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Exosome-derived miR-5p-72106_14 in vascular endothelial cells regulates fate determination of BMSCs
Toxicol Appl Pharmacol. 2023 Dec 18:116793. doi: 10.1016/j.taap.2023.116793. Online ahead of print.ABSTRACTVascular endothelial cells have recently been shown to be associated with osteogenic activity. However, the mechanism of vascular endothelial cells promoting osteogenesis is unclear. Here, we found that exosomes secreted from human microvascular endothelial cells (HMEC-1) promoted osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and inhibited adipogenic differentiation. Aged and ovariectomy mice treated with exosomes showed increased bone formation and decreased lipid accumulation in the bone m...
Source: Toxicology and Applied Pharmacology - December 20, 2023 Category: Toxicology Authors: Hang Li Jiaojiao Wang Xinyan Xie Yun Chen Qiyue Zheng Jieyu He Qiong Lu Source Type: research

Apoptotic mechanism of development inhibition in zebrafish induced by esketamine
Toxicol Appl Pharmacol. 2023 Dec 15;482:116789. doi: 10.1016/j.taap.2023.116789. Online ahead of print.ABSTRACTEsketamine, a widely used intravenous general anesthetic, is also employed for obstetric and pediatric anesthesia, and depression treatment. However, concerns regarding esketamine abuse have emerged. Moreover, the potential in vivo toxicity of esketamine on growth and development remains unclear. To address these concerns, we investigated the effects of esketamine exposure on developmental parameters, cell apoptosis, and gene expression in zebrafish. Esketamine exposure concentration-dependently decreased the hear...
Source: Toxicology and Applied Pharmacology - December 16, 2023 Category: Toxicology Authors: Wenjuan Yuan Yinggang Xiao Yang Zhang Kuilin Xiang Tianfeng Huang Mohamed Diaby Ju Gao Source Type: research

Luteolin inhibits the JAK/STAT pathway to alleviate auditory cell apoptosis of acquired sensorineural hearing loss based on network pharmacology, molecular docking, molecular dynamics simulation, and experiments in vitro
CONCLUSION: This study manifested that luteolin could reduce acquired SNHL-related auditory cell apoptosis through the JAK/STAT pathway, which provided a new idea for acquired SNHL pharmacological treatment.PMID:38103742 | DOI:10.1016/j.taap.2023.116790 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - December 16, 2023 Category: Toxicology Authors: Fang Guo Yingyuan Guo Dejun Zhang Zeming Fu Shuang Han Yining Wan Guofang Guan Source Type: research

Recent advances in the cardiotoxicity of anti-cancer drugs: Navigating the landscape of anthracycline-induced cardiotoxicity
Toxicol Appl Pharmacol. 2023 Dec 14:116791. doi: 10.1016/j.taap.2023.116791. Online ahead of print.NO ABSTRACTPMID:38103743 | DOI:10.1016/j.taap.2023.116791 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - December 16, 2023 Category: Toxicology Authors: Mark Chandy Daniel J Conklin Source Type: research

Apoptotic mechanism of development inhibition in zebrafish induced by esketamine
Toxicol Appl Pharmacol. 2023 Dec 14:116789. doi: 10.1016/j.taap.2023.116789. Online ahead of print.ABSTRACTEsketamine, a widely used intravenous general anesthetic, is also employed for obstetric and pediatric anesthesia, and depression treatment. However, concerns regarding esketamine abuse have emerged. Moreover, the potential in vivo toxicity of esketamine on growth and development remains unclear. To address these concerns, we investigated the effects of esketamine exposure on developmental parameters, cell apoptosis, and gene expression in zebrafish. Esketamine exposure concentration-dependently decreased the heart ra...
Source: Toxicology and Applied Pharmacology - December 16, 2023 Category: Toxicology Authors: Wenjuan Yuan Yinggang Xiao Yang Zhang Kuilin Xiang Tianfeng Huang Mohamed Diaby Ju Gao Source Type: research

Arsenic up-regulates PD-L1 and enhances lung tumorigenesis through activation of STAT3 in alveolar epithelial type 2 cells
Toxicol Appl Pharmacol. 2023 Dec 14;482:116787. doi: 10.1016/j.taap.2023.116787. Online ahead of print.ABSTRACTArsenic is a carcinogen and chronic exposure to arsenic increases the risk of many cancers, including lung cancer. However, the underlying mechanism is not clear. Using A/J mice as a model, our previous animal study has shown that chronic arsenic exposure up-regulates PD-L1 on lung tumor cells which interacts with PD-1 on T cells and inhibits T cell anti-tumor function resulting in increased lung tumorigenesis. In a subsequent in vitro study, we further found that arsenic up-regulated PD-L1 by activating STAT3 at ...
Source: Toxicology and Applied Pharmacology - December 15, 2023 Category: Toxicology Authors: Wenhua Xu Jiajun Cui Abdulrahman M Busayli Tong Zhang Gang Chen Source Type: research

Arsenic up-regulates PD-L1 and enhances lung tumorigenesis through activation of STAT3 in alveolar epithelial type 2 cells
Toxicol Appl Pharmacol. 2023 Dec 13:116787. doi: 10.1016/j.taap.2023.116787. Online ahead of print.ABSTRACTArsenic is a carcinogen and chronic exposure to arsenic increases the risk of many cancers, including lung cancer. However, the underlying mechanism is not clear. Using A/J mice as a model, our previous animal study has shown that chronic arsenic exposure up-regulates PD-L1 on lung tumor cells which interacts with PD-1 on T cells and inhibits T cell anti-tumor function resulting in increased lung tumorigenesis. In a subsequent in vitro study, we further found that arsenic up-regulated PD-L1 by activating STAT3 at tyro...
Source: Toxicology and Applied Pharmacology - December 15, 2023 Category: Toxicology Authors: Wenhua Xu Jiajun Cui Abdulrahman M Busayli Tong Zhang Gang Chen Source Type: research

Regulation of Hippo-YAP/CTGF signaling by combining an HDAC inhibitor and 5-fluorouracil in gastric cancer cells
Toxicol Appl Pharmacol. 2023 Dec 10:116786. doi: 10.1016/j.taap.2023.116786. Online ahead of print.ABSTRACTHistone deacetylase (HDAC) inhibitors diminish carcinogenesis, metastasis, and cancer cell proliferation by inducing death in cancer cells. Tissue regeneration and organ development are highly dependent on the Hippo signaling pathway. Targeting the dysregulated hippo pathway is an excellent approach for cancer treatment. According to the results of this study, the combination of panobinostat, a histone deacetylase inhibitor, and 5-fluorouracil (5-FU), a chemotherapy drug, can act synergistically to induce apoptosis in...
Source: Toxicology and Applied Pharmacology - December 12, 2023 Category: Toxicology Authors: Yanling Wu Cong Shan Li Ruo Yu Meng Hua Jin Ok Hee Chai Soo Mi Kim Source Type: research

Plasticizer acetyl triethyl citrate (ATEC) induces lipogenesis and obesity
This study for the first time provided initial evidence suggesting the obesogenic and fatty liver-inducing effect of ATEC at low doses near human exposure levels, and ATEC might be a potential environmental obesogen and its effect on human health need to be further evaluated.PMID:38086441 | DOI:10.1016/j.taap.2023.116788 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - December 12, 2023 Category: Toxicology Authors: Peiqi Li Qian Xu Weigao Zhang Danyang Zhang Xin Liao Xunan Zhao Jianfa Zhang Tingzhe Sun Dan Weng Source Type: research