The role and mechanism of NLRP3 in wasp venom-induced acute kidney injury
CONCLUSION: NLRP3 activation is associated with renal failure, inflammatory response and pyroptosis in the hyper early phase of wasp venom-induced AKI. The inhibition of NLRP3 significantly weakened this phenomenon. These findings could potentially offer a viable therapeutic approach for AKI triggered by wasp venom.PMID:38103798 | DOI:10.1016/j.toxicon.2023.107570 (Source: Toxicon)
Source: Toxicon - December 16, 2023 Category: Toxicology Authors: Haoran Li Jianhua Gong Fang Bian Fanglin Yu Hai Yuan Fengqi Hu Source Type: research
Molecular diversity assessed by MALDI mass spectrometry of two scorpion species venom from two different locations in Morocco
In conclusion, MFPs assessed by MALDI-MS represent a fast, non-supervised, sensitive, reliable and cost-efficient approach for taxonomic identification and molecular variability characterization. This study undoubtedly represents a step forward for understanding the scorpion venom plasticity, intra/inter variations, and their temporal and geographical variability.PMID:38103799 | DOI:10.1016/j.toxicon.2023.107562 (Source: Toxicon)
Source: Toxicon - December 16, 2023 Category: Toxicology Authors: Boujemaa Ajdi Abdelhafed El Asbahani Moulay Abdelmonaim El Hidan Michel Bocquet L éna Falconnet Mohamed Ait Hamza Abdessamad Elmourid Oulaid Touloun Hassan Boubaker Philippe Bulet Source Type: research
Baccharis anomala DC. extract reduces inflammation and attenuates hepatic fibrosis in vivo by decreasing NF-kB and extracellular matrix compounds
Toxicon. 2023 Dec 11;237:107560. doi: 10.1016/j.toxicon.2023.107560. Online ahead of print.ABSTRACTBaccharis anomala DC. (BA) is a plant species found in the tropical regions of South America and is widely used for its hepatoprotective effects, as well as for the treatment of gastrointestinal diseases. Studies have recently reported its antioxidant and anti-inflammatory potential. BA extract can reverse the activated phenotype of hepatic stellate cells (HSC), which plays a central role in extracellular matrix (ECM) deposition in the development of liver fibrosis. Thus, this study aimed to evaluate the effects of the treatm...
Source: Toxicon - December 13, 2023 Category: Toxicology Authors: Bruno de Souza Basso Matheus Scherer Bastos G éssica Luana Antunes Lucas Strassburger Matzenbacher K étlin Fernanda Rodrigues Maria Claudia Rosa Garcia Arieli Cruz de Sousa Vitor Giancarlo Levorse Carolina Luft Giovana Vivan Tonial Giovanna Mezzomo Pava Source Type: research
Roles of Cyt-c/Caspase-9/Caspase-3/Bax/Bcl-2 pathway in Cd-induced testicular injury in rats and the protective effect of quercetin
Toxicon. 2023 Dec 12;237:107561. doi: 10.1016/j.toxicon.2023.107561. Online ahead of print.ABSTRACTCadmium (Cd) exposure causes oxidative damage to mitochondria, which would adversely affect rat testicular tissue. Quercetin (Que) is a natural antioxidant with anti-inflammatory, antioxidant and anti-apoptotic effects. However, the mechanism by which Que inhibits Cd-induced apoptosis of testicular cells remains unclear. The purpose of this study was to investigate the role of mitochondrial apoptosis pathway (Cyt-c/Caspase-9/Caspase-3/Bax/Bcl-2 pathway) in inhibiting Cd-induced apoptosis of testicular cells by Que. We used SD...
Source: Toxicon - December 13, 2023 Category: Toxicology Authors: Wenjing Yu Huali Zhu Ruxue Huang Bingzhao Yan Bing Xu Yaning Shi Junbing Mao Zongping Liu Jicang Wang Source Type: research
Baccharis anomala DC. extract reduces inflammation and attenuates hepatic fibrosis in vivo by decreasing NF-kB and extracellular matrix compounds
Toxicon. 2023 Dec 11;237:107560. doi: 10.1016/j.toxicon.2023.107560. Online ahead of print.ABSTRACTBaccharis anomala DC. (BA) is a plant species found in the tropical regions of South America and is widely used for its hepatoprotective effects, as well as for the treatment of gastrointestinal diseases. Studies have recently reported its antioxidant and anti-inflammatory potential. BA extract can reverse the activated phenotype of hepatic stellate cells (HSC), which plays a central role in extracellular matrix (ECM) deposition in the development of liver fibrosis. Thus, this study aimed to evaluate the effects of the treatm...
