Toxicology and Applied Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The SMAC mimetic GDC-0152 is a direct ABCB1-ATPase activity modulator and BIRC5 expression suppressor in cancer cells
In conclusion, GDC-0152 has the potential for use in the management of cancer patients with ABCB1 and BIRC5-related drug resistance. The findings of our study provide essential information to physicians for designing a more patient-specific GDC-0152 clinical trial program in the future.PMID:38452945 | DOI:10.1016/j.taap.2024.116888 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 7, 2024 Category: Toxicology Authors: I-Li Lin Yu-Ting Lin Yung-Chieh Chang Sree Karani Kondapuram Kai-Hsuan Lin Pin-Chen Chen Chung-Ying Kuo Mohane Selvaraj Coumar Chun Hei Antonio Cheung Source Type: research

Bronchioalveolar organoids: A preclinical tool to screen toxicity associated with antibody-drug conjugates
Toxicol Appl Pharmacol. 2024 Mar 5:116886. doi: 10.1016/j.taap.2024.116886. Online ahead of print.ABSTRACTDespite extensive preclinical testing, cancer therapeutics can result in unanticipated toxicity to non-tumor tissue in patients. These toxicities may pass undetected in preclinical experiments due to modeling limitations involving poor biomimicry of 2-dimensional in vitro cell cultures and due to lack of interspecies translatability in in vivo studies. Instead, primary cells can be grown into miniature 3-dimensional structures that recapitulate morphological and functional aspects of native tissue, termed "organoids." ...
Source: Toxicology and Applied Pharmacology - March 7, 2024 Category: Toxicology Authors: Tara N McCray Vy Nguyen Jake S Heins Elizabeth Nguyen Kristen Stewart Colby T Ford Calvin Neace Priyanka Gupta David J Ortiz Source Type: research

Role of MST2/YAP1 signaling pathway in retinal cells apoptosis and diabetic retinopathy
Toxicol Appl Pharmacol. 2024 Mar 4:116885. doi: 10.1016/j.taap.2024.116885. Online ahead of print.ABSTRACTDiabetic retinopathy (DR) is a main factor affecting vision of patients, and its pathogenesis is not completely clear. The purpose of our study was to investigate correlations between MST2 and DR progression, and to study the possible mechanism of MST2 and its down pathway in high glucose (HG)-mediated RGC-5 apoptosis. The diabetic rat model was established by intraperitoneal injection of streptozotocin (STZ) 60 mg/kg. HE and TUNEL staining were used to evaluate the pathological changes and apoptosis of retinal cells i...
Source: Toxicology and Applied Pharmacology - March 6, 2024 Category: Toxicology Authors: Xiao Zhang Dongmei Su Dong Wei Xiaoya Chen Yuzhu Hu Sijia Li Yue Zhang Xu Ma Shanshan Hu Zhaoyi Sun Source Type: research

Molecular docking, characterization, ADME/toxicity prediction, and anti-ulcer activity of new quercetin derivatives on indomethacin-induced gastric ulcer in mice
Toxicol Appl Pharmacol. 2024 Mar 4:116880. doi: 10.1016/j.taap.2024.116880. Online ahead of print.ABSTRACTGastric ulcer (GU) is a serious upper gastrointestinal tract disorder that affects people worldwide. The drugs now available for GU treatment have a high rate of relapses and drug interactions, as well as mild to severe side effects. As a result, new natural therapeutic medications for treating GU with fewer negative side effects are desperately needed. Because of quercetin's (QCT) diverse pharmacological effects and unique structural features, we decided to semi-synthesize new QCT derivatives and test them for antiulc...
Source: Toxicology and Applied Pharmacology - March 6, 2024 Category: Toxicology Authors: Maha B Salem Abdulrahman M Saleh Sayed H Seif El-Din Safia Samir Olfat A Hammam Naglaa M El-Lakkany Source Type: research

Pinoresinol diglucoside mitigates dexamethasone-induced osteoporosis and chondrodysplasia in zebrafish
CONCLUSION: PDG mitigates dexamethasone-induced osteoporosis and chondrodysplasia by promoting bone formation and activating Wnt signaling.PMID:38442791 | DOI:10.1016/j.taap.2024.116884 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 5, 2024 Category: Toxicology Authors: Yuhua Zuo Chao Chen Fasheng Liu Hongmei Hu Si Dong Qinyuan Shen Junquan Zeng Ling Huang Xinjun Liao Zigang Cao Zilin Zhong Huiqiang Lu Jianjun Chen Source Type: research

