Rats' testicular toxicity induced by bisphenol A is lessened by crocin via an antiapoptotic mechanism and bumped P-glycoprotein expression
In conclusion; Cr lessens the oxidative stress conditions to safeguard rats from the BPA-induced testicular toxicity and sex hormones abnormalities, reducing apoptosis and up-regulating P-gp.PMID:38458495 | DOI:10.1016/j.toxicon.2024.107674 (Source: Toxicon)
Source: Toxicon - March 8, 2024 Category: Toxicology Authors: Hesham A El-Beshbishy Dania S Waggas Rabab A Ali Source Type: research
Rats' testicular toxicity induced by bisphenol A is lessened by crocin via an antiapoptotic mechanism and bumped P-glycoprotein expression
In conclusion; Cr lessens the oxidative stress conditions to safeguard rats from the BPA-induced testicular toxicity and sex hormones abnormalities, reducing apoptosis and up-regulating P-gp.PMID:38458495 | DOI:10.1016/j.toxicon.2024.107674 (Source: Toxicon)
Source: Toxicon - March 8, 2024 Category: Toxicology Authors: Hesham A El-Beshbishy Dania S Waggas Rabab A Ali Source Type: research
Biochemical and toxicological profiles of venoms from an adult female South American bushmaster (Lachesis muta rhombeata) and her offspring
Toxicon. 2024 Mar 5:107680. doi: 10.1016/j.toxicon.2024.107680. Online ahead of print.ABSTRACTIn this work, we compared the biochemical and toxicological profiles of venoms from an adult female specimen of Lachesis muta rhombeata (South American bushmaster) and her seven offspring born in captivity, based on SDS-PAGE, RP-HPLC, enzymatic, coagulant, and hemorrhagic assays. Although adult and juvenile venoms showed comparable SDS-PAGE profiles, juveniles lacked some chromatographic peaks compared with adult venom. Adult venom had higher proteolytic (caseinolytic) activity than juvenile venoms (p < 0.05), but there were no...
Source: Toxicon - March 7, 2024 Category: Toxicology Authors: Nath ália C Galizio Laura S Moraes-Santos Ana C Yabunaka Poliana J Demico Kristian A Torres-Bonilla Julian C G Var ón Nelson J da Silva Anita M Tanaka-Azevedo Marisa M Teixeira da Rocha Stephen Hyslop Rafael S Floriano Karen de Morais-Zani Source Type: research
Biochemical and toxicological profiles of venoms from an adult female South American bushmaster (Lachesis muta rhombeata) and her offspring
Toxicon. 2024 Mar 5:107680. doi: 10.1016/j.toxicon.2024.107680. Online ahead of print.ABSTRACTIn this work, we compared the biochemical and toxicological profiles of venoms from an adult female specimen of Lachesis muta rhombeata (South American bushmaster) and her seven offspring born in captivity, based on SDS-PAGE, RP-HPLC, enzymatic, coagulant, and hemorrhagic assays. Although adult and juvenile venoms showed comparable SDS-PAGE profiles, juveniles lacked some chromatographic peaks compared with adult venom. Adult venom had higher proteolytic (caseinolytic) activity than juvenile venoms (p < 0.05), but there were no...
Source: Toxicon - March 7, 2024 Category: Toxicology Authors: Nath ália C Galizio Laura S Moraes-Santos Ana C Yabunaka Poliana J Demico Kristian A Torres-Bonilla Julian C G Var ón Nelson J da Silva Anita M Tanaka-Azevedo Marisa M Teixeira da Rocha Stephen Hyslop Rafael S Floriano Karen de Morais-Zani Source Type: research
β-keto amyrin isolated from Cryptostegia grandiflora R. br. inhibits inflammation caused by Daboia russellii viper venom: Direct binding of β-keto amyrin to phospholipase A < sub > 2 < /sub >
Toxicon. 2024 Mar 4:107679. doi: 10.1016/j.toxicon.2024.107679. Online ahead of print.ABSTRACTThe search for mechanism-based anti-inflammatory therapies is of fundamental importance to avoid undesired off-target effects. Phospholipase A2 (PLA2) activity is a potential molecular target for anti-inflammatory drugs because it fuels arachidonic acid needed to synthesize inflammation mediators, such as prostaglandins. Herein, we aim to investigate the molecular mechanism by which β-keto amyrin isolated from a methanolic extract of Cryptostegia grandiflora R. Br. Leaves can inhibit inflammation caused by Daboia russellii viper ...
