Toxicology and Applied Pharmacology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.The co-regulation of the gut microbiome and host genes might play essential roles in metformin gastrointestinal intolerance
In conclusion, this study suggests that metformin intolerance may be attributed to a decrease in anti-inflammatory-related flora and genes, and also alterations in PBAs accumulation-related flora. These findings open up possibilities for future research targeting gut flora and host genes to prevent metformin intolerance.PMID:37871735 | DOI:10.1016/j.taap.2023.116732 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - October 23, 2023 Category: Toxicology Authors: Huixiang Zhang Jiao Lai Lihuan Zhang Wei Zhang Xun Liu Qilin Gong Hongxi Tian Mingzhi Yang Tao Yang Rui Zhao Dongqing Li Hehua Huang Ya Zhao Shan Yan Ming Yu Yanbin Xiyang Lanlan Shi Lirong Yang Limei Wang Weiwen Chen Xue Cao Source Type: research
Distribution of morphine and methadone to the brain in a developmental chicken embryo model
Toxicol Appl Pharmacol. 2023 Oct 20:116731. doi: 10.1016/j.taap.2023.116731. Online ahead of print.ABSTRACTThe use and/or misuse of opioids by pregnant women would expose the fetuses to these drugs during critical stages of development with serious effects for the newborn, like the neonatal abstinence syndrome (NAS). We have revisited an established chicken model for NAS to describe the distribution of morphine and methadone to the brain and explore its validity as a valuable alternative to rodent models. For this purpose, chicken eggs were injected with a single dose of 10 mg/kg or 20 mg/kg morphine or 20 mg/kg methadone ...
Source: Toxicology and Applied Pharmacology - October 22, 2023 Category: Toxicology Authors: Dhaksshaginy Rajalingam Fernando Boix Ala Khoder Jannike M ørch Andersen Ragnhild Elisabeth Paulsen Source Type: research
Clonal variability in chromosomal instability as a potential driver in the acquisition of tumorigenic phenotype in chronic arsenic-exposed and hsa-miR-186 overexpressing human keratinocytes
Toxicol Appl Pharmacol. 2023 Oct 20:116730. doi: 10.1016/j.taap.2023.116730. Online ahead of print.ABSTRACTChronic arsenic exposure through drinking water is a global health issue, affecting >200 million people. Arsenic is a group I human carcinogen and causes chromosomal instability (CIN). Arsenic exposure is the second most common cause of skin cancer after UV radiation. hsa-miR-186 is overexpressed in arsenic-induced squamous cell carcinoma relative to premalignant hyperkeratosis. Among predicted targets of hsa-miR-186 are cell cycle regulators including regulators of mitotic progression. Disruption of mitotic progre...
Source: Toxicology and Applied Pharmacology - October 22, 2023 Category: Toxicology Authors: Angeliki Lykoudi Ana P Ferragut Cardoso Sandra S Wise Mayukh Banerjee J Christopher States Source Type: research
Towards translating in vitro measures of thyroid hormone system disruption to in vivo responses in the pregnant rat via a biologically based dose response (BBDR) model
Toxicol Appl Pharmacol. 2023 Oct 20:116733. doi: 10.1016/j.taap.2023.116733. Online ahead of print.ABSTRACTDespite the number of in vitro assays that have been recently developed to identify chemicals that interfere with the hypothalamic-pituitary-thyroid axis (HPT), the translation of those in vitro results into in vivo responses (in vitro to in vivo extrapolation, IVIVE) has received limited attention from the modeling community. To help advance this field a steady state biologically based dose response (BBDR) model for the HPT axis was constructed for the pregnant rat on gestation day (GD) 20. The BBDR HPT axis model pr...
Source: Toxicology and Applied Pharmacology - October 22, 2023 Category: Toxicology Authors: Jeffrey Fisher Conrad Housand David Mattie Andy Nong Marjory Moreau Mary Gilbert Source Type: research
Distribution of morphine and methadone to the brain in a developmental chicken embryo model
Toxicol Appl Pharmacol. 2023 Oct 20:116731. doi: 10.1016/j.taap.2023.116731. Online ahead of print.ABSTRACTThe use and/or misuse of opioids by pregnant women would expose the fetuses to these drugs during critical stages of development with serious effects for the newborn, like the neonatal abstinence syndrome (NAS). We have revisited an established chicken model for NAS to describe the distribution of morphine and methadone to the brain and explore its validity as a valuable alternative to rodent models. For this purpose, chicken eggs were injected with a single dose of 10 mg/kg or 20 mg/kg morphine or 20 mg/kg methadone ...
Source: Toxicology and Applied Pharmacology - October 22, 2023 Category: Toxicology Authors: Dhaksshaginy Rajalingam Fernando Boix Ala Khoder Jannike M ørch Andersen Ragnhild Elisabeth Paulsen Source Type: research
