Toxicology and Applied Pharmacology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Acetyl-11-keto-beta-boswellic acid inhibits cell proliferation and growth of oral squamous cell carcinoma via RAB7B-mediated autophagy
Toxicol Appl Pharmacol. 2024 Mar 19;485:116906. doi: 10.1016/j.taap.2024.116906. Online ahead of print.ABSTRACTNatural products can overcome the limitations of conventional chemotherapy. Acetyl-11-keto-beta-boswellic acid (AKBA) as a natural product extracted from frankincense, exhibited chemotherapeutic activities in different cancers. However, whether AKBA exerts inhibiting effect of oral squamous cell carcinoma (OSCC) cells growth and the mechanism need to be explored. We attempted to investigate the therapeutic effects of AKBA against OSCC and explore the mechanism involved. Here we attempt to disclose the cell-killing...
Source: Toxicology and Applied Pharmacology - March 21, 2024 Category: Toxicology Authors: Dan Pan Qing Wang Shouyi Tang Xingbo Wu Luyao Cai Zhen Wang Ying Li Mei Huang Yu Zhou Ying-Qiang Shen Source Type: research
Role of macrophage bioenergetics in N-acetylcysteine-mediated mitigation of lung injury and oxidative stress induced by nitrogen mustard
Toxicol Appl Pharmacol. 2024 Mar 19:116908. doi: 10.1016/j.taap.2024.116908. Online ahead of print.ABSTRACTNitrogen mustard (NM) is a toxic vesicant that causes acute injury to the respiratory tract. This is accompanied by an accumulation of activated macrophages in the lung and oxidative stress which have been implicated in tissue injury. In these studies, we analyzed the effects of N-acetylcysteine (NAC), an inhibitor of oxidative stress and inflammation on NM-induced lung injury, macrophage activation and bioenergetics. Treatment of rats with NAC (150 mg/kg, i.p., daily) beginning 30 min after administration of NM (0.12...
Source: Toxicology and Applied Pharmacology - March 21, 2024 Category: Toxicology Authors: Rama Malaviya Jaclynn Meshanni Vasanthi R Sunil Alessandro Venosa Changjiang Guo Elena V Abramova Kinal N Vayas Chenghui Jiang Jessica A Cervelli Andrew J Gow Jeffrey D Laskin Debra L Laskin Source Type: research
Acetyl-11-keto-beta-boswellic acid inhibits cell proliferation and growth of oral squamous cell carcinoma via RAB7B-mediated autophagy
Toxicol Appl Pharmacol. 2024 Mar 19:116906. doi: 10.1016/j.taap.2024.116906. Online ahead of print.ABSTRACTNatural products can overcome the limitations of conventional chemotherapy. Acetyl-11-keto-beta-boswellic acid (AKBA) as a natural product extracted from frankincense, exhibited chemotherapeutic activities in different cancers. However, whether AKBA exerts inhibiting effect of oral squamous cell carcinoma (OSCC) cells growth and the mechanism need to be explored. We attempted to investigate the therapeutic effects of AKBA against OSCC and explore the mechanism involved. Here we attempt to disclose the cell-killing eff...
Source: Toxicology and Applied Pharmacology - March 21, 2024 Category: Toxicology Authors: Dan Pan Qing Wang Shouyi Tang Xingbo Wu Luyao Cai Zhen Wang Ying Li Mei Huang Yu Zhou Ying-Qiang Shen Source Type: research
Role of macrophage bioenergetics in N-acetylcysteine-mediated mitigation of lung injury and oxidative stress induced by nitrogen mustard
Toxicol Appl Pharmacol. 2024 Mar 19:116908. doi: 10.1016/j.taap.2024.116908. Online ahead of print.ABSTRACTNitrogen mustard (NM) is a toxic vesicant that causes acute injury to the respiratory tract. This is accompanied by an accumulation of activated macrophages in the lung and oxidative stress which have been implicated in tissue injury. In these studies, we analyzed the effects of N-acetylcysteine (NAC), an inhibitor of oxidative stress and inflammation on NM-induced lung injury, macrophage activation and bioenergetics. Treatment of rats with NAC (150 mg/kg, i.p., daily) beginning 30 min after administration of NM (0.12...
