Individual cytotoxicity of three major type A trichothene, T-2, HT-2, and diacetoxyscirpenol in human Jurkat T cells
Toxicon. 2024 Apr 11:107718. doi: 10.1016/j.toxicon.2024.107718. Online ahead of print.ABSTRACTMycotoxins are toxic, fungal secondary metabolites that contaminate agricultural commodities, food, and feed. Among them, T-2, HT-2, and diacetoxyscirpenol (DAS; the major type A trichothecene) are primarily produced from Fusarium species. These mycotoxins exert numerous toxicological effects in animals and humans, such as dermatotoxicity, haematotoxicity, hepatotoxicity, nephrotoxicity, neurotoxicity, and immunotoxicity. In the present study, human Jurkat T cells were used as a model to investigate apoptotic cell death induced b...
Source: Toxicon - April 13, 2024 Category: Toxicology Authors: Phattarawadee Wattanasuntorn Patchara Phuktes Saranya Poapolathep Sontana Mimapan Muncharee Tattiyapong Johanna Fink-Gremmels Isabelle P Oswald Amnart Poapolathep Source Type: research
ROLE OF NITRIC OXIDE AND SIGNALING PATHWAYS MODULATING THE STIMULATORY EFFECT OF SNAKE VENOM SECRETORY PLA < sub > 2 < /sub > S ON NON-OPSONIZED ZYMOSAN PHAGOCYTOSIS BY MACROPHAGES
Toxicon. 2024 Apr 11:107716. doi: 10.1016/j.toxicon.2024.107716. Online ahead of print.ABSTRACTThe phagocytic activity of macrophages activated with MT-II, a Lys-49 PLA2 homolog, and MT-III, an Asp-49 PLA2, from Bothrops asper snake venom, was investigated in this study using a pharmacological approach. Stimulating thioglycollate-elicited macrophages with both venom components enhanced their ability to phagocytose non-opsonized zymosan particles. MT-II and MT-III-induced phagocytosis was drastically inhibited by pretreating cells with L-NAME, aminoguanidine or L-NIL, cNOS or iNOS inhibitors, or with ODQ (sGC inhibitor) or ...
Source: Toxicon - April 13, 2024 Category: Toxicology Authors: Juliana Pavan Zuliani Jos é María Gutiérrez Catarina Teixeira Source Type: research
The PLA < sub > 2 < /sub > inhibitor from Crotalus durissus terrificus blood plasma (CNF) inhibits group III-PLA < sub > 2 < /sub > from honeybee venom
Toxicon. 2024 Apr 5;242:107711. doi: 10.1016/j.toxicon.2024.107711. Online ahead of print.ABSTRACTCrotalus neutralizing factor (CNF) is an endogenous glycoprotein from Crotalus durissus terrificus snake blood that inhibits secretory phospholipases A2 (sPLA2) from the Viperid but not from Elapid venoms (subgroups IA and IIA, respectively). In the present study, we demonstrated that CNF can inhibit group III-PLA2 from bee venom by forming a stable enzyme-inhibitor complex. This finding opens up new possibilities for the potential use of CNF and/or CNF-based derivatives in the therapeutics of bee stings.PMID:38583578 | DOI:10...
Source: Toxicon - April 7, 2024 Category: Toxicology Authors: Paula Ladeira Ortolani Patr ícia Cota Campos Consuelo Latorre Fortes-Dias Source Type: research
The PLA < sub > 2 < /sub > inhibitor from Crotalus durissus terrificus blood plasma (CNF) inhibits group III-PLA < sub > 2 < /sub > from honeybee venom
Toxicon. 2024 Apr 5;242:107711. doi: 10.1016/j.toxicon.2024.107711. Online ahead of print.ABSTRACTCrotalus neutralizing factor (CNF) is an endogenous glycoprotein from Crotalus durissus terrificus snake blood that inhibits secretory phospholipases A2 (sPLA2) from the Viperid but not from Elapid venoms (subgroups IA and IIA, respectively). In the present study, we demonstrated that CNF can inhibit group III-PLA2 from bee venom by forming a stable enzyme-inhibitor complex. This finding opens up new possibilities for the potential use of CNF and/or CNF-based derivatives in the therapeutics of bee stings.PMID:38583578 | DOI:10...
Source: Toxicon - April 7, 2024 Category: Toxicology Authors: Paula Ladeira Ortolani Patr ícia Cota Campos Consuelo Latorre Fortes-Dias Source Type: research
The PLA < sub > 2 < /sub > inhibitor from Crotalus durissus terrificus blood plasma (CNF) inhibits group III-PLA < sub > 2 < /sub > from honeybee venom
Toxicon. 2024 Apr 5;242:107711. doi: 10.1016/j.toxicon.2024.107711. Online ahead of print.ABSTRACTCrotalus neutralizing factor (CNF) is an endogenous glycoprotein from Crotalus durissus terrificus snake blood that inhibits secretory phospholipases A2 (sPLA2) from the Viperid but not from Elapid venoms (subgroups IA and IIA, respectively). In the present study, we demonstrated that CNF can inhibit group III-PLA2 from bee venom by forming a stable enzyme-inhibitor complex. This finding opens up new possibilities for the potential use of CNF and/or CNF-based derivatives in the therapeutics of bee stings.PMID:38583578 | DOI:10...
