Toxicology and Applied Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Ondansetron attenuates cisplatin-induced behavioral and cognitive impairment through downregulation of NOD-like receptor inflammasome pathway
Toxicol Appl Pharmacol. 2024 Mar 2:116875. doi: 10.1016/j.taap.2024.116875. Online ahead of print.ABSTRACTCisplatin is an effective and commonly used chemotherapeutic drug; however, its use is accompanied by several adverse effects, including chemobrain. Ondansetron is a 5-HT3 antagonist, commonly used in prophylactic against chemotherapy-induced nausea and vomiting. Moreover, it has been identified as a novel neuroprotective agent in different animal models. However, its protective role against chemotherapy-induced chemobrain has not been investigated. The current study was the first study that explored the potential neur...
Source: Toxicology and Applied Pharmacology - March 4, 2024 Category: Toxicology Authors: Mennat-Allah M Hassan Sara A Wahdan Reem N El-Naga Tamer M Abdelghany Ebtehal El-Demerdash Source Type: research

Role of noradrenergic and dopaminergic systems in the antinociceptive effect of N-(3-(phenylselanyl)prop-2-yn-1-yl)benzamide in mice
Toxicol Appl Pharmacol. 2024 Mar 2:116881. doi: 10.1016/j.taap.2024.116881. Online ahead of print.ABSTRACTPain has a negative impact on public health, reducing quality of life. Unfortunately, current treatments are not fully effective and have adverse effects. Therefore, there is a need to develop new analgesic compounds. Due to promising results regarding the antinociceptive effect of N-(3-(phenylselanyl)prop-2-in-1-yl)benzamide (SePB), this study aimed to evaluate the participation of the dopaminergic and noradrenergic systems in this effect in mice, as well as its toxicity. To this, the antagonists sulpiride (D2/D3 rece...
Source: Toxicology and Applied Pharmacology - March 4, 2024 Category: Toxicology Authors: Kauane Nayara Bahr Ledebuhr Gustavo D'Avila Nunes Marcelo Heinemann Presa Cleidi Maria Hartmann Benhur Godoi Cristiani Folharini Bortolatto C ésar Augusto Brüning Source Type: research

Ursolic acid alleviates paclitaxel-induced peripheral neuropathy through PPAR γ activation
CONCLUSIONS: Taken together, the present study suggests ursolic acid has potential as a new PPARγ agonist targeting ER stress-related apoptotic pathways to ameliorate pacilitaxel-induced peripheral neuropathic pain and nerve injury, providing new clinical therapeutic method for CIPN.PMID:38437959 | DOI:10.1016/j.taap.2024.116883 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 4, 2024 Category: Toxicology Authors: Yulian Yang Zhongzheng He Shuangchan Wu Source Type: research

Aspongopus chinensis ach-miR-276a-3p induces breast cancer cell cycle arrest by targeting APPL2 to regulate the CDK2-Rb-E2F1 signaling pathway
Toxicol Appl Pharmacol. 2024 Feb 29:116877. doi: 10.1016/j.taap.2024.116877. Online ahead of print.ABSTRACTBreast cancer, the most common cancer, presents a significant challenge to the health and longevity of women. Aspongopus chinensis Dallas is an insect with known anti-breast cancer properties. However, the anti-breast cancer effects and underlying mechanisms have not been elucidated. Exogenous microRNAs (miRNAs), which are derived from plants and animals, have been revealed to have notable capacities for controlling the proliferation of cancerous cells. To elucidate the inhibitory effects of miRNAs derived from A. chi...
Source: Toxicology and Applied Pharmacology - March 2, 2024 Category: Toxicology Authors: Renlian Cai Samiullah Khan Xumei Chen Haiyin Li Jun Tan Ying Tian Shuai Zhao Zhiyong Yin Tongxian Liu Daochao Jin Jianjun Guo Source Type: research

Discovery of anticancer function of Febrifugine: Inhibition of cell proliferation, induction of apoptosis and suppression steroid synthesis in bladder cancer cells
Toxicol Appl Pharmacol. 2024 Feb 29:116878. doi: 10.1016/j.taap.2024.116878. Online ahead of print.ABSTRACTBladder cancer is a prevalent malignancy affecting the urinary system, which presents a significant global health concern. Although there are many treatments for bladder cancer, identifying more effective drugs and methods remains an urgent problem. As a pivotal component of contemporary medical practice, traditional Chinese medicine (TCM) assumes a crucial role in the realm of anti-tumor therapy, especially with the identification of active ingredients and successful exploration of pharmacological effects. Febrifugin...
Source: Toxicology and Applied Pharmacology - March 2, 2024 Category: Toxicology Authors: Jingyuan Chen Shuhao Fan Jianhua Guo Jian Yang Le Pan Yong Xia Source Type: research

Predicting the in vivo developmental toxicity of fenarimol from in vitro toxicity data using PBTK modelling-facilitated reverse dosimetry approach
In this study, a minimal-PBTK model was constructed to predict the in-vivo kinetic profile of fenarimol (FNL) in rats and humans. The model was verified by comparing the observed and predicted pharmacokinetics of FNL for rats (calibrator) and further applied to humans. Using the PBTK-RD approach, the reported in vitro developmental toxicity data for FNL was translated to in vivo dose-response data to predict the assay equivalent oral dose in rats and humans. The predicted assay equivalent rat oral dose (36.46 mg/kg) was comparable to the literature reported in vivo BMD10 value (22.8 mg/kg). The model was also employed to d...
Source: Toxicology and Applied Pharmacology - March 2, 2024 Category: Toxicology Authors: Manisha Bhateria Isha Taneja Kajal Karsauliya Ashish Kumar Sonker Yukihiro Shibata Hiromi Sato Sheelendra Pratap Singh Akihiro Hisaka Source Type: research

