Urinary sepsis after endourological ureterorenoscopy for the treatment of lithiasis
Publication date: Available online 20 June 2019Source: Actas Urológicas Españolas (English Edition)Author(s): D. Díaz Pérez, I. Laso García, C. Sánchez Guerrero, Á. Fernández Alcalde, M. Ruiz Hernández, J. Brasero Burgos, J. Lorca Álvaro, G. Duque Ruiz, F. Arias Funez, F.J. Burgos RevillaAbstractObjectiveTo evaluate the incidence, clinical presentation and factors associated with the development of urinary sepsis after performing ureterorenoscopy.Material and methodsRetrospective study of patients undergoing ureterorenoscopy for the treatment of lithiasi...
Source: Actas Urologicas Espanolas - June 21, 2019 Category: Urology & Nephrology Source Type: research

Oxidative Stress and Hemostatic Parameters in Patients With Nephrolithiasis Before and After Ureteroscopic Lithotripsy
Conclusion We suggest URSL does not induce the oxidative modifications of plasma proteins and does not change hemostatic parameters in patients with nephrolithiasis. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - June 21, 2019 Category: Physiology Source Type: research

Metabolic consequences of cystinuria
Cystinuria is an inherited disorder of renal amino acid transport that causes recurrent nephrolithiasis and significant morbidity in humans. It has an incidence of 1 in 7000 worldwide making it one of the most... (Source: BMC Nephrology)
Source: BMC Nephrology - June 20, 2019 Category: Urology & Nephrology Authors: Lauren E. Woodard, Richard C. Welch, Ruth Ann Veach, Thomas M. Beckermann, Feng Sha, Edward J. Weinman, Talat Alp Ikizler, Jay A. Tischfield, Amrik Sahota and Matthew H. Wilson Tags: Research article Source Type: research

Local Anesthetic Flexible Ureterorenoscopy in the Management of Urolithiasis
Journal of Endourology, Ahead of Print. (Source: Journal of Endourology)
Source: Journal of Endourology - June 20, 2019 Category: Urology & Nephrology Authors: Aakash Pai Hassan Kadhim Simon Mackie Graham Watson Source Type: research

Comparing Micro-Percutaneous Nephrolithotomy and Retrograde Intrarenal Surgery in Treating 1 –2 cm Solitary Renal Stones in Pediatric Patients Younger Than 3 Years
To compare the effects of micropercutaneous nephrolithotomy (micro-PCNL) and retrograde intrarenal surgery (RIRS) in treating 1 –2 cm solitary renal stones in pediatric patients aged less than 3 years. (Source: Journal of Pediatric Urology)
Source: Journal of Pediatric Urology - June 20, 2019 Category: Urology & Nephrology Authors: Wenying Wang, Yucheng Ge, Zhipeng Wang, Lei Wang, Jun Li, Ye Tian Source Type: research

Extracorporeal Shock Wave Lithotripsy Versus Ureteroscopy for Management of Pediatric Nephrolithiasis in Upper Tract Urinary Stones: Multi-Institutional Outcomes of Efficacy and Morbidity
As the incidence of pediatric nephrolithiasis rises, understanding the efficacy and morbidity of surgical treatment options is critical. Currently, there is limited comparative data assessing shock wave lithotripsy (SWL) and ureteroscopy (URS) outcomes in children. (Source: Journal of Pediatric Urology)
Source: Journal of Pediatric Urology - June 20, 2019 Category: Urology & Nephrology Authors: Kathryn Ann Marchetti, Ted Lee, Nicholas Raja, Lauren Corona, Kate H. Kraft, Julian Wan, Jonathan S. Ellison Source Type: research

