Nephrology: What You May Have Missed in 2023
This article highlights a selection of important nephrology studies published in 2023 that have relevance for nonnephrologist physicians. Four studies examined progression of chronic kidney disease or cardiovascular disease with respect to finerenone use, magnesium supplementation, iron markers, and COVID-19. Two studies examined treatments to improve specific aspects of chronic kidney disease management, including daprodustat to address anemia and patiromer to address hyperphosphatemia. One study showed that acetazolamide added to loop diuretics increased diuresis in acute decompensated heart failure across a wide range o...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Ali A M AlHabobi Ashwaq M S Almutairi Danah A S Y Bohemid Ashwini R Sehgal Source Type: research
Trends in Emergency Department Admissions Due to Renal Colic in the Pediatric Population: A Multicenter Study
CONCLUSIONS: ED admissions oscillated during the period investigated and had a downward trend. Unlike in the adult population, rates of renal colic ED admissions in the pediatric population were not affected by seasonal changes or rise in maximum ambient temperature.PMID:38616665 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - April 15, 2024 Category: General Medicine Authors: Dor Golomb Hanan Goldberg Paz Lotan Ilan Kafka Stanislav Kotcherov Guy Verhovsky Asaf Shvero Ron Barrent Ilona Pilosov Solomon David Ben Meir Ezekiel H Landau Amir Cooper Orit Raz Source Type: research
Basal metabolic rate and the risk of urolithiasis: a two-sample Mendelian randomization study
ConclusionsBMR has causal effects on urolithiasis in an MR study, and the risk of urolithiasis in patients with lower levels of BMR is higher. (Source: World Journal of Urology)
Source: World Journal of Urology - April 14, 2024 Category: Urology & Nephrology Source Type: research
Develop a radiomics-based machine learning model to predict the stone-free rate post-percutaneous nephrolithotomy
The objective of this study was to integrate clinical variables and radiomic features to develop a machine learning model for predicting the stone-free rate (SFR) following percutaneous nephrolithotomy (PCNL). A total of 212 eligible patients who underwent PCNL surgery at the Second Affiliated Hospital of Nanchang University were included in a retrospective analysis. Preoperative clinical variables and non-contrast-enhanced CT images of all patients were collected, and radiomic features were extracted a fter delineating the stone ROI. Univariate analysis was conducted to identify clinical variables strongly correlated wi...
Source: Urolithiasis - April 13, 2024 Category: Urology & Nephrology Source Type: research
Carboxymethylated Rhizoma alismatis polysaccharides reduces the risk of calcium oxalate stone formation by reducing cellular inflammation and oxidative stress
This study aims to elucidate the mechanism and potential ofRhizoma alismatis polysaccharides (RAPs) in preventing oxidative damage to human renal proximal tubule epithelial cells. The experimental approach involved incubating HK-2 cells with 100 nm calcium oxalate monohydrate for 24 h to establish a cellular injury model. Protection was provided by RAPs with varying carboxyl group contents: 3.57%, 7.79%, 10.84%, and 15.33%. The safeguarding effect of RAPs was evaluated by analyzing relevant cellular biochemical indicators. Findings demo nstrate that RAPs exhibit notable antioxidative properties. They effectively dimini...
Source: Urolithiasis - April 13, 2024 Category: Urology & Nephrology Source Type: research
Ureteral stricture rate after endoscopic treatments for urolithiasis and related risk factors: systematic review and meta-analysis
ConclusionsThe overall US rate ranges from 0.3 to 4.9%, with an increasing trend in the last few years. It is influenced by type of treatment, stone location and impaction, preoperative hydronephrosis and intraoperative perforation. Future standardized reporting and prospective and more extended follow-up studies might contribute to a better understanding of US risks related to calculi treatment. (Source: World Journal of Urology)
Source: World Journal of Urology - April 13, 2024 Category: Urology & Nephrology Source Type: research
Is “Kidney Stone Calculator” efficient in predicting ureteroscopic lithotripsy duration? A holmium:YAG and thulium fiber lasers comparative analysis
ConclusionKSC is a reliable tool for predicting the lithotripsy duration estimation during flexible ureteroscopy for both Ho:YAG and TFL. However, some variables not including laser source may lead to underestimating this estimation. (Source: World Journal of Urology)
Source: World Journal of Urology - April 13, 2024 Category: Urology & Nephrology Source Type: research
Develop a radiomics-based machine learning model to predict the stone-free rate post-percutaneous nephrolithotomy
The objective of this study was to integrate clinical variables and radiomic features to develop a machine learning model for predicting the stone-free rate (SFR) following percutaneous nephrolithotomy (PCNL). A total of 212 eligible patients who underwent PCNL surgery at the Second Affiliated Hospital of Nanchang University were included in a retrospective analysis. Preoperative clinical variables and non-contrast-enhanced CT images of all patients were collected, and radiomic features were extracted a fter delineating the stone ROI. Univariate analysis was conducted to identify clinical variables strongly correlated wi...
