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NMNATs expression inhibition mediated NAD < sup > + < /sup > deficiency plays a critical role in doxorubicin-induced hepatotoxicity in mice
In conclusion, NAD+ deficiency due to NMNATs expression inhibition may attribute to the pathogenesis of DOX-induced hepatotoxicity, thus providing new insights for mitigating DOX side effects.PMID:38160893 | DOI:10.1016/j.taap.2023.116799 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - December 31, 2023 Category: Toxicology Authors: Fang Cheng Yongtai Zhang Hongli Xiong Minzhu Zhao Qi Wang Ying Zhu Yongguo Li Renkuan Tang Jianbo Li Source Type: research

Vitamin C enhances the sensitivity of osteosarcoma to arsenic trioxide via inhibiting aerobic glycolysis
Toxicol Appl Pharmacol. 2023 Dec 29:116798. doi: 10.1016/j.taap.2023.116798. Online ahead of print.ABSTRACTOsteosarcoma (OS) is a common malignant tumor disease in the department of orthopedics, which is prone to the age of adolescents and children under 20 years old. Arsenic trioxide (ATO), an ancient poison, has been reported to play a critical role in a variety of tumor treatments, including OS. However, due to certain poisonous side effects such as cardiotoxicity and hepatotoxicity, clinical application of ATO has been greatly limited. Here we report that low doses of ATO (1 μM) observably reduced the half-effective i...
Source: Toxicology and Applied Pharmacology - December 31, 2023 Category: Toxicology Authors: Ying Liu Jinrui Yue Zijing Ren Mingyu He Ao Wang Jiajie Xie Tao Li Guoxin Liu Xuting He Shiyu Ge Ye Yuan Lei Yang Source Type: research

Effects of exposure to the neonicotinoid pesticide clothianidin on mouse intestinal microbiota under unpredictable environmental stress
This study revealed that the combined exposure to CLO and stress not only amplifies their individual effects on intestinal microbiota but also demonstrates combined and multifaceted toxicities.PMID:38160895 | DOI:10.1016/j.taap.2023.116795 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - December 31, 2023 Category: Toxicology Authors: Sakura Yonoichi Tetsushi Hirano Yukako Hara Yuya Ishida Asuka Shoda Mako Kimura Midori Murata Youhei Mantani Toshifumi Yokoyama Yoshinori Ikenaka Nobuhiko Hoshi Source Type: research

Lactational transfer of sulforaphane-N-acetylcysteine in vivo and in human breast milk
Toxicol Appl Pharmacol. 2023 Dec 23:116796. doi: 10.1016/j.taap.2023.116796. Online ahead of print.ABSTRACTSulforaphane (SFN) is a bioactive phytonutrient found in cruciferous vegetables. There is a lack of detailed information on the lactational transfer of SFN and SFN metabolites, and potential pharmacological effects on breastfeeding infants. We carried out two maternal supplementation studies in a mouse model, wherein lactating dams received either vehicle, 300 or 600 ppm SFN from postnatal day (PND) 1 to 5, or in a second experiment, vehicle or 600 ppm SFN from PND 1 to 14. The parent compound was only detectable in m...
Source: Toxicology and Applied Pharmacology - December 25, 2023 Category: Toxicology Authors: Ross Shore Jonathan Behlen Dylan McBee Keerthana Prayaga Faith Haugen Lenore Craig Michael Shields Toriq Mustapha Navada Harvey Natalie Johnson Source Type: research

Lactational transfer of sulforaphane-N-acetylcysteine in vivo and in human breast milk
Toxicol Appl Pharmacol. 2023 Dec 23:116796. doi: 10.1016/j.taap.2023.116796. Online ahead of print.ABSTRACTSulforaphane (SFN) is a bioactive phytonutrient found in cruciferous vegetables. There is a lack of detailed information on the lactational transfer of SFN and SFN metabolites, and potential pharmacological effects on breastfeeding infants. We carried out two maternal supplementation studies in a mouse model, wherein lactating dams received either vehicle, 300 or 600 ppm SFN from postnatal day (PND) 1 to 5, or in a second experiment, vehicle or 600 ppm SFN from PND 1 to 14. The parent compound was only detectable in m...
Source: Toxicology and Applied Pharmacology - December 25, 2023 Category: Toxicology Authors: Ross Shore Jonathan Behlen Dylan McBee Keerthana Prayaga Faith Haugen Lenore Craig Michael Shields Toriq Mustapha Navada Harvey Natalie Johnson Source Type: research

