goel Source Type: research

Racial Differences in Risk Factors for Kidney Stone Formation.
Abstract BACKGROUND AND OBJECTIVES: Incidence of kidney stone disease is rising. It is not known whether mechanisms of stone formation differ across racial groups. Our objective was to identify differing lithogenic risk factors across racial groups in idiopathic nephrolithiasis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a retrospective cohort study evaluating metabolic risk factors in black and age-matched white idiopathic stone formers at our tertiary referral center. We compared serum and urine metabolic risk factors pre- and post-treatment across racial groups using analysis of covari...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 19, 2020 Category: Urology & Nephrology Authors: Zisman AL, Coe FL, Cohen AJ, Riedinger CB, Worcester EM Tags: Clin J Am Soc Nephrol Source Type: research

Understanding the relationship between health insurance and kidney stones: an examination of NHANES data.
CONCLUSIONS: Individuals with state-assisted insurance were found to have significantly increased odds of a kidney stone compared to those with private insurance. Urologists, primary care, and policy makers should recognize this disparity exists and target opportunities to elucidate mechanisms and provide intervention for this high-risk group. PMID: 32544047 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - June 18, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

A history of urolithiasis risk in space.
CONCLUSION: From the early vision of Dr. Cockett to the astronaut studies of Dr. Whitson, we have a better understanding of the risks of urolithiasis in space, resulting in preventive measures for urolithiasis in future long duration space exploration. PMID: 32544046 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - June 18, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

[Strategies and recommendations for urolithiasis treatment and follow-up in COVID-19 pandemia.]
CONCLUSION: Treatment of Urolithiasis in COVID-19 pandemic calls for prioritization of patients, maximum efficiency in treatments, adequate protection of healthcare personnel, and the implementation of telemedicine as a measure to reduce patient attendance to the hospital. PMID: 32538815 [PubMed - in process] (Source: Archivos Espanoles de Urologia)
Source: Archivos Espanoles de Urologia - June 18, 2020 Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research

Characteristics of the genotype and phenotype in Chinese primary hyperoxaluria type 1 populations
Conclusions: heterogeneity between genotype and phenotype was observed and described in Chinese PH1 patients. c.815_816insGA and c.33_34insC which were recognized asAGXT mutation hotspot regions in China implied a poor prognosis. And c.1049G>A was not determined as the race-specific mutation of Pakistani. (Source: Urolithiasis)
Source: Urolithiasis - June 18, 2020 Category: Urology & Nephrology Source Type: research

Discussion
DR MELANIE GOLFARB (Santa Monica, CA): I commend the authors for trying to address one of the many important topics in the sometimes-nebulous disease of primary hyperparathyroidism. I say nebulous because, although we know how to diagnose and treat it, many nuances of the disease presentation, such as the underlying molecular mechanisms of the genotype and phenotype of the disease and the specific long-term outcomes, are still unknown. Kidney stone symptomatology in patients with primary hyperparathyroidism is one of the more common, and sometimes debilitating, symptoms that accompany the disease, and should always lead to...
Source: Journal of the American College of Surgeons - June 17, 2020 Category: Surgery Tags: Western surgical association article Source Type: research

293 Individuals with pseudoxanthoma elasticum have a significantly increased incidence of kidney stones
Kidney stone disease (nephrolithiasis) has an incidence of 9.2% in the general U.S. population above the age of 20, according to a cumulative analysis of the National Health and Nutrition Examination Survey (NHANES) from 2007-2016. Pseudoxanthoma elasticum (PXE), a genetic disorder caused by inactivating mutations in the ABCC6 gene, is characterized by progressive calcification of connective tissues in the skin, blood vessels, and retina. Two sisters, aged 11 and 13 years, presented with skin lesions characteristic of PXE, and histopathology of the lesions revealed mineral deposition in the reticular dermis, confirming the...
Source: Journal of Investigative Dermatology - June 17, 2020 Category: Dermatology Authors: D. Ralph, R. Allawh, L. Kowal, I. Terry, S. Terry, J. Uitto, Q. Li Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research

