Thromboembolic events following a pit viper bite from Protobothrops mucrosquamatus (Taiwan Habu): A report of two cases
This report presents two cases of individuals bitten by the Taiwan Habu who subsequently experienced thromboembolism. In the first case, an 88-year-old male, bitten on his fourth toe, suffered a cerebral infarction 32 hours post-bite. In the second case, an 82-year-old female, bitten on her ankle, experienced cardiac arrest 19 hours later. Both patients promptly received antivenom and showed no signs of coagulopathy either before or after the snakebite. However, elevated coagulation factor VIII levels were observed in the first case. Our aim is to understand the mechanism behind these thromboembolic events. This report emp...
Source: Toxicon - December 25, 2023 Category: Toxicology Authors: I Sun Siou-Ting Lee Yu-Guang Chen Yan-Chiao Mao Feng-Chen Chen Yen-Hsiu Chen Shih-Hung Tsai Cheng-Hsuan Ho Source Type: research
The need to expand cover of polyvalent snake antivenom in Iran
Toxicon. 2023 Dec 23:107585. doi: 10.1016/j.toxicon.2023.107585. Online ahead of print.NO ABSTRACTPMID:38145880 | DOI:10.1016/j.toxicon.2023.107585 (Source: Toxicon)
Source: Toxicon - December 25, 2023 Category: Toxicology Authors: Amir Jalali Sedigheh Mohajer Zahra Jowkar Seyed Mahdi Kazemi Source Type: research
Thromboembolic events following a pit viper bite from Protobothrops mucrosquamatus (Taiwan Habu): A report of two cases
This report presents two cases of individuals bitten by the Taiwan Habu who subsequently experienced thromboembolism. In the first case, an 88-year-old male, bitten on his fourth toe, suffered a cerebral infarction 32 hours post-bite. In the second case, an 82-year-old female, bitten on her ankle, experienced cardiac arrest 19 hours later. Both patients promptly received antivenom and showed no signs of coagulopathy either before or after the snakebite. However, elevated coagulation factor VIII levels were observed in the first case. Our aim is to understand the mechanism behind these thromboembolic events. This report emp...
Source: Toxicon - December 25, 2023 Category: Toxicology Authors: I Sun Siou-Ting Lee Yu-Guang Chen Yan-Chiao Mao Feng-Chen Chen Yen-Hsiu Chen Shih-Hung Tsai Cheng-Hsuan Ho Source Type: research
Evaluation of therapeutic benefits of botulinum toxin for foot dystonia associated with Parkinson's disease
CONCLUSION: Botulinum toxin injection for foot dystonia in patients with PD can reduce spasms and pain and normalize plantar pressure distribution, which improves balance and lower extremity function.PMID:38142904 | DOI:10.1016/j.toxicon.2023.107587 (Source: Toxicon)
Source: Toxicon - December 24, 2023 Category: Toxicology Authors: Ping Ni Ying-Ying Xu Lin-Na Wang Jia-Qian Cao Wei-Feng Luo Qi-Lin Zhang Xiang Li Xu-Ping Zhou Jing Liu Source Type: research
Evaluation of therapeutic benefits of botulinum toxin for foot dystonia associated with Parkinson's disease
CONCLUSION: Botulinum toxin injection for foot dystonia in patients with PD can reduce spasms and pain and normalize plantar pressure distribution, which improves balance and lower extremity function.PMID:38142904 | DOI:10.1016/j.toxicon.2023.107587 (Source: Toxicon)
Source: Toxicon - December 24, 2023 Category: Toxicology Authors: Ping Ni Ying-Ying Xu Lin-Na Wang Jia-Qian Cao Wei-Feng Luo Qi-Lin Zhang Xiang Li Xu-Ping Zhou Jing Liu Source Type: research
Prolonged venom-induced consumptive coagulopathy following Mangshan pit viper (Protobothrops mangshanensis) envenomation despite Hemato Polyvalent antivenom administration
Toxicon. 2023 Dec 21:107563. doi: 10.1016/j.toxicon.2023.107563. Online ahead of print.ABSTRACTThis case report summarizes an envenomation by the Mangshan pit viper (Protobothrops mangshanensis), a rare, endangered, venomous snake endemic to Mount Mang of China, and the first reported use of Hemato Polyvalent antivenom (HPAV) for this species. The snakebite occurred in a United States zoo to a 46-year-old male zookeeper. He presented via emergency medical services to a tertiary center after sustaining a single P. mangshanensis bite to the abdomen and was transported with antivenom from the zoo. Within 2 hours of envenomati...
