Candida die-off: Adverse effect and neutralization with phytotherapy approaches
In conclusion, this article serves as a meticulous compilation of knowledge on the intriguing subject of Candida die-off, presenting a distinct and informative perspective that has the potential to pave the way for new insights in the realm of plant-based antifungal therapeutics.PMID:38072320 | DOI:10.1016/j.toxicon.2023.107555 (Source: Toxicon)
Source: Toxicon - December 10, 2023 Category: Toxicology Authors: Neha Jaiswal Awanish Kumar Source Type: research
Paris polyphylla saponins II inhibits invasive, migration and epithelial-mesenchymal transition of melanoma cells through activation of autophagy
This study explored the role of PPII in promoting autophagy to inhibit EMT of melanoma cells, the role of PI3K/Akt signaling pathway in the invasion and migration of melanoma cells induced by PPII. We found that PPII effectively inhibited the proliferation, invasion and migration of melanoma B16 and B16F10 in vitro, and induced autophagy. We also established the xenograft tumor and metastatic tumor model of C57BL/6 mice with B16F10 cells. Results showed that PPII effectively inhibited the growth of transplanted tumor, induced autophagy and inhibited the expression level of EMT related protein; Metastasis experiment showed ...
Source: Toxicon - December 10, 2023 Category: Toxicology Authors: Hui Cheng Jing Chu Yuting Yang Yueyue Li Meng Wang Huan Wu Manman Wang Jingjing Su Qinglin Li Source Type: research
Chlorophyllum molybdites poisoning on Reunion Island
Toxicon. 2023 Dec 8:107554. doi: 10.1016/j.toxicon.2023.107554. Online ahead of print.ABSTRACTIn France, mushroom picking is part of the culture. The practice is not without risk, as around 1300 people are poisoned each year by eating wild mushrooms on the French mainland. However, this practice is not part of local culture on Reunion Island, a French territory located in the Indian Ocean. Indeed, there are practically no reports of mushroom poisoning on Reunion Island. Here we describe, through a retrospective study, cases of mushroom poisoning recorded in the Indian Ocean toxicosurveillance system database from 2020 to 2...
Source: Toxicon - December 10, 2023 Category: Toxicology Authors: Adrien Maillot Adrien Marteau J érémy Lecot Chloe Bruneau Gael Le Roux Luc De Haro Elliott Chaumont Source Type: research
Metatranscriptome analysis reveals the putative venom toxin repertoire of the biofouling hydroid Ectopleura larynx
In this study, we generated a whole transcriptome of E. larynx, and identified its putative expressed venom toxin proteins (predicted toxin proteins, not functionally characterized) based on in silico transcriptome annotation mining and protein sequence analysis. The results uncovered a broad and diverse repertoire of putative toxin proteins for this hydroid species. Its toxic arsenal appears to include a wide and complex selection of toxin proteins, covering a large panel of potential biological functions that play important roles in envenomation. The putative toxins identified in this species, such as neurotoxins, GTPase...
Source: Toxicon - December 10, 2023 Category: Toxicology Authors: Laur ène Alicia Lecaudey Roman Netzer Daniel Wibberg Tobias Busche Nina Bloecher Source Type: research
A case of rotenone poisoning from ingesting Derris trifoliata Lour. (Tuba fruit/pod) in Malaysia
Toxicon. 2023 Dec 8:107557. doi: 10.1016/j.toxicon.2023.107557. Online ahead of print.ABSTRACTDerris trifoliata is mainly found in mangrove area in tropical regions and the plant extract is traditionally used for fishing by poisoning. This is the first case report of rotenone poisoning in a child from ingesting Derris trifoliata seed. The child developed altered consciousness, vomiting, hypotension, metabolic acidosis, and acute kidney injury. Species identification of this case requires the collaborative efforts of various agencies. She survived from the poisoning with no neurological sequelae.PMID:38072318 | DOI:10.1016/...
Source: Toxicon - December 10, 2023 Category: Toxicology Authors: Si Ling Yeoh Pheik Sian Choong Rahmad Zakaria Nur Azzalia Kamaruzaman Sazaroni Md Rashid Mohd Fadhli Razali Ahmad Khaldun Ismail Source Type: research
Spirulina platensis ameliorates hepatic oxidative stress and DNA damage induced by aflatoxin B1 in rats
Toxicon. 2023 Dec 8:107553. doi: 10.1016/j.toxicon.2023.107553. Online ahead of print.ABSTRACTAflatoxin B1 (AFB1) is a widely distributed mycotoxin, causing hepatotoxicity and oxidative stress. One of the most famous unicellular cyanobacteria is Spirulina platensis (SP) which is well known for its antioxidant characteristics against many toxicants. Therefore, this study aimed to investigate the antioxidant potential and hepatoprotective ability of SP against oxidative stress and cytotoxicity in male Wistar albino rats intraperitoneally injected with AFB1. Rats were separated into five groups as follows: negative control ad...
