Toxicology and Applied Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Efficacy of a combined anti-seizure treatment against cholinergic established status epilepticus following a sarin nerve agent insult in rats
Toxicol Appl Pharmacol. 2024 Feb 21:116870. doi: 10.1016/j.taap.2024.116870. Online ahead of print.ABSTRACTThe development of refractory status epilepticus (SE) following sarin intoxication presents a therapeutic challenge. Here, we evaluated the efficacy of delayed combined double or triple treatment in reducing abnormal epileptiform seizure activity (ESA) and the ensuing long-term neuronal insult. SE was induced in rats by exposure to 1.2 LD50 sarin followed by treatment with atropine and TMB4 (TA) 1 min later. Double treatment with ketamine and midazolam or triple treatment with ketamine, midazolam and levetiracetam was...
Source: Toxicology and Applied Pharmacology - February 23, 2024 Category: Toxicology Authors: Lazar Shlomi Neufeld-Cohen Adi Egoz Inbal Baranes Shlomi Gez Rellie Glick Pnina Cohen Maayan Gutman Hila Chapman Shira Gore Ariel Source Type: research

Branching morphogenesis of the mouse mammary gland after exposure to benzophenone-3
In conclusion, exposure to BP3 does not impair mammary branching morphogenesis in our models. However, BP3 affects PR transcriptional expression and its downstream mediators, suggesting that exposure to BP3 might affect other developmental stages of the mammary gland.PMID:38382712 | DOI:10.1016/j.taap.2024.116868 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - February 21, 2024 Category: Toxicology Authors: Gonzalo Schierano-Marotti Gabriela A Altamirano Sofia Oddi Ayelen L Gomez Nicole Meyer M ónica Muñoz-de-Toro Ana C Zenclussen Horacio A Rodr íguez Laura Kass Source Type: research

Fenpropathrin provoked kidney damage via controlling the NLRP3/Caspase-1/GSDMD-mediated pyroptosis: The palliative role of curcumin-loaded chitosan nanoparticles
This study assessed the ability of formulated curcumin-loaded chitosan nanoparticles (CU-CS-NPs) to reduce the kidney damage resulting from fenpropathrin (FPN) in rats compared to curcumin (CU) in rats. Sixty male Sprague Dawley rats were separated into six groups and orally administered 1 mL/kg b.wt corn oil, 50 mg CU/kg b.wt, 50 mg CU-CS-NPs /kg b.wt., 15 mg FPN /kg b.wt, CU+ FPN or CU-CS-NPs + FPN for 60 days. Then, serum renal damage products were assessed. Total antioxidant capacity, reactive oxygen species, interleukin 1β (IL-1β), malondialdehyde, NF-κB P65, cleaved-Caspase-1, and Caspase-8 were estimated in kidne...
Source: Toxicology and Applied Pharmacology - February 21, 2024 Category: Toxicology Authors: Yasmina M Abd-Elhakim Amany Abdel-Rahman Mohamed Ahmed E Noreldin Tarek Khamis Areej A Eskandrani Ghalia Shamlan Wafa S Alansari Badriyah S Alotaibi Manal Alosaimi Mohammed Ageeli Hakami Samah S Abuzahrah Source Type: research

Can exposure to lisdexamfetamine dimesylate from juvenile period to peripubertal compromise male reproductive parameters in adult rats?
This study evaluated the effects of exposure to LDX from the juvenile to peripubertal period (critical stages of development) on systemic and reproductive toxicity parameters in male rats. Male Wistar rats (23 days old) were treated with 0; 5.2; 8.6 or 12.1 mg/kg/day of LDX from post-natal day (PND) 23 to 53, by gavage. LDX treatment led to reduced daily food and water consumption, as well as a decrease in social behaviors. The day of preputial separation remained unaltered, although the treated animals exhibited reduced weight. At PND 54, the treated animals presented signs of systemic toxicity, evidenced by a reduction i...
Source: Toxicology and Applied Pharmacology - February 20, 2024 Category: Toxicology Authors: Julia Stein B árbara Campos Jorge L ívia Trippe Nagaoka Ana Carolina Casali Reis Beatriz de Matos Manoel Alana Rezende Godoi Vanessa Caroline Fioravante Francisco Eduardo Martinez Patr ícia Fernanda Felipe Pinheiro Andr é Sampaio Pupo Arielle Cristina Source Type: research

Chronic arsenic exposure induces malignant transformation of human HaCaT cells through both deterministic and stochastic changes in transcriptome expression
In this study, we applied simple computational techniques to quantify (i) The impact of chronic arsenic (iAs) exposure as well as passaging time on stochastic gene expression and (ii) Which genes were expressed deterministically and which were expressed stochastically at each of the three stages of cancer development. Using biological coefficient of variation as an empirical measure of stochasticity we demonstrate that chronic iAs exposure consistently suppressed passaging related stochastic gene expression at multiple time points tested, selecting for a homogenous cell population that undergo transformation. Employing mul...
Source: Toxicology and Applied Pharmacology - February 19, 2024 Category: Toxicology Authors: Mayukh Banerjee Sudhir Srivastava Shesh N Rai J Christopher States Source Type: research

Foretinib, a c-MET receptor tyrosine kinase inhibitor, tackles multidrug resistance in cancer cells by inhibiting ABCB1 and ABCG2 transporters
CONCLUSION: Overall, our results suggest that foretinib can target MDR-linked ABCB1 and ABCG2 transporters in clinical cancer therapy.PMID:38367674 | DOI:10.1016/j.taap.2024.116866 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - February 17, 2024 Category: Toxicology Authors: Somayeh Nazari Fatemeh Mosaffa Alireza Poustforoosh Motahareh Mortazavi Luciano Saso Omidreza Firuzi Fatemeh Moosavi Source Type: research

Translation of nonclinical to clinical safety findings for 27 biotherapeutics
Toxicol Appl Pharmacol. 2024 Feb 10:116854. doi: 10.1016/j.taap.2024.116854. Online ahead of print.ABSTRACTHuman adverse drug reactions (ADRs), and nonclinical adverse and nonadverse findings were identified in 27 biotherapeutic programs and placed into organ categories to determine translation. The sensitivity of detecting human ADRs was 30.8% with a positive predictive value (PPV) of 53.3% for nonclinical adverse findings; sensitivity increased to 67.3% and PPV fell to 35.0% when including nonadverse findings. Nonclinical findings were associated with a greater likelihood of a human ADR in that organ category, especially...
Source: Toxicology and Applied Pharmacology - February 12, 2024 Category: Toxicology Authors: Michael W Leach Payal Rana Wenyue Hu Rajendar K Mittapalli Jason Pinkstaff David Potter Xing Min Qiu Lila Ramaiah Cynthia Rohde Feng Xia K Nasir Khan Source Type: research