A single center ’s experience in pediatric cystine stone disease management: what changed over time?
AbstractThe authors aimed to evaluate the factors affecting clinical outcomes of cystine stone disease in children and to understand the change in disease management over time. Between January 1991 and September 2017, the demographic and clinical data of pediatric patients with documented cystine stone disease were retrospectively analyzed. Patients with at least 12-month follow-up were included. Disease management and clinical outcomes were compared between the first and second 35 patients managed during the study ’s time frame. A total of 70 patients were included. The female to male ratio was 30/40. The mean age a...
Source: Urolithiasis - June 17, 2020 Category: Urology & Nephrology Source Type: research

Effects of crude protein and sodium intake on water turnover in cats fed extruded diets
AbstractThe comprehension of strategies to increase urine production may be important, especially in kibble diets to prevent urolithiasis in cats. The effects of increasing amounts of crude protein (CP) and sodium on the water turnover of cats were evaluated using the water balance (WB) method and the deuterium dilution technique. The study followed a randomized block design, with three blocks of eight cats, two cats per food type in each block, and six cats per food. Four extruded diets with different amounts of CP and sodium were evaluated (on DM basis): 28% CP and 0.58% sodium; 39% CP and 0.64% sodium; 52% CP and 0.76% ...
Source: Journal of Animal Physiology and Animal Nutrition - June 17, 2020 Category: Zoology Authors: Caroline A. Garcia, Bruna A. Loureiro, Francine M. Peres, Camila Goloni, Ludmilla G. Di Santo, Fernanda S. Mendon ça, Aulus C. Carciofi Tags: SUPPLEMENT ARTICLE Source Type: research

Analysis of performance factors in 240 consecutive cases of robot-assisted flexible ureteroscopic stone treatment
AbstractFlexible ureteroscopy is the keystone of modern kidney stone treatment. Although a simple surgical technique achieves good clinical results and a low complication rate, there are high demands on the surgeon ’s dexterity and ergonomic restrictions. Robotic-assisted flexible ureteroscopy (rfURS) could overcome these limitations. After 4 years of use of rfURS at a tertiary stone center, performance factors were analyzed to define the role of rfURS in kidney stone management. A rfURS system was installe d in August 2014 at the SLK Kliniken (Heilbronn, Germany). Treatment data ofN = 240 consecut...
Source: Journal of Robotic Surgery - June 16, 2020 Category: Surgery Source Type: research

Bacterial spectrum and antibiotic resistance of urinary tract infections in patients treated for upper urinary tract calculi: a multicenter analysis
AbstractThe purpose of this study is to collect information on the bacterial resistance to antibiotics of bacteria isolated from urine cultures of patients treated for upper urinary tract calculi. Data of patients with urinary tract infection and urolithiasis were retrospectively reviewed to collect information on age, gender, stone size, location, hydronephrosis, procedure of stone removal and antibiotic treatment, identification and susceptibility of pathogens, symptoms, and infectious complications. A total of 912 patients from 11 centers in 7 countries (Bulgaria, Greece, Italy, North Macedonia, Spain, and Turkey) were ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - June 16, 2020 Category: Microbiology Source Type: research

Integrated Real-Time Digital Measurement During Ureteroscopic Procedures for Nephrolithiasis: A Workflow Feasibility Study
Journal of Endourology, Ahead of Print. (Source: Journal of Endourology)
Source: Journal of Endourology - June 16, 2020 Category: Urology & Nephrology Authors: Kevin Koo Tareq Aro Russell E.N. Becker Sunghwan Lim Jared S. Winoker Doru Petrisor Dan Stoianovici Brian R. Matlaga Source Type: research

Renal disorders in rheumatologic diseases: the spectrum is changing (part 2. Arthridides).
Abstract This review is devoted to rheumatologic diseases mainly characterized by different types of arthritis. They may involve also different organs, including the kidney, but renal disease is more frequently caused by the nephrotoxicity of drugs to relieve pain or to interfere with the pathophysiology of the underlying disease. Rheumatoid arthritis is the prototype of arthropathies. This autoimmune disease mainly attacks joints, tendons and ligaments but can also involve internal organs including the kidney. Psoriatic arthritis is a complex disease in which psoriasis, a chronic inflammatory disease, is associat...
Source: Journal of Nephrology - June 16, 2020 Category: Urology & Nephrology Authors: Ponticelli C, Doria A, Moroni G Tags: J Nephrol Source Type: research