Source: Toxicon - April 7, 2024 Category: Toxicology Authors: Paula Ladeira Ortolani Patr ícia Cota Campos Consuelo Latorre Fortes-Dias Source Type: research
The PLA < sub > 2 < /sub > inhibitor from Crotalus durissus terrificus blood plasma (CNF) inhibits group III-PLA < sub > 2 < /sub > from honeybee venom
Toxicon. 2024 Apr 5:107711. doi: 10.1016/j.toxicon.2024.107711. Online ahead of print.ABSTRACTCrotalus neutralizing factor (CNF) is an endogenous glycoprotein from Crotalus durissus terrificus snake blood that inhibits secretory phospholipases A2 (sPLA2) from the Viperid but not from Elapid venoms (subgroups IA and IIA, respectively). In the present study, we demonstrated that CNF can inhibit group III-PLA2 from bee venom by forming a stable enzyme-inhibitor complex. This finding opens up new possibilities for the potential use of CNF and/or CNF-based derivatives in the therapeutics of bee stings.PMID:38583578 | DOI:10.101...
Source: Toxicon - April 7, 2024 Category: Toxicology Authors: Paula Ladeira Ortolani Patr ícia Cota Campos Consuelo Latorre Fortes-Dias Source Type: research
The PLA < sub > 2 < /sub > inhibitor from Crotalus durissus terrificus blood plasma (CNF) inhibits group III-PLA < sub > 2 < /sub > from honeybee venom
Toxicon. 2024 Apr 5:107711. doi: 10.1016/j.toxicon.2024.107711. Online ahead of print.ABSTRACTCrotalus neutralizing factor (CNF) is an endogenous glycoprotein from Crotalus durissus terrificus snake blood that inhibits secretory phospholipases A2 (sPLA2) from the Viperid but not from Elapid venoms (subgroups IA and IIA, respectively). In the present study, we demonstrated that CNF can inhibit group III-PLA2 from bee venom by forming a stable enzyme-inhibitor complex. This finding opens up new possibilities for the potential use of CNF and/or CNF-based derivatives in the therapeutics of bee stings.PMID:38583578 | DOI:10.101...
Source: Toxicon - April 7, 2024 Category: Toxicology Authors: Paula Ladeira Ortolani Patr ícia Cota Campos Consuelo Latorre Fortes-Dias Source Type: research
Temporal variation in the concentrations and profiles of paralytic shellfish toxins and tetrodotoxin in scallop (Mizuhopecten yessoensis) and bloody clam (Anadara broughtonii) collected from the coast of Miyagi Prefecture, Japan
Toxicon. 2024 Apr 3:107710. doi: 10.1016/j.toxicon.2024.107710. Online ahead of print.ABSTRACTFor food safety, the concentrations and profiles of paralytic shellfish toxins (PSTs) and tetrodotoxin were examined in economically important scallops and bloody clams collected from the coast of the Miyagi Prefecture, Japan. PSTs were the major toxins in both species. The tetrodotoxin concentration in scallops increased in summer, although the highest value (18.7 μg/kg) was lower than the European Food Safety Authority guideline threshold (44 μg/kg). This confirmed the safety for tetrodotoxin in this area.PMID:38579982 | DOI:1...
Source: Toxicon - April 5, 2024 Category: Toxicology Authors: Tatsunari Shingai Yoshiko Chiba Mitsue Kondo Mari Yotsu-Yamashita Source Type: research
Cu-doped Fe < sub > 3 < /sub > O < sub > 4 < /sub > nanoparticles for efficient detoxification of epsilon toxin: Toward substituting magnetically recyclable detoxifying agent for formaldehyde
This study provides valuable insights into the development of an efficient and safe detoxifying agent, enabling the production of toxoids with a native-like structure. The magnetically recoverable and reusable nature of Cu-Fe3O4 nanoparticles offers practical advantages for easy recovery and reuse in detoxification reactions.PMID:38579983 | DOI:10.1016/j.toxicon.2024.107707 (Source: Toxicon)
Source: Toxicon - April 5, 2024 Category: Toxicology Authors: Parvaneh Esmaeilnejad-Ahranjani Marzieh Lotfi Azadeh Zahmatkesh Abbass Ali Esskandary Source Type: research
Temporal variation in the concentrations and profiles of paralytic shellfish toxins and tetrodotoxin in scallop (Mizuhopecten yessoensis) and bloody clam (Anadara broughtonii) collected from the coast of Miyagi Prefecture, Japan
Toxicon. 2024 Apr 3:107710. doi: 10.1016/j.toxicon.2024.107710. Online ahead of print.ABSTRACTFor food safety, the concentrations and profiles of paralytic shellfish toxins (PSTs) and tetrodotoxin were examined in economically important scallops and bloody clams collected from the coast of the Miyagi Prefecture, Japan. PSTs were the major toxins in both species. The tetrodotoxin concentration in scallops increased in summer, although the highest value (18.7 μg/kg) was lower than the European Food Safety Authority guideline threshold (44 μg/kg). This confirmed the safety for tetrodotoxin in this area.PMID:38579982 | DOI:1...
