Toxicology and Applied Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Flavokawain B inhibits NF- κB inflammatory signaling pathway activation in inflammatory bowel disease by targeting TLR2
In this study, we aimed to investigate the effects and mechanisms of FKB targeting TLR2 in IBD. C57BL/6 J mice were treated with 2.5% dextran sulfate sodium (DSS) for 7 days, with administration of FKB or TLR2 inhibitor C29 starting on day 2 to establish the model of IBD. In vitro, bone marrow-derived macrophages (BMDMs) were stimulated with the TLR2 agonist Pam3CSK4 to explore the therapeutic effect of FKB and its pharmacological mechanism. Compared with the model group, the FKB-treated group showed significant reductions in colitis-related injuries in the IBD mouse model, including weight gain, increased colon length and...
Source: Toxicology and Applied Pharmacology - April 7, 2024 Category: Toxicology Authors: Yi Chen Tianyang Jin Mengpei Zhang Bo Hong Bo Jin Chenghong Hu Jiong Wang Yue Chen Lingxi Zhang Yi Wang Lijiang Huang Source Type: research

Insufficient secretion of pancreatic FGF21 is the toxicological mechanism and therapeutic target of asparaginase-associated pancreatitis
In this study, we found that the decrease of FGF21 in pancreas is closely related to AAP. Pegaspargase (1 IU/g) induces widespread edema and inflammatory infiltration in the pancreas of rats/mice. The specific expression of FGF21 in the acinar tissue of AAP rats was significantly downregulated. Asparaginase caused dysregulation of the ATF4/ATF3/FGF21 axis in acinar tissue or cells, and thus mediated the decrease of FGF21. It greatly activated ATF3 in the acinar, which competed with ATF4 for the Fgf21 promoter, thereby inhibiting the expression of FGF21. Pharmacological replacement of FGF21 (1 mg/kg) or PERK inhibitors (GSK...
Source: Toxicology and Applied Pharmacology - April 6, 2024 Category: Toxicology Authors: Jiang He Yajing Chen Wen Zhong Lu Jun Dong Chen Hui Cheng Wang Mei Source Type: research

Network toxicology, molecular docking technology, and experimental verification revealed the mechanism of cantharidin-induced testicular injury in mice
In this study, the toxic effects of CTD on mouse testis were confirmed in vivo and the potential mechanism was predicted by network toxicology (NT) and molecular docking technology. Proteins involved in the signaling pathways and core targets were verified. The results showed that different concentrations of CTD induced weight loss increased the testicular coefficient, and caused obvious pathological damage to testicular cells. The NT results showed that the main targets of CTD-induced testicular injury (TI) included AKT1, Caspase 3, Bcl-2, and Bax. The results of pathway enrichment analysis showed that CTD-induced TI was ...
Source: Toxicology and Applied Pharmacology - April 6, 2024 Category: Toxicology Authors: Ruxia Liu Changfu Yang Xin Yang Jia Yu Wenchao Tang Source Type: research

Exposure to topiramate and acetazolamide causes endocrine disrupting effects in female rats during estrus
CONCLUSION: These results demonstrate that both acetazolamide and topiramate have endocrine disrupting effects in rats. Topiramate primarily targeted the choroid plexus and the pituitary gland while acetazolamide had broader systemic effects. Furthermore, topiramate predominantly targeted sex hormones, whereas acetazolamide widely affected all classes of hormones. A similar effect in humans has not yet been documented but these concerning findings warrants further investigations.PMID:38580201 | DOI:10.1016/j.taap.2024.116919 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - April 5, 2024 Category: Toxicology Authors: Christina Kamp-Jensen Louise Norgil Donslund Bjarne Styrishave Rigmor H øjland Jensen Connar Stanley James Westgate Source Type: research

Development of fentanyl-specific monoclonal antibody (mAb) to antagonize the pharmacological effects of fentanyl
In conclusion, mAb passive immunization represents a viable strategy for addressing fentanyl addiction and overdose.PMID:38570042 | DOI:10.1016/j.taap.2024.116918 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - April 3, 2024 Category: Toxicology Authors: Xiao-Yi Chen Li Wang Xiao Ma Fan Yang Xiao Wang Peng Xu Li-Li Xu Bin Di Source Type: research

Indole-3 acetic acid induced cardiac hypertrophy in Wistar albino rats
Toxicol Appl Pharmacol. 2024 Mar 28:116917. doi: 10.1016/j.taap.2024.116917. Online ahead of print.ABSTRACTIndole-3-acetic acid (IAA) is the most widely utilized plant growth regulator. Despite its extensive usage, IAA is often overlooked as an environmental pollutant. Due to its protein-binding nature, it also functions as a uremic toxin, contributing to its association with chronic kidney disease (CKD). While in vitro and epidemiological research have demonstrated this association, the precise impact of IAA on cardiovascular disease in animal models is unknown. The main objective of this study is to conduct a mechanistic...
Source: Toxicology and Applied Pharmacology - March 30, 2024 Category: Toxicology Authors: S P Ramya Ranjan Nayak Seenivasan Boopathi Muniswamy Chandrasekar B Yamini Vellapandian Chitra Bader O Almutairi Selvaraj Arokiyaraj Ajay Guru Jesu Arockiaraj Source Type: research

Sulforaphane inhibits the migration and invasion of BPDE-induced lung adenocarcinoma cells by regulating NLRP12
This study aims to explore the impact and underlying mechanism of sulforaphane (SFN) intervention on the migration and invasion of lung adenocarcinoma induced by 7, 8-dihydroxy-9, 10-epoxy-benzo (a) pyrene (BPDE). Human lung adenocarcinoma A549 cells were exposed to varying concentrations of BPDE (0.25, 0.50, and 1.00 μM) and subsequently treated with 5 μM SFN. Cell viability was determined using CCK8 assay, while migration and invasion were assessed using Transwell assays. Lentivirus transfection was employed to establish NLRP12 overexpressing A549 cells. ELISA was utilized to quantify IL-33, CXCL12, and CXCL13 levels i...
Source: Toxicology and Applied Pharmacology - March 27, 2024 Category: Toxicology Authors: Wei Wang Shufan Chang Xi He XiaoLei Zhou Pingping Shang Yusong Chen Xiaoke Wang Lijuan Chen Qiao Zhang Yahong Qiao Feifei Feng Source Type: research