N-acetylcysteine regulates oxalate induced injury of renal tubular epithelial cells through CDKN2B/TGF- β/SMAD axis
In conclusion, we found that NAC could play an anti-calculus role by mediating CDKN2B/TGF-β/SMAD axis. (Source: Urolithiasis)
Source: Urolithiasis - March 23, 2024 Category: Urology & Nephrology Source Type: research
Understanding formation processes of calcareous nephrolithiasis in renal interstitium and tubule lumen
J Cell Mol Med. 2024 Apr;28(7):e18235. doi: 10.1111/jcmm.18235.ABSTRACTKidney stone, one of the oldest known diseases, has plagued humans for centuries, consistently imposing a heavy burden on patients and healthcare systems worldwide due to their high incidence and recurrence rates. Advancements in endoscopy, imaging, genetics, molecular biology and bioinformatics have led to a deeper and more comprehensive understanding of the mechanism behind nephrolithiasis. Kidney stone formation is a complex, multi-step and long-term process involving the transformation of stone-forming salts from free ions into asymptomatic or sympt...
Source: J Cell Mol Med - March 21, 2024 Category: Molecular Biology Authors: Caitao Dong Jiawei Zhou Xiaozhe Su Ziqi He Qianlin Song Chao Song Hu Ke Chuan Wang Wenbiao Liao Sixing Yang Source Type: research
Understanding formation processes of calcareous nephrolithiasis in renal interstitium and tubule lumen
J Cell Mol Med. 2024 Apr;28(7):e18235. doi: 10.1111/jcmm.18235.ABSTRACTKidney stone, one of the oldest known diseases, has plagued humans for centuries, consistently imposing a heavy burden on patients and healthcare systems worldwide due to their high incidence and recurrence rates. Advancements in endoscopy, imaging, genetics, molecular biology and bioinformatics have led to a deeper and more comprehensive understanding of the mechanism behind nephrolithiasis. Kidney stone formation is a complex, multi-step and long-term process involving the transformation of stone-forming salts from free ions into asymptomatic or sympt...
Source: Molecular Medicine - March 21, 2024 Category: Molecular Biology Authors: Caitao Dong Jiawei Zhou Xiaozhe Su Ziqi He Qianlin Song Chao Song Hu Ke Chuan Wang Wenbiao Liao Sixing Yang Source Type: research
Native nephrectomy in polycystic kidney disease patients on transplant lists: how and when?
J Nephrol. 2024 Mar 21. doi: 10.1007/s40620-024-01899-7. Online ahead of print.ABSTRACTAutosomal dominant polycystic kidney disease (ADPKD), the most common hereditary kidney disease, accounts for approximately 10% of the patients on kidney transplantation waitlists. High rates of complications including hemorrhage, infections, nephrolithiasis and kidney size-related compressive complaints have been reported among ADPKD patients. Therefore, the need for routine native nephrectomy and timing of such procedure in ADPKD patients being prepared for transplantation are debated. Even though pre-transplant nephrectomy has the pot...
Source: Journal of Nephrology - March 21, 2024 Category: Urology & Nephrology Authors: Sidar Copur Lasin Ozbek Mustafa Guldan Ahmet Umur Topcu Mehmet Kanbay Source Type: research
Donor-transmitted cystinuria in a renal transplant recipient
We present a case of acquired cystinuria in a renal transplant recipient, that is, to the best of our knowledge, the first case of acquired cystinuria ever documented in the literature.PMID:38512367 | DOI:10.1007/s40620-023-01877-5 (Source: Journal of Nephrology)
Source: Journal of Nephrology - March 21, 2024 Category: Urology & Nephrology Authors: Prathap K Simhadri Pradeep K Vaitla Rachana Marathi Abdul Khan Source Type: research
Understanding formation processes of calcareous nephrolithiasis in renal interstitium and tubule lumen
J Cell Mol Med. 2024 Apr;28(7):e18235. doi: 10.1111/jcmm.18235.ABSTRACTKidney stone, one of the oldest known diseases, has plagued humans for centuries, consistently imposing a heavy burden on patients and healthcare systems worldwide due to their high incidence and recurrence rates. Advancements in endoscopy, imaging, genetics, molecular biology and bioinformatics have led to a deeper and more comprehensive understanding of the mechanism behind nephrolithiasis. Kidney stone formation is a complex, multi-step and long-term process involving the transformation of stone-forming salts from free ions into asymptomatic or sympt...