Source: Toxicon - April 5, 2024 Category: Toxicology Authors: Tatsunari Shingai Yoshiko Chiba Mitsue Kondo Mari Yotsu-Yamashita Source Type: research
Cu-doped Fe < sub > 3 < /sub > O < sub > 4 < /sub > nanoparticles for efficient detoxification of epsilon toxin: Toward substituting magnetically recyclable detoxifying agent for formaldehyde
This study provides valuable insights into the development of an efficient and safe detoxifying agent, enabling the production of toxoids with a native-like structure. The magnetically recoverable and reusable nature of Cu-Fe3O4 nanoparticles offers practical advantages for easy recovery and reuse in detoxification reactions.PMID:38579983 | DOI:10.1016/j.toxicon.2024.107707 (Source: Toxicon)
Source: Toxicon - April 5, 2024 Category: Toxicology Authors: Parvaneh Esmaeilnejad-Ahranjani Marzieh Lotfi Azadeh Zahmatkesh Abbass Ali Esskandary Source Type: research
Temporal variation in the concentrations and profiles of paralytic shellfish toxins and tetrodotoxin in scallop (Mizuhopecten yessoensis) and bloody clam (Anadara broughtonii) collected from the coast of Miyagi Prefecture, Japan
Toxicon. 2024 Apr 3:107710. doi: 10.1016/j.toxicon.2024.107710. Online ahead of print.ABSTRACTFor food safety, the concentrations and profiles of paralytic shellfish toxins (PSTs) and tetrodotoxin were examined in economically important scallops and bloody clams collected from the coast of the Miyagi Prefecture, Japan. PSTs were the major toxins in both species. The tetrodotoxin concentration in scallops increased in summer, although the highest value (18.7 μg/kg) was lower than the European Food Safety Authority guideline threshold (44 μg/kg). This confirmed the safety for tetrodotoxin in this area.PMID:38579982 | DOI:1...
Source: Toxicon - April 5, 2024 Category: Toxicology Authors: Tatsunari Shingai Yoshiko Chiba Mitsue Kondo Mari Yotsu-Yamashita Source Type: research
Cu-doped Fe < sub > 3 < /sub > O < sub > 4 < /sub > nanoparticles for efficient detoxification of epsilon toxin: Toward substituting magnetically recyclable detoxifying agent for formaldehyde
This study provides valuable insights into the development of an efficient and safe detoxifying agent, enabling the production of toxoids with a native-like structure. The magnetically recoverable and reusable nature of Cu-Fe3O4 nanoparticles offers practical advantages for easy recovery and reuse in detoxification reactions.PMID:38579983 | DOI:10.1016/j.toxicon.2024.107707 (Source: Toxicon)
Source: Toxicon - April 5, 2024 Category: Toxicology Authors: Parvaneh Esmaeilnejad-Ahranjani Marzieh Lotfi Azadeh Zahmatkesh Abbass Ali Esskandary Source Type: research
Exploration of antimicrobial and anticancer activities of L-amino acid oxidase from Egyptian Naja haje venom
Toxicon. 2024 Apr 2:107708. doi: 10.1016/j.toxicon.2024.107708. Online ahead of print.ABSTRACTHepatocellular carcinoma and bacterial resistance are major health burdens nowadays. Thus, providing new therapies that overcome that resistance is of great interest, particularly those derived from nature rather than chemotherapeutics to avoid cytotoxicity on normal cells. Venomous animals are among the natural sources that assisted in the discovery of novel therapeutic regimens. L-amino acid oxidase Nh-LAAO (140 kDa), purified from Egyptian Naja haje venom by a successive two-step chromatography protocol, has an optimal pH and t...
Source: Toxicon - April 4, 2024 Category: Toxicology Authors: Walaa H Salama Ahmed A Abd-Rabou Roqaya I Bassuiny Amr E ElHakim Yasser E Shahein Source Type: research
Acute death as a result of poisoning tropical (Bos taurus indicus) but not temperate (Bos taurus taurus) cattle after oral dosing with Lupinus leucophyllus (velvet lupine)
Toxicon. 2024 Apr 1:107706. doi: 10.1016/j.toxicon.2024.107706. Online ahead of print.ABSTRACTDue to climate change and increasing summer temperatures, tropical cattle may graze where temperate cattle have grazed, exposing tropical cattle to toxic plants they may be unfamiliar with. This work compared the toxicity of Lupinus leucophyllus (velvet lupine) in temperate and tropical cattle. Orally dosed velvet lupine in tropical cattle caused death. If producers opt to graze tropical cattle, additional care must be taken on rangelands where toxic lupines like velvet lupine grow.PMID:38570167 | DOI:10.1016/j.toxicon.2024.107706 (Source: Toxicon)
Source: Toxicon - April 3, 2024 Category: Toxicology Authors: Benedict T Green Kevin D Welch Stephen T Lee T Zane Davis Clinton A Stonecipher Bryan L Stegelmeier Daniel Cook Source Type: research