Lactational transfer of sulforaphane-N-acetylcysteine in vivo and in human breast milk
Toxicol Appl Pharmacol. 2023 Dec 23:116796. doi: 10.1016/j.taap.2023.116796. Online ahead of print.ABSTRACTSulforaphane (SFN) is a bioactive phytonutrient found in cruciferous vegetables. There is a lack of detailed information on the lactational transfer of SFN and SFN metabolites, and potential pharmacological effects on breastfeeding infants. We carried out two maternal supplementation studies in a mouse model, wherein lactating dams received either vehicle, 300 or 600 ppm SFN from postnatal day (PND) 1 to 5, or in a second experiment, vehicle or 600 ppm SFN from PND 1 to 14. The parent compound was only detectable in m...
Source: Toxicology and Applied Pharmacology - December 25, 2023 Category: Toxicology Authors: Ross Shore Jonathan Behlen Dylan McBee Keerthana Prayaga Faith Haugen Lenore Craig Michael Shields Toriq Mustapha Navada Harvey Natalie Johnson Source Type: research

Lactational transfer of sulforaphane-N-acetylcysteine in vivo and in human breast milk
Toxicol Appl Pharmacol. 2023 Dec 23:116796. doi: 10.1016/j.taap.2023.116796. Online ahead of print.ABSTRACTSulforaphane (SFN) is a bioactive phytonutrient found in cruciferous vegetables. There is a lack of detailed information on the lactational transfer of SFN and SFN metabolites, and potential pharmacological effects on breastfeeding infants. We carried out two maternal supplementation studies in a mouse model, wherein lactating dams received either vehicle, 300 or 600 ppm SFN from postnatal day (PND) 1 to 5, or in a second experiment, vehicle or 600 ppm SFN from PND 1 to 14. The parent compound was only detectable in m...
Source: Toxicology and Applied Pharmacology - December 25, 2023 Category: Toxicology Authors: Ross Shore Jonathan Behlen Dylan McBee Keerthana Prayaga Faith Haugen Lenore Craig Michael Shields Toriq Mustapha Navada Harvey Natalie Johnson Source Type: research

Lactational transfer of sulforaphane-N-acetylcysteine in vivo and in human breast milk
Toxicol Appl Pharmacol. 2023 Dec 23:116796. doi: 10.1016/j.taap.2023.116796. Online ahead of print.ABSTRACTSulforaphane (SFN) is a bioactive phytonutrient found in cruciferous vegetables. There is a lack of detailed information on the lactational transfer of SFN and SFN metabolites, and potential pharmacological effects on breastfeeding infants. We carried out two maternal supplementation studies in a mouse model, wherein lactating dams received either vehicle, 300 or 600 ppm SFN from postnatal day (PND) 1 to 5, or in a second experiment, vehicle or 600 ppm SFN from PND 1 to 14. The parent compound was only detectable in m...
Source: Toxicology and Applied Pharmacology - December 25, 2023 Category: Toxicology Authors: Ross Shore Jonathan Behlen Dylan McBee Keerthana Prayaga Faith Haugen Lenore Craig Michael Shields Toriq Mustapha Navada Harvey Natalie Johnson Source Type: research

Resveratrol protects against doxorubicin-induced cardiotoxicity by attenuating ferroptosis through modulating the MAPK signaling pathway
This study demonstrates that Res effectively alleviates DIC by suppressing ferroptosis possibly through modulating the MAPK signaling pathway. Our results highlight that targeting ferroptosis can be a potential cardioprotective strategy for DIC.PMID:38142782 | DOI:10.1016/j.taap.2023.116794 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - December 24, 2023 Category: Toxicology Authors: Lu Chen Xingang Sun Zhen Wang Miao Chen Yuxian He Han Zhang Deheng Han Liangrong Zheng Source Type: research

Repositioning of FDA approved kinase inhibitor bosutinib for mitigation of radiation induced damage via inhibition of JNK pathway
Toxicol Appl Pharmacol. 2023 Dec 22:116792. doi: 10.1016/j.taap.2023.116792. Online ahead of print.ABSTRACTRadiotherapy is a common modality for cancer treatment. However, it is often associated with normal tissue toxicity in 20-80% of the patients. Radioprotectors can improve the outcome of radiotherapy by selectively protecting normal cells against radiation toxicity. In the present study, compound libraries containing 54 kinase inhibitors and 80 FDA-approved drugs were screened for radioprotection of lymphocytes using high throughput cell analysis. A second-generation FDA-approved kinase inhibitor, bosutinib, was identi...
Source: Toxicology and Applied Pharmacology - December 24, 2023 Category: Toxicology Authors: Babita Singh Raghavendra S Patwardhan Debojyoti Pal Dharmendra K Maurya Beena Singh Rahul Checker Deepak Sharma Santosh K Sandur Source Type: research