Evaluation of inactive Matrix-Gla-Protein (MGP) as a biomarker for incident and recurrent kidney stones.
Abstract BACKGROUND: Matrix-Gla-protein (MGP) is an inhibitor of vascular calcification. Its dephosphorylated and uncarboxylated inactive form, dpucMGP, is a marker of vitamin K status and of cardio-vascular outcomes in chronic kidney disease. We hypothesized that higher serum dpucMGP would be a biomarker of kidney stone disease. METHODS: We measured serum dpucMGP in incident symptomatic kidney stone-formers and non-stone formers at a baseline visit. Symptomatic stone recurrence was assessed in the stones formers over a 5-year period. The association of dpucMGP with incident or recurrent kidney stones was ass...
Source: Journal of Nephrology - June 20, 2019 Category: Urology & Nephrology Authors: Castiglione V, Pottel H, Lieske JC, Lukas P, Cavalier E, Delanaye P, Rule AD Tags: J Nephrol Source Type: research

Recurrent Calcium Kidney Stones.
PMID: 31221735 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 20, 2019 Category: Urology & Nephrology Authors: Beara-Lasic L, Goldfarb DS Tags: Clin J Am Soc Nephrol Source Type: research

Gut microbiome and kidney stone disease: not just an Oxalobacter story
Intestinal regulation of oxalate absorption is a complex mechanism, not exclusively reliant on the oxalate-degrading anaerobe Oxalobacter formigenes. Using metagenomics, Miller et  al. were able to describe a network of bacterial taxa co-occurring with Oxalobacter formigenes in fecal samples from non–stone forming controls and less represented in stone formers. These findings may help to illuminate why previous intervention studies with probiotics have failed to reduce the risk of hyperoxaluria, opening new possibilities for future research. (Source: Kidney International)
Source: Kidney International - June 19, 2019 Category: Urology & Nephrology Authors: Andrea Ticinesi, Antonio Nouvenne, Tiziana Meschi Tags: Commentary Source Type: research

Adherence to the European Association of Urology Guidelines Regarding the Therapeutic Indications for the Treatment of Urinary Lithiasis: A Spanish Multicenter Study
Conclusions: In our study, the overall adherence to the clinical guidelines regarding the therapeutic indication for urinary lithiasis has been low. In the case of both renal and ureteral stones, the adherence in small lithiasis has been greater, compared with larger ones. In our survey, a trend has been observed in favor of endoscopic procedures even in large lithiasis.Urol Int (Source: Urologia Internationalis)
Source: Urologia Internationalis - June 19, 2019 Category: Urology & Nephrology Source Type: research

Increasing Use, Geographic Variation, and Disparities in Emergency Department CT for Suspected Urolithiasis
Publication date: Available online 17 June 2019Source: Journal of the American College of RadiologyAuthor(s): Patricia Balthazar, Gelareh Sadigh, Danny Hughes, Andrew B. Rosenkrantz, Tarek Hanna, Richard DuszakAbstractPurposeThe aim of this study was to examine changing characteristics of utilization and potential disparities in US emergency department (ED) patients undergoing CT of the abdomen and pelvis (CTAP) for suspected urolithiasis.MethodsA retrospective study was conducted among all patients from 2006 to 2015 with a primary diagnosis of suspected urolithiasis within the Nationwide Emergency Department Sample, the l...
Source: Journal of the American College of Radiology - June 19, 2019 Category: Radiology Source Type: research

Response to the letter to editor: 24-h urine osmolality should be used in combination with other urine parameters in urolithiasis patients
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - June 19, 2019 Category: Urology & Nephrology Source Type: research

Better sleep quality could reinforce the relationship between sleep posture and kidney stone laterality in obstructive sleep apnea patients
AbstractUrolithiasis is a common urologic problem among adults worldwide. It is interesting that urinary stones tend to recur on the same side and the pathophysiology of unilateral stone formation is not clearly understood. Researchers found that sleep posture could alter renal perfusion, and subsequent vascular injury may lead to urolithiasis formation. The aim of this study is to retrospectively evaluate the correlations between the specific sleep postures recorded in polysomnography (PSG) and the stone laterality in unilateral urinary stone formers with obstructive sleep apnea (OSA). We retrospectively reviewed patients...
Source: Urolithiasis - June 17, 2019 Category: Urology & Nephrology Source Type: research

