Elucidating the binding properties of methemoglobin in red blood cell to cyanide, hydrosulfide, and azide ions using artificial red blood cell
This study aimed to elucidate the binding properties of metHb in RBC under physiological and poisoned conditions using artificial RBC, which was hemoglobin encapsulated in a liposome. The mimic-circumstances of metHb in RBC (metHb-V) was prepared by oxidizing the hemoglobin in artificial RBC. Spectroscopic analysis indicated that the metHb in metHb-V exhibited a binding behavior different from that of naked metHb, depending on the toxic substance: When the pH decreased, (i) the cyanide binding affinity of metHb-V remained unchanged, but that of naked metHb decreased (ii) the hydrosulfide binding affinity was increased in m...
Source: Toxicology and Applied Pharmacology - November 13, 2023 Category: Toxicology Authors: Yuto Suzuki Yo Arakida Hiromi Sakai Yuki Enoki Kazuaki Matsumoto Kazuaki Taguchi Source Type: research

Intranasal delivery of sunitinib: A new therapeutic approach for targeting angiogenesis of glioblastoma
This study was designed to evaluate the effects of sunitinib, a multityrosine kinase inhibitor with tumor proliferation and angiogenesis inhibitory properties, on GBM-bearing rats. Given the ineffective drug delivery to the brain due to the presence of the blood-brain barrier (BBB), intra-nasal (IN) drug delivery has recently been considered as a non-invasive method to bypass BBB. Therefore, in the current study, IN was used as an ideal method for the delivery of sunitinib to the brain, and the effects of this method were also compared to the OR administration of the sunitinib. GBM was induced in the brain of male Wistar r...
Source: Toxicology and Applied Pharmacology - November 13, 2023 Category: Toxicology Authors: Elham Seidkhani Fatemeh Moradi Auob Rustamzadeh Sara Simorgh Sakine Shirvalilou Mehdi Mehdizadeh Hamed Dehghani Zeinab Akbarnejad Manijeh Motevalian Enam Alhagh Charkhat Gorgich Source Type: research

Elucidating the binding properties of methemoglobin in red blood cell to cyanide, hydrosulfide, and azide ions using artificial red blood cell
This study aimed to elucidate the binding properties of metHb in RBC under physiological and poisoned conditions using artificial RBC, which was hemoglobin encapsulated in a liposome. The mimic-circumstances of metHb in RBC (metHb-V) was prepared by oxidizing the hemoglobin in artificial RBC. Spectroscopic analysis indicated that the metHb in metHb-V exhibited a binding behavior different from that of naked metHb, depending on the toxic substance: When the pH decreased, (i) the cyanide binding affinity of metHb-V remained unchanged, but that of naked metHb decreased (ii) the hydrosulfide binding affinity was increased in m...
Source: Toxicology and Applied Pharmacology - November 13, 2023 Category: Toxicology Authors: Yuto Suzuki Yo Arakida Hiromi Sakai Yuki Enoki Kazuaki Matsumoto Kazuaki Taguchi Source Type: research

Intranasal delivery of sunitinib: A new therapeutic approach for targeting angiogenesis of glioblastoma
This study was designed to evaluate the effects of sunitinib, a multityrosine kinase inhibitor with tumor proliferation and angiogenesis inhibitory properties, on GBM-bearing rats. Given the ineffective drug delivery to the brain due to the presence of the blood-brain barrier (BBB), intra-nasal (IN) drug delivery has recently been considered as a non-invasive method to bypass BBB. Therefore, in the current study, IN was used as an ideal method for the delivery of sunitinib to the brain, and the effects of this method were also compared to the OR administration of the sunitinib. GBM was induced in the brain of male Wistar r...
Source: Toxicology and Applied Pharmacology - November 13, 2023 Category: Toxicology Authors: Elham Seidkhani Fatemeh Moradi Auob Rustamzadeh Sara Simorgh Sakine Shirvalilou Mehdi Mehdizadeh Hamed Dehghani Zeinab Akbarnejad Manijeh Motevalian Enam Alhagh Charkhat Gorgich Source Type: research