Source: Toxicology and Applied Pharmacology - March 21, 2024 Category: Toxicology Authors: Rama Malaviya Jaclynn Meshanni Vasanthi R Sunil Alessandro Venosa Changjiang Guo Elena V Abramova Kinal N Vayas Chenghui Jiang Jessica A Cervelli Andrew J Gow Jeffrey D Laskin Debra L Laskin Source Type: research
Dantrolene and coenzyme Q10 as a suggested combination therapy to statin-induced myopathy in high fat diet rats: A possible interference with ROS/ TGF- β / Smad4 signaling pathway
Toxicol Appl Pharmacol. 2024 Mar 18:116900. doi: 10.1016/j.taap.2024.116900. Online ahead of print.ABSTRACTOne of the major hitches for statins' utilization is the development of myotoxicity. Versatile studies reported that the underlining molecular mechanisms including coenzyme Q10 (CoQ10)/ubiquinone depletion, as well as the disturbance in the cytoplasmic Ca2+ homeostasis. Therefore, we investigated the consequences of supplementing CoQ10 and dantrolene, a cytoplasmic Ca2+ reducing agent, in combination with simvastatin. This adjuvant therapy normalized the simvastatin-mediated elevation in serum ALT, AST, CK-MM, as well...
Source: Toxicology and Applied Pharmacology - March 20, 2024 Category: Toxicology Authors: Sherin Zakaria Ahmed M Elshazly Reem Alaa Samer Elsebaey Source Type: research
Dantrolene and coenzyme Q10 as a suggested combination therapy to statin-induced myopathy in high fat diet rats: A possible interference with ROS/ TGF- β / Smad4 signaling pathway
Toxicol Appl Pharmacol. 2024 Mar 18:116900. doi: 10.1016/j.taap.2024.116900. Online ahead of print.ABSTRACTOne of the major hitches for statins' utilization is the development of myotoxicity. Versatile studies reported that the underlining molecular mechanisms including coenzyme Q10 (CoQ10)/ubiquinone depletion, as well as the disturbance in the cytoplasmic Ca2+ homeostasis. Therefore, we investigated the consequences of supplementing CoQ10 and dantrolene, a cytoplasmic Ca2+ reducing agent, in combination with simvastatin. This adjuvant therapy normalized the simvastatin-mediated elevation in serum ALT, AST, CK-MM, as well...
Source: Toxicology and Applied Pharmacology - March 20, 2024 Category: Toxicology Authors: Sherin Zakaria Ahmed M Elshazly Reem Alaa Samer Elsebaey Source Type: research
orced expression of microRNA-221-3p exerts protective effects against manganese-induced cytotoxicity in human lung epithelial cells
In conclusion, miR-221-3p may be the most likely target that accounts for the cytotoxicity of Mn2+-exposed lung epithelial cells.PMID:38503349 | DOI:10.1016/j.taap.2024.116904 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 19, 2024 Category: Toxicology Authors: Deepa Gandhi Sneha Bhandari Sehal Mishra Ashwinkumar P Rudrashetti Umashankar Vetrivel Rajesh K Thimmulappa Subbiah Rajasekaran Source Type: research
Crosstalk between autophagy and inflammasomes in ricin-induced inflammatory injury
In conclusion, RT promoted NLRP3 inflammasome activation and autophgay. Inflammation induced by RT was attenuated by autophagy activation, which suppressed the NLRP3 inflammasome. These findings suggest Rapa as a potential therapeutic drug for the treatment of RT-induced inflammation-related diseases.PMID:38492674 | DOI:10.1016/j.taap.2024.116890 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 16, 2024 Category: Toxicology Authors: Shiji Zhang Na Zhao Suli Song Yanchun Wang Yan Wang Chengbiao Sun Mingxin Dong Mengqi Huo Na Xu Wensen Liu Guorui Li Source Type: research
Empagliflozin and pirfenidone confer renoprotection through suppression of glycogen synthase kinase-3 β and promotion of tubular regeneration in rats with induced metabolic syndrome
This study investigated the effect empagliflozin and/or pirfenidone against MetS-induced kidney dysfunction, and to clarify additional underpinning mechanisms particularly the GSK-3β signaling pathway. Adult male rats received 10%w/v fructose in drinking water for 20 weeks to develop MetS, then treated with either drug vehicle, empagliflozin (30 mg/kg/day) and/or pirfenidone (100 mg/kg/day) via oral gavage for subsequent 4 weeks, concurrently with the high dietary fructose. Age-matched rats receiving normal drinking water were used as controls. After 24 weeks, blood and kidneys were harvested for subsequent analyses. Rats...