Increasing Use, Geographic Variation, and Disparities in Emergency Department CT for Suspected Urolithiasis
The aim of this study was to examine changing characteristics of utilization and potential disparities in US emergency department (ED) patients undergoing CT of the abdomen and pelvis (CTAP) for suspected urolithiasis. (Source: Journal of the American College of Radiology : JACR)
Source: Journal of the American College of Radiology : JACR - June 17, 2019 Category: Radiology Authors: Patricia Balthazar, Gelareh Sadigh, Danny Hughes, Andrew B. Rosenkrantz, Tarek Hanna, Richard Duszak Tags: Original article Source Type: research

Association of vitamin D receptor polymorphisms and nephrolithiasis: A meta-analysis.
Posadas-Sánchez R, Vargas-Alarcón G, Rodríguez-Pérez JM Abstract Nephrolithiasis is a complex disease in which its pathophysiology is strongly influenced by genetics. Polymorphisms of the vitamin D receptor (VDR) gene have been reported to be associated with the development of kidney stones which in most cases are composed predominantly of calcium salts. For the purpose of this study, we performed a systematic review and meta-analysis to analyze the association of BsmI (rs1544410), ApaI (rs7975232), TaqI (rs731236) and FokI (rs2228570) polymorphisms with nephrolithiasis. A systematic s...
Source: Gene - June 15, 2019 Category: Genetics & Stem Cells Authors: González-Castro TB, Blachman-Braun R, Hernández-Díaz Y, Tovilla-Zárate CA, Pérez-Hernández N, Moscardi PRM, Alam A, Borgonio-Cuadra VM, Reyes-López PA, Juárez-Rojop IE, López-Narváez ML, Posadas-Sánchez R, Vargas-Alarcón G, Rodríguez-Pérez J Tags: Gene Source Type: research

Multiple complications of a 14-year-old hemodialysis catheter.
We describe a case of a 65-year-old woman undergoing hemodialysis treatment since 1986 after a bilateral nephrectomy due to complicated nephrolithiasis. Her last access, two Tesio® tunneled cuffed catheters implanted via the right internal jugular vein functioned correctly for 14 years without complications, and so, was not replaced in the meantime. She was referred to our hospital due to a rupture in a catheter lumen, which was corrected conservatively by creating a more proximal tunnel and excising the affected area. A few weeks later, a new rupture in the same lumen was identified, so the catheter was replace...
Source: The Journal of Vascular Access - June 14, 2019 Category: Surgery Tags: J Vasc Access Source Type: research

Climate Change and the Kidney
The worldwide increase in temperature has resulted in a marked increase in heat waves (heat extremes) that carries a markedly increased risk for morbidity and mortality. The kidney has a unique role not only in protecting the host from heat and dehydration but also is an important site of heat-associated disease. Here we review the potential impact of global warming and heat extremes on kidney diseases. High temperatures can result in increased core temperatures, dehydration, and blood hyperosmolality. Heatstroke (both clinical and subclinical whole-body hyperthermia) may have a major role in causing both acute kidney dise...
Source: Annals of Nutrition and Metabolism - June 14, 2019 Category: Nutrition Source Type: research

Induction of enteric oxalate secretion by Oxalobacter formigenes in mice does not require the presence of either apical oxalate transport proteins Slc26A3 or Slc26A6
AbstractOxalobacter sp. promotion of enteric oxalate excretion, correlating with reductions in urinary oxalate excretion, was previously reported in rats and mice, but the mechanistic basis for this affect has not been described. The main objective of the present study was to determine whether the apical oxalate transport proteins, PAT1 (slc26a6) and DRA (slc26a3), are involved in mediating theOxalobacter-induced net secretory flux across colonized mouse cecum and distal colon. We measured unidirectional and net fluxes of oxalate across tissues removed from colonized PAT1 and DRA knockout (KO) mice and also across two doub...
Source: Urolithiasis - June 14, 2019 Category: Urology & Nephrology Source Type: research

