Ursolic acid alleviates paclitaxel-induced peripheral neuropathy through PPAR γ activation

CONCLUSIONS: Taken together, the present study suggests ursolic acid has potential as a new PPARγ agonist targeting ER stress-related apoptotic pathways to ameliorate pacilitaxel-induced peripheral neuropathic pain and nerve injury, providing new clinical therapeutic method for CIPN.PMID:38437959 | DOI:10.1016/j.taap.2024.116883
Source: Toxicology and Applied Pharmacology - Category: Toxicology Authors: Source Type: research