Letter to the Editor RE: Giusti et al., Editorial Comment on: Influence of Lower Pole Infundibulopelvic Angle on Success of Retrograde Flexible Ureteroscopy and Laser Lithotripsy for the Treatment of Renal Stones by Dresner et al. (J Endourol 2020;34(6):660 –661; DOI: 10.1089/end.2020.0209)
Journal of Endourology,Volume 34, Issue 6, Page 662-662, June 2020. (Source: Journal of Endourology)
Source: Journal of Endourology - June 16, 2020 Category: Urology & Nephrology Authors: Stephanie L. Dresner Stephen Y. Nakada Source Type: research

Editorial Comment on: Buyer Beware: Evidence ‐Based Evaluation of Dietary Supplements for Nephrolithiasis by Koo et al. (J Endourol 2020;34(6):702–707; DOI: 10.1089/end.2019.0828)
Journal of Endourology,Volume 34, Issue 6, Page 707-708, June 2020. (Source: Journal of Endourology)
Source: Journal of Endourology - June 16, 2020 Category: Urology & Nephrology Authors: Jodi Antonelli Source Type: research

Letter to the Editor RE: Antonelli, Editorial Comment on: Buyer Beware: Evidence ‐Based Evaluation of Dietary Supplements for Nephrolithiasis by Koo et al. (J Endourol 2020;34(6):707–708; DOI: 10.1089/end.2020.0285)
Journal of Endourology,Volume 34, Issue 6, Page 708-708, June 2020. (Source: Journal of Endourology)
Source: Journal of Endourology - June 16, 2020 Category: Urology & Nephrology Authors: Kevin Koo Tareq Aro Brian R. Matlaga Source Type: research

Letter to the Editor RE: Application of Digital Tomosynthesis in the Diagnosis of Urolithiasis: Comparison with MDCT by Liu et al. (J Endourol 2019;34(2):145 –150; DOI: 10.1089/end.2019.0327)
Journal of Endourology,Volume 34, Issue 6, Page 711-711, June 2020. (Source: Journal of Endourology)
Source: Journal of Endourology - June 16, 2020 Category: Urology & Nephrology Authors: Linjie Peng Wen Zhong Source Type: research

The teleost fish intestine is a major oxalate-secreting epithelium [SHORT COMMUNICATION]
Jonathan M. Whittamore Oxalate is a common constituent of kidney stones, but the mechanism of its transport across epithelia is not well understood. With prior research on the role of the intestine focused on mammals, the present study considered oxalate handling by teleost fish. Given the osmotic challenge of seawater (SW), marine teleosts have limited scope for urinary oxalate excretion relative to freshwater (FW) taxa. The marine teleost intestine was hypothesized as the principal route for oxalate elimination, thus demanding epithelial secretion. To test this, intestinal 14C-oxalate flux was compared between FW- and S...
Source: Journal of Experimental Biology - June 15, 2020 Category: Biology Authors: Whittamore, J. M. Tags: SHORT COMMUNICATION Source Type: research

Crystalline pathologies in the human body: first steps of pathogenesis.
Abstract The prevalence of crystalline pathologies including urolithiasis, gallstones, vascular calcifications and crystalline arthritis, is very high in the general population beyond 60 years old. Characterization of microcrystals in tissue at the micrometer and at the nanometer scale through physico-chemical techniques constitutes a new opportunity for the physician to decipher the early stage of the pathogenesis of these biological entities. In this review, such description indicates a wide variety of the chemical process associated to the nucleation process directly from supersaturated solution or from organic...
Source: Annales de Biologie Clinique - June 13, 2020 Category: Biochemistry Authors: Bazin D, Letavernier E, Haymann JP, Frochot V, Daudon M Tags: Ann Biol Clin (Paris) Source Type: research

The Association Between 24-Hour Urine and Stone Recurrence Among High Risk Kidney Stone Formers: A Population Level Assessment
To determine if obtaining a 24-hour urine collection (24HU) in stone formers is associated with decreased recurrent stone episodes. (Source: Urology)
Source: Urology - June 12, 2020 Category: Urology & Nephrology Authors: Patrick C. Samson, Sarah K. Holt, Ryan S. Hsi, Mathew D. Sorensen, Jonathan D. Harper Tags: Endourology and Stones Source Type: research