Twenty-four-hour urine osmolality should be used in combination with other urine parameters in urolithiasis patients
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - June 14, 2019 Category: Urology & Nephrology Source Type: research

Regulation of Renal NaDC1 Expression and Citrate Excretion by NBCe1-A.
This study's purpose was to determine the role of the NBCe1 A variant (NBCe1-A) in citrate metabolism under basal conditions and in response to acid-loading and hypokalemia. NBCe1-A deletion increased citrate excretion and decreased NaDC1 expression in proximal convoluted tubule (PCT) and proximal straight tubule (PST) in medullary ray (PST-MR), but not in PST in outer medulla (PST-OM). Acid-loading wild-type (WT) mice decreased citrate excretion. NaDC1 expression increased only in PCT and PST-MR, and not in PST-MR. In NBCe1-A KO mice, the acid-loading change in citrate excretion was unaffected, changes in PCT NaDC1 expres...
Source: Am J Physiol Renal P... - June 12, 2019 Category: Urology & Nephrology Authors: Osis G, Webster KL, Harris AN, Lee HW, Chen C, Fang L, Romero MF, Khattri RB, Merritt ME, Verlander JW, Weiner ID Tags: Am J Physiol Renal Physiol Source Type: research

TRPV5 in renal tubular calcium handling and its potential relevance for nephrolithiasis
Nephrolithiasis or renal stone disease is an increasingly common problem, and its relatively high recurrence rate demands for better treatment options. The majority of patients with nephrolithiasis have calcium (Ca2+)-containing stones, which develop upon "supersaturation" of the urine with insoluble Ca2+ salts. Hence, processes that influence the delivery and renal handling of Ca2+ may influence stone formation. Idiopathic hypercalciuria is indeed frequently observed in patients with Ca2+-containing kidney stones. (Source: Kidney International)
Source: Kidney International - June 11, 2019 Category: Urology & Nephrology Authors: Jenny van der Wijst, Mark K. van Goor, Michiel F. Schreuder, Joost G. Hoenderop Tags: Review Source Type: research

A Patient With Abnormal Abdominal CT Scan Findings
A man with a history of nephrolithiasis and laparotomy for trauma had left flank and left upper quadrant pain. He had mild leukocytosis, but the physical examination and other laboratory testing were unremarkable; abdominal CT revealed a well-circumscribed, extraluminal mass with central high density. What is the diagnosis and what would you do next? (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - June 10, 2019 Category: General Medicine Source Type: research

P38 MAPK signaling pathway mediates COM crystal-induced crystal adhesion change in rat renal tubular epithelial cells
This study demonstrated that the p38 MAPK signaling pathway mediated the COM crystal-induced crystal adhesion change in NRK-52E cells and required the involvement of NLRP3 inflammasome. (Source: Urolithiasis)
Source: Urolithiasis - June 10, 2019 Category: Urology & Nephrology Source Type: research

A Study of Diet and Lifestyle and the Risk of Urolithiasis in 1,519 Patients in Southern China.
CONCLUSIONS High consumptions of pickled foods and animal protein were the main risk factors for the development of urolithiasis in a population of southern China, but high fluid intake with a preference for strong tea, a diet of vegetables, and physical exercise were protective factors. PMID: 31170122 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

EMS Lithoclast Trilogy ™: an effective single-probe dual-energy lithotripter for mini and standard PCNL
AbstractPurposeSeveral energy sources are available to clear stones during PCNL. Required improvements are faster stone clearance, optimized suction and ease of use while maintaining high patient safety standard. EMS LithoClast® Trilogy, is the first device combining electromagnetic impactor with ultrasonic energy and suction, all-in-one probe. Animal studies and in vitro phantom stone studies have proven safety and efficacy of this device. We aim to study safety and clinical efficacy of Trilogy in our patients.Methods31 patients with renal stones were included. Amplatz sheath sizes/Trilogy probe size was 22 –28 ...
Source: World Journal of Urology - June 8, 2019 Category: Urology & Nephrology Source Type: research