Source: Toxicon - December 10, 2023 Category: Toxicology Authors: Ahmed E Altyar Osama A Kensara Ahmed E Noreldin Ghadeer M Albadrani Fatma M El-Demerdash Amany A Sayed Marina Piscopo Zuhair M Mohammedsaleh Muath Q Al-Ghadi Nehmat Ghaboura Mohamed M Abdel-Daim Source Type: research
Candida die-off: Adverse effect and neutralization with phytotherapy approaches
In conclusion, this article serves as a meticulous compilation of knowledge on the intriguing subject of Candida die-off, presenting a distinct and informative perspective that has the potential to pave the way for new insights in the realm of plant-based antifungal therapeutics.PMID:38072320 | DOI:10.1016/j.toxicon.2023.107555 (Source: Toxicon)
Source: Toxicon - December 10, 2023 Category: Toxicology Authors: Neha Jaiswal Awanish Kumar Source Type: research
Extraction and analysis by liquid chromatography - tandem mass spectrometry of intra- and extracellular microcystins and nodularin to study the fate of cyanobacteria and cyanotoxins across the freshwater-marine continuum
Toxicon. 2023 Dec 7;237:107551. doi: 10.1016/j.toxicon.2023.107551. Online ahead of print.ABSTRACTThe presence of microcystins (MCs) is increasingly being reported in coastal areas worldwide. To provide reliable data regarding this emerging concern, reproducible and accurate methods are required to quantify MCs in salt-containing samples. Herein, we characterized methods of extraction and analysis by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) for nine MCs and one nodularin (NOD) variants in both cyanobacteria (intracellular) and dissolved forms (extracellular). Different approaches have been used ...
Source: Toxicon - December 9, 2023 Category: Toxicology Authors: Damien R éveillon Maxime Georges des Aulnois V éronique Savar Elise Robert Amandine M N Caruana Enora Briand Myriam Bormans Source Type: research
Venomics of Leiurus abdullahbayrami, the most lethal scorpion in the Levant region of the Middle East
We report on the composition of L. abdullahbayrami venom collected from Lebanese specimens using nESI-MS/MS, MALDI-TOF MS, SDS-PAGE and RP-HPLC. Venom lethality, through LD50 determination in mice (intraperitoneal), was also assessed (0.75 (0.16-1.09) mg/kg), confirming L.abdullahbayrami venom vertebrate toxicity. Fifty-four peaks were detected using RP-HPLC, half of which eluted in the gradient region between 20 and 40% acetonitrile. In reducing SDS-PAGE, most predominant components were <10 kDa, with minor components at higher molecular masses of 24.4, 43.1, and 48.9 kDa. Venom mass fingerprint by MALDI-TOF detected 2...
Source: Toxicon - December 8, 2023 Category: Toxicology Authors: Adolfo Borges Bruno Lomonte Source Type: research
Unveiling the secrets of snakes: Analysis of environmental, socioeconomic, and spatial factors associated with snakebite risk in Paran á, Southern Brazil
This study aimed to ascertain the spatial, environmental, and socioeconomic factors associated with snakebite risk by analyzing notification data of cases in the state of Paraná. Notification and socioeconomic data were gathered from the online platforms of the National System of Notifiable Diseases (SINAN) and the Brazilian Institute of Geography and Statistics (IBGE). Land cover and land use maps were obtained from the Mapbiomas platform in raster format and subsequently converted into vectors using QGis software. The proportions of land use and land cover in square kilometers (km2) were then calculated. All acquired da...
Source: Toxicon - December 8, 2023 Category: Toxicology Authors: Isabelli Sayuri Kono Victor C ésar Freitas Pandolfi Melca Niceia Alto é de Marchi Nicolas Freitas Roberta Lemos Freire Source Type: research
Three snake venoms from Bothrops genus induced apoptosis and cell cycle arrest in K562 human leukemic cell line
Toxicon. 2023 Dec 6:107547. doi: 10.1016/j.toxicon.2023.107547. Online ahead of print.ABSTRACTCancer is indisputably one of the leading causes of death worldwide. Snake venoms are a potential source of bioactive compounds, complex mixtures constituted mainly of proteins and peptides with several pharmacological possibilities, including the potential to inhibit tumoral cell growth. In the present study, it was evaluated the antitumor effect of crude venom of Bothrops erythromelas (BeV), Bothrops jararaca (from Southern and Southeastern- BjsV and BjsdV, respectively) and Bothrops alternatus (BaV) in in vitro Chronic myeloid ...