Source: J Cell Mol Med - March 21, 2024 Category: Molecular Biology Authors: Caitao Dong Jiawei Zhou Xiaozhe Su Ziqi He Qianlin Song Chao Song Hu Ke Chuan Wang Wenbiao Liao Sixing Yang Source Type: research
Understanding formation processes of calcareous nephrolithiasis in renal interstitium and tubule lumen
J Cell Mol Med. 2024 Apr;28(7):e18235. doi: 10.1111/jcmm.18235.ABSTRACTKidney stone, one of the oldest known diseases, has plagued humans for centuries, consistently imposing a heavy burden on patients and healthcare systems worldwide due to their high incidence and recurrence rates. Advancements in endoscopy, imaging, genetics, molecular biology and bioinformatics have led to a deeper and more comprehensive understanding of the mechanism behind nephrolithiasis. Kidney stone formation is a complex, multi-step and long-term process involving the transformation of stone-forming salts from free ions into asymptomatic or sympt...
Source: Molecular Medicine - March 21, 2024 Category: Molecular Biology Authors: Caitao Dong Jiawei Zhou Xiaozhe Su Ziqi He Qianlin Song Chao Song Hu Ke Chuan Wang Wenbiao Liao Sixing Yang Source Type: research
Native nephrectomy in polycystic kidney disease patients on transplant lists: how and when?
J Nephrol. 2024 Mar 21. doi: 10.1007/s40620-024-01899-7. Online ahead of print.ABSTRACTAutosomal dominant polycystic kidney disease (ADPKD), the most common hereditary kidney disease, accounts for approximately 10% of the patients on kidney transplantation waitlists. High rates of complications including hemorrhage, infections, nephrolithiasis and kidney size-related compressive complaints have been reported among ADPKD patients. Therefore, the need for routine native nephrectomy and timing of such procedure in ADPKD patients being prepared for transplantation are debated. Even though pre-transplant nephrectomy has the pot...
Source: Journal of Nephrology - March 21, 2024 Category: Urology & Nephrology Authors: Sidar Copur Lasin Ozbek Mustafa Guldan Ahmet Umur Topcu Mehmet Kanbay Source Type: research
Donor-transmitted cystinuria in a renal transplant recipient
We present a case of acquired cystinuria in a renal transplant recipient, that is, to the best of our knowledge, the first case of acquired cystinuria ever documented in the literature.PMID:38512367 | DOI:10.1007/s40620-023-01877-5 (Source: Journal of Nephrology)
Source: Journal of Nephrology - March 21, 2024 Category: Urology & Nephrology Authors: Prathap K Simhadri Pradeep K Vaitla Rachana Marathi Abdul Khan Source Type: research
Native nephrectomy in polycystic kidney disease patients on transplant lists: how and when?
J Nephrol. 2024 Mar 21. doi: 10.1007/s40620-024-01899-7. Online ahead of print.ABSTRACTAutosomal dominant polycystic kidney disease (ADPKD), the most common hereditary kidney disease, accounts for approximately 10% of the patients on kidney transplantation waitlists. High rates of complications including hemorrhage, infections, nephrolithiasis and kidney size-related compressive complaints have been reported among ADPKD patients. Therefore, the need for routine native nephrectomy and timing of such procedure in ADPKD patients being prepared for transplantation are debated. Even though pre-transplant nephrectomy has the pot...