Source: Toxicon - December 23, 2023 Category: Toxicology Authors: Lt Mallori Wilson Catherine Dong Andrew Chambers Sean Whitty Michelle Troendle Brandon K Wills Source Type: research
Structural switching aptamer-based electrochemical sensor for mycotoxin patulin detection
In this study, an electrochemical and aptamer-based aptasensor was developed for the sensitive detection of patulin, a mycotoxin commonly found in fruits and fruit-based products. The aptasensor used an innovative structural switching signal-off platform for detecting patulin. The aptamer immobilization on screen-printed carbon electrodes was achieved through Au electrodeposition and thiol group (-SH) route. Response surface methodology was used to determine the optimal incubation times for the aptamer, blocking agent, and target molecule, which were found to be 180 min, 40 min, and 89 min, respectively. The response of th...
Source: Toxicon - December 23, 2023 Category: Toxicology Authors: Netice K üçük Şevval Kaya Samet Şahin Mustafa Oguzhan Ca ğlayan Source Type: research
Unveiling Sticholysin II and plasmid DNA interaction: Implications for developing non-viral vectors
In this study, we aimed to investigate the interaction between StII, and a model plasmid (pDNA) as an initial step towards designing an improved vector with enhanced endosomal escape capability. The electrophoretic mobility shift assay (EMSA) confirmed the formation of complexes between StII and pDNA. Computational predictions identified specific residues involved in the StII-DNA interaction interface, highlighting the importance of electrostatic interactions and hydrogen bonds in mediating the binding. Atomic force microscopy (AFM) of StII-pDNA complexes revealed the presence of nodular fiber and toroid shapes. These comp...
Source: Toxicon - December 23, 2023 Category: Toxicology Authors: Felipe A Escalona-Rodriguez Yoelys Cruz Leal Javier La O-Bonet Julio A PerezErviti Mario Ernesto Vald és Tresanco Ada L Rivero-Hern ández Maricary Sifontes-Niebla Alexis MansoVargas Belinda S ánchez Carlos Alvarez Leandro R S Barbosa Rosangela Itri Mar Source Type: research
Aflatoxin B1 administration causes inflammation and apoptosis in the lungs and spleen
Toxicon. 2023 Dec 19:107581. doi: 10.1016/j.toxicon.2023.107581. Online ahead of print.ABSTRACTAflatoxin is a naturally occurring mycotoxin that has numerous toxic effects. The main aim of the present study was to evaluate the toxic effects of aflatoxin B1 (AFB1) on the lungs and spleen. Mice were repeatedly exposed to AFB1 (0.3 mg/kg body weight) on alternate days for four weeks via oral route. The histopathological data in AFB1-treated mice show alveolar epithelial hyperplasia with inflammation and the presence of numerous alveolar macrophages with minimal hemorrhage. There was an increase in vascular neutrophils and int...
Source: Toxicon - December 21, 2023 Category: Toxicology Authors: Sumit Rajaura Ram Babu Nitin Bhardwaj Pooja Chauhan Ashutosh Singh Mohd Afzal Source Type: research
First aid and pre-hospital practices in snakebite victims: The persistent use of harmful interventions
In this study, we have reviewed the literature concerning the use of these practices in various regions of the world in the period 1947-2023 based on published prospective studies. A total of 71 publications fulfilled the inclusion criteria. In terms of the total number of patients in all studies that used each FAPH intervention, the most common practice was the application of tourniquets (45.8%). Other FAPH practices described include cuts/incisions (6.7%), the application of a variety of natural or synthetic substances at the bite site (5.6%), and ingestion of natural, usually herbal, remedies (2.9%). Washing the site of...
Source: Toxicon - December 21, 2023 Category: Toxicology Authors: Maduwage Kalana Sujani Kodagoda Gamage Jos é María Gutiérrez Source Type: research
Aflatoxin B1 administration causes inflammation and apoptosis in the lungs and spleen
Toxicon. 2023 Dec 19:107581. doi: 10.1016/j.toxicon.2023.107581. Online ahead of print.ABSTRACTAflatoxin is a naturally occurring mycotoxin that has numerous toxic effects. The main aim of the present study was to evaluate the toxic effects of aflatoxin B1 (AFB1) on the lungs and spleen. Mice were repeatedly exposed to AFB1 (0.3 mg/kg body weight) on alternate days for four weeks via oral route. The histopathological data in AFB1-treated mice show alveolar epithelial hyperplasia with inflammation and the presence of numerous alveolar macrophages with minimal hemorrhage. There was an increase in vascular neutrophils and int...
