Exploring the neuroprotective potential of antimicrobial peptides from Dinoponera quadriceps venom against pentylenetetrazole-induced seizures in vivo
Toxicon. 2023 Nov 27:107538. doi: 10.1016/j.toxicon.2023.107538. Online ahead of print.ABSTRACTEpilepsy affects around 50 million people worldwide and 30% of patients have difficulty controlling the disease. The search for substances that can fill the existing gaps in the treatment of epilepsy is of great importance. Arthropod venoms are promising sources for this purpose due to the presence of small peptides that modulate the activity of ion channels and neuron receptors. The aim of this study was to investigate dinoponeratoxins from the Dinoponera quadriceps ant venom (M-PONTX-Dq3a, M-PONTX-Dq3b and M-PONTX-Dq3c) as pote...
Source: Toxicon - November 29, 2023 Category: Toxicology Authors: Livia Correia Fernandes Paes D ânya Bandeira Lima Daniel Moreira Alves da Silva Jos é Tiago Valentin Pedro Alexandre Everson de Aquino Alicia Bel én García-Jareño Mar Orza éz Marta Maria de Fran ça Fonteles Alice Maria Costa Martins Source Type: research
Amaranthus hybridus (syn. quitensis) intoxication in cattle in Argentina: Case report
Toxicon. 2023 Nov 25:107533. doi: 10.1016/j.toxicon.2023.107533. Online ahead of print.ABSTRACTAmaranthus spp. is a nephrotoxic plant with unknown toxic principle, affecting production animals worldwide, mainly in South America. The aim of this paper is to describe 5 spontaneous outbreaks of A. hybridus intoxication in beef cattle, where 7 autopsies were performed. Main gross findings were pale diffuse and enlarged kidneys. Microscopically, kidneys were characterized by severe tubular acute to subacute nephrosis, with dilatated tubules showing different degrees of epithelial degeneration and necrosis, and containing intral...
Source: Toxicon - November 28, 2023 Category: Toxicology Authors: Juan Agust ín García Gina Rustichelli Mill án Valeria Scioli Gast ón Britos Eleonora Morrell Ernesto Odriozola Juan Francisco Micheloud Germ án Cantón Source Type: research
Integrating network pharmacology and experimental validation to explore the mechanisms of luteolin in alleviating fumonisin B1-induced intestinal inflammatory injury
Toxicon. 2023 Nov 25:107531. doi: 10.1016/j.toxicon.2023.107531. Online ahead of print.ABSTRACTContamination with fumonisin B1 (FB1) represents a global health problem. FB1 exposure may also trigger intestinal injury by activating inflammatory responses, leading to a reduction in production performance and economic benefits. However, the mechanism of FB1-induced intestinal inflammatory injury is still unclear. At the same time, it is urgent to develop antibiotic alternatives and therapeutic targets to alleviate antibiotic resistance and to ensure effective treatment of intestinal inflammatory injury. We combined network ph...
Source: Toxicon - November 28, 2023 Category: Toxicology Authors: Defeng Wen Wantong Han Quan Chen Guanhui Qi Mengling Gao Pu Guo Yu Liu Zhongyuan Wu Shulin Fu Qirong Lu Yinsheng Qiu Source Type: research
Structural, biochemical and immunochemical characterization of an acidic phospholipase A2 from Lachesis acrochorda (Viperidae: Crotalinae) venom
Toxicon. 2023 Nov 25:107528. doi: 10.1016/j.toxicon.2023.107528. Online ahead of print.ABSTRACTViperids of the genus Lachesis, also known as bushmasters, are capable of injecting great amounts of venom that cause severe envenomation incidents. Since phospholipases type A2 are mainly involved in edema and myonecrosis within the snakebite sites, in this work, the isolation, amino acid sequence and biochemical characterization of the first phospholipase type A2 from the venom of Lachesis acrochorda, named Lacro_PLA2, is described. Lacro_PLA2 is an acidic aspartic 49 calcium-dependent phospholipase A2 with 93% similarity to th...