Source: Toxicon - December 13, 2023 Category: Toxicology Authors: Bruno de Souza Basso Matheus Scherer Bastos G éssica Luana Antunes Lucas Strassburger Matzenbacher K étlin Fernanda Rodrigues Maria Claudia Rosa Garcia Arieli Cruz de Sousa Vitor Giancarlo Levorse Carolina Luft Giovana Vivan Tonial Giovanna Mezzomo Pava Source Type: research
Roles of Cyt-c/caspase-9/caspase-3/Bax/Bcl-2 pathway in Cd-induced testicular injury in rats and the protective effect of quercetin
Toxicon. 2023 Dec 11:107561. doi: 10.1016/j.toxicon.2023.107561. Online ahead of print.ABSTRACTCadmium (Cd) exposure causes oxidative damage to mitochondria, which would adversely affect rat testicular tissue. Quercetin (Que) is a natural antioxidant with anti-inflammatory, antioxidant and anti-apoptotic effects. However, the mechanism by which Que inhibits Cd-induced apoptosis of testicular cells remains unclear. The purpose of this study was to investigate the role of mitochondrial apoptosis pathway (Cyt-c/Caspase-9/Caspase-3/Bax/Bcl-2 pathway) in inhibiting Cd-induced apoptosis of testicular cells by Que. We used SD rat...
Source: Toxicon - December 13, 2023 Category: Toxicology Authors: Wenjing Yu Huali Zhu Ruexue Huang Bingzhao Yan Bing Xu Yaning Shi Junbing Mao Zongping Liu Jicang Wang Source Type: research
Baccharis anomala DC. extract reduces inflammation and attenuates hepatic fibrosis in vivo by decreasing NF-kB and extracellular matrix compounds
Toxicon. 2023 Dec 11:107560. doi: 10.1016/j.toxicon.2023.107560. Online ahead of print.ABSTRACTBaccharis anomala DC. (BA) is a plant species found in the tropical regions of South America and is widely used for its hepatoprotective effects, as well as for the treatment of gastrointestinal diseases. Studies have recently reported its antioxidant and anti-inflammatory potential. BA extract can reverse the activated phenotype of hepatic stellate cells (HSC), which plays a central role in extracellular matrix (ECM) deposition in the development of liver fibrosis. Thus, this study aimed to evaluate the effects of the treatment ...
Source: Toxicon - December 13, 2023 Category: Toxicology Authors: Bruno de Souza Basso Matheus Scherer Bastos G éssica Luana Antunes Lucas Strassburger Matzenbacher K étlin Fernanda Rodrigues Maria Claudia Rosa Garcia Arieli Cruz de Sousa Vitor Giancarlo Levorse Carolina Luft Giovana Vivan Tonial Giovanna Mezzomo Pava Source Type: research
Roles of Cyt-c/caspase-9/caspase-3/Bax/Bcl-2 pathway in Cd-induced testicular injury in rats and the protective effect of quercetin
Toxicon. 2023 Dec 11:107561. doi: 10.1016/j.toxicon.2023.107561. Online ahead of print.ABSTRACTCadmium (Cd) exposure causes oxidative damage to mitochondria, which would adversely affect rat testicular tissue. Quercetin (Que) is a natural antioxidant with anti-inflammatory, antioxidant and anti-apoptotic effects. However, the mechanism by which Que inhibits Cd-induced apoptosis of testicular cells remains unclear. The purpose of this study was to investigate the role of mitochondrial apoptosis pathway (Cyt-c/Caspase-9/Caspase-3/Bax/Bcl-2 pathway) in inhibiting Cd-induced apoptosis of testicular cells by Que. We used SD rat...
Source: Toxicon - December 13, 2023 Category: Toxicology Authors: Wenjing Yu Huali Zhu Ruexue Huang Bingzhao Yan Bing Xu Yaning Shi Junbing Mao Zongping Liu Jicang Wang Source Type: research
Paris polyphylla saponins II inhibits invasive, migration and epithelial-mesenchymal transition of melanoma cells through activation of autophagy
This study explored the role of PPII in promoting autophagy to inhibit EMT of melanoma cells, the role of the PI3K/Akt signaling pathway in the invasion and migration of melanoma cells induced by PPII. We found that PPII effectively inhibited the proliferation, invasion and migration of melanoma B16 and B16F10 in vitro, and induced autophagy. We also established the xenograft tumor and metastatic tumor model of C57BL/6 mice with B16F10 cells. Results showed that PPII effectively inhibited the growth of transplanted tumors, induced autophagy and inhibited the expression level of EMT related protein; Metastasis experiment sh...
Source: Toxicon - December 10, 2023 Category: Toxicology Authors: Hui Cheng Jing Chu Yuting Yang Yueyue Li Meng Wang Huan Wu Manman Wang Jingjing Su Qinglin Li Source Type: research
Chlorophyllum molybdites poisoning on Reunion Island
Toxicon. 2023 Dec 10;237:107554. doi: 10.1016/j.toxicon.2023.107554. Online ahead of print.ABSTRACTIn France, mushroom picking is part of the culture. The practice is not without risk, as around 1300 people are poisoned each year by eating wild mushrooms on the French mainland. However, this practice is not part of local culture on Reunion Island, a French territory located in the Indian Ocean. Indeed, there are practically no reports of mushroom poisoning on Reunion Island. Here we describe, through a retrospective study, cases of mushroom poisoning recorded in the Indian Ocean toxicosurveillance system database from 2020...