Resveratrol protects against doxorubicin-induced cardiotoxicity by attenuating ferroptosis through modulating the MAPK signaling pathway
This study demonstrates that Res effectively alleviates DIC by suppressing ferroptosis possibly through modulating the MAPK signaling pathway. Our results highlight that targeting ferroptosis can be a potential cardioprotective strategy for DIC.PMID:38142782 | DOI:10.1016/j.taap.2023.116794 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - December 24, 2023 Category: Toxicology Authors: Lu Chen Xingang Sun Zhen Wang Miao Chen Yuxian He Han Zhang Deheng Han Liangrong Zheng Source Type: research

Repositioning of FDA approved kinase inhibitor bosutinib for mitigation of radiation induced damage via inhibition of JNK pathway
Toxicol Appl Pharmacol. 2023 Dec 22:116792. doi: 10.1016/j.taap.2023.116792. Online ahead of print.ABSTRACTRadiotherapy is a common modality for cancer treatment. However, it is often associated with normal tissue toxicity in 20-80% of the patients. Radioprotectors can improve the outcome of radiotherapy by selectively protecting normal cells against radiation toxicity. In the present study, compound libraries containing 54 kinase inhibitors and 80 FDA-approved drugs were screened for radioprotection of lymphocytes using high throughput cell analysis. A second-generation FDA-approved kinase inhibitor, bosutinib, was identi...
Source: Toxicology and Applied Pharmacology - December 24, 2023 Category: Toxicology Authors: Babita Singh Raghavendra S Patwardhan Debojyoti Pal Dharmendra K Maurya Beena Singh Rahul Checker Deepak Sharma Santosh K Sandur Source Type: research

Exosome-derived miR-5p-72106_14 in vascular endothelial cells regulates fate determination of BMSCs
Toxicol Appl Pharmacol. 2023 Dec 18;482:116793. doi: 10.1016/j.taap.2023.116793. Online ahead of print.ABSTRACTVascular endothelial cells have recently been shown to be associated with osteogenic activity. However, the mechanism of vascular endothelial cells promoting osteogenesis is unclear. Here, we found that exosomes secreted from human microvascular endothelial cells (HMEC-1) promoted osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and inhibited adipogenic differentiation. Aged and ovariectomy mice treated with exosomes showed increased bone formation and decreased lipid accumulation in the bo...
Source: Toxicology and Applied Pharmacology - December 20, 2023 Category: Toxicology Authors: Hang Li Jiaojiao Wang Xinyan Xie Yun Chen Qiyue Zheng Jieyu He Qiong Lu Source Type: research

Exosome-derived miR-5p-72106_14 in vascular endothelial cells regulates fate determination of BMSCs
Toxicol Appl Pharmacol. 2023 Dec 18:116793. doi: 10.1016/j.taap.2023.116793. Online ahead of print.ABSTRACTVascular endothelial cells have recently been shown to be associated with osteogenic activity. However, the mechanism of vascular endothelial cells promoting osteogenesis is unclear. Here, we found that exosomes secreted from human microvascular endothelial cells (HMEC-1) promoted osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and inhibited adipogenic differentiation. Aged and ovariectomy mice treated with exosomes showed increased bone formation and decreased lipid accumulation in the bone m...
Source: Toxicology and Applied Pharmacology - December 20, 2023 Category: Toxicology Authors: Hang Li Jiaojiao Wang Xinyan Xie Yun Chen Qiyue Zheng Jieyu He Qiong Lu Source Type: research

Exosome-derived miR-5p-72106_14 in vascular endothelial cells regulates fate determination of BMSCs
Toxicol Appl Pharmacol. 2023 Dec 18:116793. doi: 10.1016/j.taap.2023.116793. Online ahead of print.ABSTRACTVascular endothelial cells have recently been shown to be associated with osteogenic activity. However, the mechanism of vascular endothelial cells promoting osteogenesis is unclear. Here, we found that exosomes secreted from human microvascular endothelial cells (HMEC-1) promoted osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and inhibited adipogenic differentiation. Aged and ovariectomy mice treated with exosomes showed increased bone formation and decreased lipid accumulation in the bone m...
Source: Toxicology and Applied Pharmacology - December 20, 2023 Category: Toxicology Authors: Hang Li Jiaojiao Wang Xinyan Xie Yun Chen Qiyue Zheng Jieyu He Qiong Lu Source Type: research