Acute death as a result of poisoning tropical (Bos taurus indicus) but not temperate (Bos taurus taurus) cattle after oral dosing with Lupinus leucophyllus (velvet lupine)
Toxicon. 2024 Apr 1:107706. doi: 10.1016/j.toxicon.2024.107706. Online ahead of print.ABSTRACTDue to climate change and increasing summer temperatures, tropical cattle may graze where temperate cattle have grazed, exposing tropical cattle to toxic plants they may be unfamiliar with. This work compared the toxicity of Lupinus leucophyllus (velvet lupine) in temperate and tropical cattle. Orally dosed velvet lupine in tropical cattle caused death. If producers opt to graze tropical cattle, additional care must be taken on rangelands where toxic lupines like velvet lupine grow.PMID:38570167 | DOI:10.1016/j.toxicon.2024.107706 (Source: Toxicon)
Source: Toxicon - April 3, 2024 Category: Toxicology Authors: Benedict T Green Kevin D Welch Stephen T Lee T Zane Davis Clinton A Stonecipher Bryan L Stegelmeier Daniel Cook Source Type: research
Protobothrops jerdonii (Jerdon's pit-viper) and Protobothrops himalayanus bites: Clinical report on envenomings from North-East India, managed through remote consultation by a national-level Poison control center
Toxicon. 2024 Mar 31:107704. doi: 10.1016/j.toxicon.2024.107704. Online ahead of print.ABSTRACTMembers of the genus Protobothrops are amongst the more than twenty-eight range-restricted Indian pit-viper species. Their bites and envenomings are rarely documented from India. Pit-viper envenomings can be challenging to treat in the Indian setting, since available antivenoms do not satisfactorily neutralize their venoms. Herein, we present the first Indian reports on bites and envenoming by Protobothrops jerdonii and Protobothrops himalayanus resulting in local effects, coagulopathy and acute kidney injury in the case of the f...
Source: Toxicon - April 2, 2024 Category: Toxicology Authors: Ravikar Ralph Deepak Sharma Rohit Jain Amith Balachandran Yu-Wei Chiang Ganesh S R Source Type: research
Protobothrops jerdonii (Jerdon's pit-viper) and Protobothrops himalayanus bites: Clinical report on envenomings from North-East India, managed through remote consultation by a national-level Poison control center
Toxicon. 2024 Mar 31:107704. doi: 10.1016/j.toxicon.2024.107704. Online ahead of print.ABSTRACTMembers of the genus Protobothrops are amongst the more than twenty-eight range-restricted Indian pit-viper species. Their bites and envenomings are rarely documented from India. Pit-viper envenomings can be challenging to treat in the Indian setting, since available antivenoms do not satisfactorily neutralize their venoms. Herein, we present the first Indian reports on bites and envenoming by Protobothrops jerdonii and Protobothrops himalayanus resulting in local effects, coagulopathy and acute kidney injury in the case of the f...
Source: Toxicon - April 2, 2024 Category: Toxicology Authors: Ravikar Ralph Deepak Sharma Rohit Jain Amith Balachandran Yu-Wei Chiang Ganesh S R Source Type: research
Varespladib mitigates acute liver injury via suppression of excessive mitophagy on Naja atra envenomed mice by inhibiting PLA < sub > 2 < /sub >
Toxicon. 2024 Mar 29:107694. doi: 10.1016/j.toxicon.2024.107694. Online ahead of print.ABSTRACTSnakebite envenomation often leads to severe visceral injuries, including acute liver injury (ALI). However, the toxicity mechanism remains unclear. Moreover, varespladib can directly inhibit phospholipase A2 (PLA2) in snake venom, but its protective effect on snakebite-induced ALI and the mechanism have not been clarified. Previous studies have shown that snake PLA2 leads to neuron cell death via reactive oxygen species (ROS), one of the initial factors related to the mitophagy pathway. The present study group also found that RO...