Elucidating the binding properties of methemoglobin in red blood cell to cyanide, hydrosulfide, and azide ions using artificial red blood cell
This study aimed to elucidate the binding properties of metHb in RBC under physiological and poisoned conditions using artificial RBC, which was hemoglobin encapsulated in a liposome. The mimic-circumstances of metHb in RBC (metHb-V) was prepared by oxidizing the hemoglobin in artificial RBC. Spectroscopic analysis indicated that the metHb in metHb-V exhibited a binding behavior different from that of naked metHb, depending on the toxic substance: When the pH decreased, (i) the cyanide binding affinity of metHb-V remained unchanged, but that of naked metHb decreased (ii) the hydrosulfide binding affinity was increased in m...
Source: Toxicology and Applied Pharmacology - November 13, 2023 Category: Toxicology Authors: Yuto Suzuki Yo Arakida Hiromi Sakai Yuki Enoki Kazuaki Matsumoto Kazuaki Taguchi Source Type: research

Nickel-induced transcriptional memory in lung epithelial cells promotes interferon signaling upon nicotine exposure
In this study, we investigated whether nickel-induced transcriptional memory influences the outcome of the cell's response to a second respiratory toxicant, nicotine. Nicotine, an addictive compound in tobacco is associated with the development of chronic lung diseases including chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis. Our results show that nicotine exposure upregulated a subset of genes only in the cells previously exposed to nickel. Furthermore, our analyses indicate robust activation of interferon (IFN) signaling in these cells. IFN signaling is a driver of inflammation, which is associated w...
Source: Toxicology and Applied Pharmacology - November 11, 2023 Category: Toxicology Authors: Xiaoru Zhang Beatrix Bradford Sahdev Baweja Taotao Tan Hyun-Wook Lee Cynthia C Jose Nicholas Kim Manpreet Katari Suresh Cuddapah Source Type: research

Nickel-induced transcriptional memory in lung epithelial cells promotes interferon signaling upon nicotine exposure
In this study, we investigated whether nickel-induced transcriptional memory influences the outcome of the cell's response to a second respiratory toxicant, nicotine. Nicotine, an addictive compound in tobacco is associated with the development of chronic lung diseases including chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis. Our results show that nicotine exposure upregulated a subset of genes only in the cells previously exposed to nickel. Furthermore, our analyses indicate robust activation of interferon (IFN) signaling in these cells. IFN signaling is a driver of inflammation, which is associated w...
Source: Toxicology and Applied Pharmacology - November 11, 2023 Category: Toxicology Authors: Xiaoru Zhang Beatrix Bradford Sahdev Baweja Taotao Tan Hyun-Wook Lee Cynthia C Jose Nicholas Kim Manpreet Katari Suresh Cuddapah Source Type: research

Nickel-induced transcriptional memory in lung epithelial cells promotes interferon signaling upon nicotine exposure
In this study, we investigated whether nickel-induced transcriptional memory influences the outcome of the cell's response to a second respiratory toxicant, nicotine. Nicotine, an addictive compound in tobacco is associated with the development of chronic lung diseases including chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis. Our results show that nicotine exposure upregulated a subset of genes only in the cells previously exposed to nickel. Furthermore, our analyses indicate robust activation of interferon (IFN) signaling in these cells. IFN signaling is a driver of inflammation, which is associated w...
Source: Toxicology and Applied Pharmacology - November 11, 2023 Category: Toxicology Authors: Xiaoru Zhang Beatrix Bradford Sahdev Baweja Taotao Tan Hyun-Wook Lee Cynthia C Jose Nicholas Kim Manpreet Katari Suresh Cuddapah Source Type: research

Platinum-based chemotherapy induces demyelination of Schwann cells in oral squamous cell carcinoma treatment
CONCLUSION: Cisplatin and carboplatin, but not oxaliplatin, caused mitochondrial dysfunction and induced demyelination in RSC96 while showing similar toxicity to head and neck cancer cells. Oxaliplatin may be a potential chemotherapy drug to prevent CIPN in patients with head and neck cancer.PMID:37944569 | DOI:10.1016/j.taap.2023.116751 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - November 9, 2023 Category: Toxicology Authors: Xian Wang Weifa Yang Leilei Wang Liwu Zheng Wing Shan Choi Source Type: research