75 - Comparison of retrograde intrarenal surgery and percutaneous nephrolithotomy costs in surgical treatment of kidney stones
Publication date: May 2019Source: European Urology Supplements, Volume 18, Issue 2Author(s): S. Tonyali, M. Yilmaz (Source: European Urology Supplements)
Source: European Urology Supplements - June 7, 2019 Category: Urology & Nephrology Source Type: research

49 - ESWL in children in one-day surgery - safe and effective treatment of urolithiasis in children – a prospective study
Publication date: May 2019Source: European Urology Supplements, Volume 18, Issue 2Author(s): A.H. Halinski, A.H. Halinski (Source: European Urology Supplements)
Source: European Urology Supplements - June 7, 2019 Category: Urology & Nephrology Source Type: research

Effects of physical properties of nano-sized hydroxyapatite crystals on cellular toxicity in renal epithelial cells
Publication date: October 2019Source: Materials Science and Engineering: C, Volume 103Author(s): Chen-Ying Rao, Xin-Yuan Sun, Jian-Ming OuyangAbstractHydroxyapatite (HAP) is not only a common component of most idiopathic CaOx stones, but also the core of Randall's plaque. HAP is a nest that can induce the formation of Randall's plaques and even kidney stones. We studied the toxic effects and mechanisms of four different types of nano-HAP crystals (H-Sphere, 72.5 nm × 72.5 nm; H-Needle, 37.2 nm × 162.7 nm; H-Rod, 42.3 nm × 115.3 nm; and H-Plate, 145.5 nm × 272.9 nm) on...
Source: Materials Science and Engineering: C - June 7, 2019 Category: Materials Science Source Type: research

RE: Geobiology reveals how human kidney stones dissolve in vivo (by: Sivaguru et al. 2018)
(Source: World Journal of Urology)
Source: World Journal of Urology - June 7, 2019 Category: Urology & Nephrology Source Type: research

The Durability of Active Surveillance in Patients with Asymptomatic Kidney Stones: A Systematic Review
Journal of Endourology, Ahead of Print. (Source: Journal of Endourology)
Source: Journal of Endourology - June 7, 2019 Category: Urology & Nephrology Authors: David S. Han Benjamin A.Y. Cher Dongheon Lee Sreevaishali Rajendran Natalie B.V. Riblet Vernon M. Pais Source Type: research

The idiopathic hypercalciuria reviewed. Metabolic abnormality or disease?
Authors: García Nieto VM, Luis Yanes MI, Tejera Carreño P, Perez Suarez G, Moraleda Mesa T Abstract Idiopathic hypercalciuria (IH) is defined as that clinical situation in which an increase in urinary calcium excretion is observed, in the absence of hypercalcemia and other known causes of hypercalciuria. In recent years, its diagnosis in pediatric age has been more frequent because it has been known that it can debut with very different symptoms, in the absence of kidney stone formation. The discovery of genetic hypercalciuric stone-forming rats has allowed us to glimpse the pathophysiological mechani...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - June 6, 2019 Category: Urology & Nephrology Tags: Nefrologia Source Type: research

Identification of ureteral stones at reduced radiation exposure: a pilot study comparing conventional versus digital low-dosage linear slot scanning (Lodox ® ) radiography
AbstractPurposeDigital low-dosage, linear slot scanning radiography (Lodox®) is an imaging modality that can emit down to one-tenth the radiation of conventional X-ray systems. We prospectively evaluated Lodox® as a diagnostic imaging modality in patients with ureterolithiasis.MethodsConventional kidney –ureter–bladder (KUB) X-ray and Lodox® were performed in 41 patients presenting with acute flank pain due to unilateral ureteral stone confirmed by computed tomography. KUB X-ray and Lodox® images were then reviewed by four blinded readers (urology expert/resident, radiology expert/resident). Ide...
Source: World Journal of Urology - June 5, 2019 Category: Urology & Nephrology Source Type: research