Source: Journal of Nephrology - March 21, 2024 Category: Urology & Nephrology Authors: Sidar Copur Lasin Ozbek Mustafa Guldan Ahmet Umur Topcu Mehmet Kanbay Source Type: research
Donor-transmitted cystinuria in a renal transplant recipient
We present a case of acquired cystinuria in a renal transplant recipient, that is, to the best of our knowledge, the first case of acquired cystinuria ever documented in the literature.PMID:38512367 | DOI:10.1007/s40620-023-01877-5 (Source: Journal of Nephrology)
Source: Journal of Nephrology - March 21, 2024 Category: Urology & Nephrology Authors: Prathap K Simhadri Pradeep K Vaitla Rachana Marathi Abdul Khan Source Type: research
Native nephrectomy in polycystic kidney disease patients on transplant lists: how and when?
J Nephrol. 2024 Mar 21. doi: 10.1007/s40620-024-01899-7. Online ahead of print.ABSTRACTAutosomal dominant polycystic kidney disease (ADPKD), the most common hereditary kidney disease, accounts for approximately 10% of the patients on kidney transplantation waitlists. High rates of complications including hemorrhage, infections, nephrolithiasis and kidney size-related compressive complaints have been reported among ADPKD patients. Therefore, the need for routine native nephrectomy and timing of such procedure in ADPKD patients being prepared for transplantation are debated. Even though pre-transplant nephrectomy has the pot...
Source: Journal of Nephrology - March 21, 2024 Category: Urology & Nephrology Authors: Sidar Copur Lasin Ozbek Mustafa Guldan Ahmet Umur Topcu Mehmet Kanbay Source Type: research
Donor-transmitted cystinuria in a renal transplant recipient
We present a case of acquired cystinuria in a renal transplant recipient, that is, to the best of our knowledge, the first case of acquired cystinuria ever documented in the literature.PMID:38512367 | DOI:10.1007/s40620-023-01877-5 (Source: Journal of Nephrology)
Source: Journal of Nephrology - March 21, 2024 Category: Urology & Nephrology Authors: Prathap K Simhadri Pradeep K Vaitla Rachana Marathi Abdul Khan Source Type: research
Spasmolytic Effect of Flopropione Does Not Involve Catechol-O- methyltransferase (COMT) Inhibition
Biol Pharm Bull. 2024;47(3):660-668. doi: 10.1248/bpb.b23-00808.ABSTRACTFlopropione (Flo) has been used for gallstone and urolithiasis as a spasmolytic agent almost exclusively in Japan. According to the package insert, its main mechanism is catechol-O-methyltransferase (COMT) inhibition and anti-serotonergic effect. This is obviously contrary to pharmacological common sense, but it is described that way in pharmacology textbooks and occurs in questions in the National Examination for Pharmacists in Japan. As this is a serious problem in education, we re-examined the action of Flo. The guinea pig ureter was hardly contract...
Source: Biological and Pharmaceutical Bulletin - March 20, 2024 Category: Drugs & Pharmacology Authors: Yoko Amagase Mari Hoshiyama Shiho Hasegawa Miwa Kanbara Yumiko Mizukawa Tetsuro Urushidani Source Type: research
Spasmolytic Effect of Flopropione Does Not Involve Catechol-O- methyltransferase (COMT) Inhibition
Biol Pharm Bull. 2024;47(3):660-668. doi: 10.1248/bpb.b23-00808.ABSTRACTFlopropione (Flo) has been used for gallstone and urolithiasis as a spasmolytic agent almost exclusively in Japan. According to the package insert, its main mechanism is catechol-O-methyltransferase (COMT) inhibition and anti-serotonergic effect. This is obviously contrary to pharmacological common sense, but it is described that way in pharmacology textbooks and occurs in questions in the National Examination for Pharmacists in Japan. As this is a serious problem in education, we re-examined the action of Flo. The guinea pig ureter was hardly contract...
Source: Biological and Pharmaceutical Bulletin - March 20, 2024 Category: Drugs & Pharmacology Authors: Yoko Amagase Mari Hoshiyama Shiho Hasegawa Miwa Kanbara Yumiko Mizukawa Tetsuro Urushidani Source Type: research
