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Genetic polymorphisms of CYP2B6 is a risk of metabolic associated fatty liver disease in Chinese population
CONCLUSION: Our study revealed that rs3745274 variants in CYP2B6 is associated with susceptibility to MAFLD in the Han Chinese population.PMID:37995809 | DOI:10.1016/j.taap.2023.116770 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - November 23, 2023 Category: Toxicology Authors: Jingwei Zhang Shijie Ma Wei Zhou Jing Feng Yuwei Kang Wei Yang Heping Zhang Fei Deng Source Type: research

The anti-cancer drug candidate CBL0137 induced necroptosis via forming left-handed Z-DNA and its binding protein ZBP1 in liver cells
Toxicol Appl Pharmacol. 2023 Nov 21:116765. doi: 10.1016/j.taap.2023.116765. Online ahead of print.ABSTRACTCBL0137, a promising small molecular anti-cancer drug candidate, has been found to effectively induce apoptosis via activating p53 and suppressing nuclear factor-kappa B (NF-κB). However, it is still not clear whether CBL0137 can induce necroptosis in liver cancer; and if so, what is the underlying molecular mechanism. Here we found that CBL0137 could significantly induce left-handed double helix structure Z-DNA formation in HepG2 cells as shown by Z-DNA specific antibody assay, which was further confirmed by observi...
Source: Toxicology and Applied Pharmacology - November 23, 2023 Category: Toxicology Authors: Jun Li Miao Tang Ruo-Xian Ke Pei-Lin Li Zhi-Guo Sheng Ben-Zhan Zhu Source Type: research

In vitro and in vivo approaches to assess atherosclerosis following exposure to low-dose mixtures of arsenic and cadmium
Toxicol Appl Pharmacol. 2023 Nov 18;481:116763. doi: 10.1016/j.taap.2023.116763. Online ahead of print.ABSTRACTWorldwide, millions of people are co-exposed to arsenic and cadmium. Environmental exposure to both metals is linked with a higher risk of atherosclerosis. While studies have characterized the pro-atherosclerotic effects of arsenic and cadmium as single agents, little is known about the potential effects of metal mixtures, particularly at low doses. Here, we used a combination of in vitro and in vivo models to assess the effects of low-dose metals individually and as mixtures on early events and plaque development...
Source: Toxicology and Applied Pharmacology - November 19, 2023 Category: Toxicology Authors: Nivetha K Subramaniam Natascha Gagnon Kiran Makhani Nikola Kukolj Michael H Mouradian Braeden H Giles Harinee Srikannan Victoria Fruh Jaymie Meliker Gregory A Wellenius Koren K Mann Source Type: research

Antioxidant, anti-inflammatory, and anti-apoptotic effects of genkwanin against aflatoxin B 1 -induced testicular toxicity
Toxicol Appl Pharmacol. 2023 Nov 18;481:116750. doi: 10.1016/j.taap.2023.116750. Online ahead of print.ABSTRACTAflatoxin B1 (AFB1) is the most hazardous aflatoxin that causes significant damage to the male reproductive system. Genkwanin (GNK) is a bioactive flavonoid that shows antioxidant and anti-inflammatory potential. Therefore, the current study was planned to evaluate the effects of GNK against AFB1-induced testicular toxicity. Forty-eight male rats were distributed into four groups (n = 12 rats). AFB1 (50 μg/kg) and GNK (20 mg/kg) were administered to the rats for eight weeks. Results of the current study revealed ...
Source: Toxicology and Applied Pharmacology - November 19, 2023 Category: Toxicology Authors: Muhammad Umar Ijaz Ayesha Ishtiaq Arfa Tahir Mughees Aizaz Alvi Azhar Rafique Peng Wang Guo-Ping Zhu Source Type: research

In vitro and in vivo approaches to assess atherosclerosis following exposure to low-dose mixtures of arsenic and cadmium
Toxicol Appl Pharmacol. 2023 Nov 17:116763. doi: 10.1016/j.taap.2023.116763. Online ahead of print.ABSTRACTWorldwide, millions of people are co-exposed to arsenic and cadmium. Environmental exposure to both metals is linked with a higher risk of atherosclerosis. While studies have characterized the pro-atherosclerotic effects of arsenic and cadmium as single agents, little is known about the potential effects of metal mixtures, particularly at low doses. Here, we used a combination of in vitro and in vivo models to assess the effects of low-dose metals individually and as mixtures on early events and plaque development ass...
Source: Toxicology and Applied Pharmacology - November 19, 2023 Category: Toxicology Authors: Nivetha K Subramaniam Natascha Gagnon Kiran Makhani Nikola Kukolj Michael H Mouradian Braeden Giles Harinee Srikannan Victoria Fruh Jaymie Meliker Gregory A Wellenius Koren K Mann Source Type: research