Source: Toxicon - March 31, 2024 Category: Toxicology Authors: Wenjie Zhao Jiahao Liu Sidan Wang Qinqin Tao Qiongqiong Lei Chunhong Huang Source Type: research
Knockdown of lncRNA NEAT1 suppresses streptococcus pneumoniae-induced ferroptosis in alveolar epithelial cells by regulating the Nrf2-GPX4 pathway
CONCLUSIONS: LncRNA NEAT1 knockdown suppressed SP-induced HPAEpiC ferroptosis by activating Nrf2-GPX4 pathway, thereby alleviating cell injury and inflammatory response.PMID:38556062 | DOI:10.1016/j.toxicon.2024.107705 (Source: Toxicon)
Source: Toxicon - March 31, 2024 Category: Toxicology Authors: Lin Xu Lu Zhang Yang Xiang Xiangyan Zhang Source Type: research
Varespladib mitigates acute liver injury via suppression of excessive mitophagy on Naja atra envenomed mice by inhibiting PLA < sub > 2 < /sub >
Toxicon. 2024 Mar 29:107694. doi: 10.1016/j.toxicon.2024.107694. Online ahead of print.ABSTRACTSnakebite envenomation often leads to severe visceral injuries, including acute liver injury (ALI). However, the toxicity mechanism remains unclear. Moreover, varespladib can directly inhibit phospholipase A2 (PLA2) in snake venom, but its protective effect on snakebite-induced ALI and the mechanism have not been clarified. Previous studies have shown that snake PLA2 leads to neuron cell death via reactive oxygen species (ROS), one of the initial factors related to the mitophagy pathway. The present study group also found that RO...
Source: Toxicon - March 31, 2024 Category: Toxicology Authors: Wenjie Zhao Jiahao Liu Sidan Wang Qinqin Tao Qiongqiong Lei Chunhong Huang Source Type: research
Knockdown of lncRNA NEAT1 suppresses streptococcus pneumoniae-induced ferroptosis in alveolar epithelial cells by regulating the Nrf2-GPX4 pathway
CONCLUSIONS: LncRNA NEAT1 knockdown suppressed SP-induced HPAEpiC ferroptosis by activating Nrf2-GPX4 pathway, thereby alleviating cell injury and inflammatory response.PMID:38556062 | DOI:10.1016/j.toxicon.2024.107705 (Source: Toxicon)
Source: Toxicon - March 31, 2024 Category: Toxicology Authors: Lin Xu Lu Zhang Yang Xiang Xiangyan Zhang Source Type: research
Indian green pit vipers: A lesser-known snake group of north-east India
In this study, a comparative venomic of green pit vipers of Northern and North-eastern India, their clinical manifestation as well as treatment protocol has been reviewed.PMID:38531479 | DOI:10.1016/j.toxicon.2024.107689 (Source: Toxicon)
Source: Toxicon - March 26, 2024 Category: Toxicology Authors: Susmita Thakur Surajit Giri H T Lalremsanga Robin Doley Source Type: research
Indian green pit vipers: A lesser-known snake group of north-east India
In this study, a comparative venomic of green pit vipers of Northern and North-eastern India, their clinical manifestation as well as treatment protocol has been reviewed.PMID:38531479 | DOI:10.1016/j.toxicon.2024.107689 (Source: Toxicon)
Source: Toxicon - March 26, 2024 Category: Toxicology Authors: Susmita Thakur Surajit Giri H T Lalremsanga Robin Doley Source Type: research
Indian green pit vipers: A lesser-known snake group of north-east India
In this study, a comparative venomic of green pit vipers of Northern and North-eastern India, their clinical manifestation as well as treatment protocol has been reviewed.PMID:38531479 | DOI:10.1016/j.toxicon.2024.107689 (Source: Toxicon)
Source: Toxicon - March 26, 2024 Category: Toxicology Authors: Susmita Thakur Surajit Giri H T Lalremsenga Robin Doley Source Type: research
Indian green pit vipers: A lesser-known snake group of north-east India
