Toxicology and Applied Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Microcystin-LR sensitizes the Oncorhynchus mykiss intestinal epithelium and interacts with paralytic shellfish toxins to alter oxidative balance
Toxicol Appl Pharmacol. 2024 Mar 13;485:116891. doi: 10.1016/j.taap.2024.116891. Online ahead of print.ABSTRACTIn the context of harmful algal blooms, fish can be exposed to the combined effects of more than one toxin. We studied the effects of consecutive exposure to Microcystin-LR (MCLR) in vivo and paralytic shellfish toxins (PST) ex vivo/in vitro (MCLR+PST) in the rainbow trout Oncorhynchus mykiss's middle intestine. We fed juvenile fish with MCLR incorporated in the feed every 12 h and euthanized them 48 h after the first feeding. Immediately, we removed the middle intestine to make ex vivo and in vitro preparations a...
Source: Toxicology and Applied Pharmacology - March 14, 2024 Category: Toxicology Authors: Julio C Painefil ú Carolina Gonz ález Bernd Krock Flavia Bieczynski Carlos M Luquet Source Type: research

Microcystin-LR sensitizes the Oncorhynchus mykiss intestinal epithelium and interacts with paralytic shellfish toxins to alter oxidative balance
Toxicol Appl Pharmacol. 2024 Mar 12:116891. doi: 10.1016/j.taap.2024.116891. Online ahead of print.ABSTRACTIn the context of harmful algal blooms, fish can be exposed to the combined effects of more than one toxin. We studied the effects of consecutive exposure to Microcystin-LR (MCLR) in vivo and paralytic shellfish toxins (PST) ex vivo/in vitro (MCLR+PST) in the rainbow trout Oncorhynchus mykiss's middle intestine. We fed juvenile fish with MCLR incorporated in the feed every 12 h and euthanized them 48 h after the first feeding. Immediately, we removed the middle intestine to make ex vivo and in vitro preparations and e...
Source: Toxicology and Applied Pharmacology - March 14, 2024 Category: Toxicology Authors: Julio C Painefil ú Carolina Gonz ález Bernd Krock Flavia Bieczynski Carlos M Luquet Source Type: research

Transcriptomic analysis reveals particulate hexavalent chromium regulates key inflammatory pathways in human lung fibroblasts as a possible mechanism of carcinogenesis
This study showed for the first time that Cr(VI) regulates key inflammatory pathways in human lung fibroblasts, providing novel insights into the mechanisms by which Cr(VI) causes lung cancer.PMID:38479592 | DOI:10.1016/j.taap.2024.116889 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 13, 2024 Category: Toxicology Authors: J Calvin Kouokam Rachel M Speer Idoia Meaza Jennifer H Toyoda Haiyan Lu John Pierce Wise Source Type: research

Downregulation of mesenteric afferent sensitivity following long-term systemic treatment of vincristine in mice
CONCLUSIONS: These results suggest that the direct stimulation by VCR increases the mesenteric afferent sensitivity by activating TRPV1, which may be the reason of VCR-induced abdominal pain; the long-term systemic treatment of VCR decreases mesenteric afferent sensitivity by reducing TRPV1, which may be the reason of VCR-induced constipation.PMID:38458354 | DOI:10.1016/j.taap.2024.116887 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 8, 2024 Category: Toxicology Authors: Shuang Li Mengyuan Yang Yao Shi Jingxin Li Chuanyong Liu Source Type: research

Downregulation of mesenteric afferent sensitivity following long-term systemic treatment of vincristine in mice
CONCLUSIONS: These results suggest that the direct stimulation by VCR increases the mesenteric afferent sensitivity by activating TRPV1, which may be the reason of VCR-induced abdominal pain; the long-term systemic treatment of VCR decreases mesenteric afferent sensitivity by reducing TRPV1, which may be the reason of VCR-induced constipation.PMID:38458354 | DOI:10.1016/j.taap.2024.116887 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 8, 2024 Category: Toxicology Authors: Shuang Li Mengyuan Yan Yao Shi Jingxin Li Chuanyong Liu Source Type: research