Source: Toxicon - December 21, 2023 Category: Toxicology Authors: Sumit Rajaura Ram Babu Nitin Bhardwaj Pooja Chauhan Ashutosh Singh Mohd Afzal Source Type: research
First aid and pre-hospital practices in snakebite victims: The persistent use of harmful interventions
In this study, we have reviewed the literature concerning the use of these practices in various regions of the world in the period 1947-2023 based on published prospective studies. A total of 71 publications fulfilled the inclusion criteria. In terms of the total number of patients in all studies that used each FAPH intervention, the most common practice was the application of tourniquets (45.8%). Other FAPH practices described include cuts/incisions (6.7%), the application of a variety of natural or synthetic substances at the bite site (5.6%), and ingestion of natural, usually herbal, remedies (2.9%). Washing the site of...
Source: Toxicon - December 21, 2023 Category: Toxicology Authors: Maduwage Kalana Sujani Kodagoda Gamage Jos é María Gutiérrez Source Type: research
Aflatoxin B1 administration causes inflammation and apoptosis in the lungs and spleen
Toxicon. 2023 Dec 19:107581. doi: 10.1016/j.toxicon.2023.107581. Online ahead of print.ABSTRACTAflatoxin is a naturally occurring mycotoxin that has numerous toxic effects. The main aim of the present study was to evaluate the toxic effects of aflatoxin B1 (AFB1) on the lungs and spleen. Mice were repeatedly exposed to AFB1 (0.3 mg/kg body weight) on alternate days for four weeks via oral route. The histopathological data in AFB1-treated mice show alveolar epithelial hyperplasia with inflammation and the presence of numerous alveolar macrophages with minimal hemorrhage. There was an increase in vascular neutrophils and int...
Source: Toxicon - December 21, 2023 Category: Toxicology Authors: Sumit Rajaura Ram Babu Nitin Bhardwaj Pooja Chauhan Ashutosh Singh Mohd Afzal Source Type: research
First aid and pre-hospital practices in snakebite victims: The persistent use of harmful interventions
In this study, we have reviewed the literature concerning the use of these practices in various regions of the world in the period 1947-2023 based on published prospective studies. A total of 71 publications fulfilled the inclusion criteria. In terms of the total number of patients in all studies that used each FAPH intervention, the most common practice was the application of tourniquets (45.8%). Other FAPH practices described include cuts/incisions (6.7%), the application of a variety of natural or synthetic substances at the bite site (5.6%), and ingestion of natural, usually herbal, remedies (2.9%). Washing the site of...
Source: Toxicon - December 21, 2023 Category: Toxicology Authors: Maduwage Kalana Sujani Kodagoda Gamage Jos é María Gutiérrez Source Type: research
Bothrops snake venom L-amino acid oxidases impair biofilm formation of clinically relevant bacteria
Toxicon. 2023 Dec 18:107569. doi: 10.1016/j.toxicon.2023.107569. Online ahead of print.ABSTRACTThe present work addressed the abilities of two L-amino acid oxidases isolated from Bothrops moojeni (BmooLAAO-I) and Bothrops jararacussu (BjussuLAAO-II) snake venoms to control the growth and prevent the biofilm formation of clinically relevant bacterial pathogens. Upon S. aureus (ATCC BAA44) and S. aureus (clinical isolates), BmooLAAO-I (MIC = 0.12 and 0.24 μg/mL, respectively) and BjussuLAAO-II (MIC = 0.15 μg/mL) showed a potent bacteriostatic effect. Against E. coli (ATCC BAA198) and E. coli (clinical isolates), BmooLAAO-I...
Source: Toxicon - December 20, 2023 Category: Toxicology Authors: Thales Alves de Melo Fernandes T ássia Rafaella Costa Ralciane de Paula Menezes Meliza Arantes de Souza Carlos Henrique Gomes Martins Nilson Nicolau Junior Fernanda Gobbi Amorim Lo ïc Quinton Lorena Polloni Samuel Cota Teixeira Eloisa Am ália Vieira Fe Source Type: research