Source: Toxicology and Applied Pharmacology - March 16, 2024 Category: Toxicology Authors: Hoda E Mohamed Merna A Abdelhady Asmaa M Elmaghraby Rania A Elrashidy Source Type: research
Crosstalk between autophagy and inflammasomes in ricin-induced inflammatory injury
In conclusion, RT promoted NLRP3 inflammasome activation and autophgay. Inflammation induced by RT was attenuated by autophagy activation, which suppressed the NLRP3 inflammasome. These findings suggest Rapa as a potential therapeutic drug for the treatment of RT-induced inflammation-related diseases.PMID:38492674 | DOI:10.1016/j.taap.2024.116890 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 16, 2024 Category: Toxicology Authors: Shiji Zhang Na Zhao Suli Song Yanchun Wang Yan Wang Chengbiao Sun Mingxin Dong Mengqi Huo Na Xu Wensen Liu Guorui Li Source Type: research
Empagliflozin and pirfenidone confer renoprotection through suppression of glycogen synthase kinase-3 β and promotion of tubular regeneration in rats with induced metabolic syndrome
This study investigated the effect empagliflozin and/or pirfenidone against MetS-induced kidney dysfunction, and to clarify additional underpinning mechanisms particularly the GSK-3β signaling pathway. Adult male rats received 10%w/v fructose in drinking water for 20 weeks to develop MetS, then treated with either drug vehicle, empagliflozin (30 mg/kg/day) and/or pirfenidone (100 mg/kg/day) via oral gavage for subsequent 4 weeks, concurrently with the high dietary fructose. Age-matched rats receiving normal drinking water were used as controls. After 24 weeks, blood and kidneys were harvested for subsequent analyses. Rats...
Source: Toxicology and Applied Pharmacology - March 16, 2024 Category: Toxicology Authors: Hoda E Mohamed Merna A Abdelhady Asmaa M Elmaghraby Rania A Elrashidy Source Type: research
Crosstalk between autophagy and inflammasomes in ricin-induced inflammatory injury
In conclusion, RT promoted NLRP3 inflammasome activation and autophgay. Inflammation induced by RT was attenuated by autophagy activation, which suppressed the NLRP3 inflammasome. These findings suggest Rapa as a potential therapeutic drug for the treatment of RT-induced inflammation-related diseases.PMID:38492674 | DOI:10.1016/j.taap.2024.116890 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 16, 2024 Category: Toxicology Authors: Shiji Zhang Na Zhao Suli Song Yanchun Wang Yan Wang Chengbiao Sun Mingxin Dong Mengqi Huo Na Xu Wensen Liu Guorui Li Source Type: research
Empagliflozin and pirfenidone confer renoprotection through suppression of glycogen synthase kinase-3 β and promotion of tubular regeneration in rats with induced metabolic syndrome
This study investigated the effect empagliflozin and/or pirfenidone against MetS-induced kidney dysfunction, and to clarify additional underpinning mechanisms particularly the GSK-3β signaling pathway. Adult male rats received 10%w/v fructose in drinking water for 20 weeks to develop MetS, then treated with either drug vehicle, empagliflozin (30 mg/kg/day) and/or pirfenidone (100 mg/kg/day) via oral gavage for subsequent 4 weeks, concurrently with the high dietary fructose. Age-matched rats receiving normal drinking water were used as controls. After 24 weeks, blood and kidneys were harvested for subsequent analyses. Rats...
Source: Toxicology and Applied Pharmacology - March 16, 2024 Category: Toxicology Authors: Hoda E Mohamed Merna A Abdelhady Asmaa M Elmaghraby Rania A Elrashidy Source Type: research
Crosstalk between autophagy and inflammasomes in ricin-induced inflammatory injury
In conclusion, RT promoted NLRP3 inflammasome activation and autophgay. Inflammation induced by RT was attenuated by autophagy activation, which suppressed the NLRP3 inflammasome. These findings suggest Rapa as a potential therapeutic drug for the treatment of RT-induced inflammation-related diseases.PMID:38492674 | DOI:10.1016/j.taap.2024.116890 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 16, 2024 Category: Toxicology Authors: Shiji Zhang Na Zhao Suli Song Yanchun Wang Yan Wang Chengbiao Sun Mingxin Dong Mengqi Huo Na Xu Wensen Liu Guorui Li Source Type: research
Empagliflozin and pirfenidone confer renoprotection through suppression of glycogen synthase kinase-3 β and promotion of tubular regeneration in rats with induced metabolic syndrome
This study investigated the effect empagliflozin and/or pirfenidone against MetS-induced kidney dysfunction, and to clarify additional underpinning mechanisms particularly the GSK-3β signaling pathway. Adult male rats received 10%w/v fructose in drinking water for 20 weeks to develop MetS, then treated with either drug vehicle, empagliflozin (30 mg/kg/day) and/or pirfenidone (100 mg/kg/day) via oral gavage for subsequent 4 weeks, concurrently with the high dietary fructose. Age-matched rats receiving normal drinking water were used as controls. After 24 weeks, blood and kidneys were harvested for subsequent analyses. Rats...
Source: Toxicology and Applied Pharmacology - March 16, 2024 Category: Toxicology Authors: Hoda E Mohamed Merna A Abdelhady Asmaa M Elmaghraby Rania A Elrashidy Source Type: research