In this study, a comparative venomic of green pit vipers of Northern and North-eastern India, their clinical manifestation as well as treatment protocol has been reviewed.PMID:38531479 | DOI:10.1016/j.toxicon.2024.107689 (Source: Toxicon)
Source: Toxicon - March 26, 2024 Category: Toxicology Authors: Susmita Thakur Surajit Giri H T Lalremsenga Robin Doley Source Type: research
Indian green pit vipers: A lesser-known snake group of north-east India
In this study, a comparative venomic of green pit vipers of Northern and North-eastern India, their clinical manifestation as well as treatment protocol has been reviewed.PMID:38531479 | DOI:10.1016/j.toxicon.2024.107689 (Source: Toxicon)
Source: Toxicon - March 26, 2024 Category: Toxicology Authors: Susmita Thakur Surajit Giri H T Lalremsenga Robin Doley Source Type: research
Consumption of toxic benthic cyanobacteria by two common demersal fish: Growth, antioxidant and liver histopathology responses
This study investigated the physio-chemical responses of two demersal fish (Xenocypris davidi and Crucian carp) after exposure to benthic Oscillatoria (producing cylindrospermopsin, 2 × 106 cells/mL) for 7 days. Interestingly, benthic Oscillatoria had less adverse effects on X. davidi than C. carp. The two demersal fish effectively ingested Oscillatoria, but Oscillatoria cell sheathes could not be fully digested in C. carp intestines and led to growth inhibition. Oscillatoria consumption induced oxidative stress and triggered alterations in detoxification enzyme activities in the X. davidi liver. Superoxide dismutase (SOD...
Source: Toxicon - March 24, 2024 Category: Toxicology Authors: Hongmin Li Yuan Yuan Huiting Yang Xinyue Xu Wenxia Wang Yanfeng Chen Changlin Kan Hengji Zhufu Chen Gong Source Type: research
Pharmacokinetic evaluation of a single chain antibody fragment against scorpion toxins in sheep
Toxicon. 2024 Mar 22:107691. doi: 10.1016/j.toxicon.2024.107691. Online ahead of print.ABSTRACTA key aspect during the development of antivenoms is the evaluation of the efficiency and security of the therapeutic molecules. In this work, we report the pharmacokinetic analysis of a neutralizing single chain antibody fragment named LR (scFv LR) where three sheep were used as a large animal model. The animals were injected through i.v. route with 2 mg of scFv LR. Blood samples were drawn every minute within the first 15 min, the sampling continues at 20, 25, 30, 45, 60, 90, 120 min, subsequently at one-hour intervals, 3, 4, 5...
Source: Toxicon - March 24, 2024 Category: Toxicology Authors: Roberto Olivares Hern ández Lidia Ria ño Umbarila Baltazar Becerril Alejandro Alag ón Cano Hilda Vazquez Lopez Source Type: research
Consumption of toxic benthic cyanobacteria by two common demersal fish: Growth, antioxidant and liver histopathology responses
This study investigated the physio-chemical responses of two demersal fish (Xenocypris davidi and Crucian carp) after exposure to benthic Oscillatoria (producing cylindrospermopsin, 2 × 106 cells/mL) for 7 days. Interestingly, benthic Oscillatoria had less adverse effects on X. davidi than C. carp. The two demersal fish effectively ingested Oscillatoria, but Oscillatoria cell sheathes could not be fully digested in C. carp intestines and led to growth inhibition. Oscillatoria consumption induced oxidative stress and triggered alterations in detoxification enzyme activities in the X. davidi liver. Superoxide dismutase (SOD...
Source: Toxicon - March 24, 2024 Category: Toxicology Authors: Hongmin Li Yuan Yuan Huiting Yang Xinyue Xu Wenxia Wang Yanfeng Chen Changlin Kan Hengji Zhufu Chen Gong Source Type: research