Stone composition and vascular calcifications in patients with nephrolithiasis.
In conclusion, we demonstrated a significant direct association of AAC and the amount of calcium phosphate was found, suggesting an increased cardiovascular risk. Our study suggests that some subtypes of kidney stone disease deserve a closer cardiovascular risk assessment. PMID: 31165423 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - June 4, 2019 Category: Urology & Nephrology Authors: Ferraro PM, Marano R, Primiano A, Gervasoni J, Bargagli M, Rovere G, Bassi PF, Gambaro G Tags: J Nephrol Source Type: research

Theoretical and laboratory investigations of the effects of hydroxyproline ingestion on the metabolic and physicochemical risk factors for calcium oxalate kidney stone formation in a small group of healthy subjects
ConclusionsWe attribute the decrease in iCa2+ to increases in the concentrations of several Ca –phosphate species, the formation of which is due to the increase in pH. We speculate that the absence of an increase in oxalate excretion despite an increase in glycolate excretion may be due to the mixed racial composition of our test group in which some pathways may be preferred to others. Our findings alert stone researchers to the importance of measuring urinary pH in their workup of subjects and to select racially homogenous groups for investigation. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - June 3, 2019 Category: Urology & Nephrology Source Type: research

The use of antibiotics and risk of kidney stones
Purpose of review The effect of the intestinal microbiome on urine chemistry and lithogenicity has been a popular topic. Here we review the evidence for exposure to antibiotics increasing the risk of nephrolithiasis. Recent findings Studies of the intestinal microbiome have focused on Oxalobacter formigenes, an anaerobe that frequently colonizes the human colon. As a degrader of fecal oxalate its presence is associated with lower urinary oxalate, which would be protective against calcium oxalate stone formation. It also appears capable of stimulating colonic oxalate secretion. A recent study showed that antibiotics ca...
Source: Current Opinion in Nephrology and Hypertension - May 31, 2019 Category: Urology & Nephrology Tags: MINERAL METABOLISM: Edited by Aline Martin and Tamara Isakova Source Type: research

Acute Renal Colic Due to Immunoglobulin Free Light Chain Kidney Stones: A Case Report of an Unusual Complication of Multiple Myeloma
We report the case of a 74-year-old man with recurrent renal colic and acute kidney injury. He presented with κ light chain Bence-Jones proteinuria, hypogammaglobulinemia, anemia, and high plasma κ light chain level, leading to the diagnosis of κ light chain multiple myeloma. One calculus was collected and its analysis revealed a unique protein structure consisting of κ immunoglobulin free light chain. Genetic sequencing of the κ light chain identified a subgroup of variable domain previously identified as prone to crystallization. Eight cycles of cyclophosphamide-bortezomib-dexamethasone chem...
Source: American Journal of Kidney Diseases - May 31, 2019 Category: Urology & Nephrology Source Type: research

Molecules, Vol. 24, Pages 2074: Gallic Acid-Chitosan Conjugate Inhibits the Formation of Calcium Oxalate Crystals
Silva Costa It has recently been shown that chitosan (Chit) induces the formation of calcium oxalate (CaOx) crystals, which are mainly responsible for the appearance of kidney stones, and this might limit the use of Chit in vivo. Here, Chit was conjugated with gallic acid (Chit-Gal) to decrease the formation of CaOx crystal. This conjugation was confirmed by FTIR and NMR analyses. Chit-Gal contains 10.2 ± 1.5 mg GA per g of Chit. Compared to the control group, Chit increased the number of crystals by six-fold, mainly in the number of monohydrated CaOx crystals, which are the most harmful CaOx crystals. I...
Source: Molecules - May 31, 2019 Category: Chemistry Authors: Moacir Fernandes Queiroz Karoline Rachel Teodosio Melo Diego Araujo Sabry Guilherme Lanzi Sassaki Hugo Alexandre Oliveira Rocha Leandro Silva Costa Tags: Article Source Type: research