Source: Urolithiasis - April 13, 2024 Category: Urology & Nephrology Source Type: research
Carboxymethylated Rhizoma alismatis polysaccharides reduces the risk of calcium oxalate stone formation by reducing cellular inflammation and oxidative stress
This study aims to elucidate the mechanism and potential ofRhizoma alismatis polysaccharides (RAPs) in preventing oxidative damage to human renal proximal tubule epithelial cells. The experimental approach involved incubating HK-2 cells with 100 nm calcium oxalate monohydrate for 24 h to establish a cellular injury model. Protection was provided by RAPs with varying carboxyl group contents: 3.57%, 7.79%, 10.84%, and 15.33%. The safeguarding effect of RAPs was evaluated by analyzing relevant cellular biochemical indicators. Findings demo nstrate that RAPs exhibit notable antioxidative properties. They effectively dimini...
Source: Urolithiasis - April 13, 2024 Category: Urology & Nephrology Source Type: research
The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and kidney stones: a cross-sectional study
The relationship between the NHHR and kidney stone risk remains unknown. The purpose of this study was to evaluate the association between adult NHHR and kidney stone occurrence in USA. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 13, 2024 Category: Lipidology Authors: Hujian Hong, Yijiang He, Zhiqiang Gong, Jilong Feng and Yanli Qu Tags: Research Source Type: research
Genetic susceptibility of urolithiasis: comprehensive results from genome-wide analysis
ConclusionWe for the first time implemented genome-wide MR analysis to investigate the genetic susceptibility of urolithiasis in general population of European ancestry. Our results provided novel insights into common genetic variants of urinary stone disease, which was of great help to subsequent researches. (Source: World Journal of Urology)
Source: World Journal of Urology - April 12, 2024 Category: Urology & Nephrology Source Type: research
Citrate primarily inhibits the formation of calcium oxalate kidney stones rather than dissolving them
Asian J Surg. 2024 Apr 9:S1015-9584(24)00643-2. doi: 10.1016/j.asjsur.2024.04.011. Online ahead of print.NO ABSTRACTPMID:38599963 | DOI:10.1016/j.asjsur.2024.04.011 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 10, 2024 Category: Surgery Authors: Guang Wang Ziye Huang Hongfei Gao Jiongming Li Source Type: research
Citrate primarily inhibits the formation of calcium oxalate kidney stones rather than dissolving them
Asian J Surg. 2024 Apr 9:S1015-9584(24)00643-2. doi: 10.1016/j.asjsur.2024.04.011. Online ahead of print.NO ABSTRACTPMID:38599963 | DOI:10.1016/j.asjsur.2024.04.011 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 10, 2024 Category: Surgery Authors: Guang Wang Ziye Huang Hongfei Gao Jiongming Li Source Type: research
Cohort profile: the PERSIAN Dena Cohort Study (PDCS) of non-communicable diseases in Southwest Iran
This study conducted in Dena County is a population-based cohort study as part of the Prospective Epidemiological Research Studies in Iran (PERSIAN). The specific objectives of this study were to estimate the prevalence of region-specific modifiable risk factors and their associations with the incidence of major non-communicable diseases (NCDs).
Participants
This PERSIAN Dena Cohort Study (PDCS) was conducted on 1561 men and 2069 women aged 35–70 years from October 2016 in Dena County, Kohgiluyeh and Boyer-Ahmad Province, Southwest Iran. The overall participation rate was 82.7%.
Findings to date
Out of 3630 partici...
Source: BMJ Open - April 10, 2024 Category: General Medicine Authors: Harooni, J., Joukar, F., Goujani, R., Sikaroudi, M. K., Hatami, A., Zolghadrpour, M.-A., Hejazi, M., Karimi, Z., Rahmanpour, F., Askari Shahid, S., Jowshan, M.-R. Tags: Open access, Epidemiology Source Type: research
A new protocol for renal collecting system sterilization with antibiotic irrigation during lithotripsy in retrograde intrarenal surgery: a prospective, comparative study
ConclusionThe reliability, efficacy, and utility of antibiotic irrigation during lithotripsy in RIRS were presented in this study as a new protocol for sterilization of the renal collecting system which will be able to reduce infectious complications. (Source: World Journal of Urology)
Source: World Journal of Urology - April 10, 2024 Category: Urology & Nephrology Source Type: research