Source: Toxicon - December 8, 2023 Category: Toxicology Authors: Aline D Marinho Emerson Lucena da Silva Adrhyann Jullyanne de Sousa Portilho La ís Lacerda Brasil de Oliveira Emanuel Cintra Austreg ésilo Bezerra Beatriz Maria Dias Nogueira Moema Leit ão-Araújo Maria L úcia Machado-Alves Carlos Correa Neto Rui Seab Source Type: research
Venomics of Leiurus abdullahbayrami, the most lethal scorpion in the Levant region of the Middle East
We report on the composition of L. abdullahbayrami venom collected from Lebanese specimens using nESI-MS/MS, MALDI-TOF MS, SDS-PAGE and RP-HPLC. Venom lethality, through LD50 determination in mice (intraperitoneal), was also assessed (0.75 (0.16-1.09) mg/kg), confirming L.abdullahbayrami venom vertebrate toxicity. Fifty-four peaks were detected using RP-HPLC, half of which eluted in the gradient region between 20 and 40% acetonitrile. In reducing SDS-PAGE, most predominant components were <10 kDa, with minor components at higher molecular masses of 24.4, 43.1, and 48.9 kDa. Venom mass fingerprint by MALDI-TOF detected 2...
Source: Toxicon - December 8, 2023 Category: Toxicology Authors: Adolfo Borges Bruno Lomonte Source Type: research
Unveiling the secrets of snakes: Analysis of environmental, socioeconomic, and spatial factors associated with snakebite risk in Paran á, Southern Brazil
This study aimed to ascertain the spatial, environmental, and socioeconomic factors associated with snakebite risk by analyzing notification data of cases in the state of Paraná. Notification and socioeconomic data were gathered from the online platforms of the National System of Notifiable Diseases (SINAN) and the Brazilian Institute of Geography and Statistics (IBGE). Land cover and land use maps were obtained from the Mapbiomas platform in raster format and subsequently converted into vectors using QGis software. The proportions of land use and land cover in square kilometers (km2) were then calculated. All acquired da...
Source: Toxicon - December 8, 2023 Category: Toxicology Authors: Isabelli Sayuri Kono Victor C ésar Freitas Pandolfi Melca Niceia Alto é de Marchi Nicolas Freitas Roberta Lemos Freire Source Type: research
Three snake venoms from Bothrops genus induced apoptosis and cell cycle arrest in K562 human leukemic cell line
Toxicon. 2023 Dec 6:107547. doi: 10.1016/j.toxicon.2023.107547. Online ahead of print.ABSTRACTCancer is indisputably one of the leading causes of death worldwide. Snake venoms are a potential source of bioactive compounds, complex mixtures constituted mainly of proteins and peptides with several pharmacological possibilities, including the potential to inhibit tumoral cell growth. In the present study, it was evaluated the antitumor effect of crude venom of Bothrops erythromelas (BeV), Bothrops jararaca (from Southern and Southeastern- BjsV and BjsdV, respectively) and Bothrops alternatus (BaV) in in vitro Chronic myeloid ...
Source: Toxicon - December 8, 2023 Category: Toxicology Authors: Aline D Marinho Emerson Lucena da Silva Adrhyann Jullyanne de Sousa Portilho La ís Lacerda Brasil de Oliveira Emanuel Cintra Austreg ésilo Bezerra Beatriz Maria Dias Nogueira Moema Leit ão-Araújo Maria L úcia Machado-Alves Carlos Correa Neto Rui Seab Source Type: research
Toxicological effects of acute and repeated doses (180 days) of fruits from Malpighia emarginata (acerola) in rodents
Toxicon. 2023 Dec 5:107550. doi: 10.1016/j.toxicon.2023.107550. Online ahead of print.ABSTRACTMalpighia emarginata has a high amount of vitamin C with pharmacological or food preservation potential. However, despite its wide use and application possibilities its toxicity in repeated doses and for a long time (6 months) has not yet been studied. In this context, this study aimed to evaluate the acute toxicity and repeated doses from fruits of this plant. The extract was produced with the pulp (EMe) of the lyophilized fruit and submitted to chromatographic and spectroscopic analysis (HPLC and ESI-IT-MSn). In the acute test, ...
Source: Toxicon - December 7, 2023 Category: Toxicology Authors: Ângela Barichello Giovana T Capoani Flavia M Comachio Guilherme G Kielb Gustavo L Colpani M árcio A Fiori Max V Guti érrez Micheli Zanetti Vanessa da Silva Corralo Walter A Roman Junior Source Type: research
