Toxicology and Applied Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Tumor suppressive activity of AHR in environmental arsenic-induced carcinogenesis
Toxicol Appl Pharmacol. 2023 Nov 5:116747. doi: 10.1016/j.taap.2023.116747. Online ahead of print.ABSTRACTThe aryl hydrocarbon receptor (AHR) is a highly conserved pleiotropic transcription factor that senses environmental pollutants, microbial products, and endogenous ligands. The transcriptional targets of AHR include phase I and phase II detoxification enzymes, as well as numerous signaling molecules that affect a wide spectrum of biological and biochemical processes in a manner of cellular context-dependent. In this review, we systematically assess the latest discoveries of AHR in carcinogenesis with an emphasis on its...
Source: Toxicology and Applied Pharmacology - November 7, 2023 Category: Toxicology Authors: Ziwei Wang Yao Fu Akimasa Seno Zhuoyue Bi Aashna S Pawar Haoyan Ji Bandar Saeed Almutairy Yiran Qiu Wenxuan Zhang Chitra Thakur Fei Chen Source Type: research

Association of urinary arsenic, polycyclic aromatic hydrocarbons, and metals with cancers among the female population in the US
CONCLUSION: This study determined breast cancer and arsenic and some metal species exposure, indicating an inverse association. Arsenic acid and arsenobetaine exposure showed a positive correlation with cervical cancer. For uterine cancer, the correlations for the PAH compounds and cobalt showed a positive correlation, and the arsenic species and mercury were inversely associated. Further research is required to establish or refute the findings.PMID:37931756 | DOI:10.1016/j.taap.2023.116746 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - November 6, 2023 Category: Toxicology Authors: Humairat H Rahman Walker Toohey Stuart H Munson-McGee Source Type: research

Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasome
Toxicol Appl Pharmacol. 2023 Nov 4:116745. doi: 10.1016/j.taap.2023.116745. Online ahead of print.ABSTRACTThe aggregation of misfolded proteins, such as α-synuclein in Parkinson's disease (PD), occurs intracellularly or extracellularly in the majority of neurodegenerative diseases. The immunoproteasome has more potent chymotrypsin-like activity than normal proteasome. Thus, degradation of α-synuclein aggregation via immunoproteasome is an attractive approach for PD drug development. Herein, we aimed to determine if novel compound, 11-Hydroxy-1-(8-methoxy-5-(trifluoromethyl)quinolin-2-yl)undecan-1-one oxime (named as J243...
Source: Toxicology and Applied Pharmacology - November 6, 2023 Category: Toxicology Authors: Zhijian Pan Chao-Wu Yu Chen Zhao Min Shao Xuanjun Yang Xiaonan Liang Haitao Li Yucong Lu Qingqing Ye Ji-Wang Chern Jiahong Lu Hefeng Zhou Simon Ming-Yuen Lee Source Type: research

biquitin-specific peptidase 47 (USP47) regulates cutaneous oxidative injury through nicotinamide nucleotide transhydrogenase (NNT)
Toxicol Appl Pharmacol. 2023 Nov 2:116734. doi: 10.1016/j.taap.2023.116734. Online ahead of print.ABSTRACTHuman skin is daily exposed to oxidative stresses in the environment such as physical stimulation, chemical pollutants and pathogenic microorganisms, which are likely to cause skin diseases. As important post-translational modifications, protein ubiquitination and deubiquitination play crucial roles in maintaining cellular homeostasis by the proteolytic removal of oxidized proteins. We have previously reported that the expression of ubiquitin-specific protease 47 (USP47), a kind of deubiquitinating enzymes (DUBs), was ...
Source: Toxicology and Applied Pharmacology - November 4, 2023 Category: Toxicology Authors: Xiaoqian Li Kun Qian Yuehua Zhang Yining Zhang Yulan Liu Chuntang Sun Yang Jiao Daojiang Yu Fenghao Geng Jianping Cao Shuyu Zhang Source Type: research

The co-regulation of the gut microbiome and host genes might play essential roles in metformin gastrointestinal intolerance
In conclusion, this study suggests that metformin intolerance may be attributed to a decrease in anti-inflammatory-related flora and genes, and also alterations in PBAs accumulation-related flora. These findings open up possibilities for future research targeting gut flora and host genes to prevent metformin intolerance.PMID:37871735 | DOI:10.1016/j.taap.2023.116732 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - October 23, 2023 Category: Toxicology Authors: Huixiang Zhang Jiao Lai Lihuan Zhang Wei Zhang Xun Liu Qilin Gong Hongxi Tian Mingzhi Yang Tao Yang Rui Zhao Dongqing Li Hehua Huang Ya Zhao Shan Yan Ming Yu Yanbin Xiyang Lanlan Shi Lirong Yang Limei Wang Weiwen Chen Xue Cao Source Type: research