Source: Toxicon - March 6, 2024 Category: Toxicology Authors: K H Santhosh V Krishna K Kemparaju H Manjunatha R Shashi Kumar Mukherjee Arnab S E Gomez Mejiba D C Ramirez B S Ravindranath Source Type: research
Real-world differences in dosing and clinical utilization of OnabotulinumtoxinA and AbobotulinumtoxinA in the treatment of upper limb spasticity
Toxicon. 2024 Mar 4:107678. doi: 10.1016/j.toxicon.2024.107678. Online ahead of print.ABSTRACTAccording to prescribing information, potency units are not interchangeable between botulinum toxin A products. This exploratory study compared real-world dosing and utilization of onabotulinumtoxinA and abobotulinumtoxinA in adults with upper limb spasticity. In this retrospective study, 101 clinicians provided chart data via online surveys for 215 US post-stroke patients treated for upper limb spasticity with ≥3 onabotulinumtoxinA or abobotulinumtoxinA doses (phase 1: 9/18/2020-12/10/2020; phase 2: 9/30/2021-12/7/2021). Most p...
Source: Toxicon - March 6, 2024 Category: Toxicology Authors: Zachary Bohart Khashayar Dashtipour Heakyung Kim Marc Schwartz Aleks Zuzek Ritu Singh Mariana Nelson Source Type: research
β-keto amyrin isolated from Cryptostegia grandiflora R. br. inhibits inflammation caused by Daboia russellii viper venom: Direct binding of β-keto amyrin to phospholipase A < sub > 2 < /sub >
Toxicon. 2024 Mar 4:107679. doi: 10.1016/j.toxicon.2024.107679. Online ahead of print.ABSTRACTThe search for mechanism-based anti-inflammatory therapies is of fundamental importance to avoid undesired off-target effects. Phospholipase A2 (PLA2) activity is a potential molecular target for anti-inflammatory drugs because it fuels arachidonic acid needed to synthesize inflammation mediators, such as prostaglandins. Herein, we aim to investigate the molecular mechanism by which β-keto amyrin isolated from a methanolic extract of Cryptostegia grandiflora R. Br. Leaves can inhibit inflammation caused by Daboia russellii viper ...
Source: Toxicon - March 6, 2024 Category: Toxicology Authors: K H Santhosh V Krishna K Kemparaju H Manjunatha R Shashi Kumar Mukherjee Arnab S E Gomez Mejiba D C Ramirez B S Ravindranath Source Type: research
Real-world differences in dosing and clinical utilization of OnabotulinumtoxinA and AbobotulinumtoxinA in the treatment of upper limb spasticity
Toxicon. 2024 Mar 4:107678. doi: 10.1016/j.toxicon.2024.107678. Online ahead of print.ABSTRACTAccording to prescribing information, potency units are not interchangeable between botulinum toxin A products. This exploratory study compared real-world dosing and utilization of onabotulinumtoxinA and abobotulinumtoxinA in adults with upper limb spasticity. In this retrospective study, 101 clinicians provided chart data via online surveys for 215 US post-stroke patients treated for upper limb spasticity with ≥3 onabotulinumtoxinA or abobotulinumtoxinA doses (phase 1: 9/18/2020-12/10/2020; phase 2: 9/30/2021-12/7/2021). Most p...
Source: Toxicon - March 6, 2024 Category: Toxicology Authors: Zachary Bohart Khashayar Dashtipour Heakyung Kim Marc Schwartz Aleks Zuzek Ritu Singh Mariana Nelson Source Type: research
Morusin suppresses the stemness characteristics of gastric cancer cells induced by hypoxic microenvironment through inhibition of HIF-1 α accumulation
Toxicon. 2024 Mar 1:107675. doi: 10.1016/j.toxicon.2024.107675. Online ahead of print.ABSTRACTGastric cancer (GC) is a common, life-threatening malignancy that contributes to the global burden of cancer-related mortality, as conventional therapeutic modalities show limited effects on GC. Hence, it is critical to develop novel agents for GC therapy. Morusin, a typical prenylated flavonoid, possesses antitumor effects against various cancers. The present study aimed to demonstrate the inhibitory effect and mechanism of morusin on the stemness characteristics of human GC in vitro under hypoxia and to explore the potential mol...