The SMAC mimetic GDC-0152 is a direct ABCB1-ATPase activity modulator and BIRC5 expression suppressor in cancer cells
In conclusion, GDC-0152 has the potential for use in the management of cancer patients with ABCB1 and BIRC5-related drug resistance. The findings of our study provide essential information to physicians for designing a more patient-specific GDC-0152 clinical trial program in the future.PMID:38452945 | DOI:10.1016/j.taap.2024.116888 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 7, 2024 Category: Toxicology Authors: I-Li Lin Yu-Ting Lin Yung-Chieh Chang Sree Karani Kondapuram Kai-Hsuan Lin Pin-Chen Chen Chung-Ying Kuo Mohane Selvaraj Coumar Chun Hei Antonio Cheung Source Type: research

Bronchioalveolar organoids: A preclinical tool to screen toxicity associated with antibody-drug conjugates
Toxicol Appl Pharmacol. 2024 Mar 5:116886. doi: 10.1016/j.taap.2024.116886. Online ahead of print.ABSTRACTDespite extensive preclinical testing, cancer therapeutics can result in unanticipated toxicity to non-tumor tissue in patients. These toxicities may pass undetected in preclinical experiments due to modeling limitations involving poor biomimicry of 2-dimensional in vitro cell cultures and due to lack of interspecies translatability in in vivo studies. Instead, primary cells can be grown into miniature 3-dimensional structures that recapitulate morphological and functional aspects of native tissue, termed "organoids." ...
Source: Toxicology and Applied Pharmacology - March 7, 2024 Category: Toxicology Authors: Tara N McCray Vy Nguyen Jake S Heins Elizabeth Nguyen Kristen Stewart Colby T Ford Calvin Neace Priyanka Gupta David J Ortiz Source Type: research

Role of MST2/YAP1 signaling pathway in retinal cells apoptosis and diabetic retinopathy
Toxicol Appl Pharmacol. 2024 Mar 4:116885. doi: 10.1016/j.taap.2024.116885. Online ahead of print.ABSTRACTDiabetic retinopathy (DR) is a main factor affecting vision of patients, and its pathogenesis is not completely clear. The purpose of our study was to investigate correlations between MST2 and DR progression, and to study the possible mechanism of MST2 and its down pathway in high glucose (HG)-mediated RGC-5 apoptosis. The diabetic rat model was established by intraperitoneal injection of streptozotocin (STZ) 60 mg/kg. HE and TUNEL staining were used to evaluate the pathological changes and apoptosis of retinal cells i...
Source: Toxicology and Applied Pharmacology - March 6, 2024 Category: Toxicology Authors: Xiao Zhang Dongmei Su Dong Wei Xiaoya Chen Yuzhu Hu Sijia Li Yue Zhang Xu Ma Shanshan Hu Zhaoyi Sun Source Type: research

Molecular docking, characterization, ADME/toxicity prediction, and anti-ulcer activity of new quercetin derivatives on indomethacin-induced gastric ulcer in mice
Toxicol Appl Pharmacol. 2024 Mar 4:116880. doi: 10.1016/j.taap.2024.116880. Online ahead of print.ABSTRACTGastric ulcer (GU) is a serious upper gastrointestinal tract disorder that affects people worldwide. The drugs now available for GU treatment have a high rate of relapses and drug interactions, as well as mild to severe side effects. As a result, new natural therapeutic medications for treating GU with fewer negative side effects are desperately needed. Because of quercetin's (QCT) diverse pharmacological effects and unique structural features, we decided to semi-synthesize new QCT derivatives and test them for antiulc...
Source: Toxicology and Applied Pharmacology - March 6, 2024 Category: Toxicology Authors: Maha B Salem Abdulrahman M Saleh Sayed H Seif El-Din Safia Samir Olfat A Hammam Naglaa M El-Lakkany Source Type: research