[Three-dimensional reconstruction of human kidney based on UroMedix-3D system and its application in kidney surgery].
CONCLUSIONS: Uromedix-3D system can accurately and efficiently reconstruct the 3D structure of human kidneys and the renal lesions based on enhanced CT data. The reconstructed 3D model allows objective assessment of the spatial anatomical relationship of the lesions to provide assistance in surgical planning. PMID: 31140429 [PubMed - in process] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - May 30, 2019 Category: Universities & Medical Training Authors: Huang J, Lü S, Hu Z, Huang C, Li Y, Wei Q Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[A radiomic approach to differential diagnosis of renal cell carcinoma in patients with hydronephrosis and renal calculi].
ConclusionThe computer-aided classification model based on supervised machine learning can effectively extract the diagnostic information and improve the diagnostic rate of renal cell carcinoma associated with hydronephrosis and renal calculi. PMID: 31140418 [PubMed - in process] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - May 30, 2019 Category: Universities & Medical Training Authors: Zhang H, Li Q, Li S, Ma J, Huang J Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

Computed Tomography Radiation Exposure Among Referred Kidney Stone Patients: Results from the Registry for Stones of the Kidney and Ureter
Journal of Endourology, Ahead of Print. (Source: Journal of Endourology)
Source: Journal of Endourology - May 29, 2019 Category: Urology & Nephrology Authors: David T. Tzou Samuel Zetumer Manint Usawachintachit Kazumi Taguchi Seth K. Bechis Brian D. Duty Jonathan D. Harper Ryan S. Hsi Mathew Sorensen Roger L. Sur Shalonda Reliford-Titus Helena C. Chang Dylan Isaacson David B. Bayne Zhen J. Wang Marshall L. Stol Source Type: research

Urinary 2,8-dihydroxyadenine excretion in patients with APRT deficiency, carriers and healthy control subjects
Publication date: Available online 28 May 2019Source: Molecular Genetics and MetabolismAuthor(s): Hrafnhildur L. Runolfsdottir, Runolfur Palsson, Unnur A. Thorsteinsdottir, Olafur S. Indridason, Inger M.Sch. Agustsdottir, G. Steinunn Oddsdottir, Margret Thorsteinsdottir, Vidar O. EdvardssonAbstractBackgroundAdenine phosphoribosyltransferase (APRT) deficiency is a rare autosomal recessive disorder of adenine metabolism that results in excessive urinary excretion of the poorly soluble 2,8-dihydroxyadenine (DHA), leading to kidney stones and chronic kidney disease. The purpose of this study was to assess urinary DHA excretion...
Source: Molecular Genetics and Metabolism - May 28, 2019 Category: Genetics & Stem Cells Source Type: research

Ethnobotanical survey of medicinal plants in central abyan governorate, Yemen
ConclusionsSignificant traditional knowledge of the uses of local medicinal plant species was recorded for the first time for central Abyan in particular and southern Yemen in general. The study shows that the medicinal plants still play an important role in the primary health care in the study area. The ethnobotanical results provide a basis for further pharmacological, biological, pharmacognostical, and phytochemical investigations.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 28, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of vitamin D supplementation on 24-hour urine calcium in patients with calcium Urolithiasis and vitamin D deficiency
ABSTRACT Purpose: Hypercalciuria is one of the risk factors for calcium kidney stone formation (the most common type of urinary stones). Although vitamin D deficiency is prevalent among urolithiasis patients, the effect of vitamin D supplementation on urine calcium in these patients is still unclear. Materials and Methods: In this retrospective study, medical and laboratory tests records of 26 patients with recurrent calcium kidney stones and vitamin D deficiency treated with 50000IU vitamin D per week for 8-12 weeks were analyzed. The changes in 24-hour urine calcium (24-h Ca), serum 25-hydroxyvitamin D (25 (OH) D), serum...
Source: International Braz J Urol - May 28, 2019 Category: Urology & Nephrology Source Type: research

Renoprotective effect of tectorigenin glycosides isolated from Iris spuria L. (Zeal) against hyperoxaluria and hyperglycemia in NRK-49Fcells.
This study indicates cytoprotective, antioxidant, anti-urolithic and anti-diabetic effects of compounds 1 and 2 against oxalate and high glucose stress. PMID: 31135219 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - May 28, 2019 Category: Biochemistry Authors: Divya G, Albert A, Singab ANB, Ayoub IM, Al-Sayed E, Paul E, Manoharan K, Saso L, Selvam GS Tags: Nat Prod Res Source Type: research