Mechanisms of adverse mammary effect induced by olanzapine and therapeutic interventions in rat model
CONCLUSIONS: These results shed light on the previously overlooked effect of olanzapine on mammary development and present experimental evidence to support current clinical management strategies of antipsychotic induced side effects in the breast.PMID:38437955 | DOI:10.1016/j.taap.2024.116876 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 4, 2024 Category: Toxicology Authors: Yingyue Dong Xiaozhe Sun Hanxiao Li Chunmiao Han Yue Zhang Huiru Ding Lisha Xia Huamin Wang Shaomin Yang Lingzi Xu Guoheng Xu Source Type: research

Resveratrol alleviates inflammatory bowel disease by inhibiting JAK2/STAT3 pathway activity via the reduction of O-GlcNAcylation of STAT3 in intestinal epithelial cells
Toxicol Appl Pharmacol. 2024 Mar 2;484:116882. doi: 10.1016/j.taap.2024.116882. Online ahead of print.ABSTRACTThe role of O-linked N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) in the pathogenesis of inflammatory bowel disease (IBD) has been increasingly highlighted in recent studies. It's been reported that signal transducer and activator of transcription 3 (STAT3) O-GlcNAcylation can affect the activity of the Janus kinase2 (JAK2)/STAT3 pathway.Our recent study showed that resveratrol repairsIBDin mice.On this basis,the present study aimed to explore whether the mechanism of IBD repair by resveratrol is a...
Source: Toxicology and Applied Pharmacology - March 4, 2024 Category: Toxicology Authors: Zhang Yaqin Wu Kehan Zhu Yi Wang Naijian Qiu Wei Mao Fei Source Type: research

Ondansetron attenuates cisplatin-induced behavioral and cognitive impairment through downregulation of NOD-like receptor inflammasome pathway
Toxicol Appl Pharmacol. 2024 Mar 2:116875. doi: 10.1016/j.taap.2024.116875. Online ahead of print.ABSTRACTCisplatin is an effective and commonly used chemotherapeutic drug; however, its use is accompanied by several adverse effects, including chemobrain. Ondansetron is a 5-HT3 antagonist, commonly used in prophylactic against chemotherapy-induced nausea and vomiting. Moreover, it has been identified as a novel neuroprotective agent in different animal models. However, its protective role against chemotherapy-induced chemobrain has not been investigated. The current study was the first study that explored the potential neur...
Source: Toxicology and Applied Pharmacology - March 4, 2024 Category: Toxicology Authors: Mennat-Allah M Hassan Sara A Wahdan Reem N El-Naga Tamer M Abdelghany Ebtehal El-Demerdash Source Type: research

Role of noradrenergic and dopaminergic systems in the antinociceptive effect of N-(3-(phenylselanyl)prop-2-yn-1-yl)benzamide in mice
Toxicol Appl Pharmacol. 2024 Mar 2;484:116881. doi: 10.1016/j.taap.2024.116881. Online ahead of print.ABSTRACTPain has a negative impact on public health, reducing quality of life. Unfortunately, current treatments are not fully effective and have adverse effects. Therefore, there is a need to develop new analgesic compounds. Due to promising results regarding the antinociceptive effect of N-(3-(phenylselanyl)prop-2-in-1-yl)benzamide (SePB), this study aimed to evaluate the participation of the dopaminergic and noradrenergic systems in this effect in mice, as well as its toxicity. To this, the antagonists sulpiride (D2/D3 ...
Source: Toxicology and Applied Pharmacology - March 4, 2024 Category: Toxicology Authors: Kauane Nayara Bahr Ledebuhr Gustavo D'Avila Nunes Marcelo Heinemann Presa Cleidi Maria Hartmann Benhur Godoi Cristiani Folharini Bortolatto C ésar Augusto Brüning Source Type: research

Ursolic acid alleviates paclitaxel-induced peripheral neuropathy through PPAR γ activation
CONCLUSIONS: Taken together, the present study suggests ursolic acid has potential as a new PPARγ agonist targeting ER stress-related apoptotic pathways to ameliorate pacilitaxel-induced peripheral neuropathic pain and nerve injury, providing new clinical therapeutic method for CIPN.PMID:38437959 | DOI:10.1016/j.taap.2024.116883 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 4, 2024 Category: Toxicology Authors: Yulian Yang Zhongzheng He Shuangchan Wu Source Type: research