Platinum-based chemotherapy induces demyelination of Schwann cells in oral squamous cell carcinoma treatment
CONCLUSION: Cisplatin and carboplatin, but not oxaliplatin, caused mitochondrial dysfunction and induced demyelination in RSC96 while showing similar toxicity to head and neck cancer cells. Oxaliplatin may be a potential chemotherapy drug to prevent CIPN in patients with head and neck cancer.PMID:37944569 | DOI:10.1016/j.taap.2023.116751 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - November 9, 2023 Category: Toxicology Authors: Xian Wang Weifa Yang Leilei Wang Liwu Zheng Wing Shan Choi Source Type: research

Quantitative transcriptomic and proteomic analysis reveals corosolic acid inhibiting bladder cancer via suppressing cell cycle and inducing mitophagy in vitro and in vivo
This study provides a comprehensive understanding of the pharmacological mechanism of CA inhibition in bladder cancer, which is helpful for the development of new anti-tumor drugs based on CA.PMID:37939859 | DOI:10.1016/j.taap.2023.116749 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - November 8, 2023 Category: Toxicology Authors: Anfang Cui Xiangling Li Xiaolei Ma Zhigang Song Xiao Wang Chao Wang Yong Xia Source Type: research

Quantitative transcriptomic and proteomic analysis reveals corosolic acid inhibiting bladder cancer via suppressing cell cycle and inducing mitophagy in vitro and in vivo
This study provides a comprehensive understanding of the pharmacological mechanism of CA inhibition in bladder cancer, which is helpful for the development of new anti-tumor drugs based on CA.PMID:37939859 | DOI:10.1016/j.taap.2023.116749 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - November 8, 2023 Category: Toxicology Authors: Anfang Cui Xiangling Li Xiaolei Ma Zhigang Song Xiao Wang Chao Wang Yong Xia Source Type: research

Tumor suppressive activity of AHR in environmental arsenic-induced carcinogenesis
Toxicol Appl Pharmacol. 2023 Nov 5:116747. doi: 10.1016/j.taap.2023.116747. Online ahead of print.ABSTRACTThe aryl hydrocarbon receptor (AHR) is a highly conserved pleiotropic transcription factor that senses environmental pollutants, microbial products, and endogenous ligands. The transcriptional targets of AHR include phase I and phase II detoxification enzymes, as well as numerous signaling molecules that affect a wide spectrum of biological and biochemical processes in a manner of cellular context-dependent. In this review, we systematically assess the latest discoveries of AHR in carcinogenesis with an emphasis on its...
Source: Toxicology and Applied Pharmacology - November 7, 2023 Category: Toxicology Authors: Ziwei Wang Yao Fu Akimasa Seno Zhuoyue Bi Aashna S Pawar Haoyan Ji Bandar Saeed Almutairy Yiran Qiu Wenxuan Zhang Chitra Thakur Fei Chen Source Type: research

Tumor suppressive activity of AHR in environmental arsenic-induced carcinogenesis
Toxicol Appl Pharmacol. 2023 Nov 5:116747. doi: 10.1016/j.taap.2023.116747. Online ahead of print.ABSTRACTThe aryl hydrocarbon receptor (AHR) is a highly conserved pleiotropic transcription factor that senses environmental pollutants, microbial products, and endogenous ligands. The transcriptional targets of AHR include phase I and phase II detoxification enzymes, as well as numerous signaling molecules that affect a wide spectrum of biological and biochemical processes in a manner of cellular context-dependent. In this review, we systematically assess the latest discoveries of AHR in carcinogenesis with an emphasis on its...
Source: Toxicology and Applied Pharmacology - November 7, 2023 Category: Toxicology Authors: Ziwei Wang Yao Fu Akimasa Seno Zhuoyue Bi Aashna S Pawar Haoyan Ji Bandar Saeed Almutairy Yiran Qiu Wenxuan Zhang Chitra Thakur Fei Chen Source Type: research

Association of urinary arsenic, polycyclic aromatic hydrocarbons, and metals with cancers among the female population in the US
CONCLUSION: This study determined breast cancer and arsenic and some metal species exposure, indicating an inverse association. Arsenic acid and arsenobetaine exposure showed a positive correlation with cervical cancer. For uterine cancer, the correlations for the PAH compounds and cobalt showed a positive correlation, and the arsenic species and mercury were inversely associated. Further research is required to establish or refute the findings.PMID:37931756 | DOI:10.1016/j.taap.2023.116746 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - November 6, 2023 Category: Toxicology Authors: Humairat H Rahman Walker Toohey Stuart H Munson-McGee Source Type: research