Source: Toxicon - November 28, 2023 Category: Toxicology Authors: Adri án Marcelo Franco-Vásquez Fernando Lazcano-P érez Miguel Angel Mej ía-Sánchez Gerardo Corzo Fernando Zamudio Alejandro Carbajal-Saucedo Sergio Agust ín Román-González Sa úl Gómez-Manzo Roberto Arregu ín-Espinosa Source Type: research
Toxicity of the emerging mycotoxins beauvericin and enniatins: A mini-review
Toxicon. 2023 Nov 25:107534. doi: 10.1016/j.toxicon.2023.107534. Online ahead of print.ABSTRACTBeauvericin and enniatins, emerging mycotoxins produced mainly by Fusarium species, are natural contaminants of cereals and cereal products. These mycotoxins are cyclic hexadepsipeptides with ionophore properties and their toxicity mechanism is related to their ability to transport cations across the cell membrane. Beauvericin and enniatins are cytotoxic, as they decrease cell viability, promote cell cycle arrest, and increase apoptosis and the generation of reactive oxygen species in several cell lines. They also cause changes a...
Source: Toxicon - November 28, 2023 Category: Toxicology Authors: Amanda Lopes Hasuda Ana Paula F R L Bracarense Source Type: research
Hemoperitoneum after a Bothrops snakebite: Case report
This report describes a case of human envenomation by a juvenile Bothrops jararaca snake in São Paulo, Brazil, in a 71 years-old man, previously healthy. He presented a life-threatening envenomation, which developed to severe hypotension, acute kidney injury and extensive peritoneal hemorrhage. The hemoperitoneum was diagnosed due to persistent hypotension associated with anemia, pain and gastrointestinal complaints. Abdominal Computed Tomography scans showed a moderate to large amount of presumable hematic material inside the abdominal cavity, predominantly in the perihepatic and perisplenic spaces. The intra-abdominal h...
Source: Toxicon - November 28, 2023 Category: Toxicology Authors: Adriana Baqueiro Abad Ribeiro Marcelo Larami Santoro Marcelo Ribeiro Duarte Cristiana Cruz Virgulino Gerson Sobrinho Salvador de Oliveira Francisco Oscar de Siqueira Fran ça Source Type: research
Amaranthus hybridus (syn. quitensis) intoxication in cattle in Argentina: Case report
Toxicon. 2023 Nov 25:107533. doi: 10.1016/j.toxicon.2023.107533. Online ahead of print.ABSTRACTAmaranthus spp. is a nephrotoxic plant with unknown toxic principle, affecting production animals worldwide, mainly in South America. The aim of this paper is to describe 5 spontaneous outbreaks of A. hybridus intoxication in beef cattle, where 7 autopsies were performed. Main gross findings were pale diffuse and enlarged kidneys. Microscopically, kidneys were characterized by severe tubular acute to subacute nephrosis, with dilatated tubules showing different degrees of epithelial degeneration and necrosis, and containing intral...
Source: Toxicon - November 28, 2023 Category: Toxicology Authors: Juan Agust ín García Gina Rustichelli Mill án Valeria Scioli Gast ón Britos Eleonora Morrell Ernesto Odriozola Juan Francisco Micheloud Germ án Cantón Source Type: research
Integrating network pharmacology and experimental validation to explore the mechanisms of luteolin in alleviating fumonisin B1-induced intestinal inflammatory injury
Toxicon. 2023 Nov 25:107531. doi: 10.1016/j.toxicon.2023.107531. Online ahead of print.ABSTRACTContamination with fumonisin B1 (FB1) represents a global health problem. FB1 exposure may also trigger intestinal injury by activating inflammatory responses, leading to a reduction in production performance and economic benefits. However, the mechanism of FB1-induced intestinal inflammatory injury is still unclear. At the same time, it is urgent to develop antibiotic alternatives and therapeutic targets to alleviate antibiotic resistance and to ensure effective treatment of intestinal inflammatory injury. We combined network ph...
Source: Toxicon - November 28, 2023 Category: Toxicology Authors: Defeng Wen Wantong Han Quan Chen Guanhui Qi Mengling Gao Pu Guo Yu Liu Zhongyuan Wu Shulin Fu Qirong Lu Yinsheng Qiu Source Type: research
Structural, biochemical and immunochemical characterization of an acidic phospholipase A2 from Lachesis acrochorda (Viperidae: Crotalinae) venom
Toxicon. 2023 Nov 25:107528. doi: 10.1016/j.toxicon.2023.107528. Online ahead of print.ABSTRACTViperids of the genus Lachesis, also known as bushmasters, are capable of injecting great amounts of venom that cause severe envenomation incidents. Since phospholipases type A2 are mainly involved in edema and myonecrosis within the snakebite sites, in this work, the isolation, amino acid sequence and biochemical characterization of the first phospholipase type A2 from the venom of Lachesis acrochorda, named Lacro_PLA2, is described. Lacro_PLA2 is an acidic aspartic 49 calcium-dependent phospholipase A2 with 93% similarity to th...