Bioactive C-phycocyanin exerts immunomodulatory and antitumor activity in mice with induced melanoma
Toxicol Appl Pharmacol. 2024 Feb 28:116874. doi: 10.1016/j.taap.2024.116874. Online ahead of print.ABSTRACTMelanoma is the most aggressive and deadly skin cancer. The difficulty in its treatment arises from its ability to suppress the immune system, making it crucial to find a substance that increases anti-tumor immunity. C-phycocyanin (C-PC) appears as a promising bioactive, with multifaceted effects against several cancers, but its efficacy against melanoma has only been tested in vitro. Therefore, we investigated C-PC's the anti-tumor and immunomodulatory action in a murine melanoma model. The tumor was subcutaneously i...
Source: Toxicology and Applied Pharmacology - March 1, 2024 Category: Toxicology Authors: Mariana Teixeira Santos Figueiredo Salgado Mayara Cristini Sebasti ão Silva Camilly Fratelli Anna Rafaela Cavalcante Braga Thacyana Beatriz Guimar ães Lopes Enio Ferreira Istefani Luciene Dayse da Silva Luciana Souza de Paiva Ana Paula de Souza Votto Source Type: research

Tetramethylpyrazine inhibits the inflammatory response by downregulating the TNFR1/I κB-α/NF-κB p65 pathway after spinal cord injury
In conclusion, TMP inhibits inflammatory response and oxidative stress, thereby exerting a neuroprotective effect that may be related to the regulation of the TNFR1/IκB-α/NF-κB p65 signaling pathway.PMID:38428465 | DOI:10.1016/j.taap.2024.116872 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 1, 2024 Category: Toxicology Authors: Gang Liu Luyao Huo Bowen Deng Shengyuan Jiang Yi Zhao Yanjun Mo Huizhong Bai Lin Xu Chuanyu Hu Xiaohong Mu Source Type: research

Elucidating the distinctive regulatory effects and mechanisms of active compounds in Salvia miltiorrhiza Bunge via network pharmacology: Unveiling their roles in the modulation of platelet activation and thrombus formation
This study aimed to find out the potential targets and mechanisms of DS in the modulation of platelet activation and thrombosis, using network pharmacology and biological experimental. These compounds with anti-thrombotic activity in DS, cryptotanshinone (CPT), isoeugenol (ISO) and tanshinone IIA (TSA), together with the corresponding targets being Src, Akt and RhoA are screened by network pharmacology. We confirmed that ISO, CPT and TSA dose-dependently inhibited platelet activation in vitro, mainly by inhibiting agonist-induced clot retraction, aggregation and P-selectin and ATP release. The western blot findings indicat...
Source: Toxicology and Applied Pharmacology - February 29, 2024 Category: Toxicology Authors: Ying Zhang Guang Xin Qilong Zhou Xiuxian Yu Lijuan Feng Ao Wen Kun Zhang Tingyu Wen Xiaoli Zhou Qiuling Wu Hongchen He Wen Huang Source Type: research

Maternal exposure to glyphosate-based herbicide causes vascular dysfunction in offspring female rats
This study analyzed how glyphosate exposure in the gestational period affects vascular function in their female offspring and whether oxidative stress is involved in this effect. To this, pregnant Wistar rats were exposed through drinking water to 0.2% of a glyphosate commercial formulation, and we analyzed the response to acetylcholine and phenylephrine in the aorta from offspring of Glyphosate-based herbicide (O-GBH) and controls (O-CON) rats at six months of age. Relaxation to acetylcholine was reduced in O-GBH than in O-CON. Acute Indomethacin and Apocynin increased relaxation to acetylcholine in O-GBH. The aorta from ...
Source: Toxicology and Applied Pharmacology - February 28, 2024 Category: Toxicology Authors: Jeniffer Ailane Nunes Dayanne Cintia Alves de Lima Vivian Giselly Da Silva Moraes Marcos Ver íssimo de Oliveira Cardoso Luciano Augusto de Ara újo Ribeiro Diego Barbosa de Queiroz Fabr ício Souza Silva Source Type: research

Efficacy of a combined anti-seizure treatment against cholinergic established status epilepticus following a sarin nerve agent insult in rats
Toxicol Appl Pharmacol. 2024 Feb 21:116870. doi: 10.1016/j.taap.2024.116870. Online ahead of print.ABSTRACTThe development of refractory status epilepticus (SE) following sarin intoxication presents a therapeutic challenge. Here, we evaluated the efficacy of delayed combined double or triple treatment in reducing abnormal epileptiform seizure activity (ESA) and the ensuing long-term neuronal insult. SE was induced in rats by exposure to 1.2 LD50 sarin followed by treatment with atropine and TMB4 (TA) 1 min later. Double treatment with ketamine and midazolam or triple treatment with ketamine, midazolam and levetiracetam was...
Source: Toxicology and Applied Pharmacology - February 23, 2024 Category: Toxicology Authors: Lazar Shlomi Neufeld-Cohen Adi Egoz Inbal Baranes Shlomi Gez Rellie Glick Pnina Cohen Maayan Gutman Hila Chapman Shira Gore Ariel Source Type: research