Source: Toxicon - March 3, 2024 Category: Toxicology Authors: Mo Chen Shufeng Xiao Ping Sun Yongfu Li Zhixing Xu Jun Wang Source Type: research
Highly in vitro anti-cancer activity of melittin-loaded niosomes on non-small cell lung cancer cells
CONCLUSIONS: Melittin-loaded niosomes had more anti-cancer effects and less toxicity on normal cells than free melittin. Furthermore, it induced apoptosis and inhibited cancer cells migration. Our results showed that melittin-loaded niosomes may be a drug lead and it has the potential to be future developed for lung cancer treatment.PMID:38432612 | DOI:10.1016/j.toxicon.2024.107673 (Source: Toxicon)
Source: Toxicon - March 3, 2024 Category: Toxicology Authors: Pooyan Honari Delavar Shahbazzadeh Mahdi Behdani Kamran Pooshang Bagheri Source Type: research
Morusin suppresses the stemness characteristics of gastric cancer cells induced by hypoxic microenvironment through inhibition of HIF-1 α accumulation
Toxicon. 2024 Mar 1:107675. doi: 10.1016/j.toxicon.2024.107675. Online ahead of print.ABSTRACTGastric cancer (GC) is a common, life-threatening malignancy that contributes to the global burden of cancer-related mortality, as conventional therapeutic modalities show limited effects on GC. Hence, it is critical to develop novel agents for GC therapy. Morusin, a typical prenylated flavonoid, possesses antitumor effects against various cancers. The present study aimed to demonstrate the inhibitory effect and mechanism of morusin on the stemness characteristics of human GC in vitro under hypoxia and to explore the potential mol...
Source: Toxicon - March 3, 2024 Category: Toxicology Authors: Mo Chen Shufeng Xiao Ping Sun Yongfu Li Zhixing Xu Jun Wang Source Type: research
Highly in vitro anti-cancer activity of melittin-loaded niosomes on non-small cell lung cancer cells
CONCLUSIONS: Melittin-loaded niosomes had more anti-cancer effects and less toxicity on normal cells than free melittin. Furthermore, it induced apoptosis and inhibited cancer cells migration. Our results showed that melittin-loaded niosomes may be a drug lead and it has the potential to be future developed for lung cancer treatment.PMID:38432612 | DOI:10.1016/j.toxicon.2024.107673 (Source: Toxicon)
Source: Toxicon - March 3, 2024 Category: Toxicology Authors: Pooyan Honari Delavar Shahbazzadeh Mahdi Behdani Kamran Pooshang Bagheri Source Type: research
Morusin suppresses the stemness characteristics of gastric cancer cells induced by hypoxic microenvironment through inhibition of HIF-1 α accumulation
Toxicon. 2024 Mar 1:107675. doi: 10.1016/j.toxicon.2024.107675. Online ahead of print.ABSTRACTGastric cancer (GC) is a common, life-threatening malignancy that contributes to the global burden of cancer-related mortality, as conventional therapeutic modalities show limited effects on GC. Hence, it is critical to develop novel agents for GC therapy. Morusin, a typical prenylated flavonoid, possesses antitumor effects against various cancers. The present study aimed to demonstrate the inhibitory effect and mechanism of morusin on the stemness characteristics of human GC in vitro under hypoxia and to explore the potential mol...
Source: Toxicon - March 3, 2024 Category: Toxicology Authors: Mo Chen Shufeng Xiao Ping Sun Yongfu Li Zhixing Xu Jun Wang Source Type: research
Highly in vitro anti-cancer activity of melittin-loaded niosomes on non-small cell lung cancer cells
CONCLUSIONS: Melittin-loaded niosomes had more anti-cancer effects and less toxicity on normal cells than free melittin. Furthermore, it induced apoptosis and inhibited cancer cells migration. Our results showed that melittin-loaded niosomes may be a drug lead and it has the potential to be future developed for lung cancer treatment.PMID:38432612 | DOI:10.1016/j.toxicon.2024.107673 (Source: Toxicon)
Source: Toxicon - March 3, 2024 Category: Toxicology Authors: Pooyan Honari Delavar Shahbazzadeh Mahdi Behdani Kamran Pooshang Bagheri Source Type: research
Evaluation of the toxicological effects of Neltuma alpataco (Prosopis alpataco) pod alkaloid extract
This study aimed to determine the alkaloid content, as well as the in vitro and in vivo effects of an alkaloid-enriched extract (AEE) from N. alpataco pods. High performance liquid chromatography-high resolution mass spectrometry (HPLC-HRMS) identified juliprosine and juliprosopine as primary alkaloids, with juliprosine being most abundant. AEE from N. alpataco demonstrated dose-dependent cytotoxicity on glioma cells after 48 h, with a 50% cytotoxic concentration (CC50) of 24.69 μg/mL. However, the release of LDH was observed only at the highest tested concentration, indicating cellular damage. Further examination through...
Source: Toxicon - March 1, 2024 Category: Toxicology Authors: Luciana Cholich Mar ía Pistán Angelica Cabrera Ben ítez Ana Torres Enrique Nicolas Garc ía Agust ín Martinez Dale Gardner Soledad Bustillo Source Type: research