Source: Toxicon - November 28, 2023 Category: Toxicology Authors: Adri án Marcelo Franco-Vásquez Fernando Lazcano-P érez Miguel Angel Mej ía-Sánchez Gerardo Corzo Fernando Zamudio Alejandro Carbajal-Saucedo Sergio Agust ín Román-González Sa úl Gómez-Manzo Roberto Arregu ín-Espinosa Source Type: research
Toxicity of the emerging mycotoxins beauvericin and enniatins: A mini-review
Toxicon. 2023 Nov 25:107534. doi: 10.1016/j.toxicon.2023.107534. Online ahead of print.ABSTRACTBeauvericin and enniatins, emerging mycotoxins produced mainly by Fusarium species, are natural contaminants of cereals and cereal products. These mycotoxins are cyclic hexadepsipeptides with ionophore properties and their toxicity mechanism is related to their ability to transport cations across the cell membrane. Beauvericin and enniatins are cytotoxic, as they decrease cell viability, promote cell cycle arrest, and increase apoptosis and the generation of reactive oxygen species in several cell lines. They also cause changes a...
Source: Toxicon - November 28, 2023 Category: Toxicology Authors: Amanda Lopes Hasuda Ana Paula F R L Bracarense Source Type: research
Hemoperitoneum after a Bothrops snakebite: Case report
This report describes a case of human envenomation by a juvenile Bothrops jararaca snake in São Paulo, Brazil, in a 71 years-old man, previously healthy. He presented a life-threatening envenomation, which developed to severe hypotension, acute kidney injury and extensive peritoneal hemorrhage. The hemoperitoneum was diagnosed due to persistent hypotension associated with anemia, pain and gastrointestinal complaints. Abdominal Computed Tomography scans showed a moderate to large amount of presumable hematic material inside the abdominal cavity, predominantly in the perihepatic and perisplenic spaces. The intra-abdominal h...
Source: Toxicon - November 28, 2023 Category: Toxicology Authors: Adriana Baqueiro Abad Ribeiro Marcelo Larami Santoro Marcelo Ribeiro Duarte Cristiana Cruz Virgulino Gerson Sobrinho Salvador de Oliveira Francisco Oscar de Siqueira Fran ça Source Type: research
Assessment of Aflatoxin M1 in human breast and powdered milk in Tehran, Iran
This study concludes that given the importance of breast milk and formula to maternal and infant health, monitoring and regulating the toxin levels in these products in Tehran is crucial.PMID:38008384 | DOI:10.1016/j.toxicon.2023.107530 (Source: Toxicon)
Source: Toxicon - November 26, 2023 Category: Toxicology Authors: MohammadHossein Movassaghghazani Nazanin Shabansalmani Source Type: research
Assessment of Aflatoxin M1 in human breast and powdered milk in Tehran, Iran
This study concludes that given the importance of breast milk and formula to maternal and infant health, monitoring and regulating the toxin levels in these products in Tehran is crucial.PMID:38008384 | DOI:10.1016/j.toxicon.2023.107530 (Source: Toxicon)
Source: Toxicon - November 26, 2023 Category: Toxicology Authors: MohammadHossein Movassaghghazani Nazanin Shabansalmani Source Type: research
Case study: Boomslang envenomation in North-Eastern South Africa
We present a case of severe Boomslang envenomation, secondary to a man being bitten on bilateral upper limbs while inside his house, which required three vials of antivenom to treat effectively.PMID:37984680 | DOI:10.1016/j.toxicon.2023.107347 (Source: Toxicon)
Source: Toxicon - November 20, 2023 Category: Toxicology Authors: S A M Vieira L M M Fourie J Marais G V Oosthuizen Source Type: research
Potential low-impact immunogen for the production of anti-bothropic serum: Bothrops alternatus venom treated with Na < sub > 2 < /sub > EDTA
In conclusion, the B.aV/Na2EDTA formulation, free of excess Na2EDTA, proved to be a promising candidate as an immunogen for antivenom production.PMID:37984681 | DOI:10.1016/j.toxicon.2023.107351 (Source: Toxicon)
Source: Toxicon - November 20, 2023 Category: Toxicology Authors: Gisela Lumila Lopez Andrea Van de Velde David Hern ández Soledad Bustillo Laura Leiva Luciano Sebastian Fusco Source Type: research