Switching to single-use flexible ureteroscopes for stones management: financial impact and solutions to reduce the cost over a 5-year period
To assess the financial impact of switching to single-use ureteroscopes (sURS) in urolithiasis management for a hospital, over a 5-year period, and to identify possible solutions to contain or reduce it. (Source: Urology)
Source: Urology - June 12, 2020 Category: Urology & Nephrology Authors: S. Dubnitskiy-Robin, B. Prad ère, B. Faivre d'Arcier, S. Watt, T. Le Fol, F. Bruyère, E. Rusch, F. Monmousseau, S. Brunet-Houdard Tags: Endourology and Stones Source Type: research

Genetics of kidney stone disease
Nature Reviews Urology, Published online: 12 June 2020; doi:10.1038/s41585-020-0332-xKidney stone disease is common and can be associated with alterations in urinary solute composition. Here, the authors outline general approaches for stone prevention, describe current understanding of the genetic influences underlying kidney stone formation and discuss the implications of a correct diagnosis for the clinical management of recurrent stone formers. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - June 12, 2020 Category: Urology & Nephrology Authors: Sarah A. Howles Rajesh V. Thakker Source Type: research

Nephrolithiasis and elevated urinary ammonium: a matched comparative study
To describe the associations between elevated urinary ammonium and clinical characteristics of kidney stone formers. A 24-hour urine test is recommended in high-risk patients to identify urinary abnormalities and select interventions to reduce the recurrence risk. While elevations in urine ammonium may be seen in acidosis, diarrhea, high protein diets or due to pathogenic bacteria, the clinical characteristics of these patients has not been previously described. (Source: Urology)
Source: Urology - June 12, 2020 Category: Urology & Nephrology Authors: Wilson Sui, Joel Hancock, John R. Asplin, Edward R Gould, Ryan S. Hsi Tags: Endourology and Stones Source Type: research

Glycemic Status, Insulin Resistance, and the Risk of Nephrolithiasis: A Cohort Study
Publication date: Available online 10 June 2020Source: American Journal of Kidney DiseasesAuthor(s): Seolhye Kim, Yoosoo Chang, Hyun-Suk Jung, Young Youl Hyun, Kyu-Beck Lee, Kwan Joong Joo, Heung Jae Park, Young-Sam Cho, Hyeonyoung Ko, Eunju Sung, Hocheol Shin, Seungho Ryu (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - June 11, 2020 Category: Urology & Nephrology Source Type: research

Long Pulse-Width Setting Improves Holmium-YAG Laser Lithotripsy - Enhanced Fragmentation and Retropulsion Characteristics of Renal Calculi in a Novel In-Vivo Setting.
Authors: Kam J, Jackson S, Yuminaga Y, Winter M, Ko R, Khadra M Abstract The aim of this novel in vivo study was to characterize the effect of short pulse-width versus long pulse-width Holmium-YAG laser lithotripter settings on retropulsion and fragmentation in a real-life setting. A prospective, crossover study was conducted at a tertiary teaching hospital in NSW, Australia. Patients who underwent flexible ureteroscopy with laser lithotripsy for renal calculi in 2018 were included. All patients underwent flexible ureteroscopy using a Flexor® 10.7/12 French ureteric access sheath (Cook Medical LLC, Bloomington,...
Source: Surgical Technology International - June 11, 2020 Category: Surgery Tags: Surg Technol Int Source Type: research

ADPKD, Tolvaptan, and Nephrolithiasis Risk.
PMID: 32527947 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 11, 2020 Category: Urology & Nephrology Authors: Hoorn EJ, Zietse R Tags: Clin J Am Soc Nephrol Source Type: research