Evaluation of Renal Stone Comminution and Injury by Burst Wave Lithotripsy in a Pig Model
Journal of Endourology, Ahead of Print. (Source: Journal of Endourology)
Source: Journal of Endourology - May 27, 2019 Category: Urology & Nephrology Authors: Adam D. Maxwell Yak-Nam Wang Wayne Kreider Bryan W. Cunitz Frank Starr Donghoon Lee Yasser Nazari James C. Williams Michael R. Bailey Mathew D. Sorensen Source Type: research

Comparing intranasal ketamine with intravenous fentanyl in reducing pain in patients with renal colic: A double-blind randomized clinical trial
Kidney stones are a fairly common problem that manifests itself as symptoms of acute abdominal and flank pains in patients presenting to emergency departments. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - May 26, 2019 Category: Emergency Medicine Authors: Javad Mozafari, Mohammadreza Maleki Verki, Hassan Motamed, Alireza Sabouhi, Fatemeh Tirandaz Source Type: research

The Comparison Study of Flexible Ureteroscopic Suctioning Lithotripsy With Intelligent Pressure Control Versus Minimally Invasive Percutaneous Suctioning Nephrolithotomy in Treating Renal Calculi of 2 to 3 cm in Size.
CONCLUSION: Both the operative methods are safe and efficacious in treating solitary renal calculus at 2 to 3 cm in size. However, FURS has more advantages including shorter hospital stay, less complication, and less bleeding. PMID: 31130072 [PubMed - as supplied by publisher] (Source: Surgical Innovation)
Source: Surgical Innovation - May 26, 2019 Category: Surgery Authors: Chen H, Qiu X, Du C, Xie D, Liu T, Wang G, Song L Tags: Surg Innov Source Type: research

[Renal and Urinary Manifestations of Inflammatory Bowel Disease].
Abstract The incidence of inflammatory bowel disease (IBD) is increasing rapidly and extra-intestinal manifestations in IBD are also increasing. The prevalence of renal and urinary involvement in IBD ranges from 4-23%. Nephrolithiasis is the most common urinary complication in IBD patients. Parenchymal renal disease is rare but has been well documented and presents most commonly as glomerulonephritis or tubulointerstitial nephritis. The overall morbidity of IBD-related renal manifestations is significant. Therefore, a high index of clinical suspicion and optimal monitoring of the renal function are needed for the ...
Source: Korean J Gastroenter... - May 25, 2019 Category: Gastroenterology Authors: Kim YN, Jung Y Tags: Korean J Gastroenterol Source Type: research

Influence of socioeconomic factors on stone burden at presentation to tertiary referral center: Data from the Registry for Stones of the Kidney and Ureter
To determine social factors associated with advanced stone disease (defined as unilateral stone burden>2cm) at time of presentation to a regional stone referral center. Little is known about social determinants of urolithiasis. We hypothesize that socioeconomic factors impact kidney stone severity at intake to referral centers. (Source: Urology)
Source: Urology - May 24, 2019 Category: Urology & Nephrology Authors: David Bayne, Manint Usawachintachit, Manuel Armas-Phan, David Tzou, Scott Wiener, Timothy T. Brown, Marshall Stoller, Thomas L. Chi Source Type: research

Change of Trends in the Treatment Modality for Pediatric Nephrolithiasis: Retrospective Analysis of a US-Based Insurance Claims Database
Journal of Endourology, Ahead of Print. (Source: Journal of Endourology)
Source: Journal of Endourology - May 24, 2019 Category: Urology & Nephrology Authors: Hyoung Keun Park Jae Heon Kim Gyeong Eun Min Woo Suk Choi Shufeng Li Kyung Jin Chung Benjamin I. Chung Source Type: research