Source: Toxicon - December 10, 2023 Category: Toxicology Authors: Adrien Maillot Adrien Marteau J érémy Lecot Chloe Bruneau Gael Le Roux Luc De Haro Elliott Chaumont Source Type: research
Metatranscriptome analysis reveals the putative venom toxin repertoire of the biofouling hydroid Ectopleura larynx
In this study, we generated a whole transcriptome of E. larynx, and identified its putative expressed venom toxin proteins (predicted toxin proteins, not functionally characterized) based on in silico transcriptome annotation mining and protein sequence analysis. The results uncovered a broad and diverse repertoire of putative toxin proteins for this hydroid species. Its toxic arsenal appears to include a wide and complex selection of toxin proteins, covering a large panel of potential biological functions that play important roles in envenomation. The putative toxins identified in this species, such as neurotoxins, GTPase...
Source: Toxicon - December 10, 2023 Category: Toxicology Authors: Laur ène Alicia Lecaudey Roman Netzer Daniel Wibberg Tobias Busche Nina Bloecher Source Type: research
A case of rotenone poisoning from ingesting Derris trifoliata Lour. (Tuba fruit/pod) in Malaysia
Toxicon. 2023 Dec 8:107557. doi: 10.1016/j.toxicon.2023.107557. Online ahead of print.ABSTRACTDerris trifoliata is mainly found in mangrove area in tropical regions and the plant extract is traditionally used for fishing by poisoning. This is the first case report of rotenone poisoning in a child from ingesting Derris trifoliata seed. The child developed altered consciousness, vomiting, hypotension, metabolic acidosis, and acute kidney injury. Species identification of this case requires the collaborative efforts of various agencies. She survived from the poisoning with no neurological sequelae.PMID:38072318 | DOI:10.1016/...
Source: Toxicon - December 10, 2023 Category: Toxicology Authors: Si Ling Yeoh Pheik Sian Choong Rahmad Zakaria Nur Azzalia Kamaruzaman Sazaroni Md Rashid Mohd Fadhli Razali Ahmad Khaldun Ismail Source Type: research
Spirulina platensis ameliorates hepatic oxidative stress and DNA damage induced by aflatoxin B1 in rats
Toxicon. 2023 Dec 9;237:107553. doi: 10.1016/j.toxicon.2023.107553. Online ahead of print.ABSTRACTAflatoxin B1 (AFB1) is a widely distributed mycotoxin, causing hepatotoxicity and oxidative stress. One of the most famous unicellular cyanobacteria is Spirulina platensis (SP) which is well known for its antioxidant characteristics against many toxicants. Therefore, this study aimed to investigate the antioxidant potential and hepatoprotective ability of SP against oxidative stress and cytotoxicity in male Wistar albino rats intraperitoneally injected with AFB1. Rats were separated into five groups as follows: negative contro...
Source: Toxicon - December 10, 2023 Category: Toxicology Authors: Ahmed E Altyar Osama A Kensara Ahmed E Noreldin Ghadeer M Albadrani Fatma M El-Demerdash Amany A Sayed Marina Piscopo Zuhair M Mohammedsaleh Muath Q Al-Ghadi Nehmat Ghaboura Mohamed M Abdel-Daim Source Type: research
Candida die-off: Adverse effect and neutralization with phytotherapy approaches
In conclusion, this article serves as a meticulous compilation of knowledge on the intriguing subject of Candida die-off, presenting a distinct and informative perspective that has the potential to pave the way for new insights in the realm of plant-based antifungal therapeutics.PMID:38072320 | DOI:10.1016/j.toxicon.2023.107555 (Source: Toxicon)
Source: Toxicon - December 10, 2023 Category: Toxicology Authors: Neha Jaiswal Awanish Kumar Source Type: research
Paris polyphylla saponins II inhibits invasive, migration and epithelial-mesenchymal transition of melanoma cells through activation of autophagy
This study explored the role of PPII in promoting autophagy to inhibit EMT of melanoma cells, the role of PI3K/Akt signaling pathway in the invasion and migration of melanoma cells induced by PPII. We found that PPII effectively inhibited the proliferation, invasion and migration of melanoma B16 and B16F10 in vitro, and induced autophagy. We also established the xenograft tumor and metastatic tumor model of C57BL/6 mice with B16F10 cells. Results showed that PPII effectively inhibited the growth of transplanted tumor, induced autophagy and inhibited the expression level of EMT related protein; Metastasis experiment showed ...
Source: Toxicon - December 10, 2023 Category: Toxicology Authors: Hui Cheng Jing Chu Yuting Yang Yueyue Li Meng Wang Huan Wu Manman Wang Jingjing Su Qinglin Li Source Type: research
