Toxicology and Applied Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Mechanisms related to carbon nanotubes genotoxicity in human cell lines of respiratory origin
Toxicol Appl Pharmacol. 2023 Dec 7:116784. doi: 10.1016/j.taap.2023.116784. Online ahead of print.ABSTRACTPotential genotoxicity and carcinogenicity of carbon nanotubes (CNT), as well as the underlying mechanisms, remains a pressing topic. The study aimed to evaluate and compare the genotoxic effect and mechanisms of DNA damage under exposure to different types of CNT. Immortalized human cell lines of respiratory origin BEAS-2B, A549, MRC5-SV40 were exposed to three types of CNT: MWCNT Taunit-M, pristine and purified SWCNT TUBALL™ at concentrations in the range of 0.0006-200 μg/ml. Data on the CNT content in the workpla...
Source: Toxicology and Applied Pharmacology - December 9, 2023 Category: Toxicology Authors: Liliya M Fatkhutdinova Gulnaz F Gabidinova Amina G Daminova Ayrat M Dimiev Timur L Khamidullin Elena V Valeeva Agboigba Esperant Elvis Cokou Shamil Z Validov Gyuzel A Timerbulatova Source Type: research

Inhibitory effects of phthalate esters (PAEs) and phthalate monoesters towards human carboxylesterases (CESs)
Toxicol Appl Pharmacol. 2023 Dec 7:116785. doi: 10.1016/j.taap.2023.116785. Online ahead of print.ABSTRACTPhthalate esters (PAEs), accompanied by phthalate monoesters as hydrolysis metabolites in humans, have been widely used as plasticizers and exhibited disruptive effects on the endocrine and metabolic systems. The present study aims to investigate the inhibition behavior of PAEs and phthalate monoesters on the activity of the important hydrolytic enzymes, carboxylesterases (CESs), to elucidate the toxicity mechanism from a new perspective. The results showed significant inhibition on CES1 and CES2 by most PAEs, but not ...
Source: Toxicology and Applied Pharmacology - December 9, 2023 Category: Toxicology Authors: Jia-Min Gong Xiao-Lei Yi Jia-Hong Liang Zhen-Zhong Liu Zuo Du Source Type: research

Evaluation of dermal toxicity and toxicokinetics of povidone ‑iodine in Göttingen minipigs
CONCLUSION: Once-daily dermal application of 7.5% and 10% PVP-I for up to 39 weeks was safe and well tolerated in Göttingen Minipigs® and was not associated with skin irritation, thyroid dysfunction, or endocrine disruption. As the anatomy and physiology of the minipig skin closely resembles that of human skin, the findings of this study suggest that 7.5% and 10% PVP-I may be translated into antimicrobial benefits for humans without the risk of endocrine disruption.PMID:38061611 | DOI:10.1016/j.taap.2023.116783 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - December 7, 2023 Category: Toxicology Authors: Evangeline Priya Eddy Manjunath S Shet Marc Cataldo David Grob Sailaja Bhaskar Source Type: research

Icariin rescues developmental BPA exposure induced spatial memory deficits in rats
This study investigated the therapeutic effect of Icariin (10 mg/kg/day, from postnatal day (PND) 21 to PND 60 by gavage) on spatial memory deficits in rat induced by developmental BPA exposure (1 mg/kg/day, from embryonic to PND 60), demonstrating that Icariin can markedly improve spatial memory in BPA-exposed rat. Furthermore, intra-gastric administration of Icariin could attenuate abnormal hippocampal cell dispersion and loss, improved the dendritic spine density and Nissl bodies. Moreover, Icariin reversed BPA induced reduction of frequency of miniature excitatory postsynaptic currents(mEPSC) and decrease of Vesicular ...
Source: Toxicology and Applied Pharmacology - December 3, 2023 Category: Toxicology Authors: Danyang Li Shu Ai Chengqing Huang Zhi-Hua Liu Hui-Li Wang Source Type: research

MicroRNA-195-5p mediates arsenic-induced cytotoxicity in human lung epithelial cells: Beneficial role of plant-derived tannic acid
Toxicol Appl Pharmacol. 2023 Nov 30:116775. doi: 10.1016/j.taap.2023.116775. Online ahead of print.ABSTRACTArsenic (As), a highly toxic metalloid, which causes environmental lung diseases and affects millions of people worldwide. Respiratory epithelial cells are essential for maintaining lung homeostasis, aberrant epithelial damage and death due to exposure to a wide range of environmental pollutants, which are considered to be the initial trigger for many pulmonary diseases. Accumulating evidence has shown that microRNAs (miRNAs) appear to be important players in various normal physiological and pathological processes. Th...
Source: Toxicology and Applied Pharmacology - December 2, 2023 Category: Toxicology Authors: Sehal Mishra Neetu Kalra Mahendran Botlagunta Subbiah Rajasekaran Source Type: research

Saroglitazar mitigated NASH-associated hepatic injury in dexamethasone-treated rats via modulating autophagy, apoptosis, and necroptosis
This study aimed to evaluate the possible ameliorative effects of saroglitazar (SAR) on aspects of hepatic injury in dexamethasone (DEX)-induced nonalcoholic steatohepatitis (NASH) in rats. Wistar rats received SAR (2 or 4 mg/kg/day, orally) or metformin (MET, 500 mg/kg/day, orally) for one week before and concurrently with DEX administration (8 mg/kg/day, i.p., for 6 days. Control and drug control groups received vehicle or the higher dose of SAR, respectively. At the end of the experiment, an oral glucose tolerance test (OGTT) was conducted, serum hepatic function parameters and lipid profile were assessed, and hepatic h...
Source: Toxicology and Applied Pharmacology - December 1, 2023 Category: Toxicology Authors: Ahmed E Amer Hamdy A Ghoneim Rania R Abdelaziz George S G Shehatou Ghada M Suddek Source Type: research

Determining the safety of the tobacco cembranoid (1S,2E,4R,6R,7E,11E)-Cembratriene-4,6-diol (4R): A translational study in nonhuman primates
In conclusion, our results reinforce the notion that 4R is non-toxic in nonhuman primates under the conditions of this study.PMID:38036230 | DOI:10.1016/j.taap.2023.116772 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - November 30, 2023 Category: Toxicology Authors: Nadezhda Sabeva William Castro Yancy Ferrer Acosta Pedro A Ferchmin Vesna A Eterovi ć Demetrio Sierra-Mercado Naydi P érez Rios Sona Rivas-Tumanyan Antonio H Martins Source Type: research

Arsenic and UVR co-exposure results in unique gene expression profile identifying key co-carcinogenic mechanisms
Toxicol Appl Pharmacol. 2023 Nov 28:116773. doi: 10.1016/j.taap.2023.116773. Online ahead of print.ABSTRACTChanges in gene expression underlie many pathogenic endpoints including carcinogenesis. Metals, like arsenic, alter gene expression; however, the consequences of co-exposures of metals with other stressors are less understood. Although arsenic acts as a co-carcinogen by enhancing the development of UVR skin cancers, changes in gene expression in arsenic UVR co-carcinogenesis have not been investigated. We performed RNA-sequencing analysis to profile changes in gene expression distinct from arsenic or UVR exposures alo...
Source: Toxicology and Applied Pharmacology - November 30, 2023 Category: Toxicology Authors: Rachel M Speer Hui Yu Xixi Zhou Shuvro Nandi Ludmil Alexandrov Yan Guo Laurie G Hudson Ke Jian Liu Source Type: research