Urinary Lithogenic Risk Profile in ADPKD Patients Treated with Tolvaptan.
Abstract BACKGROUND AND OBJECTIVES: Nephrolithiasis is a common health problem in autosomal dominant polycystic kidney disease (ADPKD) and significantly contributes to patient morbidity. Recently, Tolvaptan has been introduced for the treatment of ADPKD, but whether it is associated with alterations of the urinary lithogenic risk profile remains unknown. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted an analysis of participants enrolled in the Bern ADPKD registry, a prospective observational cohort study. Twenty-four-hour urine analyses were performed at baseline and then at yearly follow-ups...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 11, 2020 Category: Urology & Nephrology Authors: Bargagli M, Dhayat NA, Anderegg M, Semmo M, Huynh-Do U, Vogt B, Ferraro PM, Fuster DG Tags: Clin J Am Soc Nephrol Source Type: research

Trends in Opioids Prescribed at Discharge From Emergency Departments Among Adults: United States, 2006-2017.
This report describes trends in opioid prescribing at emergency department (ED) discharge among adults from 2006-2007 through 2016-2017, by selected patient and hospital characteristics and the type of opioids prescribed. Methods-Data are from the 2006-2017 National Hospital Ambulatory Medical Care Survey. The study population included all ED visits by patients aged 18 and over. The main outcome studied was opioids prescribed at ED discharge, defined using Cerner Multum's third-level therapeutic category codes for narcotic analgesics (Code 60) and narcotic-analgesic combinations (Code 191). Results-The percentage of ED vis...
Source: National health statistics reports - June 10, 2020 Category: American Health Tags: Natl Health Stat Report Source Type: research

Simple dietary advice targeting five urinary parameters reduces urinary supersaturation in idiopathic calcium oxalate stone formers
AbstractAmong 208 kidney stone patients referred within 2  years, 75 patients (66 men, nine women) with truly idiopathic calcium oxalate stones (ICSF) were recruited. Dietary advice (DA) aimed at (1) urine dilution, (2) reduced crystallization promotion (lowering oxalate), and (3) increased crystallization inhibition (increasing citrate). We recommended h igher intakes of fluid and calcium with meals/snacks (reducing intestinal oxalate absorption) as well as increased alkali and reduced meat protein (acid) for increasing urinary citrate. The intended effects of DA were elevations in urine volume, calcium (U-Ca) and ci...
Source: Urolithiasis - June 10, 2020 Category: Urology & Nephrology Source Type: research

RIRS with Vacuum-Assisted Ureteral Access Sheath versus MPCNL for the Treatment of 2-4  cm Renal Stone.
Conclusion: In the treatment of 2-4 cm renal stone, using V-UAS in RIRS can improve surgical efficiency with lower postoperative early pain scores. Comparing with MPCNL, its initial SFR was more depressed, and there is still a trend towards requiring more auxiliary procedures to achieve comparable final SFR. PMID: 32509870 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - June 9, 2020 Category: Research Authors: Lai D, He Y, Li X, Chen M, Zeng X Tags: Biomed Res Int Source Type: research

iTRAQ-Based Comparative Proteomics Analysis of Urolithiasis Rats Induced by Ethylene Glycol.
Abstract Nephrolithiasis is a frequent chronic urological condition with a high prevalence and recurrence rate. Proteomics studies on urolithiasis rat models are highly important in characterizing the pathophysiology of kidney stones and identifying potential approaches for preventing and treating kidney stones. The isobaric tags for relative and absolute quantification (iTRAQ) were performed to identify differentially expressed proteins (DEPs) in the kidney between urolithiasis rats and control rats. The results showed that 127 DEPs (85 upregulated and 42 downregulated) were identified in urolithiasis and control...
Source: Biomed Res - June 9, 2020 Category: Research Authors: Cao Y, Duan B, Gao X, Wang E, Dong Z Tags: Biomed Res Int Source Type: research

Chronic kidney disease and upper tract concerns after congenital and acquired urinary tract abnormalities: considerations for transition of care in teens and young adults
ConclusionIn individuals with congenital or acquired abnormalities of the urinary tract, there is an inherent risk of CKD with its associated morbidity and increased mortality risk. Interplay between the upper and lower urinary tract impacts CKD progression. Collaborative management between urology and nephrology is highly recommended to address the unique challenges for each individual over the lifetime. (Source: World Journal of Urology)
Source: World Journal of Urology - June 8, 2020 Category: Urology & Nephrology Source Type: research