Antioxidant, anti-inflammatory, and anti-apoptotic effects of genkwanin against aflatoxin B 1 -induced testicular toxicity
Toxicol Appl Pharmacol. 2023 Nov 17:116750. doi: 10.1016/j.taap.2023.116750. Online ahead of print.ABSTRACTAflatoxin B1 (AFB1) is the most hazardous aflatoxin that causes significant damage to the male reproductive system. Genkwanin (GNK) is a bioactive flavonoid that shows antioxidant and anti-inflammatory potential. Therefore, the current study was planned to evaluate the effects of GNK against AFB1-induced testicular toxicity. Forty-eight male rats were distributed into four groups (n = 12 rats). AFB1 (50 μg/kg) and GNK (20 mg/kg) were administered to the rats for eight weeks. Results of the current study revealed that...
Source: Toxicology and Applied Pharmacology - November 19, 2023 Category: Toxicology Authors: Muhammad Umar Ijaz Ayesha Ishtiaq Arfa Tahir Mughees Aizaz Alvi Azhar Rafique Peng Wang Guo-Ping Zhu Source Type: research

Up-regulation of RNA m 6 A methyltransferase like-3 expression contributes to arsenic and benzo[a]pyrene co-exposure-induced cancer stem cell-like property and tumorigenesis
This study aimed to determine whether arsenic plus BaP exposure alters RNA m6A methylation and its role in lung tumorigenic effect of arsenic plus BaP exposure. Human bronchial epithelial cells transformed by exposure to arsenic or BaP alone, and arsenic plus BaP and mouse xenograft tumorigenesis models were used in this study. It was found that arsenic plus BaP exposure-transformed cells have significantly higher levels of RNA m6A methylation than arsenic or BaP alone exposure-transformed human bronchial epithelial cells. Western blot analysis showed that arsenic plus BaP exposure greatly up-regulates the m6A writer methy...
Source: Toxicology and Applied Pharmacology - November 16, 2023 Category: Toxicology Authors: Zhishan Wang Mohammad Burhan Uddin Po-Shun Wang Zulong Liu David Barzideh Chengfeng Yang Source Type: research

Intranasal delivery of sunitinib: A new therapeutic approach for targeting angiogenesis of glioblastoma
This study was designed to evaluate the effects of sunitinib, a multityrosine kinase inhibitor with tumor proliferation and angiogenesis inhibitory properties, on GBM-bearing rats. Given the ineffective drug delivery to the brain due to the presence of the blood-brain barrier (BBB), intra-nasal (IN) drug delivery has recently been considered as a non-invasive method to bypass BBB. Therefore, in the current study, IN was used as an ideal method for the delivery of sunitinib to the brain, and the effects of this method were also compared to the OR administration of the sunitinib. GBM was induced in the brain of male Wistar r...
Source: Toxicology and Applied Pharmacology - November 13, 2023 Category: Toxicology Authors: Elham Seidkhani Fatemeh Moradi Auob Rustamzadeh Sara Simorgh Sakine Shirvalilou Mehdi Mehdizadeh Hamed Dehghani Zeinab Akbarnejad Manijeh Motevalian Enam Alhagh Charkhat Gorgich Source Type: research

Elucidating the binding properties of methemoglobin in red blood cell to cyanide, hydrosulfide, and azide ions using artificial red blood cell
This study aimed to elucidate the binding properties of metHb in RBC under physiological and poisoned conditions using artificial RBC, which was hemoglobin encapsulated in a liposome. The mimic-circumstances of metHb in RBC (metHb-V) was prepared by oxidizing the hemoglobin in artificial RBC. Spectroscopic analysis indicated that the metHb in metHb-V exhibited a binding behavior different from that of naked metHb, depending on the toxic substance: When the pH decreased, (i) the cyanide binding affinity of metHb-V remained unchanged, but that of naked metHb decreased (ii) the hydrosulfide binding affinity was increased in m...
Source: Toxicology and Applied Pharmacology - November 13, 2023 Category: Toxicology Authors: Yuto Suzuki Yo Arakida Hiromi Sakai Yuki Enoki Kazuaki Matsumoto Kazuaki Taguchi Source Type: research